Single Observation Research Articles

Substernal lead removal: experience from the EV ICD pivotal study

Abstract Background The extravascular implantable cardioverter defibrillator (EV ICD) has recently emerged as a new option for guideline indicated ICD patients. Previous study results from the EV ICD Pilot and Pivotal studies have demonstrated that the device can provide safe and effective therapy through chronic follow up. However, less has been reported regarding EV ICD lead removal. Purpose To report on the experience of lead removal in the EV ICD Pivotal Study. Methods The EV ICD Pivotal study was an international, prospective, single-arm, premarket clinical study. Patients with a class I or IIa indication for a single-chamber ICD per ESC or ACC/AHA/HRS guidelines were enrolled. Lead removal summary data was reported. Results Of 316 patients with an implant attempt, (74.7% male, age 53.8±13.1 years, 82% primary prevention, LVEF of 38.9%±15.4%, and NYHA Class I [23.7%] or II/III [65.5%]) 299 were fully implanted; 17 (5.7%) of which had a lead removal procedure (14–752 days post-implant, at 13 sites) with 3 of them having been implanted for more than 1 year. Reasons for lead removal were lead dislodgement (n=7), infection (n=5), high impedance alert due to lead fracture (n=2), pacing indication (n=1), cardiac transplant (n=1), or scheduled sternotomy (n=1). New EV ICD leads were placed in 7/17 (41.2%) patients. No serious adverse events were adjudicated as related to the explant procedures. There was a single observation of incision site haemorrhage, that was resolved with wound care. Additional details on lead removal will be included at the time of presentation. Conclusions The EV ICD lead was successfully removed 14-752 days post implant. Nine patients were re-implanted with either extravascular or transvenous systems. Longer term extraction data collection is ongoing through the EV ICD Pivotal study and through the EV ICD post-approval study and will continue to provide additional insights.Lead removed 24 months post-implant.

Assessing the desiccation crack propagation performance of cemented soil reinforced by modified polyvinyl alcohol fiber

The increasing application of fiber reinforcement to mitigate desiccation cracks induced by evaporation during backfill curing addresses the dispersion challenge associated with high fiber addition. This study aims to enhance the interfacial strength between fibers and cement-soil mixtures through chemical modification methods (NaOH, HCl, and Silane Coupling Agent). By conducting a single fiber pull-out test and microstructures observation, the outcomes reveal that modified PVA fibers exhibit a notable increase in shear strength and pull-out energy compared to unmodified ones, thereby necessitating a reduced fiber dosage for desiccation crack reduction. Furthermore, this investigation delves into the Digital Image Correlation (DIC) feasibility of employing the Digital Image Correlation (DIC) method to monitor the desiccation crack pattern of cement-soil slurry during the initial hydration stages. The findings indicate that NaOH and HCl treatment notably diminishes stress concentration under drying conditions, consequently reducing crack width and area.

Assessing the potential impact of assimilating total surface current velocities in the Met Office’s global ocean forecasting system

Accurate prediction of ocean surface currents is important for marine safety, ship routing, tracking of pollutants and in coupled forecasting. Presently, velocity observations are not routinely assimilated in global ocean forecasting systems, largely due to the sparsity of the observation network. Several satellite missions are now being proposed with the capability to measure Total Surface Current Velocities (TSCV). If successful, these would substantially increase the coverage of ocean current observations and could improve accuracy of ocean current forecasts through data assimilation. In this paper, Observing System Simulation Experiments (OSSEs) are used to assess the impact of assimilating TSCV in the Met Office’s global ocean forecasting system. Synthetic observations are generated from a high-resolution model run for all standard observation types (sea surface temperature, profiles of temperature and salinity, sea level anomaly and sea ice concentration) as well as TSCV observations from a Sea surface KInematics Multiscale monitoring (SKIM) like satellite. The assimilation of SKIM like TSCV observations is tested over an 11 month period. Preliminary experiments assimilating idealised single TSCV observations demonstrate that ageostrophic velocity corrections are not well retained in the model. We propose a method for improving ageostrophic currents through TSCV assimilation by initialising Near Inertial Oscillations with a rotated incremental analysis update (IAU) scheme. The OSSEs show that TSCV assimilation has the potential to significantly improve the prediction of velocities, particularly in the Western Boundary Currents, Antarctic Circumpolar Current and in the near surface equatorial currents. For global surface velocity the analysis root-mean-square-errors (RMSEs) are reduced by 23% and there is a 4-day gain in forecast RMSE. There are some degradations to the subsurface in the tropics, generally in regions with complex vertical salinity structures. However, outside of the tropics, improvements are seen to velocities throughout the water column. Globally there are also improvements to temperature and sea surface height when TSCV are assimilated. The TSCV assimilation largely corrects the geostrophic ocean currents, but results using the rotated IAU method show that the energy at inertial frequencies can be improved with this method. Overall, the experiments demonstrate significant potential benefit of assimilating TSCV observations in a global ocean forecasting system.

