Scour by hydraulic plucking is a fundamental process in landscape evolution in which large, competent rock blocks are eroded from a fractured rock mass by flowing water. This process also affects engineered structures interacting with water, such as dams and bridges, and often leads to operational and safety concerns because erosion of large volumes of material can compromise structure foundations and serviceability. To assess potential scour at a site, present methods either are empirically derived, assume a specific failure mode, or significantly simplify the geometry of potentially eroding rock particles. This limits the broader applicability of these methods and their ability to offer actionable insight into scour risk. Therefore, the discrete-element method coupled with the lattice Boltzmann method was applied to assess hydraulic plucking of fractured rock. In this approach, the three-dimensional shape of rock particles was considered explicitly, including how each particle interacts dynamically with fluid. Additionally, the highly turbulent flow conditions at which plucking often occurs were modeled using large-eddy simulation. The results show that this modeling methodology was able to capture the correct kinematic failure mode in block removal in two example scenarios without restricting the potential failure mechanism, and naturally captures the governing response. This capability makes this scour assessment technique broadly applicable since site-specific characteristics can be input directly into scour risk assessments to understand the influence of local features on the plucking process.