Artifact Size Research Articles

Artifacts in cranial MRI caused by extracranial foreign bodies and analysis of these foreign bodies.

Purpose:The purpose of our study was to conduct a chemical analysis of extracranial foreign bodies (FBs) causing artifacts in cranial magnetic resonance imaging (MRI) and to investigate the association between chemical composition, magnetic susceptibility, and artifact size.Materials and Methods:A total of 12 patients were included in the study. The FBs responsible for the artifacts were visualized using cranial computed tomography (CT). Artifact-causing FBs were removed from the scalps of 10 patients and analyzed using scanning electron microscope with energy dispersive spectroscopy (SEM-EDS), X-ray diffraction spectroscopy (X-RD), and Fourier-transform infrared spectroscopy (FT-IR). The magnetic susceptibility of the samples was determined using the reference standard material MnCl2.6H2O. The volume of the MRI artifacts was measured in cubic centimeters (cm3).Results:EDS results demonstrated that the mean Fe ratio was 5.82% in the stone samples and 0.08% in the glass samples. Although no phase peaks were detected in the X-RD spectra of the glass samples, peaks of Fe2O3, Al2Ca (SiO4) were detected in the X-RD spectra of the stone samples. The FT-IR spectra revealed metal oxide peaks corresponding to Fe, Al, in the stone samples and peaks confirming Al2SiO5 and Na2SiO3 structures in the glass samples. The mean volumes of the MRI artifacts produced by the stone and glass samples were 5.9 cm3 and 2.5 cm3, respectively.Conclusions:Artifacts caused by extracranial FBs containing metal/metal oxide components are directly associated with their chemical composition and the artifact size are also related to element composition and magnetic susceptibility.

Three-dimensional quantification of magnetic resonance imaging artifacts associated with shape factors.

Differences in the volumes of artifacts caused by variously shaped titanium objects on magnetic resonance imaging (MRI) were evaluated. Spherical-, square cubic-, and regular tetrahedron-shaped isotropic, and elongated spherical-, elongated cubic-, and elongated tetrahedron-shaped anisotropic objects, with identical volumes, were prepared. Samples were placed on a nickel-doped agarose gel phantom and covered with nickel-nitrate hexahydrate solution. Three-Tesla MR images were obtained using turbo spin echo and gradient echo sequences. Areas with ±30% of the signal intensity of the standard background value were considered artifacts. Sample volumes were deducted from these volumes to calculate the total artifact volumes. Isotropic samples had similar artifact volumes. For anisotropic samples, the artifact volume increased in proportion with the normalized projection area. MRI artifact size can be reduced by high anisotropic designs, and by positioning the long axis of the metal device as parallel as possible to the magnetic field axis.

Gendered Places and Depositional Histories: Reconstructing a Menstrual Lodge in the Interior Northwest

This project considered the deposition history of a burned structure located on the Kalispel Tribe of Indians ancestral lands at the Flying Goose site in northeastern Washington. Excavation of the structure revealed stratified deposits that do not conform to established Columbia Plateau architectural types. The small size, location, and absence of artifacts lead us to hypothesize that this site was once a non-domestic structure. We tested this hypothesis with paleoethnobotanical, bulk geoarchaeological, thin section, and experimental firing data to deduce the structural remains and the post-occupation sequence. The structure burned at a relatively low temperature, was buried soon afterward with imported rubified sediment, and was exposed to seasonal river inundation. Subsequently, a second fire consumed a unique assemblage of plant remains. Drawing on recent approaches to structured deposition and historic processes, we incorporate ethnography to argue that this structure was a menstrual lodge. These structures are common in ethnographic descriptions, although no menstrual lodges have been positively identified in the archaeological record of the North American Pacific Northwest. This interpretation is important to understanding the development and time depth of gendered practices of Interior Northwest groups.

Dual-layer spectral computerized tomography for metal artifact reduction: small versus large orthopedic devices.

