To examine the effect of epidural analgesia on the length of the second stage in a contemporary cohort of parturients and to establish risk factors for a prolonged second stage. A retrospective cohort study of all live singleton vaginal deliveries in a single tertiary center between 2011 and 2016. The 5%, 50% and 95% percentiles of second stage length were calculated stratified by parity and epidural analgesia during labor. Multivariate logistic regression analysis was used to assess risk factors for a prolonged second stage. During the 6-year study period, 46,638 deliveries met inclusion criteria. The 95th percentile of second stage length for primiparous women and multiparous women without epidural was 162 minutes and 40 minutes, respectively. Epidural use increased the 95th percentile of second stage length by 59 and 87 minutes in primiparous and multiparous women, respectively. It was associated with more than a two-fold increase in rates of a prolonged second stage (p<0.001, OR 2.03, CI 1.83-2.26), and more than a three-fold increase in instrumental delivery rates (p<0.001, OR 3.36, CI 2.89-3.91) regardless of parity, but did not increase rates of cesarean delivery. Primiparity was an independent risk factor for a prolonged second stage (OR 4.45, CI 4.10-4.85). Epidural use prolongs the length of the second stage of labor and increases rates of instrumental delivery in both primiparous and multiparous women.View Large Image Figure ViewerDownload Hi-res image Download (PPT)