A Comparative Study of TESS Light-curve Extraction Methods Applied to Blazars

Blazars are characterized by largely aperiodic variability on timescales ranging from minutes to decades across the electromagnetic spectrum. The Transiting Exoplanet Survey Satellite (TESS) mission provides continuous sampling of blazar variability on timescales ranging from tens of minutes to 27 days for a single sector observation. Proper removal of the background, thermal ramping, and onboard systematic effects are crucial to the extraction of a reliable blazar light curve. Multiple publicly available procedures have been created to correct for these effects. Using ground-based observations from the Zwicky Transit Facility (ZTF) and the Asteroid Terrestrial-impact Last Alert System (ATLAS) as “ground truth” observations, we compare six different methods (regression, cotrending basis vectors, pixel-level decorrelation, eleanor, quaver, and simple differential photometry) to each other, and to our “ground truth” observations, to identify which methods properly correct light curves of a sample of 11 bright blazars, including the suspected neutrino source TXS 0506+056. In addition to comparing the resulting light curves, we compare the slopes of the power spectral densities, perform least-square fitting to simultaneous ZTF data, and quantify other statistical qualities generated from the light curves of each method. We find that only three of the six methods compared (simple differential photometry, eleanor, and quaver) produce TESS light curves consistent with the ground-based ZTF and ATLAS observations.

First in situ observations of the consumption of brittle stars by the rare shrimp Phyllognathia simplex Fujino, 1973 in Indonesia and its possible presence in the western Atlantic (Decapoda, Palaemonidae)

Abstract The first evidence of the predation of brittle stars, Ophiothela sp. (Ophiotrichidae), by the palaemonid shrimp Phyllognathia simplex Fujino, 1973 (Palaemonidae), is presented based on a single observation accompanied by in situ photographs taken while scuba diving in Bali, Indonesia, also being the first ever observation of the feeding behaviour in this uncommon shrimp species. In addition, in situ photographs of three ovigerous females tentatatively identified as P. cf. simplex from southern Florida, U.S.A., suggest that P. simplex or a closely related species may be present in the western Atlantic. This is the first photographic evidence of the presence of the genus Phyllognathia Borradaile, 1915 in this part of the world.

Enhancement of superconductivity and phase diagram of Ta-doped Kagome superconductor CsV3Sb5

Kagome superconductors AV3Sb5 (A = K, Rb, and Cs) have attracted enormous interest due to the coexistence of charge density wave (CDW) order, unconventional superconductivity (SC) and anomalous Hall effect (AHE). In this paper, we reported an intensive investigation on Cs(V1−xTax)3Sb5 single crystals with systematic Ta doping. Ta was confirmed to be doped into V-site in the Kagome layer from both single crystal X-ray diffraction structural refinement and scanning transmission electron microscopy observation. The highest Ta doping level was found to be about 16%, which is more than twice as much as 7% in Nb-doped CsV3Sb5. With the increase of Ta doping, CDW order was gradually suppressed and finally vanished when the doping level reached to more than 8%. Meanwhile, superconductivity was enhanced with a maximum critical temperature (Tc) of 5.3 K, which is the highest Tc in the bulk crystal of this Kagome system at ambient pressure so far. The μ0Hc2(T) behavior demonstrates that the system is still a two-band superconductor after Ta doping. Based on the electrical transport measurement, a phase diagram was set up to exhibit the evolution of CDW and SC in the Cs(V1−xTax)3Sb5 system. These findings pave a new way to search for new superconductors with higher Tc in the AV3Sb5 family and establish a new platform for tuning and controlling the multiple orders and superconducting states.

