Homogeneous Single-phase Research Articles

Exploring the Solubility and Bioavailability of Sodium Salt and Its Free Acid Solid Dispersions of Dolutegravir.

Amorphous salt solid dispersion (ASSD) of Dolutegravir amorphous salt (DSSD) was generated using quench cooling and compared to its Dolutegravir free acid solid dispersion (DFSD) to improve the solubility and bioavailability. Soluplus (SLP) was used as a polymeric carrier in both solid dispersions. The prepared DSSD and DFSD, physical mixtures, and individual compounds were characterized by employing DSC, XRPD, and FTIR to assess the formation of the single homogenous amorphous phase and the existence of intermolecular interactions. Partial crystallinity was observed for DSSD, unlike DFSD, which is completely amorphous. No intermolecular interactions were observed between the Dolutegravir sodium (DS)/Dolutegravir free acid (DF) and SLP from the FTIR spectra of DSSD and DFSD. Both DSSD and DFSD improved the solubility of Dolutegravir (DTG) to 5.7 and 4.54 folds compared to the pure forms. Similarly, drug release from DSSD and DFSD was 2 and 1.5 folds higher than that in the pure form, owing to the rapid dissolution of the drug from the formulations. The permeability of DSSD and DFSD was estimated using the dialysis membrane, which enhanced the DTG permeability. The improvement in in vitro studies was translated into in vivo pharmacokinetic profiles of DSSD and DFSD, where 4.0 and 5.6 folds, respectively, improved the Cmax of DTG.

Isolation Effect of P-Wave By Double-Layer Wave Impeding Barrier in Unsaturated Foundations

Wave impeding block (WIB) barriers are often used to reduce vibration from different sources, but traditional vibration isolation of WIB has been limited to homogeneous materials and single-phase elastic or two-phase saturated foundations by many researchers. In fact, soils in nature are usually tri-phase unsaturated materials, and the propagation characteristics of elastic waves in unsaturated medium are completely different from those in single-phase elastic medium or two-phase saturated porous medium. In addition, the conventional WIB barrier has better vibration isolation only at low frequencies. Therefore, this paper improves the vibration isolation of the WIB by double-layer WIB with the same thickness on the basis of traditional WIB. Based on the wave theory of unsaturated porous media and elastic media, and according to the Helmholtz principle, we can obtain the solution of surface vertical displacement after setting double-layer WIB in unsaturated foundation, and then the isolation effect of double-layer WIB in unsaturated foundation under [Formula: see text]-wave incidence is investigated. The wave impedance ratio at the interface between WIB and unsaturated soil and wave impedance ratio at the interfaces among the layers of WIB is first analyzed on the vibration isolation effect of double-layer WIB, and the wave impedance ratio corresponding to the optimal vibration isolation effect of WIB barrier is achieved. Then the key factors such as incidence angle, incidence frequency, saturation, thickness, and burial depth of the double-layer WIB are evaluated on its vibration isolation properties. Finally, the isolation effects of single-layer homogeneous WIB and double-layer non-homogeneous WIB with the same thickness are compared. For the same thickness isolation barrier, the vibration isolation efficiency of double-layer WIB is 42.73% higher than single-layer at the incidence angle of [Formula: see text]–[Formula: see text]. The double-layer WIB has better isolation effect at low, medium and high frequencies than single-layer WIB.

A numerical study of the nanofluid flow over an exponentially stretching surface with Navier slip condition following Corcione model

The size of nanoparticles influences the viscosity and thermal conductivity of a nanofluid flow. In this exploration, the impacts of the dynamic viscosity and thermal conductivity of the Corcione model on the magneto-hydrodynamics (MHD) Cu-water nanofluid flow over an exponentially stretched surface are examined. It is pertinent to mention that the whole scenario is done at 300[Formula: see text]K and the freezing temperatures of 273.15[Formula: see text]K with a particle size of 25[Formula: see text]nm. The Navier slip and convective boundary conditions are assumed at the surface. A homogeneous single-phase model is adopted to formulate the problem. Nonlinear, coupled momentum, and energy balance nondimensionalized ordinary differential equations (ODEs) are constructed with suitable transformations. To solve these ODEs numerically, a renowned bvp4c technique of MATLAB software is employed. The effects of the arising parameters are represented graphically and numerically and are depicted in tables and graphs. It is witnessed that the velocity of the copper-water nanofluid declined with larger estimations of the volume fraction of nanoparticles, although the temperature distribution showed the reverse tendency. Moreover, at the surface for higher values of the slip parameter, the velocity profile reduces and the temperature of the fluid augments for higher values of the Biot number. The validation of the model is also executed by comparing it with the published result in the limiting case. An outstanding correlation is attained.

