B cells play important roles in skin diseases (Egbuniwe et al., 2015) and in cutaneous homeostasis (Geherin et al., 2016, 2012; Nihal et al., 2000). Mature class-switched IgG+ B cells have been detected in normal human skin (Saul et al., 2016) featuring clonally restricted B-cell receptors, indicating narrow antigenic repertoires (Nihal et al., 2000). However, the involvement of B cells during an antigenic stimulus in human skin remains unexplored. B cells are relatively scarce in normal human skin (Supplementary Figure S1), explaining why past studies have primarily focused on T cells, which constitute the major skin-resident lymphocyte population (Clark et al., 2006b; Jiang et al., 2012; Sanchez Rodriguez et al., 2014).