Single Family Research Articles

Infant Feeding Practice and Maternal Factors Influencing Exclusive Breast Feeding: A Cross-sectional Study in Warrap State, South Sudan

Infant and young child feeding is critical for children's health and survival in South Sudan. No association between maternal demographic information, feeding practice, and Exclusive Breast Feeding (EBF) was hypothesized. A 3-month descriptive cross-sectional study was conducted to investigate into infant feeding practice, prevalence, and the effect of maternal demographic features on EBF in rural areas of Warrap State, South Sudan. 420 breastfeeding mothers were administered structured questionnaires. Odd Ratio (OR), Confidence Interval (CI) and P value < 0.005 were used. The results showed that the mean age of breastfeeding mothers was 26.6 years. They were unemployed housewives with little or no education, delivering at home with good antenatal care. Neonates were breastfed immediately after birth and provided with colostrum (OR = 0.48, CI = (0.11-1.45). Supplementary feeding was mainly cow milk and was introduced six months ago, with Malaria as common during EBF. Knowledge of breastfeeding practice was adequate, and most women lived as single families with shared compounds and were well supported by other family members with the best economic independence practice. The provision of colostrum and prior knowledge on EBF were significantly associated with breastfeeding practice (P< 0.005) which was reflected on the prevalence of 89.04%. In conclusion, this study shows that the infant feeding practice of breastfeeding women with family support has removed barriers to EBF. Further research is needed to improve EBF practice and identify other significant maternal factors influencing EBF in rural communities for the sustainable development of children's health in South Sudan. Keywords: Children Health, Exclusive Breastfeeding, Rural Communities, South Sudan.

Quasi-Developable B-Spline Surface Design with Control Rulings

An intuitive design method is proposed for generating developable ruled B-spline surfaces from a sequence of straight line segments indicating the surface shape. The first and last line segments are enforced to be the head and tail ruling lines of the resulting surface while the interior lines are required to approximate rulings on the resulting surface as much as possible. This manner of developable surface design is conceptually similar to the popular way of the freeform curve and surface design in the CAD community, observing that a developable ruled surface is a single parameter family of straight lines. This new design mode of the developable surface also provides more flexibility than the widely employed way of developable surface design from two boundary curves of the surface. The problem is treated by numerical optimization methods with which a particular level of distance error is allowed. We thus provide an effective tool for creating surfaces with a high degree of developability when the input control rulings do not lie in exact developable surfaces. We consider this ability as the superiority over analytical methods in that it can deal with arbitrary design inputs and find practically useful results.

Thermal performance assessment and control optimization of a solar-driven seasonal sorption storage system for residential application

The present paper analyzed the thermal performance and control optimization of a solar system based on seasonal sorption storage for domestic applications. The system control, which could choose between 41 operational modes, was optimized based on operational costs and maximization of sorption system use. The system was composed by 17.5 m2 of evacuated tube collectors, 3.6 m3 of composite sorbents based on lithium chloride and a stratified water tank. High efficiency of a sorption storage system was obtained when continuous charges or discharges occur, which, in this study, depended on weather conditions (ambient temperature and solar irradiation). The operational economic benefits were maximized using a sorption system with 9% less capacity and, therefore, less storage volume. The sorption thermal energy storage system obtained energy densities of 90 and 106 kWh/m3. The whole system could supply 35% of the total thermal demand of a single family house in Nuremberg. The study concluded that the control optimization of a seasonal sorption system is a key factor to make the technology competitive, define its optimal size and, therefore, maximize its energy density in further designs.

Impact of Sociodemographic Factors on Use of Formal Social Services in an Older Swedish Population.

Background: In Sweden, societal support for older people is the responsibility of the municipalities. However, due to Sweden’s current aging-in-place policy for older people, there is a need to assess how the use of such services varies based on sociodemographic factors. The aim of this study was to describe the use of different forms of social services and institutional long-term care (ILTC) in an older population and to evaluate the impact of sociodemographic factors. Methods: This was a cross-sectional register-based study, including all individuals aged 65 years and older in two Swedish municipalities in 2010, 2015, and 2019. The study analyzed the use of social services and ILTC in relation to sex, place of birth, cohabitation status, and type of housing. Results: Women, those born in Sweden, and those living in an apartment were more likely to receive assistance than men, those born abroad, or living in single family houses, respectively. People living alone were consistently more likely to have assistance, as well as ILTC. Conclusions: There may be a discrepancy between the individual’s need and the assistance provided from the municipality in certain sociodemographic groups in the older population in Sweden.

