Sitopaladi Churna Research Articles

Quantification of the main constituents of “sitopaladi churna—Ayurvedic multi-herbal preparation” using a validated high-performance thin-layer chromatography method

Quantification of the main constituents of “sitopaladi churna—Ayurvedic multi-herbal preparation” using a validated high-performance thin-layer chromatography method

Observational Research On Urban Public Awareness of Ayurveda as an Adjuvant Therapy During COVID-19

Ayurveda labels COVID-19 as Janapadodhwamsa Vikara (epidemic disease). Charaka Samhita: Vimana Sthana Chapter 3discusses epidemics; even though there is dissimilarity in the physical constitution of human beings; still there are such factorsthat are common to all individuals, and vitiation of these factors lead to the simultaneous manifestation of diseases having thesame set of symptoms leading to the destruction of countries. All citizens share air, water, location, and seasons. The subjectswere drawn from the general population who had tested positive for COVID-19. An accurate and comprehensive questionnairewas used to conduct the online survey. All of the responses were correctly completed. All information was gathered from theonline survey and properly analysed. This study included 250 COVID-19-positive participants. A questionnaire and verbaldialogue assessed COVID-19 ayurvedic adjuvant therapy utilization. 89.6% had COVID-19. 65.6% of patients have RTPCR toconfirm COVID-19. 81.2% of COVID-19 patients initially used allopathic medication, with 59.6% reporting negative effects. Afterthat, 87.2% received ayurvedic COVID-19 medicine. 96.4% of COVID-19 patients had a fever, cold, cough, and weakness.Mahasudarshana Kadha (71.2%), Samshavani Vati (66.4%), and Sitopaladi Churna (51.2%) were the top three COVID-19 medicines.Most nations treat COVID-19 with antiviral combinations for other viral infections. SARS-COV-2 antivirals may not workclinically. Ayurveda treats sickness via mind-body-physiology. Ayurvedic medicine boosts immunity and fights viruses. Ayurvedaadjuvant therapy helped COVID-19 patients. Ayurveda can treat COVID-19 symptoms without side effects.

Uses of Twak (Cinnamon) In Ayurveda with pharmacological evidence - A Review

In Ayurveda Cinamon has been used for the treatment of various illness like trusna (thirst), Kantha roga (diseases of throat), mukha roga (diseases of mouth), Pinasa (nasaroga), Krumiroga (healmenth) Vastiroga (disease of bladder), Arsa (piles) and Hrudroga (Heart disease). Cinnamon is a common spice used by different societies around the world for several centuries. It is obtained from the inner bark of trees from the genus Cinnamomum, a tropical evergreen plant. The medicinal uses of spices were often indistinguishable from their culinary uses. The value of phytochemicals in relation to human health has been recognized for centuries. The constituents of herbs and spices can have overlapping actions, including reduction of inflammation, antioxidant effects, modulation of detoxification enzymes, modulation of the immune system, and antibacterial and antiviral effects. Therapeutically cinnamon has anti-diabetic, antioxidant, anti-clotting, anti-inflammatory, carminative, and rubefacient properties. The most important constituents of cinnamon are cinnamaldehyde and trans-cinnamaldehyde (Cin), present in the essential oil. It is an ingredient of Trijataka and Chaturjataka and Sitopaladi Churna and Talisadi Churna mentioned in different classical text of Ayurveda.

A Case Study to Evaluate the Potential of Nasya Karma and Ayurvedic Formulations against Post Covid Chronic Bronchitis.

Background- SARS-COV-2, β type corona virus affects nearly all world population after appearing in Wuhan in Nov. 2019. In Covid-19 related bronchitis there is an issue of excessive sputum production in the airways (Kaphastheevan), resulting in coughing (Kasa) and chest tightness.This recurrent cough and ongoing chest discomfort affect one’s quality of life. Aim & Objectives- Aim of this study is to create an Ayurvedic protocol (Shodhan Chikitsa -Nasya therapy and Shaman Chikitsa – Chitrak Haritaki, Sitopaladi Churna, Tankan Bhasma, Swarnavasant Malti Rasa) for treatment of post Covid19 related chronic bronchitis. Material & Methods- It is a case of 27yrs old female presented with complain of breathlessness, cough especially at night with expectoration. Assessment was done on the basis of symptoms, radiological findings (Chest X-ray PA View) and PFT (FVC & FEV1). Result- There was relief in Subjective Parameters such as Cough (Kasa), Dyspnoea (Shwasakashtata), Chest tightness (Urashool), Wheezing (Ghurghurak), Sputum and Sleep (Nidra). This Ayurvedic treatment yielded more improvement in the value of FEV1.0 (L), FVC (L), FEV1.0/FVC (%) after treatment. Discussion- Shodhan (Anu Tail Nasya) and Shaman (Chitrak Haritaki, Sitopaladi Churna, Tankan Bhasma, Svarnvasant Malti Rasa) Chikitsa have mainly VataKaphahara action. This Case study of COVID-19 related Chronic Bronchitis is highly effective in subsiding the all symptoms of Post COVID Chronic Bronchitis and also improving the Pulmonary Function.

