Skeletal Damage Research Articles

CONGENITAL RECTAL FISTULAE AND THEIR SPHINCTERS

SYNOPSIS The degree of success of surgical reconstruction of the rectum depends on the efficiency of the ultimate sphincteric control. The levator ani muscles have the dual function of sphincter and sense organ of the new anal canal. The technique of rectoplasty described preserves both of these functions and achieves a high degree of continence. Even when these functions have been impaired by other techniques of rectoplasty, in which the visceral sling component of the levator ani muscles has been by-passed or damaged, they may be restored by re-routing the visceral canal or repairing the skeletal damage.

Metabolism of Pu 239 in Adult Beagle Dogs

The metabolism of plutonium in young adult beagle dogs was studied over a period of 4 years after a single intravenous injection of Pu(IV) in citrate buffer of pH 3.5. Three time periods were arbitrarily chosen to facilitate treatment of the plasma concentration and excretion rate data. For times greater than 3 weeks after injection, the per cent retention calculated from excretion measurement is R= 90.0--0.434t/sup 0.515/ when t is in days. The major part of the plutonium deposits in the skeleton and the liver, and the results of tissue measurements agree well with the retention calculated from excretion. No effect of dose level, age at injection, or sex could be demonstrated in the excretion studies. Comparison of the results with those of some early studies in which mongrel dogs were given much larger doses showed remarkable similarities. Plutonium metabolism in the dog is more like that in man than in rat. The liver deposition persists for long times in man and dog, but not in the rat. The retention in man is a little higher than in beagles, but the distributions are quite similar. The average dose rates and average cumulative doses to the skeleton and to the livermore » of the beagles are about equal (when calculated on the basis of uniform distribution). Skeletal damage greatly predominates, however. A limited preliminary comparison of skeletal effects of Pu/sup 239/ and Ra/sup 226/ on the basis of the amoumt of emergy dissipatod in bone shows that plutomium is more toxic. (auth)« less

ハトムギの諸成分に関する薬理学的研究 (第1報)

Pearl barley decoction has long been used as a home remedy for tuberculosis, hemoptysis, and tumor, and is well known as being effective for removing wart, its clinical effect having been proved by Sakurane. However, no detailed examinations have been made on its pharmacological action and, therefore, experiments were made on the effect of pearl barley oil on relaxation of muscles, blood sugar and serum calcium. Pearl barley oil and saturated fatty acids of 10-18 carbons act on skeletal muscles and damage their contractibility, while oleic acid, one of unsaturated fatty acids, has no effect. The amount of blood sugar and serum calcium decreases by the effect of pearl barley oil and fatty acids of over 12 carbon atoms, but not by ethyl caprate. The lowering of blood sugar is antagonized by pyruvic acid. There was no significant change in the amount of inorganic phosphate in the serum.

Natural history of multiple myeloma before radiological evidence of disease.

It is a pleasure and privilege to present the Memorial Fund Lecture for 1957, and I should like to express my appreciation to Dr. Virden, Dr. Frederick O'Brien, and to the members of the Memorial Fund Committee for their invitation to address your Society on this occasion. Multiple myeloma is a disease which has been of major interest to radiologists since the introduction of the technics of diagnostic roentgenography to medicine, and several comprehensive radiographic studies of the disease are available (1–7). Certainly for this audience there is no need to review the various roentgenologic patterns of multiple myeloma. Rather, it is the purpose of this presentation to describe some recent clinical and laboratory studies which support the theses that radiographically evident disease is usually disease which has already progressed to an advanced stage, and that the diagnosis of a proliferative disorder of plasma-cell origin is frequently possible by biochemical technics before roentgen changes are demonstrable. At the outset, an examination of terminology seems appropriate. The term “myeloma” properly denotes a tumor of the marrow, which might be due to any one of a variety of infiltrations. The designation “plasma-cell myeloma” is more precise, but this still implies the presence of tumefaction, i.e., the destruction of bone by a plasmacell tumor. Several clinical studies, however, have made it clear that tumor formation and skeletal destruction may at times be a relatively late and insignificant feature of primary plasmacell proliferation. It is recognized that a certain number of patients will exhibit profound anemia, renal insufficiency, para-amyloidosis, or manifestations secondary to cryoglobulinemia as the predominating features of their clinical picture, with skeletal manifestations playing a minor or even negligible role. These cases are usually called “multiple myeloma” even if a fatal outcome ensues before any skeletal damage is evident. The designation “primary plasmacell proliferation” has been suggested as being more inclusive of the several clinical variants which we now recognize. This term could be used with the understanding that the majority, but not all, of these cases will ultimately exhibit skeletal destruction, true “myeloma,” at some stage in the progression of protein metabolism, presently to be defined, which appear to be unique and distinctive to this disease, or group of diseases. In the course of the past four years, we have had the privilege of studying a group of 24 patients whose sera were discovered to contain an abnormal protein of the myeloma type, but who displayed neither symptomatic nor radiographic evidence of osseous disease. Some of these patients were under medical observation for unrelated conditions.

Is the Sting Ray's Sting Poisonous to Vertebrates Other than Men and Fishes?

Previous articleNext article No AccessIs the Sting Ray's Sting Poisonous to Vertebrates Other than Men and Fishes?E. W. GudgerE. W. Gudger Search for more articles by this author PDFPDF PLUS Add to favoritesDownload CitationTrack CitationsPermissionsReprints Share onFacebookTwitterLinkedInRedditEmail SectionsMoreDetailsFiguresReferencesCited by The American Naturalist Volume 81, Number 799Jul. - Aug., 1947 Published for The American Society of Naturalists Article DOIhttps://doi.org/10.1086/281523 Views: 3Total views on this site Citations: 4Citations are reported from Crossref PDF download Crossref reports the following articles citing this article:DP Hocking, FG Marx, WMG Parker, JP Rule, SGC Cleuren, AD Mitchell, M Hunter, JD Bell, EMG Fitzgerald, AR Evans Inferring diet, feeding behaviour and causes of mortality from prey-induced injuries in a New Zealand fur seal, Diseases of Aquatic Organisms 139 (Apr 2020): 81–86.https://doi.org/10.3354/dao03473Ruth Hughes, Kristen Pedersen, Steve Huskey The kinematics of envenomation by the yellow stingray, Urobatis jamaicensis, Zoomorphology 137, no.33 (Mar 2018): 409–418.https://doi.org/10.1007/s00435-018-0404-0Mason N. Dean, Joseph J. Bizzarro, Brett Clark, Charlie J. Underwood, Zerina Johanson Large batoid fishes frequently consume stingrays despite skeletal damage, Royal Society Open Science 4, no.99 (Sep 2017): 170674.https://doi.org/10.1098/rsos.170674Bruce W. Halstead, Ralph R. Ocampo, F. Rene Modglin A study on the comparative anatomy of the venom apparatus of certain north American stingrays, Journal of Morphology 97, no.11 (Jul 1955): 1–21.https://doi.org/10.1002/jmor.1050970102