Abstract
B cells play important roles in skin diseases (Egbuniwe et al., 2015) and in cutaneous homeostasis (Geherin et al., 2016, 2012; Nihal et al., 2000). Mature class-switched IgG+ B cells have been detected in normal human skin (Saul et al., 2016) featuring clonally restricted B-cell receptors, indicating narrow antigenic repertoires (Nihal et al., 2000). However, the involvement of B cells during an antigenic stimulus in human skin remains unexplored. B cells are relatively scarce in normal human skin (Supplementary Figure S1), explaining why past studies have primarily focused on T cells, which constitute the major skin-resident lymphocyte population (Clark et al., 2006b; Jiang et al., 2012; Sanchez Rodriguez et al., 2014).
Highlights
B cells play important roles in skin diseases (Egbuniwe et al, 2015) and in cutaneous homeostasis (Geherin et al., 2016, 2012; Nihal et al, 2000)
Mature class-switched IgGþ B cells have been detected in normal human skin (Saul et al, 2016) featuring clonally restricted B-cell receptors, indicating narrow antigenic repertoires (Nihal et al, 2000)
Figure S1), explaining why past studies have primarily focused on T cells, which constitute the major skinresident lymphocyte population (Clark et al, 2006b; Jiang et al, 2012; Sanchez Rodriguez et al, 2014)
Summary
(e) d 3 blister aspirates and PBMCs analyzed by FACS for expression of CLA (a skin-homing marker) on CD20þ B cells and CD3þ T cells. (f) Quantification of CLAþ B and T cells within d 3 (n 1⁄4 3) and d 7 (n 1⁄4 3) VZV blister aspirates and matched donor PBMCs. We tested the specificity of healthy volunteer serum (n 1⁄4 19) and day 7 blister fluid (VZV [n 1⁄4 5] and candida [n 1⁄4 4]) to VZV2 specific IgG antibodies by ELISA. VZVspecific antibodies were found in blister fluid after both VZV and candida antigen challenge in addition to healthy volunteer serum samples, with no significant difference in specific signal among the three groups (Figure 1l; Journal of Investigative Dermatology (2021), Volume. Further studies are required to identify the signals that control the migration of B cells to cutaneous sites and their functional capabilities in situ
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