Photon Counting Research Articles

Countering Calcium Blooming With Personalized Contrast Media Injection Protocols: The 1-2-3 Rule for Photon-Counting Detector CCTA.

Photon-counting detector computed tomography (PCD-CT) enables spectral data acquisition of CT angiographies allowing for reconstruction of virtual monoenergetic images (VMIs) in routine practice. Specifically, it has potential to reduce the blooming artifacts associated with densely calcified plaques. However, calcium blooming and iodine attenuation are inversely affected by energy level (keV) of the VMIs, creating a challenge for contrast media (CM) injection protocol optimization. A pragmatic and simple rule for calcium-dependent CM injection protocols is investigated and proposed for VMI-based coronary CT angiography with PCD-CT. A physiological circulation phantom with coronary vessels including calcified lesions (maximum CT value >700 HU) with a 50% diameter stenosis was injected into at iodine delivery rates (IDRs) of 0.3, 0.5, 0.7, 1.0, 1.5, 2.0, 2.5, and 3.0 g I/s. Images were acquired using a first-generation dual-source PCD-CT and reconstructed at various VMI levels (between 45 and 190 keV). Iodine attenuation in the coronaries was measured at each IDR for each keV, and blooming artifacts from the calcified lesions were assessed including stenosis grading error (as % overestimation vs true lumen). The IDR to achieve 300 HU at each VMI level was then calculated and compared with stenosis grading accuracy to establish a general rule for CM injection protocols. Plaque blooming artifacts and intraluminal iodine attenuation decreased with increasing keV. Fixed windowing (representing absolute worst case) resulted in stenosis overestimation from 77% ± 4% at 45 keV to 5% ± 2% at 190 keV, whereas optimized windowing resulted in overestimation from 29% ± 3% at 45 keV to 4% ± 1% at 190 keV. The required IDR to achieve 300 HU showed a strong linear correlation to VMI energy (R2 = 0.98). Comparison of this linear plot versus stenosis grading error and blooming artifact demonstrated that multipliers of 1, 2, and 3 times the reference IDR for theoretical clinical regimes of no, moderate, and severe calcification density, respectively, can be proposed as a general rule. This study provides a proof-of-concept in an anthropomorphic phantom for a simple pragmatic adaptation of CM injection protocols in coronary CT angiography with PCD-CT. The 1-2-3 rule demonstrates the potential for reducing the effects of calcium blooming artifacts on overall image quality.

Simulation of a Pulsed Metastable Helium Lidar

Measurements of atmosphere density in the upper thermosphere and exosphere are of great significance for studying space–atmosphere interactions. However, the region from 200 km to 1000 km has been a blind area for traditional ground-based active remote sensing techniques due to the limitation of facilities and the paucity of neutral atmosphere. To fulfill this gap, the University of Science and Technology of China is developing a powerful metastable helium resonance fluorescent lidar incorporating a 2 m aperture telescope, a high-energy 1083 nm pulsed laser, as well as a superconducting nanowire single-photon detector (SNSPD) with high quantum efficiency and low dark noise. The system is described in detail in this work. To evaluate the performance of the lidar system, numerical simulation is implemented. The results show that metastable helium density measurements can be achieved with a relative error of less than 20% above 370 km in winter and less than 200% in 270–460 km in summer, demonstrating the feasibility of metastable helium lidar.

Analysis and reduction of back-reflection straylight in laser ranging system

In the coaxial satellite laser ranging system or the other telescope-based measurement systems, the emitted beam produces backward reflection at the center of the secondary mirror, which affects the detector in the system. To reduce the impact of straylight, a new device for reduce the backward reflection of the secondary mirror has been proposed. The specific parameters of the device have been determined through numerical calculation and computer simulation. The device has been implemented in a 1.2 m laser ranging system and has been experimentally proven to reduce the laser straylight by 32.4 % with the single photon detector and there is an increase in the camera's contrast for target imaging, making it more effective to measuring the space target.

Optimization of photon counting CT for cardiac imaging in patients with left ventricular assist devices: An in-depth assessment of metal artifacts.

