Sharp conization is a diagnostic and therapeutic intervention. From 1970 to 1990 at the clinic of the city of Graz, Austria, conization was performed in 3663 female patients aged 15-84 who had a diagnosis of cervical intraepithelial neoplasia (CIN) III. All the women were followed up with colposcopy, cytology, and palpation. In those who were not healthy (non in sano) a biopsy and/or a cervical canal curettage was also performed. Conization was done in 2984 (82%) healthy women. Within 5-7 years in 8 cases a recurrence of CIN III could be established. In 669 patients (18%) conization took place in unhealthy women. In 345 (52%) cases, the alteration extended toward the cervix, in 262 (39%) it was peripheral, and in 62 (9%) it was peripheral and extending toward the cervix in the unhealthy women. In 228 (34%) women with an average age of 45 years who did not want any children or had completed family size, hysterectomy was carried out. As a result, in 69 (30%) women, surface carcinoma could be demonstrated. During follow-up, in 4 women 1-4 years after hysterectomy, a vaginal intraepithelial neoplasia III (VAIN III) could be established. 441 (66%) of the women with an average age of 35 years who desired a child were subjected to very strict control. In 53 (12%) patients, the persistence of atypical epithelium changes could be shown by means of biopsy or cervical canal curettage, and thus hysterectomy was performed. In 1 patient a case of VAIN III occurred after hysterectomy. In the remaining 338 patients, the persistence of cervical intraepithelial neoplasia could be demonstrated. In the hysterectomy group, 5 residual findings were ascertained, while in the group without hysterectomy, only 1 occurred. The low (1%) rate of recidivity means that the issue of possible hysterectomy cannot be approved. The exact histological processing and strict follow-up guarantee that the necessary therapeutic treatment measures are always employed.
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