On time-horizons based post-processing of flow forecasts

Post-processing raw stream flow forecasts are generally understood as estimating the univariate predictive density of stage or discharge values at selected future time steps, which is conditional on a single or multiple streamflow forecasts and observations up to the forecast start time to. The predictive density indicates to a forecaster in the most comprehensive way which flood level is likely to be expected. To this end, a variety of post-processing methods were proposed, which have respective strengths and weaknesses. These methods focus near-exclusively on the probabilistic forecast of the predictand at a single set future time ti, without addressing the predictive capability over the sequence of temporal sub-horizons (to, t1] ⊂ (to, t2] ⊂ … ⊂ (to, tk] nested into the overall forecast horizon. Here, we demonstrate the advantages of time-horizon dependent processing of streamflow forecasts, which evaluates the evolution of the predictive density over the sub-horizons by considering the temporal correlation among forecast ensemble members in addition to their cross-correlation with observations. The resulting probabilistic forecast consists of a multivariate distribution of stages and/or discharges at lagged forecasting times. These multivariate predictive distributions have the advantage of providing the likelihood of exceeding a critical threshold during the forecasting horizon while simultaneously offering valuable insights into the expected time of such exceedance. This approach supports not only decisions on issuing timely flood warnings but also the planing and roll-out of mitigating actions.

Awake bruxism report in a population of dental students with and without ecological momentary assessment monitorization-A randomised trial.

The Ecological Momentary Assessment (EMA) concept was the basis for developing a smartphone application for the real-time report of awake bruxism (AB) activities. The aim of this study was to assess the effects of the EMA with a randomised controlled trial designed to compare the frequency of AB reported in two separate single observation points between a group of students monitored over time with an EMA smartphone application and a non-EMA monitored group. Sixty-four (N = 64) dental students (22.3 YO [±2.6]; 52F; 12 M) answered the Oral Behaviour Checklist (OBC-1) and were randomised into an EMA-group (EG) and control group (CG). EG were monitored with a smartphone application for AB report during seven consecutive days and completed three EMA monitoring periods (EMA-1, 2 and 3) at one-month intervals. After the third period (EMA-3), both EG and CG answered again the OBC (OBC-2). Descriptive statistics were performed to characterise the sample. Pearson's chi-squared test, Fixer Exact test and post hoc Z test with Bonferroni correction were performed. The study hypothesis was that EMA could influence the AB reported by the participants because it implies an increase in the awareness, self-recognition, and self-control of bruxism behaviours. The level of significance was set at p < .05. The percentage of participants who changed the report of the activity of clenching their teeth while awake between OBC-1 and OBC-2 was significantly higher among participants in EG, when compared to CG (p = .027). For all other behaviours reported the within- and between-group differences from OBC-1 to OBC-2 were not significant. Clenching and bracing were the most frequently reported, whilst grinding was the less frequent behaviour. A smartphone-based EMA approach demonstrated be useful to monitor AB over time, increasing individual's awareness, particularly to bracing and clenching behaviours.

A rare clinical case of diagnosis and treatment of metastases of Merkel carcinoma in the right inguinal lymph nodes without an identified primary focus

Introduction. Merkel’s carcinoma is a neuroendocrine malignant epithelial skin tumor, rapidly progressive, prone to local recurrence and metastasis to regional lymph nodes and internal organs. The etiology and pathogenesis of Merkel’s carcinoma are still an insufficiently studied issue. Because of its rare occurrence, only single observations of Merkel’s carcinoma metastasis without an identified primary focus, most often with regional lymph node involvement, have been described in the world literature.Clinical case. This article presents a clinical case of metastatic lesion of inguinal lymph nodes with microinvasion into femoral artery in Merkel’s carcinoma without identified primary focus. After a comprehensive examination and onco-consilium the patient underwent surgical treatment in the scope of cytoreductive excision of the inguinal lymph node conglomerate on the right side and artery prosthesis with an autovenous graft. According to the routine postoperative pathomorphologic and immunohistochemical studies, the diagnosis of Merkel’s carcinoma metastasis was finally confirmed.Conclusion. Identification and description of such clinical cases are practically significant and can serve for formation of certain algorithms for treatment of Merkel’s carcinoma both with local manifestations and in progressive forms. Patients with Merkel’s carcinoma should be discussed in oncological consiliums, as treatment may include surgical stage, including biopsy of sentinel lymph nodes, adjuvant radiotherapy, chemotherapy and immunotherapy in case of tumor dissemination.

