Diameter Size Research Articles

Parametric analysis of tooth surface characteristics of flexspline in harmonic reducer after hobbing

The accurate prediction of tooth surface morphology for the flexspline in harmonic reducers after hobbing is a crucial technology for achieving high-precision harmonic gearing. This study investigates the impact of process parameters on the tooth surface characteristics of the flexspline. Two models were established to study the formation of tooth surfaces using both continuous cutting with a hypothetical rack tool and interrupted cutting with a multi-cutting-edge hob. The resulting surface geometry of the models was compared, and the effect of hob axial feed, hob mounting angle deviation, and hob outer diameter size on tooth surface morphology was analyzed. The study findings indicate that the crowning of gear teeth results in overcutting on the flexspline tooth surface, which is directly proportional to the degree of crowning and hob outer diameter. Furthermore, a lower axial feed speed during the hobbing process reduces material residue, and hob mounting angle deviations can lead to overcutting on one end of the tooth surface and material residue on the other end.

Investigation of a new reverse drainage construction and the pressure-reducing effect of a tunnel in a water-rich karst location

It is quite simple to create cracking, leaking, and other disasters in the tunnel during operation because water-rich karst tunnels are subject to the action of the high head. If the drainage is not timely, this results in high-pressure water collection around the tunnel lining. The study was conducted depending on Tongzi Tunnel to resolve the issue of water pressure encountered by water-rich karst tunnel lining under high head action and to lessen the issue of operational tunnel illness under long-term water pressure. The mechanical reaction of the number of reverse drainage holes and the size of pipe diameter at the raised arch under various water heads on the tunnel construction was studied using model testing in combination with numerical simulation analysis. It was discovered that using the traditional drainage system would subject the supine arch to extremely high-water pressure, which is often hard to efficiently remove. The major issue causing the elevated arch bulging tragedy is that water pressure in the elevated arch increases as head height increases. High water pressure in the raised arch may be efficiently dealt with using the suggested reverse drainage approach. The pressure reduction rate compared to the traditional drainage method achieved 13.6 % for the investigation of the fractured Tongzi tunnel reverse drainage holes, which had a total of five holes with a diameter of roughly 100 mm. Reverse drainage structures have the potential to save project costs while also realizing “point to point” pressure reduction at the elevation arch of the tunnel and have positive effects on total tunnel pressure reduction. The study's findings can serve as a guide for designing and building comparable water-rich karst tunnel constructions as well as for maintaining drainage systems while they are in use.

“Rooting” engineering strategy for construction of highly stable, scalable, size-customized oxidized graphene/PA6 ultrafine fiber composite nanofiltration membranes for water purification

Nanofiltration membranes based on graphene oxide exhibit substantial potential for practical applications in water treatment, poised to lead the next generation of separation technology. It is noteworthy that the prominent hydration interaction among graphene–graphene oxide nanosheets stands as the primary factor influencing its stability. Simultaneously, the absence of suitable graphene substrates presents challenges to its large-scale production. In this study, our initial endeavor involved constructing a graphene-based selective layer on a PA6 substrate using a quasi-“rooting” strategy. The graphene selective layer was anchored onto the surface of PA6 fibers (with a diameter size of up to 190.0 mm and a selective layer thickness of approximately 5.0 µm). Experimental results reveal that the permeability of the hybrid graphene oxide/PA6 fiber composite nanofiltration membrane consistently maintained within the range of 7.7 to 14.9 L m⁻² h⁻¹ bar⁻1, with a remarkable dye molecule removal rate of 99.06 %. Even under challenging operating conditions (such as strong acid, strong alkali, polar solvent, oxidation, and the coexistence of salt ions), its separation performance remained stable. The permeability of composite membranes was retained between 10.6 and 12.7 L m⁻² h⁻¹ bar⁻1, and the rejection rate of CR dye reached 95.0 % under harsh conditions. Furthermore, the stability and anti-fouling performance of the composite membrane were significantly enhanced. Deposits on the membrane surface could be effectively removed through physical wiping and repeated water rinsing, maintaining membrane integrity even after vigorous ultrasonic cleaning (120 min, 950 W). Additionally, after undergoing 20 cycles of rinsing with deionized water and a 30-day soak in an aqueous solution, the PA6 substrate and graphene selective layer exhibited robust adhesion. No shedding was observed, and the dye rejection rate of the composite membrane consistently exceeded 95 %. This perfectly illustrates the exceptional structural stability and separation durability of the prepared separation membrane. Our work contributes fundamental design principles and theoretical insights for practical applications.