Proteomic Analysis of the Seeds of Four Wild Mexican Lupinus Species: Focus on Storage Proteins

Lupinus is a wide genus, comprising between 300 and 500 species, most of them represented in America. Mexico is a secondary distribution center with more than 100 species growing along the highlands. Due to morphological similarities, the taxonomy of wild Lupinus species is still incomplete. It is, therefore, useful to collect morphological, chemical, and molecular data for the correct differentiation of these plants. In the present work, the composition of the seed proteins of four species: Lupinus aschenbornii Schauer, Lupinus campestris Cham and Schlecht, Lupinus hintonii C.P. Smith, and Lupinus montanus Kunth were analyzed. Seeds were collected at Iztaccihuatl—Popocatepetl National Park. Both total proteins and single protein families, purified by chromatographic procedures, were analyzed by SDS-PAGE and 2D-electrophoresis and by LC-MS/MS analysis. Data were compared with those of domesticated species whose proteomes had been already described in the literature. The protein profile may be useful for species identification since they have specific characteristics in each single species.

Single Parent Family Communication Patterns in Girls' Self-Concepts in Wajo District, Makassar City

The purpose of this study was to determine the pattern of family communication in the development of the self-concept of girls (single parent) in Wajo District, Makassar City and to determine the pattern of development (Single Parent) in developing the self-concept of girls with their families in order to establish good communication. This research uses descriptive analysis qualitative research method. This study intends to describe the description of single parents in developing their daughter's self-concept through family communication patterns to guide and provide support to daughters. The selected informants include people who are selected on the basis of certain criteria. This research was conducted by collecting data through observation, interviews, and documentation. This research was conducted for one month and located in Wajo District, Makassar City.
 The results of this study indicate that the pattern of family communication in developing the self- concept of single mother girls by using communication patterns is given through interpersonal communication where parents are communicators and the efforts given by single parents to girls are generated from experiences that have been passed and communication with parents make the nature, behavior, emotional, and social can be positive or negative. The form of communication used by single mothers in developing their daughter's self- concept uses interpersonal communication in the form of direction, teachings, guidance, experience and word of mouth motivation. The guidance provided is maximal enough to develop the child's self-concept as a guide in the future.

Evaluating chromosomal segregation in a family where both spouses carry an autosomal translocation

Autosomal reciprocal translocations represent exchanges of chromatin fragments between non-homologous chromosomes. Translocations are facilitated by the creation of quadrivalent structures during the first meiotic division, which are characterized by the length of the translocated and centric segments, asymmetry, and the presence of terminal breakpoints, all of which may impact segregation mode. Here, we report a rare case of multiple reciprocal translocations within a single family. This includes the evaluation of the translocations in each of the spouses and an analysis of their chromosome segregation patterns as determined by the constellation of universal characteristics in each of their quadrivalents. The obtained results will be of interest to fundamental biology, as they will expand the understanding of the factors affecting chromosome segregation during meiosis.

Increased Risk of Hereditary Prostate Cancer in Italian Families with Hereditary Breast and Ovarian Cancer Syndrome Harboring Mutations in BRCA and in Other Susceptibility Genes.

Hereditary prostate cancer (HPCa) has the highest heritability of any cancer in men. Interestingly, it occurs in several hereditary syndromes, including breast and ovarian cancer (HBOC) and Lynch syndrome (LS). Several gene mutations related to these syndromes have been identified as biomarkers in HPCa. The goal of this study was to screen for germline mutations in susceptibility genes by using a multigene panel, and to subsequently correlate the results with clinical and laboratory parameters. This was undertaken in 180 HBOC families, which included 217 males with prostate cancer (PCa). Mutational analysis was further extended to 104 family members of mutated patients. Screening of HBOC families revealed that 30.5% harbored germline mutations in susceptibility genes, with 21.6% harboring pathogenic variants (PVs) and 8.9% having variants of uncertain significance (VUS). We found PVs at similar frequency in BRCA1 and BRCA2 genes (8.8% and 9.4%, respectively), while 0.56% of PVs were present in well-established susceptibility genes PALB2, TP53 and RAD51C. Moreover, 0.56% of monoallelic PVs were present in MUTYH, a gene whose function in tumorigenesis in the context of PCa is still unclear. Finally, we reported double heterozygosity (DH) in BRCA1/2 genes in a single family, and found double mutation (DM) present in BRCA2 in a separate family. There was no significant difference between the mean age of onset of PCa in HBOC families with or without germline mutations in susceptibility genes, while the mean survival was highest in mutated patients compared to wild type. Furthermore, PCa is the second most recurrent cancer in our cohort, resulting in 18% of cases in both mutated and non-mutated families. Our investigation shows that PVs were located mostly in the 3′ of BRCA1 and BRCA2 genes, and in BRCA2, most PVs fell in exon 11, suggesting a mutation cluster region relating to risk of HPCa. A total of 65 family members inherited the proband’s mutation; of these, 24 developed cancer, with 41 remaining unaffected.

