Relaxant Research Articles

Unraveling calcium dysregulation and autoimmunity in immune mediated rippling muscle disease

Rippling Muscle Disease (RMD) is a rare skeletal myopathy characterized by abnormal muscular excitability manifesting with wave-like muscle contractions and percussion-induced muscle mounding. Hereditary RMD is associated with caveolin-3 or cavin-1 mutations. Recently, we identified cavin 4 autoantibodies as a biomarker of immune-mediated RMD (iRMD), though the underlying disease-mechanisms remain poorly understood. Transcriptomic studies were performed on muscle biopsies of 8 patients (5 males; 3 females; ages 26-to-80) with iRMD. Subsequent pathway analysis compared iRMD to human non-disease control and disease control (dermatomyositis) muscle samples. Transcriptomic studies demonstrated changes in key pathways of muscle contraction and development. All iRMD samples had significantly upregulated cavin-4 expression compared to controls, likely compensatory for autoantibody-mediated protein degradation. Proteins involved in muscle relaxation (including SERCA1, PMCA and PLN) were significantly increased in iRMD compared to controls. Comparison of iRMD to dermatomyositis transcriptomics demonstrated significant overlap in immune pathways, and the IL-6 signaling pathway was markedly increased in all iRMD patient muscle biopsies and increased in the majority of iRMD patients’ serum. This study represents the first muscle transcriptomic analysis of iRMD patients and dissects underlying disease mechanisms. Increase of sarcolemmal and cellular calcium channels as well as PLN, an inhibitor of the SERCA pump for calcium into the sarcoplasm, likely alters the calcium dynamics in iRMD. These changes in crucial components of muscle relaxation may underlie rippling by altering calcium flux. Our findings provide crucial insights into the differential expression of genes regulating muscle relaxation and highlight potential disease pathomechanisms.

“A Study to Assess Effectiveness of Progressive Muscle Relaxation Technique on Reduction of Stress among Patients with Breast Cancer Admitted in Selected Cancer Hospitals of Bagalkot’’

“A Study to Assess Effectiveness of Progressive Muscle Relaxation Technique on Reduction of Stress among Patients with Breast Cancer Admitted in Selected Cancer Hospitals of Bagalkot’’

Boosting the innovation transformation of clinical medicine based on core technology in anesthesiology

The core technologies proposed in surgery have boosted the innovation transformation and disciplinary development. However, the core technologies in anesthesiology remain undefined both domestically and internationally. Through collaborative discussions among Chinese anesthesiologists, the core technologies of anesthesiology can be succinctly summarized as Relief of pain, Regulation of life, Resuscitation, and Restoration of organ function, and collectively referred to as the 4R technologies. Their primary components include: (1) Technology for sedation, analgesia and muscle relaxation; (2) Technology for the monitoring and regulation of life; (3) Technology for resuscitation and restoration of organ function; (4) Technology for diagnosis and therapy for acute and chronic pain, as well as functional regulation. Up to now, there is still a significant gap between the current situation of anesthesiology and the requirements of core technologic content. Exclusive innovation transformation can remodel the new future of anesthesiology.

Therapeutic effect of proprioceptive dolphin assisted activities on health-related quality of life and muscle tension, biomechanical and viscoelastic properties in major depressive disorder adults: case analysis