Identification of potential C1-binding sites in the immunoglobulin CL domains.

Immunoglobulin G (IgG) molecules that bind antigens on the membrane of target cells spontaneously form hexameric rings, thus recruiting C1 to initiate the complement pathway. However, our previous report indicated that a mouse IgG mutant lacking the Cγ1 domain activates the pathway independently of antigen presence through its monomeric interaction with C1q via the CL domain, as well as Fc. In this study, we investigated the potential interaction between C1q and human CL isoforms. Quantitative single-molecule observations using high-speed atomic force microscopy revealed that human Cκ exhibited comparable C1q binding capabilities with its mouse counterpart, surpassing the Cλ types, which have a higher isoelectric point than the Cκ domains. Nuclear magnetic resonance and mutation experiments indicated that the human and mouse Cκ domains share a common primary binding site for C1q, centred on Glu194, a residue conserved in the Cκ domains but absent in the Cλ domains. Additionally, the Cγ1 domain, with its high isoelectric point, can cause electrostatic repulsion to the C1q head and impede the C1q-interaction adjustability of the Cκ domain in Fab. The removal of the Cγ1 domain is considered to eliminate these factors and thus promote Cκ interaction with C1q with the potential risk of uncontrolled activation of the complement pathway in vivo in the absence of antigen. However, this research underscores the presence of potential subsites in Fab for C1q binding, offering promising targets for antibody engineering to refine therapeutic antibody design.

3D‐Var data assimilation using a variational autoencoder

AbstractData assimilation of atmospheric observations traditionally relies on variational and Kalman filter methods. Here, an alternative neural network data assimilation (NNDA) with variational autoencoder (VAE) is proposed. The three‐dimensional variational (3D‐Var) data assimilation cost function is utilised to determine the analysis that optimally fuses simulated observations and the encoded short‐range persistence forecast (background), accounting for their errors. The minimisation is performed in the reduced‐order latent space discovered by the VAE. The variational problem is autodifferentiable, simplifying the computation of the cost‐function gradient necessary for efficient minimisation. We demonstrate that the background‐error covariance (B) matrix measured and represented in the latent space is quasidiagonal. The background‐error covariances in the grid‐point space are flow‐dependent, evolving seasonally and depending on the current state of the atmosphere. Data assimilation experiments with a single temperature observation in the lower troposphere indicate that the B matrix describes both tropical and extratropical background‐error covariances simultaneously.

Tracking the Subsolar Bow Shock and Magnetopause: Applying the Magnetosheath Velocity Gradient Method

AbstractBoth the bow shock and magnetopause move in response to varying solar wind and magnetospheric conditions. Tracking their locations can provide important clues to the state of the solar wind‐magnetosphere interaction, but is difficult with single spacecraft observations. This paper employs multipoint THEMIS observations of velocity gradients in the subsolar magnetosheath to remotely sense boundary locations on a continual basis for various solar wind conditions. We present three cases: (a) continuous northward IMF and no magnetopause motion; (b) southward IMF and no magnetopause motion with evidence of nightside activity; and (c) southward IMF and pressure increase with inward motion. When observing spacecraft are located near the Sun‐Earth line, inferred boundary locations agree well with the predictions of the BATS‐R‐US global magnetohydrodynamic model, confirming the utility of both the new method and the models. Results show that boundaries often lie nearly at rest with amplitudes less than 0.5 RE. They provide evidence indicating that nightside reconnection and a strong sunward convection in the outer magnetosphere can counteract the magnetopause erosion expected when a southward interplanetary magnetic field (IMF) initiates reconnection on the dayside magnetopause.

Social, forensic, and clinical correlates in female observandi referred for non-violent crimes.

