Herein, the loss reduction of a motor drive system is experimentally studied by means of the 5th harmonic superimposition in the reference signal of a sinusoidal PWM inverter from the perspective of nonlinear magnetic characteristics. The measured data of the motor drive system loss exhibits a reduction of 1.5% in the condition when the superimposition rate is -0.15. More specifically, the motor core, copper and inverter losses are reduced. The results confirm the feasibility and efficacy of the proposed method. According to the fundamental research of a ring test with the same electrical steel as the motor, the magnetic characteristics of the B-H curve changes in the case of the 5th harmonic superimposition, which decreases the fundamental component of the current. Accordingly, the loss is considered to be reduced due to the decline in the fundamental current component and carrier frequency components.