Metal artifacts limit the diagnostic utility of computerized tomography (CT) for implant-related complications. Dual-layer spectral detector CT imaging has been suggested for artifact reduction. Our objective was to evaluate the utility of spectral CT in artifact reduction in patients with small and large metal implants. In this prospective study, patients with metallic orthopedic implants underwent CT imaging using a prototype spectral detector CT scanner. Conventional images were generated with iterative reconstruction at 120 kVp, and virtual monochromatic images were generated at 20-keV intervals between 40 to 200keV. Conventional and monochromatic images were compared quantitatively using signal-to-noise ratio (SNR) and artifact improvement. Qualitative analysis was performed independently by two musculoskeletal radiologists and included six image quality indicators. A total of 12 patients were scanned. In monochromatic images, as the energy level increased, the artifact size decreased progressively (p < 0.01). When conventional and monochromatic images were compared, maximum reduction was seen at 200keV. Using qualitative assessments, 160 and 180keV levels had the best overall diagnostic image quality. With increased energy level, there was improvement in qualitative ratings of bone-metal interface conspicuity (p = 0.002), degree of streak artifact (p = 0.010) and trabecular bone definition at 1cm from implant (p = 0.023), and a trend towards significance for bone definition at 5cm, soft tissue detail and overall diagnostic quality. Subgroup analysis revealed superior artifact reduction in small implants compared to large hardware. Our results support the utility of dual-layer spectral CT in metal artifact reduction. Virtual monochromatic images were diagnostically superior, especially for smaller implants. Virtual monoenergetic images at 160-180keV are ideal for reducing artifacts.

A study on observed ultrasonic motor-induced magnetic resonance imaging (MRI) artifacts

BackgroundThe safe performance of magnetic resonance imaging (MRI)-guided robot-assisted interventions requires full control and high precision of assistive devices. Because many currently available tools are not MRI-compatible, the characterization of existing tools and development of new ones are necessary. The purpose of this research is to identify and minimize the image artifacts generated by a USM in MR images. MethodsThe behavior of an ultrasonic motor (USM), the most common MRI-safe actuator, in a high-field scanner was investigated. The motor was located in three orientations with respect to the bore axis with the power on or off. The induced image artifacts were compared across four sequences. Three artifact reduction methods (employing ultrashort sequences, slice thickness reductions, and bandwidth increments) were tested. ResultsSignal voids, pileups, and geometric distortions were observed when the motor was off. The artifact size was minimal when the motor shaft was aligned with the bore axis. In addition to the above artifacts, zipper and motion artifacts were noted when the motor was running, and these artifacts increased with increasing motor speed. Increasing the bandwidth slightly reduced the artifacts. However, decreasing the slice thickness from 5 mm to 3 mm and from 5 mm to 1 mm reduced artifact size from 30% to 40% and from 60% to 75%, respectively. ConclusionThe image artifacts were due to the non-homogenous nature of the static and gradient fields caused by the motor structure. The operating motor interferes with the RF field, causing zipper and motion artifacts.

Artifact on MR imaging by a dental magnetic attachment keeper: Preliminary study on a new keeper removable phantom

AbstractAimsDental magnetic attachments with satisfactory retentive force and stability are now commercially available for dental treatment. The aim of this study was to investigate a new phantom for evaluation of the artifact on magnetic resonance (MR) imaging by a dental magnetic attachment keeper.Material and MethodsWe developed a new keeper removable phantom for evaluation of the artifact on MR imaging. A keeper was inserted in an acrylic pole in a PET bottle. The keeper from acrylic pole of the phantom was removable. The keeper with saline solution in the PET bottle with a head and neck coil underwent MR imaging at our university hospital. We measured the real size (unit: mm) of artifact of the phantom with the keeper using a DICOM viewer. Furthermore, the size of artifact of a patient's image with the same three keepers in the mouth was measured on the image using the DICOM viewer, too.ResultsIn MR images of the phantom with a keeper, the maximum size of artifact on axial T1‐weighted, T2‐weighted and STIR images were 78 mm, 85 mm, and 67 mm, respectively. Regarding MR images of the patient with three keepers, the maximum size of artifact on axial T1‐weighted, T2‐weighted and STIR images were 106 mm, 111 mm and 100 mm, respectively.ConclusionsWe investigated a new keeper removable phantom for evaluation of the artifact on MR imaging. The phantom can be used to evaluate the artifact on MR imaging by a dental magnetic attachment keeper.

Acoustic shadowing in pediatric kidney stone ultrasound: a retrospective study with non-enhanced computed tomography as reference standard.