Globally, crime is highly masculinised and research into female criminality is scarce. In South Africa, no research specifically investigating the characteristics of female observandi referred for non-violent crimes has been published. The study aimed to describe the socio-demographic, clinical, and forensic correlates in women referred to Sterkfontein Hospital for forensic psychiatric observation following a non-violent criminal charge between 2010 and 2019. It also sought to establish the relationship between the correlates and fitness to stand trial and criminal responsibility, as well as the relationship between the socio-demographic characteristics and the different non-violent criminal charges. Sterkfontein Hospital. A retrospective record review of all cases referred to Sterkfontein Hospital for a single observation over 10 years was conducted. Sixty-five cases were included in the study. Most observandi referred for non-violent crimes were found to be single (84.6%), unemployed (67.7%), reported abuse (55.4%), and had a high prevalence of mental illness (90.8%). Non-adherence to treatment was identified in 59.1% and substance use was identified in 72.2% of the study sample. The most common charge was theft (64.6%). The majority of the sample was found fit and responsible (57%). Bipolar (21%) and Primary Psychotic Disorders (35.7%) were associated with statistically significant outcomes of trial incompetence (p = 0.005) and lack of responsibility (p = 0.028). It is recommended that prospective studies are conducted which include comparisons with male counterparts and females referred for violent crimes. The study identified correlates that should be included in the standard of care in forensic assessments of female observandi.

Evaluating the Polarimetric Radio Occultation Technique Using NEXRAD Weather Radars

Currently, it remains a challenge to effectively monitor areas experiencing intense precipitation and the associated atmospheric conditions on a global scale. This challenge arises due to the limitations on both active and passive remote sensing methods. Apart from the lack of observations in remote areas, the quality of some observations deteriorates when heavy precipitation is present, making it difficult to obtain highly accurate measurements of the thermodynamic parameters driving these weather events. However, there is a promising solution in the form of the Global Navigation Satellite System (GNSS) Polarimetric Radio Occultation (PRO) technique. This approach provides a way to assess the large-scale bulk-hydrometeor characteristics of regions with heavy precipitation and the meteorological conditions associated with them. PRO offers vertical profiles of atmospheric variables, including temperature, pressure, water vapor pressure, and information about hydrometeors, all in a single fine-vertical resolution observation. To continue validating the PRO technique, we make use of polarimetric weather data from Next Generation Weather Radars (NEXRAD), focusing on comparing specific differential phase shift (Kdp) structures to PRO observable differential phase shift (ΔΦ). We have seen that PAZ and NEXRAD exhibit a good agreement on the vertical structure of the observable ΔΦ and that their combination could be useful for enhancing our understanding of the microphysics underlying heavy precipitation events.

PEMFC sealing modeling relating to fractal characteristics of gasket-BPP interface based on micro-contact

The interface leaking of the gasket-BPP sealing structure affects the efficiency, safety, and reliability of PEMFCs. Aiming to reveal the basic cause of interface leaking and predict the leakage rate, the contact behavior at the micro-scale had been researched by FEM with the fractal multi-scale method, which could eliminate the negative influence of a single observation scale on the gasket-BPP rough interface modeling. Furthermore, in order to relate the contacting behavior at the micro-scale to the leakage rate at the macro-scale of PEMFCs, the mapping model had been established to analyze the sealing performance of the entire interface through the self-affine and self-similar characteristics of the fractal multi-scale contacting model of the gasket-BPP. Not only macroscopic properties of gasket rubber materials are considered in this model, but also microscopic morphologies are taken in to investigate the interface leakage rate, which had not been studied in traditional macroscopic research. By comparing the compression curves and interface leakage rates of the flange sealing device in testing and calculating approaches, the accuracy and reliability of the mapping model had been verified, leading to the analysis and the prediction of the PEMFC interface leakage rate rapidly.

Agile earth observation satellite constellations scheduling for large area target imaging using heuristic search