IntroductionThe case analysis method is widely used in evaluating dolphin assisted activities due to the lack of research participants. Despite other present diagnostic features adults with major depressive disorder experience psychomotor changes, dysphoria, anhedonia, impaired concentration, and suicidal thoughts. Increasing studies assess the positive effect of proprioceptive exercises in various depressive cases.Methods14 adults diagnosed major depressive disorder included in this case study between September 2022 to April 2024. A two-week proprioceptive dolphin assisted activity program was applied for each with a two-day break after half applied activities, in total 10 activities for each were organised. Proprioceptive dolphin assisted activities varied from heavy muscle work to muscles and joints pressure which was held in a special therapeutic pool, where adults wore wetsuits. The SF—36 scale was used, with levels of QoL compared among: (a) before dolphin assisted activities, (b) after two-week proprioceptive dolphin assisted activities, (c) in a year after two-week proprioceptive dolphin assisted activities. The MyotonPro portable device was used for measuring muscle tension, biomechanical and viscoelastic properties each day of participation: (a) before dolphin assisted activities and (b) after dolphin assisted activities. The MyotonPro was applied to measure the upper (descending) part of the trapezius muscle, lateral part of the deltoids muscle, middle point of the flexor carpi radialis muscle, middle point of the long head of the biceps brachii muscle, the gastrocnemius muscle (plural gastrocnemii), and quadriceps femoris muscle.ResultsThe measuring results of SF—36 scale showed statistically significant changes in 5 subscales out of 8 (Friedman’s test p-value less than 0.05) and in one more scale a partially significant change (p < 0.1). The physical activity that increased after dolphin therapy (from 68.5 to 85) remained the same in one year. There were no statistically significant changes in role limitations due to physical health. However, role limitations due to emotional problems and partially significant changes were recorded, the situation slightly worsened a year later, but there was no statistically significant deterioration. The non-parametric Wilcoxon test was used to compare two dependent samples measured by the MyotonPro. Although the improvement was recorded in almost all muscle groups, statistically significant changes were observed only in trapezius muscle md p right, measuring stiffness, relaxation and creep; trapezius md p left measuring frequency, stiffness, relaxation and decrement; and deltoids muscle left, measuring frequency, stiffness and relaxation, i.e., the p-values of Wilcoxon test are less than 0.05.ConclusionTwo-weeks of proprioceptive dolphin assisted activities for adults with major depression have statistically significant long-term change in better physical parameters. Emotional betterment parameters were less stable. The quick reactivity of trapezius muscle revealed that dolphin assisted activities acts as stress relief, and deltoids muscle as relief of negative emotions, such as fear and anger.

NEUROMUSCULAR MONITORING DURING GENERAL ANESTHESIA

Neuromuscular monitoring during general anaesthesia is a crucial practice for the proper management of muscle blocks, allowing the dosage of muscle relaxants to be optimized and adverse effects to be minimized. The use of neuromuscular blocking agents is common in surgery, especially to facilitate intubation and muscle relaxation. However, inappropriate or excessive use of these agents can result in post-operative complications, such as residual muscle weakness, breathing difficulties and delayed recovery. Neuromuscular monitoring has proven to be an essential tool for mitigating these risks. The aim of this study is to evaluate the benefits of neuromuscular monitoring during general anesthesia, with a focus on reducing postoperative complications such as residual muscle weakness, respiratory difficulty and prolonged recovery time. The aim is also to compare the results of patients who receive real-time monitoring with those who do not. This is a qualitative literature review whose aim is to explore the implications of neuromuscular monitoring in anesthetic practices and its effects on postoperative recovery, opioid consumption and residual neuromuscular blockade. To this end, the PubMed, Scopus and Web of Science databases will be used. The review will be refined using health descriptors such as “Neuromuscular Monitoring,” “Residual Paralysis,” “Opioid Consumption,” with a time frame from 1998 to 2020, covering both review articles and clinical studies and randomized trials. Neuromuscular monitoring has shown clear benefits in reducing residual muscle weakness and improving postoperative respiratory function. Studies indicate that patients who use real-time monitoring during general anesthesia have shorter recovery times, lower rates of respiratory complications and less need for assisted ventilation. In addition, monitoring allows for more precise dosing of muscle relaxants, avoiding overuse and the occurrence of adverse effects. When applied correctly, monitoring also contributes to reducing the duration of anesthesia and improves the patient’s post-operative experience. Neuromuscular monitoring during general anesthesia is essential for reducing postoperative complications, especially residual muscle weakness and respiratory difficulty. Its effective use contributes to a faster and safer recovery for patients, allowing healthcare professionals to adjust the dosage of muscle blockers more precisely. The widespread implementation of this practice in surgical centers is recommended to optimize anesthetic management and improve postoperative outcomes.

Severe Obsessive‒compulsive Disorder of Transformation in a 13-year-old Adolescent: A Case Report

