This article deals a model to investigate the mixed convection flow of Sisko nanofluid driven by bidirectionally stretched surface. Features of Brownian motion and thermophoresis have been described. Convective conditions model the heat and mass transfer process. Transformations yield ordinary differential systems. Convergence of derived local similar series solutions for resulting problems is verified. Intervals of convergence in the series solutions are explicitly determined. Impact of numerous sundry variables for velocity, temperature and nanoparticles concentration is explored by plotting graphs. Computations for heat and mas transfer rates are declared and inspected for the influence of emerging variables. It is inspected that higher mixed convection variable results to enhance the velocity distribution whereas it diminishes fluid temperature and concentration. The results of presented analysis are compared with the available works in particular situations and good agreement has been noted.