The usefulness of acoustic shadowing as a feature of pediatric kidney stone ultrasound (US) may be underestimated. The hypothesis was that the majority of stones in children have acoustic shadowing and that its specificity is high (>90%) in pediatric kidney stones. Our retrospective observational study included children who had undergone abdominal non-enhanced computed tomography (CT) for kidney stones in a pediatric renal stone referral centre between 2015 and 2016. US examinations prior to CT were retrospectively assessed for US features such as acoustic shadowing, twinkle artifact and stone size. These features were compared to CT as reference standard. Thirty-one patients (median age: 13years, range: 1-17years) with 77 suspected kidney stones were included. The median stone size was 5mm (interquartile range [IQR]: 5mm). For acoustic shadowing, sensitivity was 70% (95% confidence interval [CI] 56-80%) and specificity was 100% (95% CI 56-100%). All kidney stones with a diameter ≥9mm demonstrated shadowing. Sensitivity for twinkle artifact was 88% (95% CI 72-96%), but specificity for twinkle artifact could not be calculated due to the lack of true negatives. All false-positive stones on US demonstrated twinkle artifact, but none showed shadowing. Acoustic shadowing was demonstrated in the majority of pediatric kidney stones. Specificity was high, but this was not significant. Twinkle artifact is a sensitive US tool for detecting (pediatric) kidney calculi, but with a risk of false-positive findings.

Assessing image artifacts from radiotherapy electromagnetic transponders with metal-artifact reduction imaging

Image artifacts due to 14 gauge radiotherapy electromagnetic (EM) transponders were assessed on conventional spin echo images, and corrected using metal artifact reduction techniques: high bandwidth, view angle tilting (VAT), and slice encoding for metal artifact correction (SEMAC). Large areas of signal loss and/or pile-up were produced in an area extending up to 15.3 mm in radius for 14G transponders in standard imaging. Using high bandwidth imaging with VAT, in-plane artifact sizes were reduced by up to 35%. SEMAC did not significantly reduce in-plane or through plane artifact size for axially oriented images, but was effective in reducing through-plane artifacts for sagittal images. Using the experimental data, magnetic field maps were simulated so that the magnetic susceptibility of the transponder could be estimated and slice profiles could be visualized. Due to the large susceptibilities involved, current correction techniques are unable to fully correct artifacts due to EM transponders and significant areas of signal loss and distortion remain. Care should be taken when planning MRI following EM transponder implantation.

Metallic artifact reduction by evaluation of the additional value of iterative reconstruction algorithms in hip prosthesis computed tomography imaging.

To evaluate iterative metal artifact reduction (iMAR) technique in images data of hip prosthesis on computed tomography (CT) and the added value of advanced modeled iterative reconstruction (ADMIRE) compared with standard filtered back projection (FBP).Twenty-eight patients addressed to CT examinations for hip prosthesis were included prospectively. Images were reconstructed with iMAR algorithm in addition to FBP and ADMIRE techniques. Measuring image noise assessed objective image quality and attenuation values with standardized region of interest (ROI) in 4 predefined anatomical structures (gluteus medius and rectus femoris muscles, inferior and anterior abdominal fat, and femoral vessels when contrast media was present). Subjective image quality was graded on a 5-point Likert scale, taking into account the size of artifacts, the metal–bone interface and the conspicuity of pelvic organs, and the diagnostic confidence.Improvement in overall image quality was statistically significant using iMAR (P<.001) compared with ADMIRE and FBP. ADMIRE did not show any impact in image noise, attenuation value, or global quality image. iMAR showed a significant decrease in image noise in all ROIs (Hounsfield Unit) as compared with FBP and ADMIRE. Interobserver agreement was high in all reconstructions (FBP, FBP+iMAR, ADMIRE, and ADMIRE + iMAR) more than 0.8. iMAR reconstructions showed emergence of new artifacts in bone–metal interface.iMAR algorithm allows a significant reduction of metal artifacts on CT images with unilateral or bilateral prostheses without additional value of ADMIRE. It improves the analysis of surrounding tissue but potentially generates new artifacts in bone–metal interface.

