Exercise is Medicine (EIM) on Campus programs have the potential to improve the health of students through exercise and other wellness interventions. PURPOSE: The purpose of this study was to evaluate a pilot exercise and wellness program designed to improve fitness and reduce cardiovascular disease risk factors. Specifically, we sought to determine whether this EIM program was successful in targeting students who were obese and/or unfit and to evaluate the effectiveness of an exercise program for promoting weight loss and improving fitness. METHODS: Subjects were 13 students (age 23.4±5.1 y) who completed a six-week intervention that included an individualized exercise program delivered through the campus wellness center. The students in this program volunteered to participate, as opposed to receiving referrals from the student health center. Body weight, BMI, waist circumference, submaximal estimation of VO2max (Rockport one mile walk test), and assessments of muscular strength, endurance, and flexibility were completed in all subjects at the beginning and end of the program. RESULTS: The subjects who enrolled were obese and had a low estimated VO2max, indicating that the program attracted students who could benefit from the exercise intervention. Following the six-week program, subjects experienced modest but significant reductions in body weight (95.8±19.8 to 94.3±20.3 kg, p<0.01), BMI (34.2±6.5 to 33.7±6.6 kg•m-2, p<0.01), and waist circumference (103.4±18.4 to 98.0±15.9 cm, p<0.05). Fitness indicators also improved, including VO2max (25.4±8.0 to 30.3±7.8 ml•kg-1•min-1, p<0.01), push-ups to fatigue (12.9±10.2 to 16.2±10.7, p<0.05), plank time (35.3±18.7 to 43.4±20.3 s, p<0.05), wall sit time (34.8±45.6 to 45.6±33.4 s, p<0.05), and sit and reach distance (46.0±49.3 to 49.3±9.5 cm, p<0.01). CONCLUSION: This EIM program was effective at targeting students who needed to lose weight and improve their fitness. Additionally, participants realized improvements in body weight, BMI, waist circumference, and fitness during the short, six-week program.