Photon counting CT (PCCT) holds promise for mitigating metal artifacts and can produce virtual mono-energetic images (VMI), while maintaining temporal resolution, making it a valuable tool for characterizing the heart. This study aimed to evaluate and optimize PCCT for cardiac imaging in patients during left ventricular assistance device (LVAD) therapy by conducting an in-depth objective assessment of metal artifacts and visual grading. Various scan and reconstruction settings were tested on a phantom and further evaluated on a patient acquisition to identify the optimal protocol settings. The phantom comprised an empty thoracic cavity, supplemented with heart and lungs from a cadaveric lamb. The heart was implanted with an LVAD (HeartMate 3) and iodine contrast. Scans were performed on a PCCT (NAEOTOM Alpha, Siemens Healthcare). Metal artifacts were assessed by three objective methods: Hounsfield units (HU)/SD measurements (DiffHU and SDARTIFACT), Fourier analysis (AmplitudeLowFreq), and depicted LVAD volume in the images (BloomVol). Radiologists graded metal artifacts and the diagnostic interpretability in the LVAD lumen, cardiac tissue, lung tissue, and spinal cord using a 5-point rating scale. Regression and correlation analysis were conducted to determine the assessment method most closely associated with acquisition and reconstruction parameters, as well as the objective method demonstrating the highest correlation with visual grading. Due to blooming artifacts, the LVAD volume fluctuated between 27.0 and 92.7 cm3. This variance was primarily influenced by kVp, kernel, keV, and iMAR (R2=0.989). Radiologists favored pacemaker iMAR, 3mm slice thickness, and T3D keV and kernel Bv56f for minimal metal artifacts in cardiac tissue assessment, and 110keV and Qr40f for lung tissue interpretation. The model adequacy for DiffHU SDARTIFACT, AmplitueLowFreq, and BloomVol was 0.28, 0.76, 0.29, and 0.99 respectively for phantom data, and 0.95, 0.98, 1.00, and 0.99 for in-vivo data. For in-vivo data, the correlation between visual grading (VGSUM) and DiffHU SDARTIFACT, AmplitueLowFreq, and BloomVol was -0.16, -0.01, -0.48, and -0.40 respectively. We found that optimal scan settings for LVAD imaging involved using 120 kVp and IQ level 80. Employing T3D with pacemaker iMAR, the sharpest allowed vascular kernel (Bv56f), and VMI at 110keV with kernel Qr40 yields images suitable for cardiac imaging during LVAD-therapy. Volumetric measurements of the LVAD for determination of the extent of blooming artifacts was shown to be the best objective method to assess metal artifacts.

Spectroscopy Detection and Imaging System Based on Line Array Single Photon Detectors

Abstract. Single-photon detectors, with their exceptional sensitivity, provide a reliable means for single-photon-level detection, demonstrating significant advantages in detecting weak signals in complex environments compared to traditional detectors. With the continuous advancement in semiconductor manufacturing technology, single-photon detectors based on linear array configurations have emerged and rapidly developed. This study utilizes a linear array single-photon detector in free-running mode combined with a scanning mechanism to design and implement a spectral detection and imaging system. Through the spectral scanning unit, this system successfully achieves precise spectral detection in the 890 nm to 1710 nm range, with a spectral resolution better than 2 nm. Utilizing the imaging scanning unit, the system effectively performs target spectral imaging under single and multiple wavelength conditions at 1064 nm, 1310 nm, and 1520 nm. By optimizing algorithms for data processing, the system can achieve rapid and accurate spectral detection and imaging even under low-light conditions where the average photon count per pixel is less than 3. The results of this study are expected to provide strong technical support for the application of spectral imaging technology in the field of high-speed detection and imaging.

Young’s double-slit interference with single hard X-ray photons

Double-slit interference experiments using monochromatic hard X-rays with the energy of 25 keV are presented. The experiments were performed at a synchrotron source with a distance of 110 m between the interferometer and the detector to produce an interference pattern with a sufficiently broad period that could be adequately sampled by a photon-counting detector with 75 micrometre pixels. In the single-particle version of the experiment, over one million image frames with a single registered photon in each one were collected. The sum of these frames showed a clear presence of the interference pattern with the expected period. Subsequent analysis provided an objective estimation of the minimal number of detected photons required to determine, in accordance with the Rose criterion, the presence of the photon interference. Apart from a general theoretical interest, these investigations were aimed at exploring the possibility of medical X-ray phase-contrast imaging in photon-counting regime at minimal radiation doses.

