Collision Site Research Articles

Long‐term data reveals increase in vehicle collisions of endangered birds in Hokkaido, Japan

AbstractWildlife‐vehicle collisions have significant consequences for both humans and animals, including injuries, deaths, and vehicle damage. Therefore, analysis of accident data is important for planning countermeasures and appropriate wildlife management. In this research field, roadkill incidents have been extensively studied in many taxa, while railway accidents have received less attention despite their obvious impact on wildlife. Here we applied a Bayesian state‐space model to 31 years of collision data, both on railways and on roads, collected by the Ministry of the Environment in Hokkaido prefecture, Japan, to reveal the spatiotemporal dynamics of accidents for white‐tailed eagles, Steller's sea eagles, and red‐crowned cranes, for which over hundred accidents were reported in the data. Our analysis suggested that the mean annual number of individuals collected per collision site across Hokkaido increased 47,377‐fold in the white‐tailed eagle, 40,277‐fold in the Steller's sea eagle, and 50,584‐fold in the red‐crowned crane between 1991 and 2021. There have been concerns about the impact of traffic accidents on the population dynamics of these endangered birds, but no formal analyses have been conducted. Our analysis showed numerically that the negative impact has been increasing annually. These results suggest that long‐term data accumulation over large spatial scales allows us to understand the dynamics of accidents and predict potential factors underlying collision risks.

An Investigation of Double Collisions of Pickup Trucks with Multiple Fatalities in Narathiwat Province, Thailand, October 2023

On 11 Oct 2023, a pickup truck crashed into a roadside tree in Narathiwat Province, southern Thailand after overtaking another vehicle. We conducted a descriptive study by reviewing medical records and interviewing rescuers, officers, survivors, and witnesses. We surveyed the collision site, reviewed video records, and used Haddon’s matrix to assist with the analysis. A pickup truck carrying 11 passengers (including the driver) overtook another pickup truck on a stretch of road. The driver of the first pickup truck lost control due to tire deflation and crashed into a tree resulting in eight deaths (72.7%) and three hospitalizations (27.3%). All deaths were caused by severe head injuries. Multiple factors during pre-crash (vehicle unfamiliarity leading to improper passing sight distance and speeding), the crash (overloaded truck and a roadside tree), and post-crash such as poor communication, contributed to the severity of this event. The driver of the truck had no driving license and was unfamiliar with the vehicle. Six passengers were sitting in the truck’s cab and three were in the cargo bed. Pre-crash and crash speeds were determined to be 80 and 100 kilometers per hour, respectively. The passing sight distance was grossly insufficient. Poor communication in the rescue process and the crowd of people at the scene resulted in improper emergency management. Strengthening law enforcement, increasing the number of speed limit signs, felling roadside trees, and practicing mass casualty incidents should be implemented.

Genome-wide identification of replication fork stalling/pausing sites and the interplay between RNA Pol II transcription and DNA replication progression

BackgroundDNA replication progression can be affected by the presence of physical barriers like the RNA polymerases, leading to replication stress and DNA damage. Nonetheless, we do not know how transcription influences overall DNA replication progression.ResultsTo characterize sites where DNA replication forks stall and pause, we establish a genome-wide approach to identify them. This approach uses multiple timepoints during S-phase to identify replication fork/stalling hotspots as replication progresses through the genome. These sites are typically associated with increased DNA damage, overlapped with fragile sites and with breakpoints of rearrangements identified in cancers but do not overlap with replication origins. Overlaying these sites with a genome-wide analysis of RNA polymerase II transcription, we find that replication fork stalling/pausing sites inside genes are directly related to transcription progression and activity. Indeed, we find that slowing down transcription elongation slows down directly replication progression through genes. This indicates that transcription and replication can coexist over the same regions. Importantly, rearrangements found in cancers overlapping transcription-replication collision sites are detected in non-transformed cells and increase following treatment with ATM and ATR inhibitors. At the same time, we find instances where transcription activity favors replication progression because it reduces histone density.ConclusionsAltogether, our findings highlight how transcription and replication overlap during S-phase, with both positive and negative consequences for replication fork progression and genome stability by the coexistence of these two processes.

