Situation In Man Research Articles

The Role of Rationalism and Thoughtfulness in Educating the Moral Society Using Imam Ali Hadiths

In Islamic culture, rationality and the implementation of the secondary meanings for rationality and wisdom have a unique interpretation in Islam that is not comparable to other religions and cultures. Rationalism has such a high status in Islamic jurisprudence that Islamic rationalism is complete. Islam considers moral education as the leading foundation for a complete education. Therefore, rational education is parallel to moral education. Moral education is the guidance and education of the human psyche through the rational side. In rational education, the heart of man is the center of rationalism. The heart of every human is educated through the verses of the Qur'an and the hadiths of the Imams. Therefore, the social structure of an Islamic society is endowed with an infinite moral aspect that stabilizes man's situation in society and clarifies his relationship with society - the demands and conditions of the new situation guide the individual and society to grow. According to Nahj-Al-Balaghah, optional behavior is attributed to a human being. A wise person is expected to improve and develop the compelling aspects of rationalism and guard against inhibiting factors of rationalism. Therefore, the wise person can appropriately benefit from the achievements of forward-looking action and begin a life of happiness and pride. In many narrations of Imam Ali (A.S.) about the qualities of wisdom and the forward-looking wise man, wisdom is the most vital source to recognize truth and falsehood and perform good deeds. This paper examines the role of rationalism and thoughtfulness in educating the moral society through the hadiths of Imam Ali (A.S.).

100 Years Sitti Nurbaya: A View on the Social Criticism in the Novel Sitti Nurbaya

Sitti Nurbaya is one of the first modern Indonesian novels, and it was published in the year 1922. It illustrates the tragic story of a teenager who is forced to marry an older man. In this research paper, the researchers want to look at the social criticism of Marah Rusli, the author of Sitti Nurbaya. Such a perspective can reveal the inner dynamics of the Minangkabau society of West Sumatra (Indonesia), the setting of the novel. Marah Rusli originates from West Sumatra, and his novel describes the process of change at the beginning of the 20th century. The researchers used a mixed approach to analyze the novel Sitti Nurbaya and detect the traditional system’s inherent criticism. The researchers used a methodology that comprised two methods, a structuralist approach and a biographical viewpoint. The research discovered that Marah Rusli criticizes the situation of men within a matrilineal society. He is also critical of the excesses of a growing capitalistic mindset.

Signs and symptoms in relation to progression, experiences of an uncertain illness situation in men with metastatic castration-resistant prostate cancer-A qualitative study.

ObjectiveSigns and symptoms are important in monitoring prostate cancer, but there is a lack of understanding about the men's interpretation of signs and symptoms in relation to disease progression in advanced phases of the disease. The aim was to illuminate the experience of signs and symptoms in relation to disease progression in men with metastatic castration‐resistant prostate cancer (mCRPC).MethodThirty longitudinal interviews were conducted with 11 men undergoing life‐prolonging treatment for mCRPC. Conventional content analysis was used.ResultsThe results illuminate an uncertainty that the men experience when interpreting signs and symptoms. The overarching theme was The experience of an uncertain illness situation within the framework of progression, with four subthemes: Symptoms triggering thoughts about disease progression; Making sense of signs, also in the absence of symptoms; Making sense of symptoms during treatment; Progression triggering thoughts about the remainder of life.ConclusionIn the uncertain illness situation, the men strive to make sense of signs and symptoms based on previous experiences and in relation to disease progression. Understanding the men's perspectives on signs and symptoms in this late phase may help health care professionals communicate about disease progression considering the balance between treatment outcome and quality of life.

Homo ethicus oder der Mensch in seiner moralischen Verantwortung Eine islamische Perspektiv