Single-photon detection using large-scale high-temperature MgB2 sensors at 20 K

Ultra-fast single-photon detectors with high current density and operating temperature can benefit space and ground applications, including quantum optical communication systems, lightweight cryogenics for space crafts, and medical use. Here we demonstrate magnesium diboride (MgB2) thin-film superconducting microwires capable of single-photon detection at 1.55 μm optical wavelength. We used helium ions to alter the properties of MgB2, resulting in microwire-based detectors exhibiting single-photon sensitivity across a broad temperature range of up to 20 K, and detection efficiency saturation for 1 μm wide microwires at 3.7 K. Linearity of detection rate vs incident power was preserved up to at least 100 Mcps. Despite the large active area of up to 400 × 400 μm2, the reset time was found to be as low as ~ 1 ns. Our research provides possibilities for breaking the operating temperature limit and maximum single-pixel count rate, expanding the detector area, and raises inquiries about the fundamental mechanisms of single-photon detection in high-critical-temperature superconductors.

Consistency of Monoenergetic Attenuation Measurements for a Clinical Dual-Source Photon-Counting Detector CT System Across Scanning Paradigms: A Phantom Study.

BACKGROUND. Use of virtual monoenergetic images (VMIs) from multienergy CT scans can mitigate inconsistencies in traditional attenuation measurements that result from variation in scan-related factors. Photon-counting detector (PCD) CT systems produce VMIs as standard image output under flexible scanning conditions. OBJECTIVE. The purpose of this article was to evaluate the consistency of monoenergetic attenuation measurements obtained from a clinical PCD CT scanner across a spectrum of scanning paradigms. METHODS. A phantom with 10 tissue-simulating inserts was imaged using a clinical dual-source PCD CT scanner. Nine scanning paradigms were obtained across combinations of tube voltages (90, 120, and 140 kVp) and image quality (IQ) levels (80, 145, and 180). Images were reconstructed at VMI levels of 50, 60, 70, and 80 keV. Consistency of attenuation measurements was assessed, using the 120 kVp with IQ level of 145 scanning paradigm as the reference scan. RESULTS. For all scanning paradigms, attenuation measurements showed intra-class correlation of 0.999 and higher with respect to the reference scan. Across inserts, mean bias relative to the reference scan ranged from -14.9 to 13.6 HU, -2.7 to 1.7 HU, and -3.9 to 3.8 HU at tube voltages of 90, 120, and 140 kVp, respectively; and from -14.9 to 13.6 HU, -6.4 to 3.8 HU, -3.7 to 1.4 HU, and -7.2 to 4.3 HU at VMI levels of 50, 60, 70, and 80 keV, respectively. Thus, mean bias did not exceed 5 HU for any insert at tube potentials of 120 kVp and 140 kVp, nor for any insert at a VMI level of 70 keV. At a VMI level of 50 keV and tube potential of 90 kVp, mean bias exceeded 5 HU for 14 of 30 possible combinations of inserts and scanning paradigms and exceeded 10 HU for four of 30 such combinations. At VMI levels of both 60 and 80 keV, mean bias exceeded 5 HU for only two combinations of inserts and scanning paradigms, all at a tube potential of 90 kVp. CONCLUSION. PCD CT generally provided consistent attenuation measurements across combinations of scanning paradigms and VMI levels. CLINICAL IMPACT. PCD CT may facilitate quantitative applications of CT data in clinical practice.

Spatial Resolution Fidelity Comparison Between Energy Integrating and Deep Silicon Photon Counting CT: Implications for Pulmonary Imaging.