NURBs Based Multi-robots Path Planning with Obstacle Avoidance

The primary problem for multi-robot displacement and motion phase solving requires that the robots prevent themselves from colliding with each other as well as stationary obstacles. In certain situations, robot conflict is unavoidable if one robot views its neighbors as immovable obstacles. Hence, this paper proposes a new NURBs (Non-Uniform Rational B-spline) based algorithm for multi-robot path planning in a crowded environment. First, the proposed technique finds each robot's free, smooth, optimal path while avoiding collision with the existing obstacles. Secondly, the prospect of possible collision between the preplanned trajectories will be computed to allow the robots to navigate in the same workspace and coordinate between them. Then, each robot's time to arrive at potential collision sites is computed based on its speed. As a result, the robots involved in the collision must choose whether to use the robot priority technique to prevent the collision. Simulation results under different scenarios and comparisons with previous works are provided to validate the work. The obtained results prove that the proposed approach is accurate (as the robot's instantaneous speed is taken into consideration), fast (as there is no need to broadcast the robots’ positions), the robots’ paths are optimal and smooth (to avoid jerk movements), and the approach ensures that the robots will not be trapped by local minima problem.

Modeling Colloidal Particle Aggregation Using Cluster Aggregation with Multiple Particle Interactions.

In this study, we investigate the aggregation dynamics of colloidal silica by generating simulated structures and comparing them to experimental data gathered through scanning transmission electron microscopy (STEM). More specifically, diffusion-limited cluster aggregation and reaction-limited cluster aggregation models with different functions for the probability of particles sticking upon contact were used. Aside from using a constant sticking probability, the sticking probability was allowed to depend on the masses of the colliding clusters and on the number of particles close to the collision between clusters. The different models of the sticking probability were evaluated based on the goodness-of-fit of spatial summary statistics. Furthermore, the models were compared to the experimental data by calculating the structures' fractal dimension and mass transport properties from simulations of flow and diffusion. The sticking probability, depending on the interaction with multiple particles close to the collision site, led to structures most similar to the STEM data.

Relationship between the atrial-activation pattern around the triangle of Koch and successful ablation sites in slow-fast atrioventricular nodal reentrant tachycardia.

The precise details of atrial activation around the triangle of Koch (ToK) remain unknown. We evaluated the relationship between the atrial-activation pattern around the ToK and success sites for slow-pathway (SP) modification ablation in slow-fast atrioventricular reentrant tachycardia (AVNRT). Thirty patients with slow-fast AVNRT who underwent successful ablation were enrolled. Atrial activation around the ToK during sinus rhythm was investigated using ultra-high-density mapping pre-ablation. The relationships among features of atrial-activation pattern and success sites were examined. Of 30 patients (22 cryoablation; 8 radiofrequency ablation), 26 patients had a collision site of two wavefronts of delayed atrial activation within ToK, indicating a success site. The activation-search function of Lumipoint software, which highlights only atrial activation with a spatiotemporal consistency, showed non-highlighted area on the tricuspid-annulus side of ToK. In 23 of the patients, a spiky potential was recorded at that collision site outside the Lumipoint-highlighted area. Fifteen cryoablation patients with a success site coincident with a collision site outside the Lumipoint-highlighted area had significantly more frequent disappearances of SP after initial cryoablation (46.7% vs. 0%, p = .029), fewer cryoablations (3.7 ± 1.8 vs. 5.3 ± 1.3, p = .045), and shorter procedure times (170 ± 57 vs. 228 ± 91 min, p = .082) compared to the seven cryoablation patients without such sites. Four patients had transient AV block by ablation inside the Lumipoint-highlighted area with fractionated signals, but no patient developed permanent AV block or recurrence post-procedure (median follow-up: 375 days). SP modification ablation at the collision site of atrial activation of the tricuspid-annulus side along with a spiky potential could provide a better outcome.

Septins provide microenvironment sensing and cortical actomyosin partitioning in motile amoeboid T lymphocytes.