Natural regeneration and early development of Scots pine seedlings after gap cutting in northern Finland

ABSTRACT In the northern boreal region, tree growth, timber yields and economic returns are low, meaning low regeneration costs are the basis of profitable forestry. If natural regeneration is successful, it may be favoured over expensive planting or seeding. We studied the regeneration success and early growth of Scots pine in gaps in terms of seedling density and height 10 years after gap cuttings in central Finnish Lapland. Three gap sizes (diameters of 20, 40, and 80 m) were studied on patch scarified xeric and sub-xeric sites in six random blocks and a total of 18 replicates of each. The number of pine seedlings was high across the gap sizes. The proportion of empty regeneration plots (size 5 m2) was ∼ 2%. Site preparation substantially increased the number of seedlings. The growth of seedlings was faster in larger gaps, but a high proportion of exposed mineral soil decreased it. The results suggest that all studied gap sizes regenerated naturally well, and that soil scarification exposing 10–20% of the surface area or even less can be enough to achieve regeneration goals. Gaps of a diameter of 40 m or more are required to achieve an optimal balance between seedling density and growth.

Predicting saturated and near-saturated hydraulic conductivity using artificial neural networks and multiple linear regression in calcareous soils.

Hydraulic conductivity (Kψ) is one of the most important soil properties that influences water and chemical movement within the soil and is a vital factor in various management practices, like drainage, irrigation, erosion control, and flood protection. Therefore, it is an essential component in soil monitoring and managerial practices. The importance of Kψ in soil-water relationship, difficulties for its measurement in the field, and its high variability led us to evaluate the potential of stepwise multiple linear regression (SMLR), and multilayer perceptron (MLPNNs) and radial-basis function (RBFNNs) neural networks approaches to predict Kψ at tensions of 15, 10, 5, and 0 cm (K15, K10, K5, and K0, respectively) using easily measurable attributes in calcareous soils. A total of 102 intact (by stainless steel rings) and composite (using spade from 0-20 cm depth) soil samples were collected from different land uses of Fars Province, Iran. The common physico-chemical attributes were determined by the common standard laboratory approaches. Additionally, the mentioned hydraulic attributes were measured using a tension-disc infiltrometer (with a 10 cm radius) in situ. Results revealed that the most of studied soil structure-related parameters (soil organic matter, soluble sodium, sodium adsorption ratio, mean weight diameter of aggregates, pH, and bulk density) are more correlated with K5 and K0 than particle-size distribution-related parameters (sand, silt, and standard deviation and geometric mean diameter of particles size). For K15 and K10, the opposite results were obtained. The applied approaches predicted K15, K10, K5, and K0 with determination coefficient of validation data (R2val) of 0.52 to 0.63 for SMLR; 0.71 to 0.82 for MLPNNs; and 0.58 to 0.78 for RBFNNs. In general, the capability of the applied methods for predicting Kψ at all the applied tensions was ranked as MLPNNs > RBFNNs > SMLR. Although the SMLR method provided easy to use pedotransfer functions for predicting Kψ in calcareous soils, the present study suggests using the MLPNNs approach due to its high capability for generating accurate predictions.

A Giant Stent for Giant Cerebral Aneurysms-The Accero®-Rex-Stent.

Until now, giant intracranial aneurysms (GIAs) have in many cases been a vascular disease that was difficult or impossible to treat, not least due to the lack of availability of a large-format stent. In this multicentre study, we report on the first five clinical applications of the Accero®-Rex-Stents (Acandis, Pforzheim, Germany) in the successful treatment of fusiform cerebral giant aneurysms. The Accero®-Rex-Stents are self-expanding, braided, fully radiopaque Nitinol stents designed for aneurysm treatment. The stent is available in three different sizes (diameter 7-10 mm, length 30-60 mm) and intended for endovascular implantation in vessels with diameters of 5.5-10 mm. Five patients (all male, age 54.4 ± 8.1 years) with large fusiform aneurysms of the posterior circulation were treated endovascularly using the Accero®-Rex-Stents. There were no technical complications. One major ischemic complication occurred. A significant remodeling and reduction in the size of the stent-covered aneurysms was already seen in the short-term post-interventional course. The Accero®-Rex-Stents were successfully and safely implanted in all five patients with fusiform giant aneurysms, showing technical feasibility with promising initial results and significant aneurysm size reduction in already available follow-up imaging. With the Accero-Rex-Stents, a new device is available that offers another treatment option for rare cerebral fusiform giant aneurysms with very large parent vessels.