Stability of Co-amorphous Solid Dispersions: Physical and Chemical Aspects

Drug amorphization is one of the major approaches in pharmaceutical sciences to improve the solubility and dissolution rate of poorly water-soluble drugs. Amorphous solid dispersions are widely discussed approach to convert the drug into an amorphous state but due to its high energy state, the system tends to recrystallize upon storage. Co-amorphous system is a single-phase low energy system that falls under the glass solution, a type of solid dispersion. Being low-energy state and single-phase, co-amorphous dispersions are more stable than amorphous solid dispersions. In co-amorphous dispersions, the homogeneous single phase is formed only with low molecular weight co-formers, so the amount of co-former required is relatively low and this reduces the bulk of the system. This aspect of co-amorphous dispersions makes it popular over the amorphous solid dispersions in the area of solid dispersion researchers. This review provides an overview of co-amorphous dispersions and their recent advances. Particularly, this review will discuss various factors (physical and chemical) that affect and provide the stability of the co-amorphous dispersions formulation.

Proton conductivity in multi-component ABO4-type oxides.

This work investigates how configurational entropy in oxides could affect proton conductivity. For this purpose, three samples of different elemental compositions are synthesized. Five, six and seven elements were introduced into the A-site of ANbO4, forming La1/5 Nd1/5 Sm1/5Gd1/5 Eu1/5NbO4, La1/6Nd1/6Sm1/6Gd1/6Eu1/6Ho1/6NbO4 and La1/7Nd1/7Sm1/7Gd1/7Eu1/7Ho1/7Er1/7NbO4, respectively. The high configuration disorder changes the local environment, which can have a notable effect on many properties, including proton transport, which is the focus of this work. The conductivity was measured in different atmospheres; dry and wet and in a different temperature range (600-800 °C) to compare the proton transport as well as study the effect of temperature. A homogenous single-phase monoclinic fergusonite was obtained for the three samples. Proton conductivity, measured by means of comparing the conductivity in dry and wet atmospheres, was observed in all samples. La1/5 Nd1/5 Sm1/5Gd1/5 Eu1/5NbO4 exhibited the highest conductivity, about 3.0 × 10-6 S cm-1 at 800 °C in the wet atmosphere, while in the dry atmosphere it was about 2.2 × 10-6 S cm-1 at the same temperature, which implies a modest proton conductivity in this class of materials.

Effects of Rare Earth Elements on Microstructure and Corrosion Resistance of Low Alloy Steel Based on Ultra-Thin Cast Strip Process

This laboratory study aimed to reveal the inner connects between the microstructure and corrosion properties of a RE microalloyed ultra-thin cast strip (UCS) steel. The microstructure mainly consisted of homogeneous polygonal ferrite (PF) with a small amount of pearlite (P), while adding multiple alloying elements led to the appearance of granular bainite (GB) and bainitic ferrite (BF). RE elements strongly promoted the homogenization and refinement of microstructure by segregating towards the solid–liquid interface. Potentiodynamic polarization, EIS, and weight loss curves under wet–dry immersion test confirmed that the corrosion behavior was significantly improved by RE, while the addition of RE had no obvious change on tensile strength. The corrosion resistance of the homogeneous single-phase microstructure was proved to be better than that of multiphase microstructure. Hence, RE had a remarkable influence on improving corrosion resistance when the experimental steels processed single-phase microstructures.

Metal deficient AlB2-type (Ti0.2Zr0.2Hf0.2Nb0.2Ta0.2)[formula omitted]B2 high-entropy diborides with high hardness

We report the synthesis and characterization of metal deficient (Ti0.2Zr0.2Hf0.2Nb0.2Ta0.2)1−δB2 high-entropy diborides (HEBs). A single homogeneous AlB2-type phase is successfully obtained over the δ range of 0.03 ≤δ≤ 0.18. With increasing δ, the unit-cell volume exhibits a nonmonotonic variation with a maximum at δ = 0.07. These metal-deficient HEBs possess high Vickers hardness of 16.6-18.9 GPa at a load of 9.8 N and their phase stability is attributed to the increased mixing entropy. Our results not only present the first series of metal-deficient AlB2-type HEBs, but also suggest the existence of similar multicomponent diborides.