Introduction: Obsessive-compulsive Disorder (OCD) with transformation obsession is a rare psychiatric disorder that can pose various diagnostic difficulties and treatment challenges. Scientific research focusing on this disorder in adolescents is scarce. In this work, we present the case of a teenage girl who was treated for severe OCD with transformation obsession. The psychiatric management of this adolescent was performed on an outpatient basis and took place in the juvenile department at Saint Ylie Hospital (France). We hope that our work will add to the existing data on the psychiatric management of this condition in adolescents. In this work, we used the Diagnostic and Statistical Manual of Mental Disorders 5th version for the evaluation of psychiatric disorders and the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) to assess the severity of symptoms. Case Presentation: The patient (13 years old) experienced persistent, intrusive, and distressing ideas about transforming into another person. Despite knowing how unreal these ideas were, she feared they would come true. She had rituals that she felt compelled to carry out to help her manage her worries temporarily. She also experienced involuntary non-rhythmic movements of the facial muscles simultaneously. The patient was diagnosed with OCD with good insight and comorbid tics. Initially, the total CY-BOCS score was 40/40. Psychosis was considered a differential diagnosis due to the atypicality of the clinical manifestation, but it was ruled out after a thorough clinical evaluation. Psychotherapeutic management was not possible before adequate pharmaceutical treatment was started because of invasive and distressing symptoms. The pharmacological management led to the administration of a combination of fluoxetine at a dose of 40mg with olanzapine at a dose of 5mg after a partial response to fluoxetine alone. Weekly individual Cognitive Behavioral Therapy (CBT) was started as soon as the adolescent's condition allowed and included psychoeducation, muscle relaxation techniques, cognitive restructuring, Exposure and Response Prevention (ERP), self-affirmation work, and relapse prevention. At the same time, parents also benefited from psychoeducational interventions. The evolution was marked by total clinical remission and clear psychometric improvement. The total CY-BOCS score ranged from 40/40 to 07/40 after 5 months of CBT. No adverse effects were reported throughout the treatment. Conclusion: This case shows the possibility of unusual and severe OCD in adolescents. It also highlights the importance of careful diagnosis so as not to be mistaken and consider it a psychosis. The management of this type of OCD requires the combination of two pharmacological treatments before starting individual CBT and psychoeducational intervention for parents. This combination allows a complete clinical remission after a few months. It is preferable that further clinical trials be conducted to protocolize the management of this type of OCD.

PENERAPAN TERAPI PROGRESSIVE MUSCLE RELAXATION TERHADAP NYERI AKUT PRE OPERASI FRACTURE NECK FEMUR

Fractures or breaks in the continuity of bone structure are a major problem in the health sector. Tissue damage causes several typical clinical manifestations, namely pain. If not treated immediately, it can cause immobilization of the individual to carry out self-care activities. This study aims to determine the application of progressive muscle relaxation therapy to acute pain in preoperative patients with left femoral neck fractures in the Agung Wilis Accident Surgery Room, Blambangan Hospital. The research design used a case study of nursing care for femoral neck fracture patients with acute pain and carried out assessment, diagnosis, action planning, implementation and evaluation. Data collection methods through interviews and direct observation. The results of Mrs. N complained of pain from a femoral neck fracture, pain like being stabbed in the thigh area radiating to the pelvis on a scale of 7, the pain seemed to come and go. Interventions are given to reduce pain levels with progressive muscle relaxation. The evaluation revealed a change in the scale before therapy was given, namely a pain scale of 7 to 5. It can be concluded that the application of progressive muscle relaxation can be an alternative in treating pain in fracture sufferers.

PROGRESSIVE MUSCLE RELAXATION THERAPY TO RELIEVE DENTAL ANXIETY

Background: Dental anxiety is complex phenomenon which is associated with the thought of visiting the dentist for therapeutic or care. It may be either physical, mental or social anxiety. The most common causes of anxiety in dental patients is fear of injections, fear of choking or gagging and fear of blood. It can be shown as fear, anxiety, phobia, stress, shivering, sweating, crying during or before dental treatment. Sympathetic nervous system is activated during dental anxiety and there is provoke of fight or flight response. This causes changes in various physiological activities such as reduction in pain threshold, increase in treatment complications, post- treatment pain, late healing. Identifying anxiety in dental patient is the first and foremost step in determining the type of treatment and schedule of appointments. Progressive muscle relaxation is one such technique a where muscles and body are allowed to relax after they are tensed. Materials and methods: PubMed, Scopus, Web of Science, Google scholar was searched using pre-specified search strategy. Narrative and systematic reviews are included for the data synthesis. Results: Extensive literature search was carried out using pre-defined search strategy was carried out. A total of 73 titles were screened rigorously by two independent evaluators and after duplicate exclusion, removal of irrelevant titles, 34 articles were included for full text. This review aims at detailing progressive muscle relaxation technique, a non-pharmacological, economical approach to relieve dental anxiety.

Potential beneficial impacts of tadalafil on cardiovascular diseases.

