The solar PV system-based water pumping plant is cost-effective in developing countries like India. This study compares remote solar water pumping systems, accounting various factors like site location, system size, and performance, in several climate-sensitive Indian regions. The PVsyst simulation software is used to design the standalone solar water pumping system. Data inputs are obtained from four different climatic locations in southern part of India. A comparative analysis is performed for the four regions based on the solar yield, performance ratio (PR), energy losses, and pump efficiency. The PVsyst simulation analysis shows that the overall pump efficiency ranges between 57% and 66%, and the performance ratio ranges between 51% and 69%. The outcome of the results is useful for making a policy decision about locating the best solar pumping station based on the climate conditions, particularly for remote villages.