Analysis of SWCNT-water nanofluid flow in wavy channel under turbulent pulsating conditions: Investigation of homogeneous and discrete phase models

Improving thermal performance in heated channels has received much attention from many researchers due to its presence in various thermal systems. The present research numerically illustrated the effect of turbulent pulsating flow and SWCNT-water nanofluids in sinusoidal wavy channel on hydrothermal characteristics and entropy production. This study aims to provide a new thermal management approach for compact heat exchangers. Two various models for describing the motion of nanoparticles in a base fluid are applied. These models are Homogeneous single-phase, SPM and Lagrangian-Eulerian model (or discrete phase model), DPM. Governing equations are computationally solved utilizing the finite volume technique. This simulation covers Reynolds number, pulsation frequency, phase shift and nanoparticles concentration in the range of (4000 ≤ Re ≤ 7000), (1 ≤ f ≤ 5), (0° ≤ θ ≤ 180°) and (0% ≤ φ ≤ 3%), respectively. CFD simulations show that the pulsation frequency, f and phase shift, θ have a significant role in improving the heat transfer ratio and controlling the entropy generation through the wavy channel. Finally, it is recommended to use SWCNT/water nanofluid with a high-volume fraction (φ = 3%) as a working fluid in the considered channel due to its high heat transfer ratio and low thermal irreversibility.

Effect of constituent cations on the electrocatalytic oxygen evolution reaction in high-entropy oxide (Mg0.2Fe0.2Co0.2Ni0.2Cu0.2)O

To find core cations driving a high electrocatalytic activity in high-entropy oxide (HEO), the medium-entropy oxides (MEOs) subtracting each cation from the HEO are prepared and evaluated toward the alkaline water-splitting oxygen evolution reaction (OER) activity. • The core cations driving a high electrocatalytic activity in the high-entropy oxide are identified. • The high and medium-entropy oxides by subtracting each cation from the HEO are prepared. • It is found that Co 3+ is the core ion driving the high OER activity. • It is regarded that Cu 2+ ions prevent the conversion of Co or Fe cations from 2 + to 3 + . • Maximizing the concentration of Co 3+ within electrocatalysts is an effective design strategy. The electrocatalytic electrode kinetics should be controlled to overcome overpotentials for the hydrogen generation via water electrolysis, which consists of the cathodic hydrogen evolution reaction (HER) and the anodic oxygen evolution reaction (OER). Although transition metal catalysts that can replace noble metal catalysts are presented, more studies are still required in terms of stability and activity. Since the compositional diversity can provide a new breakthrough in that area, a high-entropy oxide (HEO) with five cations, (Mg 0.2 Fe 0.2 Co 0.2 Ni 0.2 Cu 0.2 )O, is applied as a promising electrocatalyst toward the OER in this study. For the HEO electrocatalysts, unveiling the effect of constituent cations on the OER activity and finding core cations driving the high OER activity come as a major issue. For it, in this work, the medium-entropy oxides (MEOs) with four cations are prepared by subtracting each cation (Mg, Fe, Co, Ni, or Cu) from the HEO, exhibiting homogeneous morphology, equiatomic composition, and single-phase rocksalt structure. As a result, it is found that the highest concentration of Co 3+ in the MEO (w/o Cu) leads to the best OER activity, and thus Co 3+ is the core ion driving the high OER activity. Furthermore, it is regarded that Cu 2+ ions prevent the conversion of Co or Fe cations from 2 + to 3 + in the HEO and MEOs. Accordingly, maximizing the concentration of Co 3+ within electrocatalysts is suggested as an effective design strategy for the high-efficiency electrocatalysts based on high or medium entropy materials.

Microstructure and mechanical properties of the new TiZrHfReAl HCP high entropy alloy

ABSTRACT In the present study, the intelligent addition of Re and Al to TiZrHf equiatomic ternary alloy resulted in a new single-phase Ti30Zr30Hf30Re5Al5 HCP high entropy alloy. The XRD analyses show that the TiZrHfRex alloys have a single-phase HCP structure until x = 5 at.%. Subsequently, the TiZrHfRe5 retains its single-phase HCP microstructure with the addition of Al upto 5 at.%, leading to a new quinary TiZrHfRe5Al5 HCP HEA. Microstructural investigations using SEM revealed the formation of compositionally homogeneous single-phase HCP solid solution for TiZrHf, TiZrHfRe5 and TiZrHfRe5Al5 alloys. Vicker's microindentation measurements revealed that adding Re, followed by Al, increases the hardness of the TiZrHf ternary alloy from 7.850.37–8.350.42 GPa. In a nutshell, a novel quinary HCP alloy was developed based on transition metals, allowing HCP HEA compositional space to expand beyond rare-earth (RE) based HEAs.