The all-terrain motility of lymphocytes in tissues and tissue-like gels is best described as amoeboid motility. For amoeboid motility, lymphocytes do not require specific biochemical or structural modifications to the surrounding extracellular matrix. Instead, they rely on changing shape and steric interactions with the microenvironment. However, the exact mechanism of amoeboid motility remains elusive. Here, we report that septins participate in amoeboid motility of T cells, enabling the formation of F-actin and α-actinin-rich cortical rings at the sites of cell cortex-indenting collisions with the extracellular matrix. Cortical rings compartmentalize cells into chains of spherical segments that are spatially conformed to the available lumens, forming transient "hourglass"-shaped steric locks onto the surrounding collagen fibers. The steric lock facilitates pressure-driven peristaltic propulsion of cytosolic content by individually contracting cell segments. Our results suggest that septins provide microenvironment-guided partitioning of actomyosin contractility and steric pivots required for amoeboid motility of T cells in tissue-like microenvironments.

Mechanism of ionic dissociation of HCl in the smallest water clusters.

The dissociation of strong acids into water is a fundamental process in chemistry and biology. Determining the minimum number of water molecules that can result in an ionic dissociation of hydrochloric acid (HCl → H+ + Cl-) remains a challenging subject. In this study, the reactions of H2O with HCl(H2O)n-1 (HCl-H2O cluster), i.e., HCl(H2O)n-1 + H2O (n = 3-7), were investigated by using the direct ab initio molecular dynamics (AIMD) method. Direct AIMD calculations were performed to set the collision energy of H2O to zero for all trajectories. For n = 3, no reaction occurred. In contrast, HCl dissociated to H+ + Cl- at n = 4, forming a contact ion pair (cIP) and solvent-separated ion pair (ssIP) as products. The reactions were expressed as HCl(H2O)3 + H2O → H3O+(H2O)2Cl- (ssIP), and HCl(H2O)3 + H2O → H3O+(Cl-)(H2O)2 (cIP). The ion pair (IP) products were dependent on the collision site of H2O relative to HCl(H2O)3. For n = 5-7, both IPs were formed through the reaction between H2O and HCl(H2O)n-1 (n = 5-7). The reaction between HCl and (H2O)4 (HCl + (H2O)4 → HCl(H2O)4) was non-reactive in IP formation. The reaction mechanism was discussed based on the theoretical results.

Hole behavior captured by analysis of instantaneous amplitude and phase of sarcosynced oscillations reveals wave characteristics of sarcomeric oscillations

In this study, we performed signal analysis based on instantaneous amplitude and phase of sarcomeric oscillations, which are generated by skeletal muscle under constant calcium concentration conditions and in which sarcomeres repeatedly contract and relax autonomously. In addition to the changes in sarcomere length that have been attracting attention, we named the Z-line oscillations that partition sarcomeres sarcosynced oscillations, and analyzed their instantaneous amplitude and phase. As a result, the behavior of pairs of sarcosynced oscillations and sarcomeric oscillations, which are produced when propagating waves propagate in one direction or collide, was clearly visualized. By focusing on the behavior of the hole, which is a dip in the instantaneous amplitude accompanied by a sudden jump in the instantaneous phase in sarcosynced oscillations, we were able to discern the wave characteristics. Transient disruption occurred in the propagating waves even when they traveled in one direction. Its properties were captured by the sarcomeric defect hole (SD hole), a dip in the instantaneous amplitude accompanied by a jump in the instantaneous phase in sarcosynced oscillations. When propagating waves collide, the collision site, its persistence, movement, and disappearance process are captured as sarcomeric collision holes (SC holes) of sarcosynced oscillations. These holes are important indicators for understanding the oscillation properties of sarcomeres. In conclusion, although sarcosynced oscillations and sarcomeric oscillations are closely related, they exhibit different oscillations, and the study of the SD holes and SC holes caused by them will contribute to a detailed understanding of the muscle characteristics of sarcomeres. This finding has important implications for improving our understanding of the efficiency of muscle function and its regulatory mechanisms.

3D simulation of interosseous interference in sagittal split ramus osteotomy for mandibular asymmetry