Green HPTLC-method to estimate trans-Cinnamaldehyde in Ayurvedic formulation Sitopaladi Churna

Traditional medicine is a preferred home remedy for common cold, cough, allergic conditions, etc. in South East Asia. Ayurveda, originated in India, has a long history of treating upper respiratory disorders. Sitopaladi churn (powder) is one of the most sold “over-the-counter” herbal medicine for upper respiratory ailments cure. Quality control and validation is a hindrance for Ayurvedic product development. This study was conducted to estimate and validate for quantitative study of trans-Cinnamaldehyde in Ayurvedic medicine Sitopaladi Churna (SPC) through high-performance thin-layer chromatography (HPTLC) method. The quantitative study was performed at the wavelength 294[Formula: see text]nm and validated as per ICH guidelines. The content of trans-Cinnamaldehyde in SPC was found to be 0.093%. Green HPTLC method is simple and sensitive for standardization and is validated for trans-Cinnamaldehyde in Sitopaladi powder. This method would add a different approach for quality control and assay of SPC.

A Comparative Clinical Study to Evaluate the Efficacy of Sitopaladi Churna and Vishwadi Churna in the Management of Vataja Kasa

A Comparative Clinical Study to Evaluate the Efficacy of Sitopaladi Churna and Vishwadi Churna in the Management of Vataja Kasa

Ayurvedic management of Kasa with special reference to Chronic Bronchitis: A Case Study

Chronic bronchitis (Kasa) having major symptoms like Kasa (cough), Kapha Stheevana (expectoration) and Shwasakrichrata (Breathlessness) itis included under Pranavaha Sroto-vikaras (Respiratory disorders) it is characterized by chronic cough with expectoration for at least three months in a year for more than two consecutive years. This disease can be advanced into Chronic Obstructive Pulmonary disease COPD) only in the stage when chronic air flow obstruction occurs. Many Patients also exhibit a systemic components characterized by impaired nutrition, weight loss and skeletal muscle dysfunction. It is a case report of 57 year old male patient presented with complaints of breathlessness, cough and expectoration. Patient was treated with Agastyaharitaki Avaleha; 6 gm before food for licking method, like that Dashmoola kwatha , Vasa churna 2 gm, Bharngi churna 2 gm, and Sitopaladi Churna -2 gm, half teaspoonful both time after food along with luke warm water in combination formula. Here Agastyaharitki Avaleha may act as Brimhana and does the Shamana of kapha. He got very good effect by prescribed treatment.

Molecular Docking Approach in Screening of Ayurvedic Phytoconstituent Leads Against COVID-19

The COVID-19 is coronavirus disease 2019, better known as SARS-CoV-2. The pandemic is a global threat, with Europe as the epicenter for the spread. Currently, SARS-CoV-2 is managed with the help of antiviral agents, anti-SARS-CoV-2 monoclonal antibodies, anti-inflammatory drugs, immunomodulators, and vaccines. However, traditional medicines play an important role in developing and developed countries. In India, ayurvedic formulations, herbal medicines, and regular allopathic medicine can produce the immune-boosting effect and prevention/treatment of COVID-19. However, scientific evidence for traditional medicine is lacking. So, current research focuses on screening phytoconstituents in ayurvedic formulations using molecular docking. Phyto-constituents of Ayurvedic formulations such as Sitopaladi Churna, Tribhuvan Kirti, Sanjeevani Vati were selected to screen anti-COVID-19 activity by targeting of spike protein structures of COVID-19, COVID-19 main protease, and SARS-Cov-2 RNA-dependent RNA polymerase. Pravastatin, nelfinavir, N3, and Remdisivir were selected standard compounds. SARS-Cov-2 RNA-dependent RNA polymerase target shows more binding capacity than standard Remdisivir. This confirms that Ayurvedic formulations (Sitopaladi churna, Tribhuvan kiriti, Sanjeevani vati) may be active against COVID-19 through SARS-Cov-2 RNA-dependent RNA polymerase targeting. The molecular docking approach might be helpful to drug discovery for COVID-19.