Statistical analysis of modelling approaches for CFD simulations of high-pressure natural gas releases

The use of computational fluid dynamics (CFD) in process safety to estimate the risk of a given incidental scenario has become ever more present in common industry practice. The simulation of high-pressure, compressible natural gas jets is often performed by modelling its source with a simpler notional diameter approach, such that the highly computationally expensive nearfield zone need not to be simulated; this is particularly determining when simulating a gas release in complex scenario like liquid natural gas (LNG) regasification plants. In this study, we analysed the structure of compressible and incompressible jets, using Birch 1984 (B84) and Birch 1987 (B87) models. In this work, a study on the positioning of the notional diameter with respect to the real orifice of the released gas is performed, along with a statistical analysis to assess the limits of the simpler model approaches.It was found that no spacing is needed between the virtual and real sources, as the potential core generated by the simpler model is as large as the fully simulated nearfield zone by the compressible model. Additionally, an end-of-transition zone position correlation is reported. The incompressible models can be used instead of the fully compressible model for a wide range of release conditions, with both models providing accurate predictions of axisymmetrical mole fraction, temperature, and velocity profiles between 2.5 and 130 bar of storage pressure at a 1-inch orifice diameter. However, as the diameter increases, B84 is not a viable model for a “full bore” (10-inch diameter size) release at 65 bar. While B84 is reliable, B87 is the superior model for its ability to account for the compressible effects of the expansion. Therefore, B87 should be used when simulating cases where temperature is of particular interest to the user.

Microwave-assisted synthesis of Limonia acidissima Groff gum stabilized palladium nanoparticles for colorimetric glucose sensing

Herein, we present a novel microwave-assisted method for the synthesis of palladium nanoparticles (PdNPs) supported by Limonia acidissima Groff tree extract gum. The synthesized PdNPs were characterized using various analytical techniques, including FTIR, SEM, TEM, UV–visible, and powder XRD analyses. TEM and XRD analysis confirmed that the synthesized LAG-PdNPs are highly crystalline nature spherical shapes with an average size diameter of 7–9 nm. We employed these gum-capped PdNPs to investigate their peroxidase-like activity for colorimetric detection of hydrogen peroxide (H2O2) and glucose. The oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H2O2, catalyzed by PdNPs, produces oxidation products quantified at 652 nm using spectrophotometry. The catalytic activity of PdNPs was optimized with respect to temperature and pH. The developed method exhibited a linear range of detection from 1 to 50 µm, with detection limits of 0.35 µm for H2O2 and 0.60 µm for glucose.

Impact resistance of horsetail bio-honeycombs

Inspired by the ingenious cross-sectional structure of horsetail stems, a group of novel horsetail bio-honeycombs (HBHs) are firstly proposed to pursuit a superior impact resistance performance. The out-of-plane impact resistance characteristics and mechanical properties of the proposed HBHs are investigated by means of test, theoretical analysis, and finite element (FE) analysis. In the process of deriving the theoretical model of HBHs, the novel 5-panel and 7-panel membrane energy dissipation corner elements are firstly proposed and reasonable theoretical solutions for them are obtained. Theoretical results suggest that the errors between numerical and theoretical results for the majority of the HBHs are within 7 %. In addition, the studies indicate that the HBHs outperform the circular honeycomb (CH) in terms of crashworthiness while ensuring that their relative densities are the same. The complex proportional assessment method is utilized to evaluate the crashworthiness of HBH_n_6_1.5 (n represents the number of ribs, 6 represents the size of the outer diameter, and 1.5 represents the ratio (ζ) of the outer diameter to the inner diameter) under the same relative density. Furthermore, results suggest that energy absorption and crushing force efficiency of HBH_16_6_1.5 are 31.31 % and 25.54 % higher than those of CH, respectively. Subsequently, the influences of geometric parameters, including the ζ and the thickness-to-cell length ratio (TL), on the impact resistance of HBH_16_6_1.5 are investigated thoroughly. The findings show that when the ζ is within 1.2–1.5, the HBHs can exert their maximum potential, in which the inner diameter of HBHs is close to its outer diameter. Also, the findings demonstrate that the HBHs will undergo three distinct deformation modes. When the TL is roughly within 0.0200–0.0267, the deformation of HBHs will be in the transition deformation mode.

MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLE MIMETICS AS OSTEOINDUCTIVE MEDIATORS: AN IN VITRO INVESTIGATION

Mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) have great promise in the field of orthopaedic nanomedicine due to their regenerative, as well as immunomodulatory and anti-inflammatory properties. Researchers are interested in harnessing these biologically sourced nanovesicles as powerful therapeutic tools with intrinsic bioactivity to help treat various orthopaedic diseases and defects. Recently, a new class of EV mimetics has emerged known as nanoghosts (NGs). These vesicles are derived from the plasma membrane of ghost cells, thus inheriting the surface functionalities and characteristics of the parent cell while at the same time allowing for a more standardized and reproducible production and significantly greater yield when compared to EVs. This study aims to investigate and compare the osteoinductive potential of MSC-EVs and MSC-NGs in vitro as novel tools in the field of bone tissue engineering and nanomedicine. To carry out this investigation, MSC-EVs were isolated from serum-free MSC conditioned media through differential ultracentrifugation. The remaining cells were treated with hypotonic buffer to produce MSC-ghosts that were then homogenized and serially extruded through 400 and 200 nm polycarbonate membranes to form the MSC-NGs. The concentration, size distribution, zeta potential, and protein content of the isolated nanoparticles were assessed. Afterwards, MSCs were treated with either MSC-EVs or MSC-NGs under osteogenic conditions, and their differentiation was assessed through secreted ALP assay, qPCR, and Alizarin Red mineralization staining. Isolation of MSC-EVs and MSC-NGs was successful, with relatively similar mean diameter size and colloidal stability. No effect on MSC viability and metabolic activity was observed with either treatment. Both MSC-EV and MSC-NG groups had enhanced osteogenic outcomes compared to the control; however, a trend was observed that suggests MSC-NGs as better osteoinductive mediators compared to MSC-EVs.Acknowledgements: The authors would like to acknowledge Canada Research Chair – Tier 1 in Regenerative Medicine and Nanomedicine, CHRP, and McGill's Faculty of Dental Medicine and Oral Health Sciences for their financial support.

Size onset of metallic behavior in neutral aluminum clusters.

The excited state lifetimes of neutral (Al)n clusters up to ∼1 nm in diameter in size, where n ≤ 43, are systematically measured with femtosecond time-resolved mass spectrometry. The onset of metallic behavior is identified as a distinct change in the relaxation behavior initiated with single ultraviolet (400 nm) photon excitation. The experimentally measured excited state lifetimes gradually decrease with size for small molecular scale clusters (n < 10) before becoming indistinguishable for larger clusters (n > 9), where the measurements are comparable to electron-lattice relaxation time of bulk Al (∼300 fs). Particularly intense, or magic, Aln clusters do not exhibit any significant excited state lifetime behavior. Time-dependent density functional theory quantify the excited state properties and are presented to show that dynamics are strongly tied to the excited state charge carrier distributions and overlap, rather than detailed changes related to changes in the cluster's electronic and geometric structure. The consistency in excited state lifetimes for clusters larger than n = 9 is attributed to the hybridization of the s- and p-orbitals as well as increasing delocalization. Al3 exhibits unique temporal delay in its transient behavior that is attributed to a transition from triangular ground state to linear structure upon excitation.

Localized surface plasmon resonance effect of 3-mercaptopropionic acid capped on silver nanoparticles for sensing probe application

