We propose a space-time block coded multiple input single output (STBC-MISO) terrestrial-satellite laser communication uplink system based on orthogonal frequency division multiplexing (OFDM) modulation. It further uses Málaga distribution to simulate near-ground turbulence. Considering the combined effects of the uplink light intensity scintillation, beam wander, and angle-of-arrival fluctuation, a closed expression of the terrestrial-satellite uplink bit error rate for the proposed system is derived. The simulation analyzes the influence of transmitting radius, receiving aperture, beam divergence, zenith angle, and signal-to-noise ratio on the system's error performance, and compares it with OFDM modulated single input single output (SISO) and differential phase-shift keying-modulated SISO schemes. Finally, the experimental data are verified by the Monte Carlo method. This research provides a theoretical basis for research on MISO terrestrial-satellite laser communication uplink system coding technology.