Temperature assisted size dependent synthesis and magnetic properties of rare-earth chromium oxide nanoparticles

We report the synthesis of homogeneous single-phase nanoparticles of RCrO4 and RCrO3 (R = Sm, Gd, Dy, and Er) compounds using a modified sol–gel hydrothermal method followed by heat treatment. Annealing of the as-prepared powder sample at ambient pressure enables chromium to remain in the metastable Cr5+ (4s03d1) state by crystallizing into a zircon-type tetragonal RCrO4 (S.G. I41/amd, D4h19 symmetry) structure at 773 K, while it chooses to form orthorhombic RCrO3 (S.G. Pbnm, D4h19 symmetry) structure with a stable Cr3+ (4s03d3) state at 973 K. The analysis of DC magnetization (M) versus temperature (T) in an external magnetic field, H = 100 Oe for polycrystalline RCrO4 indicates the magnetic transition temperatures, TC ∼ 20 K. The derivative of zero-field cooled magnetic susceptibility with respect to T, dχZFCdT, versus T, indicates the presence of competing magnetic interactions due to the ferromagnetic (FM) and antiferromagnetic (AFM) ordering of Cr5+ and R3+ in RCrO4 respectively near magnetic transition. This feature specifies magnetic frustration that leads to metamagnetism in RCrO4. The fit of non-linear magnetic susceptibility, χ=MH, to χ=χ0+CT-θ, with a non-zero χ0 determined from high-T data gives effective magnetic moment, μeff, which is in accordance with the theoretical value. The analysis of M vs. T indicates that RCrO3 undergoes a paramagnetic (PM) to canted-antiferromagnetic (CAFM) transition of Cr sublattices at Néel temperature (TNCr) because of antisymmetric Dzyaloshinskii-Moriya (DM) interaction due to Cr–O–Cr superexchange with a possible antiferromagnetic (AFM) ordering of the rare-earth at low temperature (TNR < 20 K). The linear fit of χ-1 vs. T with a zero χ0 shows Curie-Weiss law is more appropriate at T>TC resulting expected μeff values for RCrO3.

Superhard high-entropy dodecaboride with high electrical conductivity

Methods used to enhance the hardness of a material often render a noticeable deterioration of electrical conductivity so that a tradeoff must be made between conductivity and hardness. Here, we report a counterintuitive strategy for the design of superhard materials with superior electrical conductivity. We subsequently synthesized a high-entropy rare-earth dodecaboride that is a highly disordered homogeneous crystalline single phase with the UB12-type structure. This material exhibits a sufficient enhancement of hardness (∼43.1 GPa under a load of 0.49 N) over its constituent binary dodecaborides, while possessing a high electrical conductivity (∼1.96 ×107 S/m) comparable to that of pure metals. A high content of lightweight boron enables a substantial reduction in its density compared with other hard metal compounds. The extraordinary metal-like conductivity, together with high hardness and low density, makes it find promising applications as body armors and hard conductors under extreme conditions.

Thermoelectric properties of composition-controlled Fe2TiSi-based full-Heusler thin films

Fe2TiSi full-Heusler thin films were synthesized with a homogeneous single-phase structure and the composition was controlled in a wide range by deposition techniques. By detailed tuning of the film composition, the Seebeck coefficient reached −184 μV K−1, which is almost the maximum for the full-Heusler alloys, with a power factor of 3.9 mW K−2 m−1. The thermal conductivity was 3.5 W K−1 m−1 and first-principles calculations clarified that this small value may be due to alloy scatterings. Consequently, ZT reached 0.36 at room temperature without any heavy element doping, indicating that Fe2TiSi is one of the promising thermoelectric materials.

