Background: Frailty is due to the combined influence of both aging and chronic disease and is increasingly a factor in T2DM clinical practice guidelines. Most definitions of frailty fall into three categories: a clinical phenotype definition (Cardiovascular Health Study Index; CHS index), a measure of accumulated deficits (Rockwood Clinical Frailty Scale, RCFS), and a single performance measure (such as gait speed). We examined the association between glycemic control and different frailty measures in older adults with type 2 diabetes (T2DM). Methods: 72 older adults (age >= 65) with type 2 diabetes were recruited sequentially from a geriatric medicine clinic (26 women, 46 men, mean age 80.5±0.6 years). Each subject had glycosylated hemoglobin (HgAIC), CHS index, RCFS and gait speed measured. Our initial models contained both age and HgAIC as predictor variables, and our outcome variables were the measures of frailty. Results: With age as a covariate, HgAIC showed a strong association with the CHS index (Standardized β=0.254±0.119, p=0.036) but no association with either the RCFS (Standardized β=0.248±0.122, p=0.840) or gait speed (Standardized β=-0.180±0.121, p=0.140). Conclusions: Glycemic control has a strong association with a phenotype-based definition of frailty but no association with other frailty models. In future diabetes guidelines for frail older adults, care must taken as to how frailty is being defined. Disclosure K. M. Madden: None. B. Feldman: None. S. Arishenkoff: None. S. M. Sy: None. G. S. Meneilly: None. Funding Allan M. McGavin Foundation