Tadalafil is a selective phosphodiesterase type 5 (PDE5) inhibitor commonly used for the treatment of erectile dysfunction and benign prostatic hyperplasia. Its mechanism of action involves the inhibition of PDE5, leading to increased levels of nitric oxide and cyclic guanosine monophosphate in the corpus cavernosum, which facilitates smooth muscle relaxation. This article reviews studies using tadalafil in the treatment of cardiovascular diseases and emphasizes its potential advantages in conditions such as pulmonary arterial hypertension, atherosclerosis, coronary artery disease, myocardial infarction, heart failure, stroke, diabetic ulcers, and cardiomyopathy. Although tadalafil shows potential efficacy in treating cardiovascular disease, further experimental studies are needed to clarify its pharmacological effects on cardiovascular protection beyond PDE5 inhibition.

Heavy gravity combined with light gravity local anesthetic in subarachnoid anesthesia for cesarean section did not reduce the incidence of intraoperative hypotension in maternal women: a prospective cohort study

BackgroundSubarachnoid anesthesia is the primary anesthetic method for elective cesarean section surgery, characterized by rapidly taking effect and reliable analgesia. However, subarachnoid anesthesia is prone to cause a high block level, resulting in a high incidence of maternal hypotension. How to reduce the incidence of maternal hypotension under subarachnoid anesthesia is a practical problem that needs to be solved urgently in clinical practice.MethodsThis prospective cohort study was performed at Nantong Maternal and Child Health Care Hospital in China between January and July 2023. This study compared the incidence of hypotension in pregnant women undergoing subarachnoid anesthesia during elective cesarean section in four groups, including group A (control group) with 10 mg of 10% glucose solution; Group B with 5 mg 10% glucose solution group; Group C with 4 mg 10% glucose solution group; Group D with 2 mg 10% glucose solution group. Each group was given a dose of 10 mg Ropivacaine with a concentration of 0.5% and a volume of 2 ml. The primary outcome was the incidence of maternal hypotension. The secondary outcomes were the plane of anesthesia, abdominal wall muscle relaxation degree and the incidence of adverse events.ResultsData from 74 (18, A group; 26, B group; 15, C group; 15, D group) participants were analyzed. Hyperbaric combined with hypobaric local anesthetic in subarachnoid anesthesia for cesarean section did not reduce the incidence of intraoperative hypotension in pregnant women (P = 0.152). The plane of anesthesia gradually shifted from T4 to T10 as the specific gravity of ropivacaine decreased (P < 0.01). Satisfaction about abdominal wall muscle relaxation degree gradually decreased with the decrease of the specific gravity of ropivacaine (P = 0.04). And the incidence of adverse events gradually increased with the decrease of the specific gravity of ropivacaine (P = 0.027).ConclusionsHyperbaric combined with hypobaric local anesthetic in subarachnoid anesthesia for cesarean section did not reduce the incidence of intraoperative hypotension in pregnant women.

Remifentanil-Propofol-Ketamine- Based Total Intravenous Anesthesia with Spontaneous Breathing for Adult Rigid Bronchoscopy

Background: Rigid bronchoscopy (RB) is the gold standard for managing central airway obstruction (CAO), a life-threatening condition caused by both malignant and benign etiologies. Anesthetic management is challenging as it requires balancing deep sedation with maintaining spontaneous breathing to avoid airway collapse. There is no consensus on the optimal anesthetic approach, with options including general anesthesia with neuromuscular blockers or spontaneous assisted ventilation (SAV). Methods: This case series presents our anesthetic protocol using remifentanil–propofol–ketamine total intravenous anesthesia (TIVA) with SAV in four patients with airway obstructions. Muscle relaxants were avoided in all cases. Results: Ketamine’s ability to preserve respiratory drive and airway reflexes, along with its bronchodilating properties, made it ideal for managing CAO. All procedures successfully restored airway patency without complications or drug-related side effects. Conclusions: Our findings suggest that remifentanil–propofol–ketamine TIVA combined with SAV is a viable anesthetic approach for therapeutic RB, offering effective sedation, maintaining airway patency, and minimizing perioperative complications.

Comparative Impact of Kinesio Taping and Post-Isometric Muscle Relaxation on Pain and Myofascial Mechanics in Chronic Low Back Pain: A Randomized Clinical Trial

Comparative Impact of Kinesio Taping and Post-Isometric Muscle Relaxation on Pain and Myofascial Mechanics in Chronic Low Back Pain: A Randomized Clinical Trial

Efficacy, Indications, and Safety of Intrathecal Baclofen Pump: A Narrative Review.