Metal artifacts with dental implants: Evaluation using a dedicated CT/MR oral phantom with registration of the CT and MR images

The aims of this study were to develop a computed tomography/magnetic resonance (CT/MR) oral phantom with insertable dental implants and to register CT/MR images to generate artifact-free MR images for patients undergoing teeth restorations. All measurements were done using a human MR scanner with spin echo (SE) and gradient echo (GRE) sequences image scan together with CT image. The metal regions and normal teeth parts are extracted with a suitable threshold from an initial image reconstructed with artifact from the CT images. Corrected metal projection regions of MR images and CT images are fused to produce artifact-free MR image that include dental restorations. After CT/MR registration, artifact size presented differences on the x- (SE, 12.0 mm; GRE, 18.0 mm) and y- (SE, 24.0 mm; GRE, 36.6 mm). When comparing the dental restoration with normal teeth, the structural similarity index metric (SSIM) of GRE 50 was lower than for the GRE 8 sequence and the SSIM of SE 145 shown higher than for the SE 490 sequence. The dedicated phantom provides a useful tool in head and neck research for multi-modality images. Therefore, CT/MR image-based approach for ground truth and registration offers visualization in diagnostic system and radiation treatment planning system.

Continuity, Variability and the Nature of Technological Change During the Late Pleistocene at Klipfonteinrand Rockshelter in the Western Cape, South Africa

This paper discusses the late Pleistocene lithic sequence at Klipfonteinrand (KFR) rockshelter in the eastern Cederberg of the Western Cape. A characteristically Robberg technological system associated with the production of small silcrete blades from small cores was in place at the site by ~ 22 ka (thousand years ago) with a hornfels-dominant, non-microlithic Oakhurst system replacing it ~ 16 ka. Key technological differences in lithic material selection, artifact size, form, and techniques relating to the manufacturing process itself are apparent between early and later components within the Robberg, and between the Robberg and Oakhurst more broadly. Results suggest that technological change during the late Pleistocene was a fluid process involving continual modifications within the broad regional technological system. Variation during the Robberg occurred within a constrained range and the nature of change through the sequence was overall relatively gradual. The KFR data contributes to the emerging picture of the Robberg as temporally, spatially, and technologically complex with nuanced variation at a very fine scale of analysis.

The Study of lithic assemblages on deflation surfaces. The case study of Arroyo Verde, Northern Patagonia coast, Argentina

This paper focuses on surface lithic artefacts from Holocene coastal hunter gatherer occupations of Arroyo Verde archaeological locality (Rio Negro province, Northern Patagonia, Argentina). The study of lithic assemblages collected at a deflation surface surrounded by stabilised sand dunes near the coastline, shows that wind produce significant corrasion (wind abrasion) of artefacts and affects preservation of small and medium size artefacts. The sample is mainly composed of chert knapping debitage with abraded and polished edges and surfaces. The artefact size distribution suggests that a subset of the assemblage exhibits good preservation, possibly due to the recent subaerial exposure. Furthermore, carbonate and mould coatings were recorded over the artefacts surface in contact with the ground, which indicates the presence of humid conditions in the sand dunes deflation area. In order to explore the factors that affected assemblage stability conditions in the locus, a machine learning based decision tree was applied. The model predicts and defines a threshold at which the occurrence of instability conditions may appear. Also, it suggests that relative altitude of artefacts within the deflation hollow is the primary variable explaining the exposure conditions recorded in the artefacts and it points out processes of differential deflation over time. The data presented here illustrates how wind alters local surface materials and emphasizes that a taphonomic perspective is needed to assess the formation processes within northern Patagonia coastal archaeological assemblages.

Quantification of image artifacts from navigation markers in dynamic guided implant surgery and the effect on registration performance in different clinical scenarios.

Different navigation markers in dynamic guided implant surgery could cause different degrees of artifacts, which would affect the accuracy and efficiency of the implant navigation system. This study aimed to quantify artifacts caused by navigation markers made of different materials and to evaluate their effects on registration accuracy under various oral conditions. Four U-shaped tubes with different navigation markers (440c stainless steel, silicon nitride, zirconium oxide, and aluminium oxide) were produced by three-dimensional printing. Four kinds of maxillary plaster models were prepared to stimulate four tooth crown conditions. U-shaped tubes combined with different tooth models were scanned using cone beam computed tomography (CBCT). The size of artifacts from different navigation markers and registration rate were measured. Abrasion performance of navigation markers was evaluated by scanning electron microscopy (SEM) images. Aluminium oxide navigation markers showed the fewest artifacts. Silicon nitride markers caused fewer artifacts than zirconium oxide and 440c stainless steel ones (P < .05) and had the best registration performance under all tooth crown conditions with the lowest volume of abrasion. Registration data suggested aluminium oxide worked badly under artificial crown and natural tooth conditions for its lower radiopacity, and zirconium oxide worked undesirably in edentulous conditions. 440c stainless steel was worst in all dental conditions. Navigation markers made of silicon nitride have the best overall performance and perform the best in registration under all circumstances owing to less artifact generation, better radiopacity, and desirable abrasion resistance. Silicon nitride can be regarded as an ideal material, including but not limited to oral implant navigator-guided surgery.