Insinuating cocktailed components in biocompatible-nanoparticles could act as an impressive neo-adjuvant strategy to combat COVID-19

The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spread rapidly worldwide, freezes all sectors, and was declared a life-threatening disease by the World Health Organization on Jan 30, 2020. So far, no specific drugs are identified or approved for treating SARS-CoV-2. In the past few years, nanomaterials are in the limelight for their ability to deliver the drugs effectively and selectively to target like siRNA, the prime infection sites, and benefiting us to visualize the particular regions, treatment reactions via non-intruding imaging techniques. As intranasal delivery interacts directly to the infection site with minimal side effects on the healthy cell, we postulate to administer a mixture of few polyherbal formulations like the golden spice curcumin, sitopaladi churna (SPC), and kaempferol in zein-chitosan nanoparticles as a life-saving measure for treating Coronavirus disease (COVID-19) cases. This viewpoint will shed light on the antiviral role of curcumin, SPC, and kaempferol zein-chitosan nanoparticle to modulate immune responses and observe its curative approach to the current pandemic COVID.

Rapid authentication of Sitopaladi churna samples by attenuated total reflectance – Fourier transform infrared spectroscopy using multivariate analysis

Ayurveda is the intangible Cultural Heritage of India and “Sitopaladi churna”, is a renowned Ayurvedic formulation which is recommended to treat the ailment like viral infection of respiratory tract, allergic situations and used as a natural anti-oxidant. The fundamental concerns in quality control of Sitopaladi churna arise due to substitution, omission, adulteration in the ingredients of Siitopaladi churna. A novel method based on Fourier transform infrared technique with attenuated total reflectance facility with a diamond Attenuated total reflectance crystal was used to evaluate samples of Sitopaladi churna. Total 35 different samples including standardized in house samples were studied. For, Fourier transform infrared spectroscopic study transmittance mode was kept to record the spectra devoid of pellets of potassium bromide. Further treatment was given with multi component tools by considering fingerprint region of the spectra. Multivariate analysis was performed by various chemometric methods like Principal component analysis and Hierarchical cluster analysis for further analysis to evaluate the differences in market samples of Sitopaladi churna. The developed method was inexpensive, simple, rapid, precise and stable. Thus, the method can be used as an efficient and practical approach for quality assessment of Sitopaladi churna.

The Effectiveness of Taalishadi Churna Compared with Sitopaladi Churna in the Management of Kasa

Introduction: Kasa is a Vata-kapha pradhana disease, caused due to Vata vimargagaman and Pranavaha shrotodusti. Due to the various similarities in its clinical presentation, Kasa can be correlated with cough (bronchitis). According to National center for health statistics, 62 million cases of common cold and cough occurs each year.
 Methodology: A total of 44 patients diagnosed as Kasa were randomly divided as per the lottery system of randomization. The patients of Group A were given 5 gram of Sitopaladi Churna twice a day for 30 days. The patients of Group B were given 5 gram of Taalishadi Churna twice a day for 30 days. The patients of both the groups were supposed to follow the dietary and behavioural advices. The response of the drug was assessed at pre-treatment and post-treatment time.
 Results: There was equal significant change in all of the Roga bala, Agni bala and Deha bala parameters by both Sitopaladi and Taalishadi Churna. It was revealed that all other blood parameters except Hb, TLC and Neutrophil count used in the study were not significant in both the groups. Both drugs were found equally highly significant (p< 0.0001) in Sushka kasa and Swarabheda. Sitopaladi churna was more effective in relieving Hritparswashool (p=0.002) whereas Taalishadi churna is more effective in reducing Pitanisthivanam (p=0.007). In case of Nirghosh, Sitopaladi churna was more effective (p<0.0001). On the other hand, Taalishadi churna was more effective in relieving Peenasa (p<0.001).
 Conclusion: Both Sitopaladi Churna and Taalishadi Churna were found to be equally effective in the treatment of Kasa.

Quality Assessment of Sitopaladi Churna Using High-Performance Liquid Chromatography Coupled with Multivariate Analysis.

"Sitopaladi churna," a well-known formulation of Ayurveda, is prescribed to treat the disease like Bronchitis, Pneumonia, allergic conditions, viral infection of the respiratory tract and as a natural antioxidant. A novel method based on reversed-phase high-performance liquid chromatography (RP-HPLC) coupled to photodiode array detector was established and validated for sitopaladi churna. Here, HPLC fingerprints data obtained for 28 samples including standard sample were then treated to chemometric analysis like principal component analysis and hierarchical clustering analysis for further analysis to evaluate the differences in market samples of sitopaladi churna. Additionally, one major marker compound, piperine was quantified and it also facilitated for relative retention time. The simulative mean spectrum was also generated. The validation results showed that the developed method was simple, precise and stable. Thus, the developed chromatographic method adjoined with multivariate analysis can be used as an efficient and practical approach for quality assessment of sitopaladi churna.