We investigated spatial resolution loss away from isocenter for a prototype deep silicon photon-counting detector (PCD) CT scanner and compare with a clinical energy-integrating detector (EID) CT scanner. We performed three scans on a wire phantom at four positions (isocenter, 6.7, 11.8, and 17.1cm off isocenter). The acquisition modes were 120kV EID CT, 120kV high-definition (HD) EID CT, and 120kV PCD CT. HD mode used double the projection view angles per rotation as the "regular" EID scan mode. The diameter of the wire was calculated by taking the full width of half max (FWHM) of a profile drawn over the radial and azimuthal directions of the wire. Change in wire diameter appearance was assessed by calculating the ratio of the radial and azimuthal diameter relative to isocenter. t tests were used to make pairwise comparisons of the wire diameter ratio with each acquisition and mean ratios' difference from unity. Deep silicon PCD CT had statistically smaller (P<0.05) changes in diameter ratio for both radial and azimuthal directions compared with both regular and HD EID modes and was not statistically different from unity (P<0.05). Maximum increases in FWMH relative to isocenter were 36%, 12%, and 1% for regular EID, HD EID, and deep silicon PCD, respectively. Deep silicon PCD CT exhibits less change in spatial resolution in both the radial and azimuthal directions compared with EID CT.

Geant4 simulation of secondary photons generated by laser–solid interaction in the presence of external magnetic field

A parametric study of the average energy and scattering angle distribution of Bremsstrahlung x-ray photons generated in over-dense fuel were investigated using the Geant4 simulation toolkit in fast ignition concept. In our simulation, over-dense fuel with the mass ρc∼(300−1000)g.cm−3, and fast ignitor with the intensity I=(1021,1023)W.cm−2 and wavelength λ=(0.35,0.53)μm were considered in the presence of an external magnetic field with the strength Bext=(0−10)kT. Further, for the produced MeV electrons in pre-plasma, two types of energy distribution functions, i.e., exponential and quasi two-temperature, were considered. The simulation results show that by applying an external magnetic field strength Bext∼(1−2)kT, a smooth increase was observed in the x-ray photon average energy and a considerable increase in scattering angle and photon counts in over-dense plasma obtained, so that the peak values mostly obtained for Bext∼1kT. Meanwhile, between the two energy distribution functions for electrons, the optimal average energy and scattering angle values were obtained by considering the quasi-two-temperature energy distribution function and for the fast igniter intensity and wavelength, I=1021W.cm−2,λ=0.35μm respectively, and the fuel density ρc∼300g.cm−3. Finally, regarding to the obtained optimal average photon energy (i.e., Ebph<0.4MeV), which could be considered as minimum photon energy loss and maximum electron penetration toward the fuel, the minimum thickness of lead and concrete shields required to reduce the flux of photons to its one-tenth value were found to be 1.5 cm and 30.7 cm, respectively.

Phenomena observed in electron EBRT using a pulse-by-pulse radioluminescence dosimetry system with cloud-based analytics

The pulse-by-pulse characteristics of electron beams from a clinical linear accelerator (linac) at high dose rates are crucial for ensuring precise dose delivery in radiation therapy. In this research, we employ a radioluminescence scintillator made from Ge-doped silica optical fiber to analyse electron beams at standard therapy dose rates 600 cGy/min with energy of 15 MeV. The scintillator is combined with a photomultiplier tube (PMT) and a photon-counting setup to achieve microsecond (μs) gating times, providing high temporal resolution. For sub-microsecond (sub-μs) temporal resolution, we utilize a multi-pixel photon counter and a rapid digital oscilloscope. Our study examines the peak time and the time it takes for pulses to return to baseline, uncovering the effects of afterglow at elevated dose rates and its potential implications for dosimetry precision. Our results indicate that monitor chambers, which have lower temporal resolution than the radioluminescence system outlined in this study, may struggle to accurately track high-rate dose delivery, emphasizing the necessity for advanced monitoring methods in FLASH radiotherapy. The dosimetric data was further analysed for deeper analytics on a cloud-based system. The dosimetric data underwent advanced analysis on a cloud-based platform, employing a prototype analytics software system comprised of Dosi-Client and Dosi-Cloud Backend components for real-time data acquisition and processing. This innovative approach revealed significant insights into radiation dosimetry, including the detection of anomalies through a reconstruction convolutional autoencoder, enhancing the precision and reliability of dosimetric measurements.

