The objective of this study was to realize a three-dimensional (3-D) geological model of the deep basin structure of the Middle Durance region (of folds and faults) by integration of geological and geophysical data, and to evaluate its fault geometry and tectonic history. All of the available geophysical and geological data were compiled in three dimensions using the gOcad geomodeler. The geological and geophysical data were used to build a 3-D geological model of the Middle Durance region. The data on the 3-D geometry of fault surfaces and stratigraphic horizons and the thickness maps of the main stratigraphic units are supported by the 3-D geological model. We show that the Middle Durance Fault cannot be interpreted as a single fault plane that affected the entire Meso-Cenozoic sedimentary layers and the Paleozoic basement but as a listric segmented faulting system in sedimentary layers, rooted in Triassic evaporites and a normal block faulting system in the basement. This decoupling level in the Triassic layers reveals thin-skin deformation, formed by strong mechanical decoupling between the Mesozoic sedimentary cover and the Paleozoic basement. This study also confirms that the Provence geological structure has resulted mainly from Pyrenean deformation, which was partly reactivated by Alpine deformation. We demonstrate that the Middle Durance Fault Zone is a transfer fault that accommodates deformation of the sedimentary filling of the South-East Basin through modified fold geometry over a zone of 7 km to 8 km around the main segment of the fault zone.