Ayurveda Treatment Protocol in the Management of Galagraha (Pharyngitis)- A Case Study

Pharyngitis is inflammation of the pharynx, which affects in back of the throat. It is most often referred to simply as sore throat; it is one of the most common reasons for doctor visit. The condition is the usual phenomenon in paediatric population due to intake of cold drinks, junk food etc. This disease is more recurrent now a days than earlier As per ayurvedic classics the condition has close similarity with the disease Galagraha. Aim: In this article management of pharyngitis with ayurvedic modalities were discussed. Material & Method: A 32 years male patient visited ENT OPD of Shalakya Tantra, I.P.G.T&R.A Hospital on 16/12/2019 with complaints of pain and foreign body sensation of throat, Recurrent moderate cough, mild fever and head ache, difficulty in swallowing along with congestion in posterior pharyngeal wall aggravate since 10 days. He consulted a local hospital near his house but didn’t get a satisfactory relief. History reveals the reccurents of disease since 3 years. We started Triphala + Darvi kwatha kawala thrice/Day, Haritaki Kwatha pana Twice BD with honey (20 ml Before food), Khadiradi vati (2 Tab -4 times/ day) for Chushanartha, Sitopaladi churna -3gm +Yastimadhu 1 gm, Naradiya Lakshmi vilasa rasa-125 mg-2 times a day for 14 days Followed by Virechana and Nasya. Marked relief was found in signs and symptoms within 7 days and cured completly within 21 days of treatment. Conclusion: Study concluded that the above Ayurvedic treatment can prove to be an effective alternate management in Chronic Catarrhal Pharyngitis with proper diet and regimen.

Phytochemical and antimicrobial screening of sitopaladi churna

Ayurvedic medicines are being used increasingly to fight or prevent common diseases. Sitopaladi churna is a polyherbal formulation containing Piper longum (Piperceae), Elettaria cardamom (Zingiberaceae), Cinnamomum zeylanicum (Lauraceae). Methanolic and Aqueous extracts of Sitopaladi Churna was screened for their antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans. The results of antimicrobial activity of Aqueous and Methanolic extracts of the Sitopaladi churna indicated that methanolic extract inhibited the growth of one or more test pathogens than aqueous extract. Sitopaladi churna formulation extracts showed a broad spectrum of antimicrobial activity. Phytochemical investigation revealed the presence of tannins, saponins, alkaloids, glycosides, flavonoids and triterpinoids. This may be due to the multifunctional effect of all the three plant ingredients of Sitopaladi churna.

Phytochemical and antimicrobial screening of sitopaladi churna

Phytochemical and antimicrobial screening of sitopaladi churna

A rare case report: Ayurvedic management of vocal cord nodules

Vocal nodules are the consequence of functional voice disorders, which are also caused by vocal abuse or misuse. An increased vocal load, for example, due to the patient's profession, demands high-volume speech for the formation of nodules. In the present case report, a 26-year-old female patient acquired this disease followed by common cold cough. Her problems were aggravating by high-volume speech and getting fatigability also. This patient was given Anutaila Nasya with Sitopaladi Churna, Naradiya Laxmi vilasa Rasa, Yashtimadhu Ghanvati (for chewing), and Dashmoola Kwatha(Kavala). The patient was advised for strict voice rest and steam inhalation for better result. After 1 month of treatment, the patient got relief from all her complaints and gained normal voice. On examination, it was found that vocal nodules disappeared in direct laryngoscopy. Hence, this single case report shows that ayurvedic management of vocal cord nodules gives excellent result and improves patients' quality of voice.

A rapid HPTLC method to estimate piperine in Ayurvedic formulations

BackgroundTrikatu, Sitopaladi, Hingavastaka, Avipattikara, Sringyadi and Talisadya are very popular Ayurvedic (churna) medicines practiced in India; however, unfortunately, they possess several quality control issues. ObjectiveThe aim of this study was to find out a simple, accurate and sensitive HPTLC method for the detection and quantification of marker molecule, piperine (alkaloid) on these Ayurvedic formulations for standardization. Materials and methodsMethanolic extraction (reflux) was performed from the above six churnas as well as three single ingredients Piper longum (pipul), Piper nigrum (marich) and Piper chaba (chai). HPTLC was done using piperine as a standard. The mobile phase was a mixture of toluene-ethyl acetate (7:3, v/v) and detection at 342λ. ResultsThe Rf was detected at 0.39. Piperine was quantified in all samples. P. nigrum showed higher piperine than P. longum and P. chaba. The maximum piperine was noted in Hingavastaka churna and followed by Sringyadi churna, Sitopaladi churna, Talisadya churna, Trikatu churna and Avipattikara churna. ConclusionThis method can be successfully employed for standardization and quantitative analysis of piperine in Ayurvedic formulations (churnas) and also be helpful to clinicians and pharmacists to draw significant role of piperine present in all these samples.