BackgroundThe purpose of this study was to evaluate the pattern of predicted interosseous interference and to determine the influencing factor to volume of bony interference using a computer-assisted simulation system. This retrospective study recruited 116 patients with mandibular prognathism who had undergone sagittal split ramus osteotomy (SSRO) with or without maxillary osteotomy. The patients were divided into 3 groups according to the amount of menton (Me) deviation: less than 2 mm (Group 1), 2–4 mm (Group 2), and more than 4 mm (Group 3). Changes in the distal segments following BSSRO and the volume of the interosseous interference between the proximal and distal segments were simulated after matching preoperative occlusion and postoperative expected occlusion with the cone-beam computed tomography data. Ramal inclinations and other skeletal measurements were analyzed before surgery, immediately after surgery, and at least 6 months after surgery.ResultsThe anticipated interosseous interference was more frequently noted on the contralateral side of chin deviation (long side) than the deviated site (short side) in Groups 2 and 3. More interference volume was predicted at the long side (186 ± 343.9 mm3) rather than the short side (54.4 ± 124.4 mm3) in Group 3 (p = 0.033). The bilateral difference in the volume of the interosseous interference of the osteotomized mandible was significantly correlated with the Me deviation (r = − 0.257, p = 0.009) and bilateral ramal inclination (r = 0.361, p < 0.001). The predictor variable that affected the volume of the osseous interference at each side was the amount of Me deviation (p = 0.010).ConclusionBy using the 3D simulation system, the potential site of bony collision could be visualized and successfully reduced intraoperatively. Since the osseous interference can be existed on any side, unilaterally or bilaterally, 3D surgical simulation is necessary before surgery to predict the osseous interference and improve the ramal inclination.

A Bright First Day for Tidal Disruption Events

Stream–stream collision may be an important prepeak energy dissipation mechanism in tidal disruption events (TDEs). We perform local three-dimensional radiation hydrodynamic simulations in a wedge geometry including the gravity to study stream self-crossing with an emphasis on resolving the collision and following the subsequent outflow. We find that the collision can contribute to prepeak optical emissions by converting ≳5% of the stream kinetic energy to radiation, yielding prompt emission of ∼1042−44 erg s−1. The radiative efficiency is sensitive to stream mass fallback rates and strongly depends on the downstream gas optical depth. Even for a sub-Eddington (10%) mass fallback rate, the strong radiation pressure produced in the collision can form a local super-Eddington region near the collision site, where a fast, aspherical outflow is launched. A higher mass fallback rate usually leads to more optically thick outflow and lower net radiative efficiency. For , the estimated photosphere size of the outflow can expand by 1–2 orders of magnitude, reaching ∼1014 cm. The average gas temperature at this photospheric surface is a few × 104 K, roughly consistent with inferred prepeak photosphere properties for some optical TDEs. We find that the dynamics is sensitive to the collision angle and radius, but the radiative efficiency or outflow properties show more complex dependency than is often assumed in ballistic models.

Early Mesoproterozoic (1.72–1.68 Ga) convergence between Bastar and Eastern Dharwar cratons along the Bhopalpatnam orogen, southcentral India and implication for paleogeography of supercontinent Columbia

Temporal constraints on orogen initiation and duration are critical for the Paleoproterozoic reconstruction of cratons presently constituting India. Recent late Paleoproterozoic paleomagnetic pole data indicate proximity of Eastern Dharwar, Bastar and Singhbhum cratons and in view of global Mesoproterozoic-aged final Columbia assembly, reconstruction sequence of Indic cratons is critical to assess whether they constituted Columbia. The initiation time and duration of the Bhopalpatnam orogen, developed between the Eastern Dharwar and Bastar cratons, range from earliest Mesoproterozoic to Neoarchean. Therefore, in order to constrain the earliest stages of cratonic convergence and crustal thickening, the time of peak metamorphism was established on tectonites, sampled from > 300 km along newly classified longitudinal domains representative of the entire Bhopalpatnam orogen, by precise combined garnet Lu-Hf and Sm-Nd chronology of amphibolite-and granulite-facies rocks. Interpreting the Lu-Hf and Sm-Nd isochron weighted mean ages, an orogenic duration of 38 ± 19 Myr is inferred between the high-pressure amphibolite-facies through to granulite-facies event at 1721 ± 14 Ma and a post-peak cooling to ≤ 650 °C at 1683 ± 6 Ma, being the Sm-Nd garnet weighted mean age. Archean two-stage depleted mantle model ages (at 1.7 Ga) of tectonites and rotated dyke swarm orientations support the reactivation and reworking of the Paleo- to Neoarchean Bastar craton marginal rocks in response to the early Mesoproterozoic orogeny. Based on the clockwise P-T path involving an early high-pressure amphibolite-facies stage (Pmax ≥ 12 kbar at ∼ 750 °C) followed by a granulite-facies stage (Tmax ≤ 850 °C at lower pressures), we interpret the orogen to represent deeply exhumed thrust slices of the reworked Bastar craton leading edge underthrusted beneath the Eastern Dharwar craton. As paleomagnetic data indicates proximity or contiguity of Bastar and Eastern Dharwar cratons by 1.79 Ga, the Bhopalapatnam orogen could represent site of early Mesoproterozoic cratonic collision or locus of post amalgamation reactivation due to convergence.

