Single-pixel cameras that measure image coefficients have various promising applications, in particular for hyper-spectral imaging. Here, we investigate deep neural networks that when fed with experimental data can output high-quality images in real time. Assuming that the measurements are corrupted by mixed Poisson-Gaussian noise, we propose to map the raw data from the measurement domain to the image domain based on a Tikhonov regularization. This step can be implemented as the first layer of a deep neural network, followed by any architecture of layers that acts in the image domain. We also describe a framework for training the network in the presence of noise. In particular, our approach includes an estimation of the image intensity and experimental parameters, together with a normalization scheme that allows varying noise levels to be handled during training and testing. Finally, we present results from simulations and experimental acquisitions with varying noise levels. Our approach yields images with improved peak signal-to-noise ratios, even for noise levels that were foreseen during the training of the networks, which makes the approach particularly suitable to deal with experimental data. Furthermore, while this approach focuses on single-pixel imaging, it can be adapted for other computational optics problems.
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