Due to the low speed of the waves, the high-power-density direct-driven wave energy generation system (DD-WEGS) is important. For the DD-WEGS, a tubular partitioned stator, single-layer winding flux-reversal linear machine (TPS-SL-FRLM) is developed in this article. First, the topology structure is introduced and compared with that of the double-layer winding one (TPS-DL-FRLM). Then, the TPS-SL-FRLM with different slot/pole combinations, i.e., 6s/5p, 6s/7p, 12s/11p, and 12s/13p, is analyzed and optimized by a single-variable method to obtain maximum no-load electromotive force (EMF). The 12s/11p TPS-SL-FRLM is selected and further optimized by global optimization methods. When compared with the TPS-DL-FRLM at both no-load and load states, the TPS-SL-FRLM has about 13% higher output voltage and 8.6% higher output power. A prototype is adopted to validate the predicted results. It means that the 12s/11p slot/pole combination and single-layer winding configuration have unique advantages to tubular linear machines in DD-WEGS.