Demand for imaging of large area targets by space-based assets such as constellations of Earth Observation Satellites (EOS) is on the rise for different applications. The area targets coverage cannot be achieved by a single satellite in a single observation opportunity, as the region for imaging spreads wider than the coverage swaths of imaging sensors. Hence, the imaging satellites are scheduled in a cooperative way to achieve maximum coverage of the area in a given planning time horizon. The scheduling algorithms also aim to maximize or minimize some specific objectives of interest while simultaneously complying with all resource constraints for an efficient use of precious space resources. As the current generation satellites are highly agile, there are many ways of choosing an imaging location in the target area for each single observation opportunity of a satellite. Even though the possible imaging region in continuous space is discretized into a finite number of strips for each observation, the huge combinatorial search space formed with all satellites’ imaging opportunities makes the problem intractable. Thus, the area target imaging scheduling is a complex combinatorial NP-hard optimization problem. Many exact and heuristic methods were evolved to provide a solution to this scheduling problem. Even though the exact methods solve the problem to optimality, they are limited to smaller problem instances because of the high computational complexities involved in those methods. More focus is seen in the literature on heuristic approaches as they guarantee scheduling performance with feasible solutions within an acceptable computational complexity. This paper presents our efficient heuristic approach proposed for the scheduling problem for imaging a large area target using a constellation of multiple satellites. Our approach is an extension of a widely used greedy approach in combination with insights from dynamic programming. In this paper, first we addressed the scheduling problem by describing it in detail and formulating it into a non-linear integer programming problem, considering the multi-objectives of achieving maximum coverage and minimum imaging resolution. The solution to the problem comprises two phases, namely the area decomposition phase and the scheduling phase. In the area decomposition phase, the area target is divided into strips dynamically for each observation opportunity of a satellite. Then exact observation period of each strip is computed using a simplified semi-analytical computational method. In the scheduling phase, we applied our heuristic search strategy, namely Forward and Backward Heuristic Search (FBHS) to obtain a near optimal solution within an acceptable computational time. Through the extensive simulations conducted under various scenarios, the effectiveness of the proposed method is verified in comparison with the baseline greedy approach.

Fast and accessible T2 mapping using off-resonance corrected DESPOT2 with application to 3D prostate

PurposeMost T1 and T2 mapping take long acquisitions or needs specialized sequences not widely accessible on clinical scanners. An available solution is DESPOT1/T2 (Driven equilibrium single pulse observation of T1/T2). DESPOT1/T2 uses Spoiled gradient-echo (SPGR) and balanced Steady-State Free Precession (bSSFP) sequences, offering an accessible and reliable way for 3D accelerated T1/T2 mapping. However, bSSFP is prone to off-resonance artifacts, limiting the application of DESPOT2 in regions with high susceptibility contrasts, like the prostate. Our proposal, DESPO+, employs the full bSSFP and SPGR models with a dictionary-based method to reconstruct 3D T1/T2 maps in the prostate region without off-resonance banding. MethodsDESPO+ modifies the bSSFP acquisition of the original variable flip angle DESPOT2. DESPO+ uses variable repetition and echo times, employing a dictionary-based method of the full bSSFP and SPGR models to reconstruct T1, T2, and Proton Density (PD) simultaneously. The proposed DESPO+ method underwent testing through simulations, T1/T2 phantoms, and on fourteen healthy subjects. ResultsThe results reveal a significant reduction in T2 map banding artifacts compared to the original DESPOT2 method. DESPO+ approach reduced T2 errors by up to seven times compared to DESPOT2 in simulations and phantom experiments. We also synthesized in-vivo T1-weighted/T2-weighted images from the acquired maps using a spin-echo model to verify the map's quality when lacking a reference. For in-vivo imaging, the synthesized images closely resemble those from the clinical MRI protocol, reducing scan time by around 50% compared to traditional spin-echo T1-weighted/T2-weighted acquisitions. ConclusionDESPO+ provides an off-resonance insensitive and clinically available solution, enabling high-resolution 3D T1/T2 mapping and synthesized T1-weighted/T2-weighted images for the entire prostate, all achieved within a short scan time of 3.6 min, similar to DESPOT1/T2.

Comparison of 2009 and 2011 WHO Guidelines, and Scoring Models for Adult Hospitalized Dengue Infection: A Single Observation in Tangerang, Indonesia

&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; World Health Organization (WHO) published a dengue guideline in 2009 and in 2011 by WHO-SEARO. However, many of dengue cases in early phase do not meet all the criteria by WHO classification. Because of this condition there is a scoring model that was published in 2015, that might help in primary health care. Therefore, a study to compare those diagnostic tools especially in adult dengue patients in Banten is needed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aims:&lt;/strong&gt; This study is to know the comparison between 2009 version and 2011 version of dengue diagnostic guidelines by WHO and scoring model version.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods and Material:&lt;/strong&gt; This study used a descriptive method with a cross-sectional design at 60 adult dengue patients. Each patient is grouped according to diagnostic tools’ classification and will be analyzed using Chi-square.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results:&lt;/strong&gt; Results are grouped according to the WHO diagnosis from 2009 and 2011, presumptive model and probable models where there are 46 (77%), 48 (78%), 31(52%), and 15 (25%) of patients diagnosed with dengue infection. Overall, the diagnosis made by the 2009 WHO and the probable models has the most superior sensitivity and specificity values of 84,6% and 25%, and 82,4% and 97,7% respectively compared to other diagnostic tools. However, from the results of positive predictive values, probable models have a higher percentage than the 2009 WHO diagnosis.&lt;/p&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; The probable model is more sensitive and specific than other diagnostic results. These conclude that probable model is best tool for dengue infection screening in early phase of infection.