Spine MR images in patients with pedicle screw fixation: Comparison of conventional and SEMAC-VAT sequences at 1.5 T

Background and purposeSlice-encoding metal artifact corrections (SEMAC)-view-angle tilting (VAT) sequences have recently been used in clinical protocols to reduce metal artifacts in MR scans of patients with spinal instrumentation. The objective of this study was to compare the SEMAC-VAT sequence with the conventional MR sequence with a low bandwidth turbo-spin echo (TSE) in terms of image quality, visibility of periprosthetic structures, and diagnostic confidence for detection of postoperative complications in patients who underwent pedicle screw fixation at 1.5 T. MethodsSeventy patients who underwent pedicle screw fixation between the thoracic vertebrae and the sacrum were included in the study. The MR scans were retrospectively evaluated by two radiologists for signal-to-noise ratio of anatomical structures and size of artifacts, visibility of periprosthetic anatomical structures, and diagnostic confidence for detection of postoperative complications on conventional TSE and on SEMAC-VAT images. Paired t-tests and Wilcoxon signed-rank tests were used for comparisons, and kappa values were used for inter-observer agreement. ResultsSEMAC-VAT images demonstrated significantly fewer metal artifacts, providing improved delineation of most periprosthetic anatomical structures and higher diagnostic confidence for detection of postoperative complications compared with conventional TSE images (p < 0.001). For the spinal canal, however, the visibility of anatomical structures and diagnostic confidence for detection of postoperative complications were better for conventional TSE than for SEMAC-VAT imaging (p < 0.001). ConclusionIn conclusion, although SEMAC-VAT can significantly reduce metal artifact and provide improved delineation of periprosthetic anatomical structures compared to conventional TSE images, TSE is better for spinal canal evaluation. Therefore, it is important to understand the advantages and disadvantages of SEMAC-VAT and to use it properly.

Assessment of MRI safety issues for stainless steel sutures used for microtia reconstruction

Potential magnetic resonance imaging issues for stainless steel sutures used for microtia reconstruction could be clinically significant for safety and diagnostic yield considerations. Therefore, the purpose of this investigation was to assess magnetic resonance issues (magnetic field interactions, heating, and artifacts) for different types of stainless steel sutures used for microtia reconstruction. Small gauge, commonly used stainless steel sutures from four different manufacturers (5/0 Steelex, Aesculap/B, Braun Medical, Inc.; Nagata 38 Gauge Microtia Wire, Bear Medical Corporation; Auricular Reco Wire, Medicon Surgical Inc.; and 5-0 B&S 35 Surgical Steel Suture, Ethicon, Inc.) were tested using standardized ex vivo techniques to assess magnetic field interactions, heating, and artifacts at 3Tesla. Before testing, the stainless steel sutures were configured in a manner same as that for cartilage reconstruction used to treat microtia. Each stainless steel suture exhibited minor magnetic field interactions at 3Tesla (translational attraction, deflection angle <10°, and no torque). Heating associated with a whole-body averaged specific absorption rate of 2.9 W/kg was not excessive (highest temperature changes, ≤1.8 °C). Artifacts were relatively minor in relation to the size and shape of each stainless steel suture (artifact size in relation to the size and shape of each stainless steel suture extending ≤5 mm). The stainless steel sutures that underwent testing do not present additional risks to patients in a 3-Tesla or less magnetic field setting (i.e., magnetic resonance conditional). Artifacts for these sutures may only be an issue within close proximity to the reconstructed ear.

MSVAT-SPACE-STIR and SEMAC-STIR for Reduction of Metallic Artifacts in 3T Head and Neck MRI.