2D signal estimation for sparse distributed target photon counting data

In this study, we explore the utilization of penalized likelihood estimation for the analysis of sparse photon counting data obtained from distributed target lidar systems. Specifically, we adapt the Poisson Total Variation processing technique to cater to this application. By assuming a Poisson noise model for the photon count observations, our approach yields denoised estimates of backscatter photon flux and related parameters. This facilitates the processing of raw photon counting signals with exceptionally high temporal and range resolutions (demonstrated here to 50 Hz and 75 cm resolutions), including data acquired through time-correlated single photon counting, without significant sacrifice of resolution. Through examination involving both simulated and real-world 2D atmospheric data, our method consistently demonstrates superior accuracy in signal recovery compared to the conventional histogram-based approach commonly employed in distributed target lidar applications.

Monolithic integrated superconducting nanowire digital encoder

Superconducting digital circuits are promising technologies that can overcome bottlenecks in both classical and quantum computation due to their ultra-high operation speed and extremely low power dissipation. Superconducting nanowire cryotrons (nTrons) are emerging as one type of superconductor switching devices, offering advantages complementary to conventional Josephson junctions. Achieving monolithic integration of a reasonable number of nTrons into a functional digital circuit is a crucial step to extend its application. In this study, we constructed a monolithic integrated nTron-based binary encoder, which includes input fanout circuits, on-chip biasing, combinational logic routing and multi-gate nTrons. This represents a monolithic nTron digital circuit comprising 137 nTron gates, 424 resistors, 274 inductors, and 164 vias developed using a two-superconducting-layer fabrication process. The performance of this monolithic nTron encoder surpasses that of our previously demonstrated circuit with discrete nTron components. The maximum bias margin is 28% for the fanout circuit and 60% for the multi-gate nTron when using a signal generator, while the minimum timing jitter is 40 ps. The total power dissipation mainly from biasing resistors is 19.6 μW, making it more power efficient than RSFQ encoders. The encoder is then packaged and connected with a superconducting nanowire single-photon detector array for demonstrating its function of addressing pixel locations. Compared to the conventional readout, the nTron encoder shows a minimum readout error rate lower than 10−4 and reduces the readout RF lines from 15 to 4. The design and fabrication technologies could enrich integrated nTron digital circuits beyond current limits and promote their applications in classical and quantum systems.

Experimental measurement of local noise power spectrum (NPS) in photon counting detector-CT (PCD-CT) using a single data acquisition.

Accurate noise power spectra (NPS) measurement in clinical X-ray CT exams is challenging due to the need for repeated scans, which expose patients to high radiation risks. A reliable method for single CT acquisition NPS estimation is thus highly desirable. To develop a method for estimating local NPS from a single photon counting detector-CT (PCD-CT)acquisition. A novel nearly statistical bias-free estimator was constructed from the raw counts data of PCD-CT scan to estimate the variance of sinogram projection data. An analytical algorithm is employed to reconstruct point-wise covariance between any two image pixel/voxel locations and . A Fourier transform is applied to obtain the desired point-wise NPS for any chosen location . The method was validated using experimental data acquired from a benchtop PCD-CT system with various physical phantoms, and the results were compared with the conventional local NPS measurement method using repeated scans and statistical ensembleaveraging. The experimental results demonstrate that (1) the proposed method can achieve pointwise/local NPS measurement for a region of interest (ROI) located at any chosen position, accurately characterizing the NPS with spatial structures resulting from image content heterogeneity; (2) the local NPS measured using the proposed method show a higher precision in the measured NPS compared to the conventional measurement method; (3) spatial averaging of the local NPS yields the conventional NPS for a given localROI. A new method was developed to enable local NPS from a single PCD-CTacquisition.

