What We're Reading| January 03 2023 A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors Author & Article Information Online Issn: 2326-6074 Print Issn: 2326-6066 ©2022 American Association for Cancer Research2022American Association for Cancer Research Cancer Immunol Res (2023) 11 (1): 1. https://doi.org/10.1158/2326-6066.CIR-11-1-WWR Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record January 3 2023 Citation A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors. Cancer Immunol Res 1 January 2023; 11 (1): 1. https://doi.org/10.1158/2326-6066.CIR-11-1-WWR Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Myocarditis is the most lethal ICI-associated adverse event (from OpenStax Anatomy and Physiology via Wikimedia Commons) Myocarditis is a rare, often fatal, and poorly mechanistically understood adverse event associated with immune checkpoint inhibitor (ICI) therapy. Axelrod et al. find that in a mouse model of ICI-associated myocarditis—Pdcd1–/–Ctla4+/–mice—CD8+ T cells are necessary for fatal myocarditis to develop. The cardiac-infiltrating CD8+ T cells are highly clonal, with the T-cell receptors (TCR) from three clones recognizing MHC class I–presented α-myosin peptides. The clinical relevance of the data is supported by the detection of α-myosin–specific MHC class I–restricted TCRs in cardiac and skeletal muscle of patients with ICI-associated myocarditis. Axelrod ML, …, Balko JM. Nature 2022 November 16;611:818–26. Research is identifying new ways to enhance the antitumor activity of CAR T cells (from Alex Ritter, Jennifer Lippincott Schwartz, and Gillian Griffiths via NIH Flickr) Many research... You do not currently have access to this content.