In his contribution, Esfahani sheds light on homo ethicus and his moral responsibility from the perspective of the Koran and Islamic tradition. He considers it necessary to first present the existential situation of man’s relationship with God, and then he develops some criteria that enable man to make moral decisions and act ethically in faith in God. According to Islamic belief, man is the highest possible representative of God in creation. Esfahani refers to Islamic mystics who described the perfect human being as a pure mirror in which the attributes and names of God should be reflected. When man reaches this stage, he has reached a height where even the angels bow before him. At the highest level, man approaches being made in the image of God, even if the boundary between creator and created remains clear. The author turns to the Koran, where God introduces Adam to the angels as his representative or successor and the angels are asked to prostrate themselves before him. It becomes clear that God has endowed his representative with a knowledge that the angels do not possess, and this knowledge is the knowledge of the names of God, which brings enormous consequences – it is a knowledge that enables man to act in all matters in accordance with the responsibility of a representative of God. As a result, people have an inner compass that enables them to follow God’s will and act ethically when making a decision. Depending on the level of consciousness achieved, the motives for human action can be varied. All names were united in the perfect human being and these would also be brought into appearance through his humanity. Man has free will, which he is not allowed to oppose to the will of the Creator. A decisive impetus for ethical action is the knowledge that in the afterlife people have to be accountable for their actions. Reason is given to man, which enables him to make the right distinction. On this basis, a rationally justified three-stage ethical model is developed. At the highest level, »mindfulness of God«, man shapes his actions in the awareness of God’s presence.

Factors of Ukrainian men involving in men’s movements that support gender equality

In recent years, Ukraine has received more attention to the issues of masculinity, the position of men and their participation in activism in support of gender equality. In Ukraine, there are several men’s organizations and initiatives that support the ideas of gender equality: dad schools, men against violence, HeforShe Ukraine and HeforShe Congresses, profeminist schools for men, national networks of male leaders against violence, an international union of courageous dads, etc. Feminist public activists appear to talk about the benefits of gender equality. The men’s movement for gender equality in the world and in Ukraine is seen as focusing on either women’s rights or men’s rights. According to men’s movement researcher Michael Messner, institutional privileges and costs of masculinity are the aspects of the classification of male movements. As a result of the analysis of six in-depth interviews with Ukrainian activists of men’s movements, Michael Messner’s ideas were illustrated with examples from Ukrainian society. Factors involving men in men’s movements for gender equality differ depending on the type of the men’s movement. Women’s rights movements were characterized by awareness of cases of discrimination against women and a corresponding sense of solidarity and compassion. Movements for men’s rights – by awareness of cases of discrimination against men in their own experience, a sense of the need to respond to the movement for women’s rights, and the situation of men’s movements in Ukraine, i.e. factors that directly affect men. In addition, it has been found that there are common factors in involving men in women’s and men’s rights movements, such as the existence of a feminist movement, a sense of the need for change, and a desire to be involved in local or global change. Expert interviews have found that the use of personal experience is the most effective way to influence the level of men’s involvement in men’s movements for gender equality, including in Ukraine. Attention to real cases of gender discrimination against women will be perceived more sincerely and openly than statistics. Attention to real cases of gender discrimination against women will be perceived more sincerely and openly than statistics. In addition, it is important to demonstrate the experience of men who understand the benefits of gender equality for men as well. They, according to experts, will be able to serve as examples for other men to follow. Separately, experts noted the role of education in the desire to join the struggle of men for the idea of gender equality. Both non-formal education programs and formal education on equal rights and opportunities can be tools for introducing changes in men’s attitudes to discrimination.

Differences between determinants of men and women monthly wages across fourteen European Union states

Research background: There is a broad discussion in the literature on the situation of men and women in the labour market, especially about the differences in their remuneration. Due to the fact that females constitute a slightly different group of employees, certain factors have different impacts on the level of their remuneration in comparison to male employees. Hence, the question arises which factors cause these differences and how large the dissimilarities are.
 Purpose of the article: The aim of the presented study is to diagnose and evaluate differences in the impact of designated determinants on the level of monthly wages of women and men in selected European Union member states. The novelty of our approach consists in both comparison of the intensity of influence examined factors to men?s and women?s earnings, and a global approach to the remuneration of male and female employees.
 Methods: Due to the nature of the dependent variable (remuneration decile, which is a variable measured on an ordinal scale), the ordered logit model is applied in the analysis. The data comes from the Eurostat?s Labour Force Survey.
 Findings & value added: Presented results indicate that many factors have significantly different intensity of impact on the level of men and women wages. However, significant differences between parameters estimated for both genders are visible for the group of family variables the most often, then for variables describing the condition of work, the human capital variables, and characteristics of the workplace. This paper adds to the empirical literature a new approach to measure the intensity of factors influencing men and women wages. In addition, our investigation is a cross-country analysis.