Metal nanoparticles such as gold and silver are often used in various nanotechnology applications due to the localized plasmon resonance effect that occurs when incident photons interact with metal nanoparticles. 3-mercaptopropionic acid (3-MPA) is one of the capping molecules that can be provided for surface functionalization on gold or silver core because it has thiol and carboxylic group as a linking biomolecule, and this allows the use of nanoparticles for biosensor applications. In this study, we successfully synthesized silver nanoparticles capped by 3-mercaptopropionic acid (AgMPA) by use of two kinds of methods i.e ligand exchange and direct reduction, which reveal the unique characteristic plasmonic peaks of AgNP around 430 nm and 436 nm, respectively with spherical shape of AgNP and diameter size about 6-20 nm. The transmittance spectra from Fourier Transform Infrared (FTIR) measurement shows that S-H coordination from 3-MPA is invisible after 3-MPA attach on Ag core due to the strong coordination between Ag and the sulfur (S) ion, while the broaden peaks at 1589 and 1385 cm-1 for AgMPA are assigned to asymmetric and symmetric vibrations of carboxylate groups which overlap between carboxylate from citrate and 3-MPA. Finally, the colorimetric detection using AgCA and AgMPA as sensing probe was carried out by use of Biocytin-Avidin system molecule as analyte, which resulted in the colour changed rapidly from yellow to transparent-yellow and the red-shifted of absorbance spectra indicating the attachment of analyte to functionalized molecule of our synthesized AgCA and AgMPA.

A dynamic system analysis study on the design of high-performance pervious concrete ratios

Abstract As permeable concrete contains more pores and larger pore size when improving its water permeability, it will affect its mechanical properties and durability, so it is of great significance to study the mixing ratio of porous concrete. Studying the mixing ratio of porous concrete is of great significance. The subject is studied in depth from the aspects of mechanical properties and water permeability, in order to prepare high-performance permeable concrete with high compressive strength and meet the requirements of infiltration. Firstly. Optimization of the performance of raw materials and mixing ratios of porous concrete, according to the aggregate gradation, aggregate particle size, and other factors on the mechanical properties of porous concrete, to determine its optimal aggregate mixing ratio. Three groups of high-performance pervious concrete specimens with different aggregate particle sizes and pore structures were examined for their real fine structure. Finally, after the preparation of high-performance pervious concrete was completed, the porosity, fractal dimension, equivalent diameter, contour coefficient, and roundness of the specimens were tested to investigate the effects of several factors mentioned above on the permeability coefficient and compressive strength properties of pervious concrete. The results show that the two-dimensional pore diameter is normally distributed, the diameter size is centrally distributed in the range of 0~10mm, and the number of pores in this range accounts for more than 70%. Gradually increasing aggregate particle size leads to an increase in the proportion of large pores inside the specimen. After the compressive strength test and porosity test, it was found that the water permeability coefficient of the porous concrete was the best for the single-grain limestone aggregate with the equivalent diameter range of 5~8mm. The results of this study have theoretical value in enriching and developing high-performance permeable concrete.

Studies on genetic variability and heritability in bulb onion (Allium cepa L.) in the South-Eastern plains of Bihar, India

The study was conducted at Vegetable Research Farm, Department of Horticulture, Bihar Agricultural University, Sabour, Bhagalpur during Rabi season 2021-22 with the objective to study genetic variability in onion (Allium cepa L.) for yield and yield attributing traits. The experimental material consisted of 15 onion genotypes from different locations in India. Experimental trial was laid out in a RBD with three replications. Analysis of variance was done by the method suggested by Panse and Sukhatme (1967). The observations were recorded on five randomly selected plants of all genotypes for plant height, number of leaves, leaf length, leaf width, pseudostem length, neck thickness, polar diameter, equatorial diameter, and average bulb weight. Analysis of variance indicated significant differences among the genotypes for all the characters under study which implied a considerable amount of genetic variability in the genotypes included in the study. The highest average weight of onion bulb was recorded in genotype LC-1 (62.13g) which was statistically at par with LC-2 (58.53g), Patna Red (57.80g), Bhima Shakti (57.28 g) and Agrifound Light Red (56.87g). High PCV and GCV were recorded for pseudostem length and neck thickness. Moderate GCV and PCV were found in leaf width, average bulb weight, plant height, leaf length, equatorial diameter and bulb size index. High heritability along with high genetic advance as percentage of mean was exhibited by all the morphological traits. The genotypes LC-1, LC-2, Patna Red and Bhima Shakti were identified as promising ones for the yield and yield contributing traits.

Cervical Collagen Network Porosity Assessed by SHG Endomicroscopy Distinguishes Preterm and Normal Pregnancy - a Pilot Study.