Baclofen, a muscle relaxant that reduces the release of excitatory neurotransmitters in the pre-synaptic neurons stimulating inhibitory neuronal signals in post-synaptic neurons, has been around for over 5 decades. Baclofen is used primarily for spasticity and since 1982, has had a role as an intrathecal agent. In the present investigation, we review research trends and updates on safety and efficacy of intrathecal baclofen (ITB) pumps. Evaluation of safety and efficacy of ITB pumps in spasticity and relevant conditions was evaluated in the present investigation. PubMed and ClinicalTrials.gov were used to review appropriate related literature. Commonly reported aspects regarding ITB efficacy include comparison with alternative treatments, maintenance efficacy, and long-term outcomes. Safety considerations and risk factors associated with ITB include postoperative complications, withdrawal symptoms, tolerance issues, long-term management, and contraindications. In summary, the present investigation reveals that ITB is efficacious for muscle spasticity; however, efforts should be made to enhance safety and efficacy by providing improved best practice guidelines on maximum safe dose with the least amount of risk with individualized treatments.

Meditation and guided imagery show reduction in chronic stress and increase in mental health-related quality of life for college students

Objective: To explore the effects of guided imagery with progressive deep muscle relaxation (PDMR) and meditation programs on chronic stress perception and health related quality of life in college students. Participants: College students were recruited from a local private university in Northeast Pennsylvania. Participants were not concurrently enrolled in another weekly meditation class. Students were randomly assigned to a meditation group (n = 16) or guided imagery with PDMR (n = 17). Method: The study design was an experimental, repeated measures design with two groups and two independent variables: the Perceived Stress Scale and Health-Related Quality of Life (SF-36v2). Results: Students in both the meditation and guided imagery groups demonstrated a decrease in chronic stress and increase in their mental-health related quality of life midway through the 8-week program and maintained throughout. Conclusion: This research lends support for weekly participation in a mind-body class as a viable method to decrease stress for college students.

Muscle relaxation enhances motor imagery capacity in people with anxiety: A randomized clinical trial.

Motor imagery is the mental representation of a movement without physical execution. When motor imagery is performed to enhance motor learning and performance, participants must reach a temporal congruence between the imagined and actual movement execution. Identifying factors that can influence this capacity could enhance the effectiveness of motor imagery programs. Anxiety frequently occurs in sports and rehabilitation where motor imagery is a relevant technique. It is associated with increased muscle tension and impairs the memory processes involved in motor imagery. This study aimed to determine whether muscle relaxation before motor imagery practice can influence motor imagery capacity and temporal congruence in anxious individuals, during internal and external visual imagery, and kinesthetic imagery. A randomized clinical trial was conducted in 55 young adults (20.3±2.8 years; 40 females; 15 males) with anxiety (percentile ≥75% on the State-Trait Anxiety Inventory). 26 participants were assigned to the relaxation group and 29 to the control group through stratified randomization. Motor imagery capacity and temporal congruence were assessed using the Movement Imagery Questionnaire-3 at 2 points (t1 and t2). Between t1 and t2, participants in the relaxation group underwent abbreviated progressive relaxation training. Electrodermal activity and heart rate variability were recorded to evaluate the relaxation effect. Data revealed a significant improvement in motor imagery capacity in the relaxation group, while the temporal congruence was not impaired in both groups. Pre-motor imagery muscle relaxation might improve motor imagery capacity in anxious individuals. This finding may contribute to better tailor motor imagery programs and to adjust motor imagery guidelines and recommendations for people with anxiety. This study has been registered in ClinicalTrials.gov (NCT04973956).

Raman spectroscopic fingerprinting for the identification and quantitative analysis of sports doping β-agonists based on gold nanopolyhedra.

Beta-stimulant, that is, β-adrenergic stimulant, also known as β-agonists, is bioactive catecholamine compounds naturally produced in animals' adrenal medulla glands that induce relaxation in asthmatic airway smooth muscles upon inhalation while also temporarily boosting athletic alertness and alleviating fatigue. However, their potential for dependency poses health risks including unnoticed exacerbation leading to severe illness or fatality prompting their inclusion on WADA's prohibited substances list. Surface-enhanced Raman spectroscopy (SERS) offers a rapid, sensitive, and label-free means for identifying characteristic peaks associated with β-agonist compounds. In our investigation, the utilization of seed-mediated synthesis technique facilitated production of gold polyhedral substrates serving as highly sensitive biosensors for detecting β-agonist presence. The unique geometry of these particles generates enhanced SERS signals due to their multiple corners, resulting low detection limits (9.33×10-7, 6.28×10-7, and 6.19×10-7 g·mL-1 for salbutamol, clenbuterol and higenamine respectively), with promising prospects for improving overall sensitivity in β-agonists detection.