Evaluation of Two Momentum Control Variable Schemes in Radar Data Assimilation and Their Impact on the Analysis and Forecast of a Snowfall Case in Central and Eastern China

To evaluate the impact of different momentum control variable (CV) schemes (CV5, the momentum control variable option with ψχ and CV7, the momentum control variable option with UV) on radar data assimilation (DA) in weather research and forecasting model data-assimilation (WRFDA) systems, a heavy snowfall in central and eastern regions of China, which started on 6 February 2022, was taken as a case in this study. The results of the wind-field increments from the single observation tests indicated that the wind-field increments had a larger range of influence when stream function and velocity potential (ψχ) were used as momentum control variables in CV5. Some spurious increments were also generated in the wind-field analysis, since CV5 tended to maintain the integrated value of the wind field. When U-wind and V-wind were used as control variables in CV7, the wind-field increments had a smaller impact range, and there was less dependence among different locations on the wind increments. For the heavy snow case, the CV7 schemes displayed some improvements in simulating the composite reflectivity compared to the other two experiments, since the composite reflectivity in the CV5 and control experiments were overestimated to some level. It was also found that the RMSEs were lower in the CV7 compared to those in the CV5 in the short-term forecasts during the data-assimilation cycles. Results also indicated that the CV7 had a more significant effect on the 6 h accumulated precipitation forecasts. Meanwhile, the experiment Exp_CV7 achieved the best ETS and FSS scores among the three groups of experiments, while Exp_CV5 appeared to be generally superior to the CTRL. In summary, the precipitation of Exp_CV7 yielded the rainfall intensity and location most close to the observation compared to those from both the CTRL and Exp_CV5 experiments.

Quantifying Brain Myelin Water Fraction in a Guinea Pig Model of Spontaneous Intrauterine Growth Restriction.

Intrauterine growth restriction (IUGR) is an obstetrical condition where a fetus has not achieved its genetic potential. A consequence of IUGR is a decrease in brain myelin content. Myelin water imaging (MWI) has been used to assess fetal myelin water fraction (MWF) and might potentially assess myelination changes associated with IUGR. To quantify and compare the MWF of non-IUGR and IUGR fetal guinea pigs (GPs) in late gestation. Prospective animal model. Dunkin-Hartley GP model of spontaneous IUGR (mean ± SD: 60 ± 1.2 days gestation; 19 IUGR, 52 control). Eight spoiled gradient-recalled (SPGR) gradient echo volumes (flip angles [α]: 2°-16°), and two sets of eight balanced steady-state free precession (bSSFP) gradient echo volumes (α: 8° - 64°), at 0° and 180° phase increments, at 3.0 T. MWF maps were generated for each fetal GP brain using multicomponent driven equilibrium single pulse observation of T1 /T2 (mcDESPOT). MWF was quantified in the fetal corpus callosum (CC), fornix (FOR), parasagittal white matter (PSW), and whole fetal brain. Linear regression was performed between five fetal IUGR markers (body volume, body-to-pregnancy volume ratio, brain-to-liver volume ratio, brain-to-placenta volume ratio, and brain-to-body volume ratio) and MWF (coefficient of determination, R2 ). A t-test with a linear mixed model compared the MWF of non-IUGR and IUGR fetal GPs (significance was determined at α < 0.05). The MWF of the control fetuses are (mean ± SD): 0.23 ± 0.02 (CC), 0.31 ± 0.02 (FOR), 0.28 ± 0.02 (PSW), and 0.20 ± 0.01 (whole brain). The MWF of the IUGR fetuses are (mean ± SD): 0.19 ± 0.02 (CC), 0.27 ± 0.01 (FOR), 0.24 ± 0.03 (PSW), and 0.16 ± 0.01 (whole brain). Significant differences in MWF were found between the non-IUGR and IUGR fetuses in every comparison. The mean MWF of IUGR fetal GPs is significantly lower than non-IUGR fetal GPs. 2 TECHNICAL EFFICACY: Stage 1.