Preterm birth (PTB) remains a pressing global health concern associated with premature cervical ripening and weakened cervical mechanical strength. Second harmonic generation (SHG) microscopy has proved instrumental in tracking progressive changes in cervical collagen morphology during pregnancy. To translate this imaging modality into clinical practice, we have developed a flexible SHG endomicroscope for label-free visualization of cervical collagen architecture. This study aims to assess the feasibility of our SHG endomicroscope for non-invasive differentiation of normal and PTB mouse models, with the ultimate goal of enabling early diagnosis and risk assessment of PTB in vivo. in this pilot investigation, we conducted endomicroscopic SHG imaging on frozen cervical tissue sections and intact cervices resected from both normal pregnant mice and mifepristone-induced PTB mouse models, and then analyzed the acquired images to identify collagen morphology characteristics associated with abnormal cervical collagen remodeling. quantitative image analysis revealed significantly altered collage spatial distribution, larger collagen fiber diameter and pore size, along with reduced pore numbers in SHG endomicroscopy images from PTB mouse models compared to normal pregnant mice. Similar trends were consistent across SHG endomicroscopy images of subepithelial collagen fibers acquired directly from intact cervices. overall, the experiment results underscore the potential of SHG endomicroscopy, coupled with quantitative image analysis, for clinically evaluating cervical collagen remodeling and PTB risk.

Predicting micropollutant removal through nanopore-sized membranes using several machine-learning approaches based on feature engineering.

Predicting the efficacy of micropollutant separation through functionalized membranes is an arduous endeavor. The challenge stems from the complex interactions between the physicochemical properties of the micropollutants and the basic principles underlying membrane filtration. This study aimed to compare the effectiveness of a modest dataset on various machine learning tools (ML) tools in predicting micropollutant removal efficiency for functionalized reverse osmosis (RO) and nanofiltration (NF) membranes. The inherent attributes of both the micropollutants and the membranes are utilized as input factors. The chosen ML tools are supervised algorithm (adaptive network-based fuzzy inference system (NF), linear regression framework (linear regression (LR)), stepwise linear regression (SLR) and multivariate linear regression (MVR)), and unsupervised algorithm (support vector machine (SVM) and ensemble boosted tree (BT)). The feature engineering and parametric dependency analysis revealed that characteristics of micropollutants, such as maximum projection diameter (MaxP), minimal projection diameter (MinP), molecular weight (MW), and compound size (CS), exhibited a notably positive impact on the correlation with removal efficiency. Model combination with key variables demonstrated high prediction accuracy in both supervised and unsupervised ML for micropollutant removal efficiency. An NF-grid partitioning (NF-GP) model achieved the highest accuracy with an R 2 value of 0.965, accompanied by low error metrics, specifically an RMSE and MAE of 3.65. It is owed to the handling of the complex spatial and temporal aspects of micropollutant data through division into consistent subsets facilitating improved identification of rejection efficiency and relationships. The inclusion of inputs with both negative and positive correlations introduces variability, amplifies the system responsiveness, and impedes the precision of predictive models. This study identified key micropollutant properties, including MaxP, MinP, MW, and CS, as crucial factors for efficient micropollutant rejection during real-time filtration applications. It also allowed the design of pore size of self-prepared membranes for the enhanced separation of micropollutants from wastewater.

Ionic flow through partially blocked nanopores.

Employing atomistic molecular dynamics simulations, we investigate the ionic conductivity mechanisms in a partially blocked nanopore containing a centrally positioned spherical constriction, exploring the effects of pore diameter, surface charge, and blockage size. Our results show that ionic mobilities are significantly influenced by the polarity of the surface charge and the size of the pore gap. Particularly, we observe ion-specific effects for K+ and Cl- ions based on their size and charge, especially in sub-nanometer pore gaps. Furthermore, we find that the current flow in partially blocked nanopores sensitively depends on the surface charges, consistent with the calculated free energy profiles. The percentage of the current drop is found to be correlated to the volume of the spherical constriction with the effects more pronounced when the sizes of the spherical blockage and nanopore are comparable.

Cardiac troponin I release after transcatheter closure of atrial septal defects is associated with supraventricular arrhythmias on early follow-up.