Hydrogeochemistry, Geothermometry, and Sourcing of High Dissolved Boron, Tungsten, and Chlorine Concentrations in the Trans-Himalayan Hotsprings of Ladakh, India

Boron (B) and Tungsten (W) are often found enriched in high-temperature geothermal waters associated with the development of subduction-related mafic to felsic arc magma. However, knowledge about the sourcing and transportation of these elements from such hydrothermal systems is sparse and ambiguous. Being the only active continental collision site in the world, the Trans-Himalaya offers a unique chance to study how continental collision sources the high boron and tungsten concentrations in geothermal fluids. This study investigated the distribution of trace elements, major cations, and anions in three physicochemically distinct hotspring sites in the Ladakh region. The results were integrated with the existing geochemical and isotopic data to address the research problem more effectively. This study exhibits that the extreme concentrations of boron, sodium, chlorine, potassium, and tungsten in the hotspring waters were primarily governed by magmatic fluid inputs. In addition, this study recorded the highest-ever chlorine and boron concentrations for the Trans-Himalayan hotspring waters. The highest-ever boron and chlorine concentrations in the hotspring waters probably represented an increase in magmatic activity in the deeper source zone.

In Atrial Fibrillation, Omnipolar Voltage Maps More Accurately Delineate Scar Than Bipolar Voltage Maps

BackgroundOptimal method for voltage assessment in AF remains unclear. ObjectivesThis study evaluated different methods for assessing atrial voltage and their accuracy in identifying pulmonary vein reconnection sites (PVRSs) in atrial fibrillation (AF). MethodsPatients with persistent AF undergoing ablation were included. De novo procedures: voltage assessment in AF with omnipolar voltage (OV) and bipolar voltage (BV) methodology and BV assessment in sinus rhythm (SR). Activation vector and fractionation maps were reviewed at voltage discrepancy sites on OV and BV maps in AF. AF voltage maps were compared with SR BV maps. Repeat ablation procedures: OV and BV maps in AF were compared to detect gaps in wide area circumferential ablation (WACA) lines that correlated with PVRS. ResultsForty patients were included: 20 de novo and 20 repeat procedures. De novo procedure: OV vs BV maps in AF; average voltage 0.55 ± 0.18 mV vs 0.38 ± 0.12 mV; P = 0.002, voltage difference of 0.20 ± 0.07 mV; P = 0.003 at coregistered points and proportion of left atrium (LA) area occupied by low-voltage zones (LVZs) was smaller on OV maps (42.4% ± 12.8% OV vs 66.7% ± 12.7% BV; P < 0.001). LVZs identified on BV maps and not on OV maps correlated frequently to wavefront collision and fractionation sites (94.7%). OV AF maps agreed better with BV SR maps (voltage difference at coregistered points 0.09 ± 0.03 mV; P = 0.24) unlike BV AF maps (0.17 ± 0.07 mV, P = 0.002). Repeat ablation procedure: OV was superior in identifying WACA line gaps that correlated with PVRS than BV maps (area under the curve = 0.89, P < 0.001). ConclusionsOV AF maps improve voltage assessment by overcoming the impact of wavefront collision and fractionation. OV AF maps correlate better with BV maps in SR and more accurately delineate gaps on WACA lines at PVRS.

(Re)ordering the Mediterranean: The evolution of security assistance as an international practice

ABSTRACT Security assistance – foreign actors training and equipping security forces in another country – has proliferated in the Mediterranean over the last decades. Now, more than a decade on from the Arab Uprisings, security assistance cannot be considered merely a tool to obtain strategic objectives, but is in itself a site of competition, collusion and potential collision. In this Introduction to the Special Issue, we develop a framework deploying reordering as a lens through which comparative and interdisciplinary explorations can develop comprehensive and critical views of the evolution of security assistance in the Mediterranean. We propose a theoretical framework centred on international practice and socio-material network theory, which brings different types of providers and recipients, as well as the discourse-material structures underpinning them, into a common frame. The framework conceptualizes security assistance as operating at vertical (between provider and recipient), and horizontal (between vertical blocks) levels. It can purposefully be analysed across three dimensions – knowledge, materiality and networks. In so doing, we may be able to observe how, despite the absence of formal institutions, norms or governing mechanisms, security assistance constitutes an international practice and contributes to the ordering, and continuous reordering, of the Mediterranean as a governable geospatial field of intervention.