Melancholy and Crisis Worldview as the Situation of Man “In His Time” in the First Third of the XX Century

Introduction. Shaping modernity in the first third of the twentieth century is tied to the private worldview of the person of this era in which the main metaphor of the individual perception of “their time” is melancholy. The crisis of this historical period forms the prism of melancholic worldview. The goal of this article is to substantiate the reasons for the perception of melancholy as a phenomenon caused in part by the problem of individual experience of time. The relationship between melancholy and modernity has already been noted in the literature, but this text raises a new question – what is the temporal nature of this mutual influence?Methodology and sources. A key role in the understanding of melancholy is played by the texts of authors of the early 20th century: Walter Benjamin, devoted to Charles Baudelaire and the work of Sigmund Freud “Mourning and Melancholy”. The issue of temporality in the work is interpreted through the reference to the phenomenological tradition, namely in reference to the modern phenomenological analysis of depressive disorder in the work of Domonkos Sik.Results and discussion. The author comes to the conclusion that the feeling of the interrelation of melancholy and the epoch is extremely specific for a person of the first third of the 20th century, evidence of which could be found in the philosophical and cultural reflection of this period. Crisis worldview is reflected in literature, painting, cinema, philosophy, social theory, etc. Thus, it is possible to represent melancholy as a phenomenon, partly caused by the problem of individual experience of time. Melancholy occurs when a crisis worldview is supplemented by an experience of circular temporality, the disappearance of the future, preoccupation with the past, passivity, or isolation.Conclusion. If these elements come together, a total worldview is formed in which real world events intensify melancholy. In this sense, phenomenologically speaking, melancholy is not so much a state as a dynamic process.

Восприятие человека и антропологическая идеология в развитии философской мысли

In the history of mankind, much indicates that the understanding of man and the knowledge of his nature is associated with the socio-historical situation of man and the level of development, as well as the way of realization of human consciousness. The author of the article adheres to the position that philosophy is directly or indirectly anthropological research, i. e. it carries out directly, having as an object of study directly human nature, or indirectly, studying any other manifestations in the light of man and the anthropic principle. The world is proportional to man, and through the study of human nature, the ways of interaction with the universe, can be made a significant contribution to the understanding of the essence of man. If we consider a person as a cultural being, which is focused primarily on the development of their own values, through the understanding and practical application of philosophical thought, can be gradually changed rather narrow horizon of philosophy of consciousness. The article presents an attempt to determine the self-existence of a person, to determine its relationship with national identity and idea.

HIV-positive men as Superheros

Summary Improvements in the prognosis for HIV infection and the impact of biomedical strategies for the prevention of transmission have created very specific situations for men who live with HIV within the homosexual minorities. Originally focused on their duty in preventing transmission, the issue at stake gradually moved towards one of power, with the HIV-infected person, the hero/martyr of the 1980s and 1990s, becoming the hero who has vanquished the fear of Aids. Undetectable viral load, the standard of current treatment, makes the individual himself undetectable, invisible. In a population so profoundly affected by the history of Aids, these are superpowers. The HIV-positive guy has become a superhero. The clinical situation for gay men living with HIV says otherwise. In addition to the modifications they have had to make to their sex-lives, be it compulsory abstinence, a change in sexual roles, limiting sexual partners to those who are also HIV-positive or forming a couple at all costs, gay HIV-positive men today seem forced to negotiate with this image that has been forced upon them, in a context where sexual encounters increasingly adopt a neoliberal model. A command to climax, to avoid any problems, to be satisfied with these superpowers even if they didn’t want them in the first place, in a context where invisibility is demanded. None of this helps HIV-positives to repair the consequences of the infection on their sexuality. By adopting the behaviours that have been assigned to them, some of them use their superpowers and transgress all the interdicts (sexual practices, drugs) simply to feel something again. It is probable that our superheros are only superheroes in the eyes of others. In the future, we can expect gays to distance themselves from the epidemic with the development of PrEP; but will that put an end to this fabricated fantasy that gets under the skin of HIV-positive gay men and provides ample opportunity for sexological clinical repercussions.

Pela superfície do mundo: objetos e memória na literatura brasileira contemporânea

Contam os especialistas em falsificação de quadros que não é o rosto ou a mão do retratado que delata o falsário – ali ele terá tomado todas as precauções. Seu erro aparecerá em um detalhe pouco importante, talvez na indumentária ou na curva de uma orelha, onde ele se sentirá mais à vontade e, sem se dar conta, deixará uma assinatura: sua própria pincelada. Abandonando, então, o foco no enredo, ou nos protagonistas das narrativas, procuro pensar a literatura brasileira contemporânea a partir de elementos considerados secundários, quando não irrelevantes: os objetos que compõem a cena. Seus significados, muitas vezes evocadores da memória das personagens, ou dos seus, marcam a situação de homens e mulheres no mundo contemporâneo e revelam algo sobre a perspectiva autoral. Este texto, inspirado em diferentes narrativas e mesmo nas artes visuais, é um breve percurso pelas inquietações que fundamentam esta reflexão.