Atrial septal defects (ASD) are prevalent congenital heart anomalies found in the adult population. Percutaneous ASD closure has become a routine clinical practice. Elevation of postprocedural transient cardiac biomarkers and exacerbation of supraventricular arrhythmias have been reported in the subject literature. To explore the relationship between cardiac troponin I (cTnI) elevation and supraventricular ectopy (SVE) following percutaneous closure of secundum atrial septal defect (ASD) in adult patients. 600 consecutive patients who underwent successful transcatheter ASD secundum closure were analyzed. Serum levels of cTnI were measured before and within 72 h of device implantation. 24-hour Holter monitoring was performed before the procedure, at 1 month, and at 6 months of follow-up. SVE burden increased 1 month after the procedure (median 1021.00; min.-max. 11.00-29 862.00) compared to baseline values (median 146.00; min.-max. 0-1865.00; p < 0.01). 61.7% of patients demonstrated a cTnI rise exceeding 50% of the upper reference limit within 24 h of the procedure. A statistically significant positive correlation between SVE burden 1 month after the procedure and periprocedural cTnI increase (p < 0.05, r = 0.41) was observed, while cTnI levels significantly correlated with procedure and fluoroscopy time (p < 0.001), device size (p < 0.001) and maximal ASD diameter (p < 0.001). A significant increase of cTnI is noted frequently after transcatheter ASD closure and seems to predict exacerbation in SVE burden on short-term follow up. The independent risk factors of cTnI rise are prolonged procedure duration and larger device sizes.

Antiplatelet or Anticoagulant Therapy for Abdominal Aortic Aneurysms: Growth and Clinical Outcomes.

Intraluminal thrombi in the abdominal aortic aneurysms (AAA) were demonstrated to increase aneurysm growth. The effect of treatments on thrombus reduction upon AAA enlargement and clinical endpoints is uncertain Therefore, this study aimed to investigate the effect of antiplatelet and anticoagulant therapy on AAA growth and clinical outcomes. A total of 357 patients with AAAs were enrolled in this study. They were divided into 2 groups based on their medical therapies. Patients on antiplatelet and anticoagulant therapy were assigned to group 1 (n = 234) and group 2 (n = 92), respectively. The greatest reduction in thrombus diameter change was observed in patients with anticoagulant therapy (group 1, -2.26 mm; group 2, -8.16 mm; P =.001). The greatest aneurysmal enlargement was found in patients with antiplatelet therapy. There was less AAA progression with anticoagulant therapy than with the other therapy (group 1, 2.08 mm; group 2, 1.31 mm P =.027. The more operational need was observed in patients with antiplatelet therapy than in patients with anticoagulant therapy ( group 1 67, group 2 16, P =.036) Conclusion: In our study, it was revealed that anticoagulant therapy has been associated with decreased thrombus diameter and less aneurysmal enlargement compared with antiplatelet therapy. Furthermore, this beneficial effect on the thrombus size and aneurysmal diameter decreased the operational need in patients with anticoagulant therapy.

The Ongoing Debate: Longevity of Biological Valves in Pulmonary Position.

In patients with tetralogy of Fallot (ToF) or ToF-like anatomy, factors possibly impacting the longevity of biological valves in the pulmonary position were investigated. Between 1997 and 2017, 79 consecutive hospital survivors with a median age of 8.7 years (range: 0.2-56.1 years; interquartile range [IQR]: 14.8 years) with ToF or ToF-like anatomy underwent surgical implantation of Contegra (n = 34), Hancock (n = 23), Perimount (n = 9), pulmonary homograft (n = 9), and miscellaneous (n = 4) conduits. The median internal graft diameter was 19 mm (range: 11-29 mm; IQR: 8 mm) which refers to a median z-score of 0.6 standard deviation (SD) (range: -1.8 to 4.0 SD; IQR: 2.1 SD). The median time of follow-up was 9.4 years (range: 1.1-18.8 years; IQR: 6.0 years). Thirty-nine patients (49%) underwent surgical (n = 32) or interventional (n = 7) pulmonary valve re-replacement. Univariate Cox regression revealed patient age (p = 0.018), body surface area (p = 0.004), internal valve diameter (p = 0.005), and prosthesis z-score (p = 0.018) to impact valve longevity. Multivariate Cox regression analysis, however, did not show any significant effect (likely related to multicollinearity). Subgroup analysis showed that valve-revised patients have a higher average z-score (p = 0.003) and younger average age (p = 0.007). A decreased longevity of biological valves in the pulmonary position is related to younger age, lower valve diameter, and higher z-score. Because valve size (diameter and z-score) can be predicted by age, patient age is the crucial parameter influencing graft longevity.