Efficacy of Cognitive Behavioral Therapy Combined with Jacobson Progressive Muscle Relaxation in Improving Sleep Quality and Overall Well-Being in Hemodialysis Patients with Insomnia: A Randomized Controlled Trial.

Efficacy of Cognitive Behavioral Therapy Combined with Jacobson Progressive Muscle Relaxation in Improving Sleep Quality and Overall Well-Being in Hemodialysis Patients with Insomnia: A Randomized Controlled Trial.

A study to assess the effectiveness of Jacobson’s progressive muscle relaxation technique on blood pressure and stress among hypertensive clients at selected hospital in Indore

A study to assess the effectiveness of Jacobson’s progressive muscle relaxation technique on blood pressure and stress among hypertensive clients at selected hospital in Indore

Sedative, Analgesic and Anaesthetic Evaluation of Propofol in Combination with Butorphanol, Dexmedetomidine and Acepromazine in Clinically Healthy Dogs

Background: Propofol is intravenous short acting general anaesthetic most popular drug for induction and maintenance of anaesthesia in veterinary practice due to its rapid induction and smooth recovery. However, as sole general anaesthetic, it is unsatisfactory because of its poor analgesic property and causing hypotension and apnoea. Therefore, it commonly used in combination with opioid or alpha 2 agonist to minimize the untoward effects. The aim of the present study was to evaluate the sedative, analgesic and anaesthetic efficacy of propofol in combination with butorphanol, dexmedetomidine or acepromazine premedication in dogs. Methods: The present study was conducted on 18 healthy adult dogs of either sex and randomly divided into three groups (ButP, DexP and AceP) with six animals in each. Glycopyrrolate @ 0.02 mg/kg was administered intramuscularly 10 minutes prior to the anaesthetic administration in all the dogs. The animals of group ButP, DexP and AceP were premedicated intramuscularly with butorphanol @ 0.3 mg/kg b.wt., dexmedetomidine @ 10 µg/kg b.wt. and acepromazine @ 0.4 mg/kg b.wt. respectively. Ten minutes later propofol was injected intravenously at a dose of 7 mg/kg b.wt. to induce general anesthesia. The following clinical parameters were recorded viz., onset of sedation, onset of anaesthesia, degree of analgesia, extent of muscle relaxation, duration of anaesthesia and complete recovery. All the data were analyzed using SPSS v 25.0 statistics software program and presented as mean±Standard Error. Result: The onset of sedation and induction of anaesthesia was earlier in group DexP followed by AceP and ButP. Group DexP exhibited significantly (P less than 0.05) longer duration of anaesthesia and complete recovery than groups ButP and AceP. All the groups had excellent analgesia; however animals of group DexP showed longer duration of analgesia. All the reflexes were abolished completely with longer duration of muscle relaxation in group DexP. The above anaesthetic study suggests that propofol in combination with dexmedetomidine; butorphanol or acepromazine can be safely used for inducing surgical anaesthesia in dogs. However, dexmedetomidine-propofol combination produced prolonged duration of anaesthesia with better quality suitable for long surgical procedure in dogs.

Combination of Progressive Muscle Relaxation - Lavender Aromatherapy in Improving Sleep Quality in Menopausal Women: A Quasy Experiment

Background: Menopausal women often experience emotional disorders such as anxiety, irritability, and depression, as well as physical problems such as pain during intercourse, hot flushes, and sleep disturbances. Poor sleep quality is a major complaint during menopause. This study aims to analyze the effect of the combination of Progressive Muscle Relaxation (PMR) and lavender aromatherapy on the sleep quality of menopausal women. Methods: This quasi-experimental research uses a pretest-posttest approach with purposive sampling, involving 20 menopausal female respondents at the Posyandu Elderly in Belangwetan Village, North Klaten, from July 14 to 29, 2024. The intervention given was a combination of PMR, which involves tensing and relaxing the muscles for 15-20 minutes a day, while inhaling lavender aromatherapy. Result: Before the intervention, the average sleep quality of the respondents was 17.25 (range 13-20), which decreased to 5.90 (range 4-9) after the intervention. The Wilcoxon test showed a p-value = 0.000, proving that this intervention was effective in improving sleep quality in menopausal women. Conclusion: The combination of PMR and lavender aromatherapy is effective in improving sleep quality because it helps relax muscles, activates the body's relaxation system, and is easy to apply.