Kyrgyz Genealogies and Lineages: Histories, Everyday Life and Patriarchal Institutions in Northwestern Kyrgyzstan

Uruu patrilineages and genealogical narratives about them are important aspects of Kyrgyz social practice and reflect some tensions and contradictions in contemporary Kyrgyz self-understanding and identities. This article explores the complex relationship of patrilineal kinship to historical knowledge and lived social experience in northwestern Kyrgyzstan. The contrasting situations of men and women within patrilineages are analyzed to reveal the shifting relationships of gender, genealogy and patrilineal kinship. Local meanings and uses of genealogy and history are shown to differ from those developed at the national level as part of Kyrgyz nation-building: Narratives about local lineages and their heroes portray different sacred and social worlds than those about the hierarchical world of elite politics and the military feats of national heroes.

A study on gender differences in newly detected leprosy cases in Sichuan, China, 2000-2015.

Many researches on gender differences in leprosy found that female patients were detected with the disease later and had more serious disabilities than male patients. We analyzed the gender differences related to epidemiological characteristics of new leprosy cases detected from 2000 to 2015 in Sichuan Province, China. A retrospective study was undertaken to analyze the gender differences with respect to age, delay in disease detection, the main modes of detection, and disability grade. The chi-squared test and t test were applied for the comparison using Epi Info 7.2 with a significance level of a = 0.05. The data were collected from the Leprosy Management Information System in China. A total of 2900 new leprosy cases were detected from 2000 to 2015, of whom 2075 (71.6%) were male and 825 (28.4%) were female with a gender ratio of 2.5. The gender ratio of patients aged 15-30 was significantly lower than that of patients aged 31-45 and 46-60. Male cases were older than female cases when they were detected. The proportion of Grade 2 Disability (G2D) among men (20.6%) was significantly higher than that among women (17.3%). The average period of delay in detection among male cases was similar with that among females cases. Gender-related differences existed among the leprosy cases detected from 2000 to 2015. Female patients were younger than male patients. The detection of leprosy in women was not later than in the case of men. The disability situation in men was more serious than in women.

Occupational health with a gender perspective

Social factors, such as education, employment status, income level, gender and ethnic origin, have a clear influence on a person’s health. In all countries, whether low, medium or high income, there are great differences in the state of health among different social groups. This essay is approached through the gender perspective for the analysis of how labor epidemiology behaves in the feminine sector; the objective is to present in a succinct and objective way the information referring to the main extra-domestic female occupations and the differences regarding the situation of men. It was found that in Mexico there is a salary difference where women face a disadvantage. In relation to work accidents in Mexican women, the main diagnoses were superfi cial trauma, dislocations, sprains and tears, followed by injuries and fractures, among others; according to their occupations, they were mainly sweepers, cleaning workers, sales employees, dispatchers and cooks, among others.

Assessment of the gender impact on the form of exit from unemployment

Numerous researches indicate that the situation of men and women on the labour market varies. In order to equalise opportunities, labour offices offer various forms of activisation to the unemployed. However, it was observed that besides deregistering people taking up employment, removal of persons, who did not accept offered position, from the register was a common reason. The aim of the research is to assess the influence of gender of the unemployed persons on the intensity of deregistration due to taking up employment, cancelling or other causes. These reasons constitute various types of competing events. In order to assess the probability of deregistration, the Kaplan-Meier estimator was used and to determine the intensity of deregistration for a specific reason — the Lunn-McNeil model. In the research individual data of persons registered in the Powiat Labour Office in Szczecin in the years 2013 and 2014 were used. The results of the research show that intensity of finding a job was higher for women than for men. Women were also more rarely cancelled from the registry. In the case of other reasons, differences in the intensity of deregistration in terms of sex were not statistically significant.