Even partially amorphous Pd2Ni2P metallic glass significantly promotes hydrogen evolution electrocatalysis

Metallic glasses are expected to be endowed with higher electrocatalytic activity, with respect to their crystalline counterparts, due to the presence of a high density of under-coordinated sites. However, glasses made of metals, as opposed to metal oxide/sulfides are harder to synthesize, with the challenge increasing with amorphousness. In light of these issues, we calibrate the increase in hydrogen evolution reactivity using the Pd2Ni2P bulk metallic glass composition as a model system. This composition has a good glass-forming ability and is interesting from a catalytic point of view, as Ni and P lie on the opposite leg of the HER volcano plot with respect to Pd. Partially amorphous (PA) Pd2Ni2P alloy displayed a five-fold higher specific electrocatalytic activity on per unit electrochemical surface area (ECSA) basis compared to its crystalline (C) counterpart. This magnitude of specific electrocatalytic activity, which is on par with that for pure Pd, has been achieved with just 40% of the precious metal, leading to a considerable saving in cost. The homogeneous single-phase structure of the highly electro-active partially amorphous alloy leads to higher electrochemical stability than its polycrystalline counterpart. This finding implies that many compositions ignored traditionally due to their poor electrocatalytic activity or stability can now be reconsidered in amorphous forms, thus expanding the material space of valuable catalysts.

Deep-eutectic solvents/ionic liquids/water mixture as a novel type of green thermo-switchable solvent system for selective extraction and separation of natural products from Rosmarinus officinalis leaves

In the present study, we designed a novel type of green thermo-switchable solvent system which is composed of ChCl:LA/[BMIM]PF6/H2O (v/v/v, 1/2/1) to extract natural products. When the temperature is 60 ℃, the system is a homogeneous single-phase system, and when cooling to 25 ℃, the system is switched into a heterogeneous two-phase system. Based on the thermo-switchable system, an integrated extraction method was developed which could efficiently extract both rosmarinic acid (hydrophilic) and carnosic acid (hydrophobic) from Rosmarinus officinalis leaves at 60 ℃ and in situ separate the extracted compounds with high recovery yields by cooling the extracts to 25 ℃. Rosmarinic acid was separated into the upper phase (88.97%) and carnosic acid was separated into the lower phase (97.46%). In addition to enhanced efficiency and no consumption of organic solvents, the method also completed the extraction and separation in a single step which further reduced the operation units.

PH-controlled reversible deep-eutectic solvent based enzyme system for simultaneous extraction and in-situ separation of isoflavones from Pueraria lobata

In this study, we developed an efficient and green pH-controlled reversible deep-eutectic solvents (DESs) based enzyme system for efficient extraction, transformation and in-situ separation of natural products from herbs. As a case study, seven isoflavones in the root of Pueraria lobata were selected as target compounds. A series of DESs were firstly prepared and the extraction efficiency for target compounds with or without cellulase catalysis was investigated. We found that [N4444][Cl]:ethylene glycol (1:2) with cellulase addition show the highest extraction efficiency for isoflavones. More importantly, the phase behavior of [N4444][Cl]:ethylene glycol (1:2) based cellulase system was found to be pH-controlled. When pH is 5.0, the system is a homogeneous single-phase system, which is conducive to the extraction of natural products. When pH is 6.4, the system changes from the single-phase to the heterogeneous two-phase, to realize the in-situ separation of the compounds. Therefore, by adjusting the pH of the system, the in-situ separation of isoflavones was successfully realized with high recovery yields. The pH-controlled DESs based enzyme-assisted extraction system overcomes the incompatibility between enzyme catalysis and conventional organic solvent in extraction, which could efficiently extract seven isoflavones from Pueraria lobata root.

Computational simulation of surface tension and gravitation-induced convective flow of a nanoliquid with cross-diffusion: An optimization procedure

The control of heat transfer in the hydromagnetic semiconductor crystal involves Marangoni convection with buoyancy forces. In this study, the conventional thermo-solutal Marangoni mixed flow model is modified by incorporating the solutal buoyancy effects that are significant in the flow phenomenon. The heat and mass transfer (HMT) characteristics of the Marangoni convective flow of a Cu − H2O nanofluid subjected to the assisting/resisting buoyancy forces and cross-diffusion are numerically studied. The homogeneous single-phase nanoliquid model is used in conjunction with experimental data of dynamic viscosity and thermal conductivity. The Dufour and Soret effects are considered. Governing equations are solved using the finite difference-based algorithm. The problem is analyzed in a unified way considering the cases of buoyancy-assisted flow and buoyancy-opposed flow. The response surface methodology (RSM) based on the face-centered composite design (CCD) is used to optimize the heat and mass transfer rates. A multivariate regression model is proposed and authenticated prior to optimization. Additionally, sensitivity analysis is performed using the full quadratic regression model. The increase in the temperature profile is more significant due to the radiative heat flux than the inclined magnetic field. Heat transfer has a high sensitivity to the appearance of thermal radiation, while mass transfer has a high sensitivity to the Soret effect. Simultaneous optimization of HMT rates is achieved with the high level of thermal radiation and low levels of the cross-diffusion aspects.