All-fiber multifunction differential absorption CO2 lidar integrating single-photon and coherent detection

All-fiber multifunction differential absorption CO2 lidar integrating single-photon and coherent detection

Accelerated molecular vibrational decay and suppressed electronic nonlinearities in plasmonic cavities through coherent Raman scattering

Molecular vibrations and their dynamics are of outstanding importance for electronic and thermal transport in nanoscale devices as well as for molecular catalysis. The vibrational dynamics of &lt;100 molecules are studied through three-color time-resolved coherent anti-Stokes Raman spectroscopy using plasmonic nanoantennas. This isolates molecular signals from four-wave mixing (FWM) while using exceptionally low nanowatt powers to avoid molecular damage via single-photon lock-in detection. FWM is found to be strongly suppressed in nanometer-wide plasmonic gaps compared to plasmonic nanoparticles. Simultaneous time-resolved incoherent anti-Stokes Raman spectroscopy allows us to separate the contributions of vibrational population decay (T1) and dephasing (T2). With increasing illumination intensity, the ultrafast vibrational dephasing rates of biphenyl-4-thiol molecules are accelerated at least tenfold, while phonon population decay rates remain constant. The extreme plasmonic field enhancement within nanogaps opens up prospects for measuring single-molecule vibrationally coupled dynamics and diverse molecular optomechanics phenomena. Published by the American Physical Society 2024

Optimal Leveraging of a Gifford-McMahon Cryocooler’s Regenerative Cooling Power for SNSPD Applications

Superconducting nanowire single photon detectors (SNSPDs) offer unparalleled efficiency, minimal dark count rates, and picosecond jitter, making them ideal for single photon detector applications across the visible to mid-IR spectrum. A common cryogenic system used to reach these detectors’ optimal operating temperatures (>1 K) consists of Sumitomo’s compact RDK101 Gifford McMahon Cryocooler (GMC) running on an Zephyr air cooled compressor, coupled with a helium four (4He) adsorption stage. In this work, our aim is to provide measurements of the RDK101 GMC second stage regenerator tube cooling power at several locations along its length. We then characterise the performance of the adsorption cooler with heat loads applied to the regenerator tube. Our measurements demonstrate that heat loads of 1.2 W can be intercepted at the tube’s section near the GMC’s first cooling stage, with a negligible effect on the performance of the adsorption cooler. The thermal conductivity of yellow brass coaxial was characterised from 4 K to 40 K. Here we show that the heat load from 64 coaxial cable can be optimally intercepted with the defined regenerator cooling power. These results indicate that a 1024-pixel SNSPD array using a 32x32 row column multiplexing architecture could be successfully implemented in this cryogenic platform.

Photon-counting detector step-wedge calibration enabling water and iodine material decomposition

Photon-counting detector computed tomography (PCD-CT) has demonstrated improvements in conventional image quality compared to energy integrating detector (EID) CT. PCD-CT has the advantage of being able to operate in conventional and spectral mode simultaneously by sorting photons according to selected energy thresholds. However, to reconstruct spectral images PCD-CT requires extensive calibration and specifically fine-tuning a spectral response. This response is then used to perform material decomposition (MD). We propose a step-wedge phantom made of water and iodine to calibrate a prototype PCD-CT system. Four methods were tested and compared based on calibration accuracy and CT image quality. The exhaustive PCD response was not well calibrated, but a reduced model was defined that was able to perform accurate water/iodine MD and to reduce the ring artifact intensity. The impact of the number of energy bins (from two to seven) was also studied. The number of bins did not affect the spectral accuracy. However, compared to the two energy bin configuration, the seven bin configuration decreased the noise by 10% and 15% in the water and iodine maps, respectively. The model was tested on ex-vivo tissue samples injected with iodine to demonstrate the results of the water/iodine MD on biological materials.

Multi-institutional Protocol Guidance for Pediatric Photon-counting CT.

Performing CT in children comes with unique challenges such as greater degrees of patient motion, smaller and densely packed anatomy, and potential risks of radiation exposure. The technical advancements of photon-counting detector (PCD) CT enable decreased radiation dose and noise, as well as increased spatial and contrast resolution across all ages, compared with conventional energy-integrating detector CT. It is therefore valuable to review the relevant technical aspects and principles specific to protocol development on the new PCD CT platform to realize the potential benefits for this population. The purpose of this article, based on multi-institutional clinical and research experience from pediatric radiologists and medical physicists, is to provide protocol guidance for use of PCD CT in the imaging of pediatric patients.

Superconducting Qubit Network as a Single Microwave Photon Detector for Galactic Axion Search

Superconducting Qubit Network as a Single Microwave Photon Detector for Galactic Axion Search