Molecular dynamics of He encapsulation in the C20H20 cage at the threshold energy

The encapsulation of He inside C20H20 cage has been investigated in the framework of molecular dynamics for incident atom energy in a range close to the threshold value, corresponding to the projectile passing through the pentagonal carbon ring. The entrance of He atom into dodecahedrane is analyzed in terms of static and dynamic potential barriers. The details of helium capture inside the molecular box is revealed by using geometric and energetic parameters, being associated with the response of the atomic configuration near the collision site on the C20H20 cage. The energy transferred from the incident atom to deformation, vibrations, and recoil of the molecule target, was calculated as a function of the distance between the projectile and the collision site on C20H20 cage. The calculations show that the noble gas atom, encapsulated at the threshold of 315.62 Å/ps, oscillates across the void of the dodecahedrane with frequencies of 2.5, 22.5, and 25.0 THz, monitored for a time interval of 10 ps starting at helium penetration into C20H20. Molecular dynamics calculations are based on ab-initio Hartree-Fock method, considering an adiabatic process. This study reveals advantageous features of helium encapsulation in dodecahedrane molecules in designing super-molecular structures for advanced nano sensors in the field of THz detectors.

Interactions between the Jet and Disk Wind in Nearby Radio-intermediate Quasar III Zw 2

Disk winds and jets are ubiquitous in active galactic nuclei (AGN), and how these two components interact remains an open question. We study the radio properties of the radio-intermediate quasar III Zw 2. We detect two jet knots, J1 and J2, on parsec scales that move at a mildly apparent superluminal speed of 1.35c. Two γ-ray flares were detected in III Zw 2 in 2009–2010, corresponding to the primary radio flare in late 2009 and the secondary radio flare in early 2010. The primary 2009 flare was found to be associated with the ejection of J2. The secondary 2010 flare occurred at a distance of ∼0.3 pc from the central engine, probably resulting from the collision of the jet with the accretion disk wind. The variability characteristics of III Zw 2 (periodic radio flares, unstable periodicity, multiple quasiperiodic signals and the possible harmonic relations between them) can be explained by the global instabilities of the accretion disk. These instabilities originating from the outer part of the warped disk propagate inward and can lead to modulation of the accretion rate and consequent jet ejection. At the same time, the wobbling of the outer disk may also lead to oscillations of the boundary between the disk wind and the jet tunnel, resulting in changes in the jet–wind collision site. Object III Zw 2 is one of the few cases observed with jet–wind interactions, and the study in this paper is of general interest for gaining insight into the dynamic processes in the nuclear regions of AGN.

What are the ideal systolic and diastolic blood pressure which do not injure the intima of iliac and coronary arteries?