Discovery of a reversible redox-induced order-disorder transition in a 10-component compositionally complex ceramic

This study discovers a reversible order-disorder transition (ODT) in a 10-component compositionally complex ceramic, (Nd0.15Pr0.15Dy0.8Ho0.8Er0.8Ti0.2Yb0.1Hf0.1Zr0.1Nb0.8)O7-δ, induced via annealing in oxidized vs. reduced environments at 1600 °C. Notably, the 10-cation oxide remains a homogenous single-phase high-entropy solid solution before and after the ODT in the pyrochlore vs. fluorite structure that can be quenched. In-situ neutron diffraction reveals the oxygen vacancy formation and atomic displacement during this ODT. This study reveals a new pathway to induce ODT via a redox transition to tailor the properties of compositionally complex fluorite-based oxides.

Nanoscale-Structured Hybrid Bragg Stacks with Orientation- and Composition-Dependent Mechanical and Thermal Transport Properties: Implications for Nacre Mimetics and Heat Management Applications.

Layered nanomaterials fascinate researchers for their mechanical, barrier, optical, and transport properties. Nacre is a biological example thereof, combining excellent mechanical properties by aligned submicron inorganic platelets and nanoscale proteinic interlayers. Mimicking nacre with advanced nanosheets requires ultraconfined organic layers aimed at nacre-like high reinforcement fractions. We describe inorganic/polymer hybrid Bragg stacks with one or two fluorohectorite clay layers alternating with one or two poly(ethylene glycol) layers. As indicated by X-ray diffraction, perfect one-dimensional crystallinity allows for homogeneous single-phase materials with up to a 84% clay volume fraction. Brillouin light spectroscopy allows the exploration of ultimate mechanical moduli without disturbance by flaws, suggesting an unprecedentedly high Young’s modulus of 162 GPa along the aligned clays, indicating almost ideal reinforcement under these conditions. Importantly, low heat conductivity is observed across films, κ⊥ = 0.11–0.15 W m–1 K–1, with a high anisotropy of κ∥/κ⊥ = 28–33. The macroscopic mechanical properties show ductile-to-brittle change with an increase in the clay volume fraction from 54% to 70%. Conceptually, this work reveals the ultimate elastic and thermal properties of aligned layered clay nanocomposites in flaw-tolerant conditions.

Study of effect of hardening cooling rate on microstructure of 12Kh17G9AN4-Sh steel

Currently, sheet rolling made of stainless austenitic steels are in demand and are widely used in various fields of industry and the national economy. It is used for the manufacture of welded structures, products for the aviation and food industries, as well as other industries. The main requirement for this type of sheet rolled is corrosion resistance and good plastic properties. Technological operations in the production of sheet rolling from corrosion-resistant steels of the austenitic class are selected in such a way as to ensure maximum resistance against corrosion, and the plastic properties are ensured by a homogeneous single-phase austenitic structure. Chromium is the main alloying element of corrosion resistant steels. With increasing chromium content, the corrosion resistance of steel increases. For maximum corrosion resistance, the chromium in the steel must be dissolved in the austenite. The precipitation of its carbides from the solid solution during cooling is an extremely undesirable process, since this will lead to a decrease in the percentage of chromium in austenite and a decrease in the resistance to intercrystalline corrosion. Insufficient cooling during quenching can lead to the precipitation of chromium carbides and deterioration of the corrosion resistance of the steel. The paper presents the results of a study of the effect of various cooling media (air, water) during quenching of thin-sheet rolled products made of corrosion-resistant steel 12Cr17Mn9NNi4-SH. An X-ray phase structural analysis was carried out, the thermodynamically equilibrium phase composition was calculated, and the microstructure and microhardness of steel were studied. Using chemical analysis, the distribution of alloying elements over the cross section of austenite grains was estimated. To assess the obtained values of microhardness, a statistical analysis was carried out.