Mucormycosis is a rare opportunistic invasive fungal infection. The most commonly reported form of the disease is rhinocerebral mucormycosis. Here, we report a 54-year-old diabetic and hypertensive male patient presented with severe frontal headache and retro-orbital pain. Anterior rhinoscopy showed deviation of nasal septum to left. Computed tomography showed soft tissue density material in sphenoid sinus with focal hyperdense component anteriorly. Cerebrospinal fluid study was negative for meningitis with a normal cerebrospinal fluid pressure. The patient underwent functional endoscopic sinus surgery and tissue sampling after which antifungal therapy with posaconazole was initiated because biopsy from sinus mucosa was consistent with mucormycosis. The patient responded well to functional endoscopic sinus surgical evacuation of the fungal debris and posaconazole and is doing well on follow-up. This report highlights the possibility of occurrence of this rapidly fatal condition even with normal looking nasal mucosa. High index of suspicion is required to prevent the complications because the course of the disease is very rapid. This case report emphasizes the fact that posaconazole is the only available oral antifungal, which can be used as a first-line agent in the management of mucormycosis, even in immunocompromised individuals.