Abstract For patients with coronary artery disease, hypertension (HTN) is a major risk factor. How could uncontrolled HTN start atherosclerosis? In our prior research, laminar flow in coronary arteries prevented the formation of plaques while turbulent flow injured the intima and triggered atherosclerosis. In this present study our question was: Which blood pressure (BP) level is optimal in not producing turbulence and so not injuring the intima? Methods At first, a systolic BP&amp;lt;120mmHg and diastolic BP&amp;lt;75mmHg) were arbitrarily set as controlled (group A) while a BP of &amp;gt;160/105mmHg as uncontrolled (group B). All patients underwent a dynamic coronary angiogram recorded at 15 images/second or 0.06 seconds per image. The first image was of the index artery completely filled with contrast. In subsequent images the blood in white color moved in over a background of black contrast (Figure 1A). In 1B, 0.06 seconds later, the blood arrived at the mid segment (white arrow). In 1C, the flood moved forward, however there was darker contrast hanging at the mid segment, marking the location of collision from the retrograde against the antegrade flow (white arrow). The reason was that in uncontrolled BP the contraction of the left ventricle was stronger so in systole, the coronary blood could reverse its course, run on a retrograde direction, collide against the antegrade flow and create turbulence (1C). At the end, before deploying a vascular closure device, an iliac angiogram was performed. In Figure 2, on a black background of contrast, the blood in white color moved forward with a pointed tip of laminar flow. 0.06 seconds later, the laminar tip was stopped abruptly with all the layers recoiling on each other like a falling stack of dominoes. In the next image. a large swirl of disorganized mixing of blood and contrast suggested the presence of turbulence caused by the collision. The data to be collected were (1) the duration of the antegrade and retrograde flow, (2) duration of the collision (turbulence at the collision site) Results In the group A (BP &amp;lt;120/75 mmHg), 90% of 20 patients had no retrograde flow nor collision in the iliac and short collision in coronary arteries (&amp;lt;0.12 secs). In 30 patients of group B (BP &amp;gt;160/105 mmHg), the duration of retrograde flow and collision in the iliac artery were prolonged at &amp;gt;0.24 msecs. In the coronary arteries, the duration was prolonged at 0.18 msecs (all p&amp;lt;0.05 compared with group A). These locations of turbulence correlated with the location of plaques in our prior studies. Conclusion In patients with uncontrolled HTN, the retrograde flow was prolonged, and the turbulence was intense. In contrary, for patients with controlled BP, there was no retrograde flow and weaker collision in coronary arteries. The results suggest that a BP of &amp;lt;120/75 mmHg may not trigger the atherosclerotic process. New clinical trials with larger number of patients should be performed in search for the lowest ideal blood pressure. Funding Acknowledgement Type of funding sources: None.

Microscale pedestrian environment surrounding pedestrian injury sites in Washington state, 2015–2020

Objective While microscale pedestrian environment features such as sidewalks and crosswalks can affect pedestrian safety, it is challenging to assess microscale environment associated risk across locations or at scale. Addressing these challenges requires an efficient auditing protocol that can be used to assess frequencies of microscale environment features. For this reason, we developed an eight-item pedestrian environment virtual audit protocol and conducted a descriptive epidemiologic study of pedestrian injury in Washington State, USA. Methods We used data from police reports at pedestrian-automotive collision sites where the pedestrian was seriously injured or died. At each collision site, high school students participating in an online summer internship program virtually audited Google Street View imagery to assess the presence of microscale pedestrian environment features such as crosswalks and streetlighting. We assessed inter-rater reliability using Cohen’s kappa and explored prevalence of eight microscale environment features in relation to injury severity and municipal boundaries. Results There were 2248 motor vehicle crashes eliciting police response and resulting in death or serious injury of a pedestrian in Washington State between January 1, 2015 and May 8, 2020. Of the crashes resulting in serious injury or death, 498 (22%) resulted in fatalities and 1840 (82%) occurred within municipal boundaries. Cohen’s kappa scores for the eight pedestrian features that were audited ranged from 0.52 to 0.86. Audit results confirmed that features such as sidewalks and crosswalks were more common at collision sites within city limits. Conclusions High school student volunteers with minimal training can reliably audit microscale pedestrian environments using limited resources.

A Quantitative Method for Determining Underground Garage Parking Comfort and Development of a BIM Based Analysis Program

The current parking space design only considers whether the parking space size meets the requirements of the specification, but because of people’s parking habits, parking technology is different and its requirements for parking comfort are different, and so our parking space design should be people-oriented to meet people’s requirements for parking comfort. At present, the main dilemma faced by designers considering the comfort of parking is that it is difficult to quantify the comfort of parking. At the same time, the number of parking spaces in underground garages is large, so manual calculation of the comfort of parking is a huge task. Therefore, in this paper, we put forward the concept of parking comfort and put forward a calculation model that can quantify the parking comfort. Considering the position coordinates of the collision-prone parts in the whole process of vehicle parking, the collision position coordinates and site obstacle coordinates are established together to form the vehicle collision constraint relationship in the process of parking, so as to quantify parking comfort into specific values. At the same time, based on the calculation model and BIM secondary development technology, we develop a program for automatic calculation and detection of parking comfort based on the BIM model, so as to automatically evaluate the parking comfort of each parking space in the whole underground garage effectively, quickly, and accurately.