“STUDY THE EFFICACY OF BALA SIDHAKSHEERA NADI SWEDAN IN VATAJA KASA.”

Vataja kasa is one among such disease which troubles the person by hindering the day today activities due to identical nidana, lakshana & upashaya. Vataj kasa a very common disease especially among geriatric age group, often diagnosis is vague and treatment is half left. In the present study experimental group was subjected to Balasidhaksheer Nadi Sweden along with shaman chikitsa as per Charak chikitsa sthan. While control group was given only Shaman Chikitsa viz. Sitopaladi churna, Kantakari ghritta & Duralabhadi yoga.Observations and results obtained after trial was presented & statistical analysis done after completion of the therapy. It was seen that in the symptom Shuska Kasa (Dry Cough), Shool in ura, Parshwashool, Swarbheda, Daurbalya trial drug has found effective as it seems statistically extremely significant.After comparison of both groups there was significant result was noted in experimental group comparatively control group as p value is significant in all subjective criteria of Vataj kasa. In the present study along with above treatment Balasidhasheera Nadiswedan has been observed very effective and giving satisfactory relief in the symptoms of Vataja Kasa.

THE QUEEN OF SPICES AND AYURVEDA: A BRIEF REVIEW

Small cardamom, well known as the ‘queen of spices’, belongs to the family Zingiberaceae, order Scitaminae is a rich spice obtained from the seeds of a perennial plant, Elettaria cardamomum Maton., in Ayurveda which is known as “ela”. Ela is known for its medicinal value from ancient times. It had also been mentioned in Greek, Egyptian and Christian scripts. In India, cardamom production is mainly concentrated in the high ranges of Idukki district, Kerala state and certain pockets of the states of Karnataka and Tamilnadu. Cardamom possesses katu (pungent) rasa (taste) as it`s main rasa followed by madhura (sweet) anurasa (taste followed by main taste). Ela pacifies all the three dosha`s i.e. vata, pitta and kapha. Cardamom owes it`s aroma due to presence of volatile oil in its seeds and capsule. Cardamom is used from ancient times with betel leaves for chewing purpose due to it`s mouth purifier property. Seeds are aromatic, cooling, stimulant, carminative, digestive, stomachic, diuretic, cardiotonic, alexiteric, and expectorant. They are useful in anorexia, dyspepsia, asthma, bronchitis, dysuria, renal and vesicle calculi, halitosis, cardiac disorders, hyperdipsia, burning sensation, debility and defects of vision. In Ayurveda, Ela is used for the treatment of various diseases. Cardamom is used in a number of classical Ayurvedic medicines like eladi vati and sitopaladi churna. Badi elaichi (Amomum subualatum Roxb.), in its action and properties, is in many ways different from that of cardamom. This article aims at reviewing detailed Ayurveda and modern perspective of Ela i.e. choti elaichi (Elettaria cardamomum Maton.)

Integration of Ayurvedic formulations with iron folic acid in the treatment of nutritional anaemia among school going adolescents of Dehradun District

Combating anaemia is a global public health challenge of the developing world. Nutritional anaemia is a serious health problem faced by Indian school children. An investigation was taken up to study the effect of non iron containing Ayurvedic preparation Sootshekhar Rasa (SR) plus Sitopaladi Churna (SC) along with iron and folic acid (IFA) for improving nutritional anaemia among adolescent school going students of Dehradun district in Northern India. The blinded, controlled randomized trial comprised of 820 adolescents anaemic students aged 11 - 18 years. The anaemic students were randomly divided into 4 groups, students of group I (control) received starch, group II, III, and IV students received daily dose of (SR 250 mg + SC 400 mg), IFA and (SR 250 mg + SC 400 mg) + IFA, respectively. All the students received treatment for 90days and were followed up for next 180days. At the end of follow-up (day 270), significant increase of haemoglobin (Hb) level from the base line was recorded in all treatment groups. The maximum gain in Hb concentration was noted in group IV (10.1 ± 0.6 g/L), which was significantly higher than any other group. There were 123 drop-outs; however, no major side effect of treatment was noted in any student. We conclude that daily dose of (SR 250 mg + SC 400 mg) along with IFA can produce sustainable improvement of nutritional anaemia in adolescent students.