Relacyjna natura sakramentu pokuty i pojednania w perspektywie usprawiedliwiającej łaski

Prawda wiary chrześcijańskiej poucza nas, że w sytuacji zniewolenia człowieka Bóg ponownie kieruje w jego stronę swoją miłość i uzdalnia go przez swoją łaskę do istotowo wewnętrznej przemiany, która stwarza nową jakość relacji stworzenia do Stwórcy i zbawcy. Pojednanie człowieka z Bogiem oraz z ludźmi wiąże się ściśle z przezwyciężeniem nieładu, który tkwi w człowieku, a więc wymaga niejako pojednania z samym sobą przez żal i postanowienie poprawy oraz zadośćuczynienie zawarte w pokucie osobowej. Z tego względu „jedność ludzi nie dokona się bez wewnętrznej przemiany każdego z osobna. Osobiste nawrócenie jest konieczną drogą do zgody pomiędzy ludźmi”. Pojednanie z Bogiem, z ludźmi i sobą samym prowadzi również do pojednania z całym stworzeniem odpowiednio do właściwego przyporządkowania celów w ramach integralnego powołania człowieka. zastanawiając się przeto nad znaczeniem Sakramentu Pokuty w życiu chrześcijan nie można przeoczyć znaczenia pokoju serca, którego źródłem jest ożywione łaską przeświadczenie o skutecznym pojednaniu z Bogiem i Kościołem w znaku sakramentalnym. to pojednanie stanowi podstawę nadziei na doskonalenie zjednoczenia z Bogiem i braćmi podczas ziemskiego pielgrzymowania ku wiecznemu wypełnieniu w społeczności zbawionych.

Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase

2-Hydroxyacyl-CoA lyase (HACL1) is a key enzyme of the peroxisomal α-oxidation of phytanic acid. To better understand its role in health and disease, a mouse model lacking HACL1 was investigated. Under normal conditions, these mice did not display a particular phenotype. However, upon dietary administration of phytol, phytanic acid accumulated in tissues, mainly in liver and serum of KO mice. As a consequence of phytanic acid (or a metabolite) toxicity, KO mice displayed a significant weight loss, absence of abdominal white adipose tissue, enlarged and mottled liver and reduced hepatic glycogen and triglycerides. In addition, hepatic PPARα was activated. The central nervous system of the phytol-treated mice was apparently not affected. In addition, 2OH-FA did not accumulate in the central nervous system of HACL1 deficient mice, likely due to the presence in the endoplasmic reticulum of an alternate HACL1-unrelated lyase. The latter may serve as a backup system in certain tissues and account for the formation of pristanic acid in the phytol-fed KO mice. As the degradation of pristanic acid is also impaired, both phytanoyl- and pristanoyl-CoA levels are increased in liver, and the ω-oxidized metabolites are excreted in urine. In conclusion, HACL1 deficiency is not associated with a severe phenotype, but in combination with phytanic acid intake, the normal situation in man, it might present with phytanic acid elevation and resemble a Refsum like disorder.

Non‐animal models of wound healing in cutaneous repair: In silico, in vitro, ex vivo, and in vivo models of wounds and scars in human skin

Tissue repair models are essential to explore the pathogenesis of wound healing and scar formation, identify new drug targets/biomarkers and to test new therapeutics. However, no animal model is an exact replicate of the clinical situation in man as in addition to differences in the healing of animal skin; the response to novel therapeutics can be variable when compared to human skin. The aim of this review is to evaluate currently available non-animal wound repair models in human skin, including: in silico, in vitro, ex vivo, and in vivo. The appropriate use of these models is extremely relevant to wound-healing research as it enables improved understanding of the basic mechanisms present in the wound healing cascade and aid in discovering better means to regulate them for enhanced healing or prevention of abnormal scarring. The advantage of in silico models is that they can be used as a first in virtue screening tool to predict the effect of a drug/stimulus on cells/tissues and help plan experimental research/clinical trial studies but remain theoretical until validated. In vitro models allow direct quantitative examination of an effect on specific cell types alone without incorporating other tissue-matrix components, which limits their utility. Ex vivo models enable immediate and short-term evaluation of a particular effect on cells and its surrounding tissue components compared with in vivo models that provide direct analysis of a stimulus in the living human subject before/during/after exposure to a stimulus. Despite clear advantages, there remains a lack of standardisation in design, evaluation and follow-up, for acute/chronic wounds and scars in all models. In conclusion, ideal models of wound healing research are desirable and should mimic not only the structure but also the cellular and molecular interactions, of wound types in human skin. Future models may also include organ/skin-on-a-chip with potential application in wound healing research.

