The classical theory of rough set was established by Pawlak, which mainly focusses on the approximation of sets characterized by a single equivalence relation over the universe. However, most of the current single granulation structure models cannot meet the user demand or the target of solving problems. Multigranulation rough sets approach can better deal with the problems, where data might be spread over various locations. In this article, we present the idea of soft preference and soft dominance relation for the development of soft dominance rough set in an incomplete information system. Subsequently, several important structural properties and results of the proposed model are carefully analyzed. After employing soft dominance based rough set approach to it for any times, we can only get six different sets at most in an incomplete information system. That is to say, every rough set in a universe can be approximated by only six sets, where the lower and upper approximations of each set in the six sets are still lying among these six sets. The relationships among these six sets are established. Based on soft dominance relation, we introduce logical disjunction/conjunction soft dominance optimistic/pessimistic multigranulation decision theoretic rough approximations in an incomplete information. Meanwhile, to measure the uncertainty of soft dominance optimistic/pessimistic multigranulation decision theoretic rough approximation and some of their interesting properties are examined. Thereafter, a novel multi attribute with multi decision making problem approach based on logical disjunction/conjunction soft dominance optimistic/pessimistic multigranulation decision theoretic rough sets approach are developed to solve the selection of medicine to treat the coronavirus disease (COVID-19). The basic principle and the detailed steps of the decision making model (algorithms) are presented in detail. To demonstrate the applicability and potentiality of the proposed model, we present a practical example of a medical diagnosis is given to validate the practicality of the technique.
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