The incidence of metallic dental restorations and implants is increasing, and head and neck MR imaging is becoming challenging regarding artifacts. Our aim was to evaluate whether multiple-slab acquisition with view angle tilting gradient based on a sampling perfection with application-optimized contrasts by using different flip angle evolution (MSVAT-SPACE)-STIR and slice-encoding for metal artifact correction (SEMAC)-STIR are beneficial regarding artifact suppression compared with the SPACE-STIR and TSE-STIR in vitro and in vivo. At 3T, 3D artifacts of 2 dental implants, supporting different single crowns, were evaluated. Image quality was evaluated quantitatively (normalized signal-to-noise ratio) and qualitatively (2 reads by 2 blinded radiologists). Feasibility was tested in vivo in 5 volunteers and 5 patients, respectively. Maximum achievable resolution and the normalized signal-to-noise ratio of MSVAT-SPACE-STIR were higher compared with SEMAC-STIR. Performance in terms of artifact correction was dependent on the material composition. For highly paramagnetic materials, SEMAC-STIR was superior to MSVAT-SPACE-STIR (27.8% smaller artifact volume) and TSE-STIR (93.2% less slice distortion). However, MSVAT-SPACE-STIR reduced the artifact size compared with SPACE-STIR by 71.5%. For low-paramagnetic materials, MSVAT-SPACE-STIR performed as well as SEMAC-STIR. Furthermore, MSVAT-SPACE-STIR decreased artifact volume by 69.5% compared with SPACE-STIR. The image quality of all sequences did not differ systematically. In vivo results were comparable with in vitro results. Regarding susceptibility artifacts and acquisition time, MSVAT-SPACE-STIR might be advantageous over SPACE-STIR for high-resolution and isotropic head and neck imaging. Only for materials with high-susceptibility differences to soft tissue, the use of SEMAC-STIR might be beneficial. Within limited acquisition times, SEMAC-STIR cannot exploit its full advantage over TSE-STIR regarding artifact suppression.

Setting pressure can change the size and shape of MRI artifacts caused by adjustable shunt valves: a study of the 4 newest models.

Adjustable shunt valves that have been developed for the management of hydrocephalus all rely on intrinsically magnetic components, and artifacts with these valves on MRI are thus inevitable. The authors have previously reported that the shapes of shunt artifacts differ under different valve pressures with the proGAV 2.0 valve. In the present study the authors compared the size and shape of artifacts at different pressure settings with 4 new-model shunt valves. The authors attached 4 new models of MRI-resistant shunt valve to the temporal scalp of a healthy volunteer: the proGAV 2.0; Codman Certas Plus; Polaris; and Strata MR. They set 3 different scales of pressures for each valve, depending on magnet orientation to the body axis. Artifacts were evaluated and compared among all valves on a 3.0-T GE scanner and 2 valves were also evaluated on a Philips scanner and a Siemens scanner. In-plane artifact sizes were evaluated as the maximum distance of the artifact from the expected scalp. The sizes and shapes of artifacts changed depending on valve pressure for all valves on the 3 different MRI scanners. Artifacts were less prominent on spin echo sequences than on gradient echo sequences. For diffusion-weighted imaging and time-of-flight MR angiography, the authors matched image numbers within the same sequence and compared appearances of artifacts. For all valves, the number of images affected by artifacts and the image number showing the largest artifact differed among valve settings. Artifacts of all adjustable shunt valves showed gross changes corresponding to pressure setting. Not only the maximum distance of artifacts but also the shape changed significantly. The authors suggest that changing pressure settings offers one of the easiest ways to minimize artifacts on MRI.

Characterization of a novel liquid fiducial marker for multimodal image guidance in stereotactic body radiotherapy of prostate cancer.