Mortality by skin color/race and urbanity of Brazilian cities

ABSTRACTObjective: The skin color/race and urbanity are structural determinants of health. The relationship between these variables produces structure of social stratification that defines inequalities in the experiences of life and death. Thus, this study describes the characteristics of the mortality indicators by skin color/race according level of urbanity and aggregation to the metropolitan region (MR) of 5565 cities in Brazil, controlling for gender and age.Design: Descriptive study which included the calculation of measures relating to 1,050,546 deaths in the year survey of 2010 by skin color/race White, Black, and Brown according to both sexes, for five age groups and three levels of urbanity of cities in Brazil that were aggregated or not to the MR in the year of study. The risk of death was estimated by calculating premature mortality rate (PMR) at 65 years of age, per 100,000 and age adjusted.Results: The structure of mortality by skin color/race Black and Brown reflects worse levels of health and excessive premature deaths, with worse situation for men. The Whites, especially women, tend to live longer and in better health than other racial groups. The age-adjusted PMR indicates distinct risk of death by skin color/race, this risk was higher in men than in women and in Blacks than in other racial groups of both sexes. There have been precarious levels of health in the urban space and the MR has intensified these inequalities.Conclusions: The research pointed out that the racial inequality in the mortality was characterized by interaction of race with other individual and contextual determinants of health. Those Blacks and Browns are the groups most vulnerable to the iniquities associated with occurrence of death, but these differences in the profile and the risk of death depend on the level of urbanity and aggregation MR of Brazilian cities in 2010.

OSLOBAĐANJE KULTURE U FIHTEOVOJ FILOZOFIJI

U Fihteovim jenskim <em>Predavanjima o određenju naučnika </em>kultura je pojmljena kao sredstvo čovekovog identiteta. Kompleksnost takvog određenja ogleda se najpre u tome što Fihte kulturu razume istovremeno kao oslobađajući proces čovekovog sticanja sposobnosti da pod vlast uma dovede sve što um već nije podvlastio i kao stečeni stepen te sposobnosti koji je činjeničko stanje čovekovog povesnog trenutka. Čovekov identitet, kao njegovu potpunu saglasnost sa sobom, Fihte misli kao moralno delanje. Kultura koja se podređuje moralnoj slobodi jedina je koja je slobodna od svih empirijskih ciljeva i zbog toga se opire sopstvenom svođenju na sklop naučnih, umetničkih, religijskih, jezičkih i istorijskih činjenica. Autor Fihteovo poimanje kulture tematizuje u širem kontekstu filozofovog ranog <em>učenja o znanosti</em>, dok uvodno i zaključno razmatranje pokušavaju da ukažu na elemente poznijeg Fihteovog razumevanja kulture koji predstavljaju ograničenja preduzetog procesa oslobađanja ljudske kulture.

Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception.

Compared to efficient and secure female contraception, a vasectomy and condoms are the only options for men. The choice of male contraceptive methods is limited, so contraception mainly rests on the shoulders of women. Several concepts are considered: testosterone administration--inhibiting pituitary secretion of lutropin (LH) and follicle stimulating hormone (FSH), progestogen--affecting the secretion of gonadotropin and gonadoliberin (GnRH) antagonists. New potential targets for non-hormonal male contraception were discovered: glyceraldehyde-3-phosphate-dehydrogenase (GAPDHS)--specific to male germ cells and voltage-gated cation channel (CatSper). Both are responsible for sperm motility. Drugs such as thioridazine used in schizophrenia treatment and phenoxybenzamine (antihypertensive activity) exhibit a contraceptive effect. Similar action exhibits an analogue of lonidamine--adjudin and an antagonist of retinoic acid receptors (BMS-189453). Researchers are working on a contraceptive vaccine, whose active ingredient is epididymal protease inhibitor (Eppin). Another promising method acts by blocking Bromodomain testis-specific proteins (Brdt) involved in the process of spermatogenesis. JQ1-the Brdt inhibitor causes reversible infertility without affecting the endocrine signaling pathways. A recent discovery of Juno as the binding partner for Izumo1 identifies these proteins as the cell-surface receptor pair, essential for gamete recognition and this interaction can be inhibited by an anti-Juno monoclonal antibody. Our review shows that the situation of men can change and investigators are close to the optimal solution. In the near future men will be able to choose the best contraceptive suited to their needs.