Shale reservoirs are characterized by low porosity and low permeability and are difficult to be developed, single horizontal well fracturing has the shortcomings of low modification and insufficient fracture coverage, so multi-well fracturing is often used in the field. Primary horizontal well pattern is one of the main modes for commercialized shale oil and gas extraction, but the interwell interference existing in multi-well fracturing will affect extraction. In this paper, a 3D hydraulic fracturing model was established with the geology‒engineering integration method, and the effects of cluster spacing, fracturing sequence, fracture placement, well spacing, horizontal stress difference and natural fractures (NFs) on hydraulic fracture (HF) propagation and cumulative gas production in multi-well fracturing were investigated. The results are described as follows. Appropriately reducing the cluster spacing to 10 m can effectively reduce interwell fracture hits while obtaining higher initial production; Zipper fracturing has a significant effect on reducing interwell fracture hits. Compared with sequential fracturing, zipper fracturing increases the HF area and cumulative gas production by 4.7% and 4.2% respectively; In order to ensure production while reducing the risk of fracture hits, the well spacing was chosen to be 400m; Compared to symmetric fracture placement, the cumulative production increased by 7.0% and 9.8% for the 1/4 staggered fracture placement and 1/2 staggered fracture placement, respectively; Although more NFs can be communicated and a larger fracture area can be obtained under small stress difference conditions, but the risk of interwell and intercluster fracture hits increases; When the NF inclination is less than 80°, the fracture hits is weakened with increase of NF inclination, when the NF inclination exceeds 80°, the HF tend to pass through the NFs and the fracture hits increases; As the NF density increases, the fracture complexity near the wellbore increases and the fracture hits decreases.