Liquid fiducial markers have shown to be a promising alternative to solid gold markers in terms of imaging artifact reduction, patient comfort, and compatibility with different imaging modalities. This study aims to investigate the performance of the novel BioXmark® liquid marker for state-of-the-art multimodal imaging used in prostate cancer (PCa) radiotherapy, encompassing kV CT/CBCT, multiparametric MRI, and kV x-ray imaging. In addition, automatic detection of the liquid markers in x-ray imaging for prostate motion monitoring during treatment was investigated. A total of eight BioXmark® liquid markers with varying volumes (range 5-300 μL) were casted on a square grid into a gelatin phantom insert. A cylindrical gold marker (QLRAD, length = 7 mm, Ø = 1 mm) was inserted for reference. Liquid marker visibility and streaking artifacts in CT/CBCT imaging were evaluated by placing the gelatin phantom into a CIRS anthropomorphic phantom. Relevant MRI characteristics such as the T2 and T1 relaxation times, the ADC value, and the relative proton density (ρH) were quantified by placing the gelatin phantom insert next to a T1MES mapping phantom and a water-filled syringe for reference. Ex vivo multiparametric MRI images were acquired by placing the gelatin phantom next to a resected prostate specimen. Anterior-posterior x-ray projection images were obtained by placing the gelatin phantom insert on top of an anthropomorphic pelvic phantom with internal pelvic bony structures and were acquired for five positions relative to the bony anatomy and 24 clinically relevant x-ray exposure settings. To quantify individual automatic marker detection, single markers were artificially isolated in the x-ray images using postprocessing. Markers of all sizes were clearly visible on CT and CBCT images with only the largest marker volumes (100-300 μL) displaying artifacts similar in size to the gold fiducial marker. Artifact size increased with increasing liquid marker volume. Liquid markers displayed good contrast in ex vivo T1-weighted and ρH-weighted images. The markers were not visible in the ex vivo T2-weighted image. The liquid markers induced a chemical shift artifact in the obtained ADC-map. Automated detection in x-ray imaging was feasible with high detection success (four of five positions) for marker volumes in the range of 25-200 μL. None of the liquid markers were detected successfully when superimposed on a bony edge, independent of their size. This study is the first to show the compatibility of BioXmark® liquid markers with multimodal image-guided radiotherapy for PCa. Compared to a solid gold marker, they had favorable results in both visibility and induced imaging artifacts. Liquid marker visibility in MRI imaging of the prostate does not solely depend on the low ρH value (not visible on T2-weighted image) but is also influenced by its relaxation times. Automated marker detection in x-ray images was feasible but better adapted marker detection algorithms are necessary for marker localization in the presence of bony edges. Hence, the liquid marker provides a minimally invasive (fine needles) and highly applicable alternative to current solid gold markers for multimodal image-guided prostate radiotherapy treatments.

Comparison of MRI in pediatric cochlear implant recipients with and without retained magnet

ObjectiveTo report and compare medical, radiological, and audiological outcomes in pediatric cochlear implant recipients who underwent 1.5 and 3 Tesla strength MRI with and without retained magnet. MethodsRetrospective chart review at a tertiary care pediatric hospital and review of literature. Patients were identified via electronic medical records database search and were included if they had MRI after cochlear implant. ResultsOf twelve instances of MRI in pediatric cochlear implant recipients at our institution, two minor complications and one major complication were recorded. The rate of complication was equal between patients who underwent MRI with and without retained magnet. All minor complications resulted from MRI with retained magnet whereas the only major complication resulted from magnet removal. Two novel complications are reported, including: magnet removal resulting in silastic tear necessitating reimplantation and magnet dislocation with spontaneous reduction. Magnet removal significantly decreased the size of artifact, but did not alter the diagnostic utility of the MRI. While audiological measures varied chronologically from MRI scans, they did not appear to be appreciably altered by MRI. ConclusionMRI with and without magnet retention appear to carry risks of both major and minor complications. For the regions of interest for each scan, MRI quality was not appreciably altered by magnet status. Audiological measures appear unaffected by magnet status during MRI however, this may reflect natural variation.

Open-air preservation of miniaturised lithics: experimental research in the Cederberg Mountains, southern Africa

Open-air archaeology plays a limited role in southern African Late Pleistocene research, with most studies focused on rock shelter assemblages. Recently, archaeologists have noted discrepancies in the composition of Late Pleistocene lithic assemblages between some of the region’s open-air and rock shelter sites. For example, although relatively abundant in rock shelters, Late Pleistocene Later Stone Age (LSA, c. 44–12 kcal. BP) bipolar cores are rare in open-air contexts. In this paper, we assess this discrepancy by testing for differential preservation of specific artefact classes and sizes in semi-arid open-air conditions. We placed a replicated assemblage of miniaturised cores and flakes on an archaeologically sterile sediment surface in the Doring River Valley (South Africa) and recorded their movements over 22 months. Our results indicate that bipolar and freehand cores moved comparable distances within the study interval and that surface slope is the strongest predictor of miniaturised tool movement. We also show that (1) relatively flat lithics move disproportionately more and (2) random artefact orientations do not preclude local (i.e. metre) scale artefact transport. In terms of the archaeology of our study area, the observed clustering of surface artefacts on sediment bodies likely results from their recent exposure. Our data suggest that the paucity of open-air bipolar artefacts in Late Pleistocene LSA assemblages may have more to do with human behavioural variability at landscape scales than differential preservation. Southern Africa’s rich rock shelter record is, therefore, unlikely to represent the full suite of prehistoric hunter-gatherer behaviours.