The Impact of Selected Aesthetic Building Restrictions on Georgia’s Single-Family Housing Markets

This paper analyzes the economic impact that selected “look and feel” or aesthetic building restrictions have on housing prices and housing availability in Georgia counties. We model the median value of homes using ordinary least squares, and as a robustness check, we also use a partial least squares structural equations model. We also estimate a supply of housing, as measured by single family housing permits, using a negative binomial regression. We find that aesthetic building restrictions do not have a statistically significant impact on the value of single-family homes or their supply.

Effects of land use on thermal enrichment of urban stormwater and potential mitigation of runoff temperature by watershed-scale stormwater control measures

Stream temperature is critical to the survival and reproduction of fauna in cold-water ecosystems. Urbanization causes abrupt increases in ambient stream temperature via stormwater inputs while concurrently decreasing groundwater recharge and stream baseflow. Relatively little is known about how various urban land uses affect thermal load discharged to streams or whether a network of green infrastructure retrofitted at the watershed scale can ameliorate these impacts. Runoff temperature and hydrology were monitored at 17 urban and two forested watershed outlets to assess 1) how urban land use affects stormwater thermal pollution and 2) if thermal pollution can be mitigated through infiltrating stormwater control measures (SCMs). Significantly and substantially larger runoff temperatures (i.e., event mean temperature, event maximum temperature) and thermal loads were observed from every urban land use (without SCMs) in comparison to forested (i.e., surrogate for pre-development) conditions. Event mean temperatures generally followed the land use trend of parking lot > light industrial > commercial > heavy industrial > multi-family residential, single family residential > low density residential > forest. Retrofitted bioretention cells and permeable pavements were not successful in mitigating runoff temperature in residential watersheds compared to (1) watersheds without SCMs or (2) restoring temperature to surrogate pre-development conditions. SCMs were seldomly able to mitigate enough runoff volume to have a significant thermal load reduction compared to watersheds without SCMs. These results suggest stormwater management and cold-water species management have not yet been successfully integrated. More work is needed to optimize green infrastructure SCMs design for sufficient treatment of runoff to protect cold-water ecosystems from urban development. Beyond SCM implementation, wholistic watershed management practices (e.g., riparian buffers, clustered imperviousness, underground storage/conveyance) are needed to stem thermal enrichment of streams and lakes by stormwater.

N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells.

Chronic inflammation of pancreatic islets is a key driver of β-cell damage that can lead to autoreactivity and the eventual onset of autoimmune diabetes (T1D). In the islet, elevated levels of proinflammatory cytokines induce the transcription of the inducible nitric oxide synthase (iNOS) gene, NOS2, ultimately resulting in increased nitric oxide (NO). Excessive or prolonged exposure to NO causes β-cell dysfunction and failure associated with defects in mitochondrial respiration. Recent studies showed that inhibition of the bromodomain and extraterminal domain (BET) family of proteins, a druggable class of epigenetic reader proteins, prevents the onset and progression of T1D in the non-obese diabetic mouse model. We hypothesized that BET proteins co-activate transcription of cytokine-induced inflammatory gene targets in β-cells and that selective, chemotherapeutic inhibition of BET bromodomains could reduce such transcription. Here, we investigated the ability of BET bromodomain small molecule inhibitors to reduce the β-cell response to the proinflammatory cytokine interleukin 1 beta (IL-1β). BET bromodomain inhibition attenuated IL-1β-induced transcription of the inflammatory mediator NOS2 and consequent iNOS protein and NO production. Reduced NOS2 transcription is consistent with inhibition of NF-κB facilitated by disrupting the interaction of a single BET family member, BRD4, with the NF-κB subunit, p65. Using recently reported selective inhibitors of the first and second BET bromodomains, inhibition of only the first bromodomain was necessary to reduce the interaction of BRD4 with p65 in β-cells. Moreover, inhibition of the first bromodomain was sufficient to mitigate IL-1β-driven decreases in mitochondrial oxygen consumption rates and β-cell viability. By identifying a role for the interaction between BRD4 and p65 in controlling the response of β-cells to proinflammatory cytokines, we provide mechanistic information on how BET bromodomain inhibition can decrease inflammation. These studies also support the potential therapeutic application of more selective BET bromodomain inhibitors in attenuating β-cell inflammation.

Aseptic meningitis in Fabry disease due to a novel GLA variant: an expanded phenotype?

F abry disease (FD) is an X-linked lysosomal storage disorder with accumulation of globotriosylceramide, causing neurologic involvement mainly as acroparesthesias and cerebrovascular disease. Aseptic meningitis has been reported in 11 patients with FD, but no prior study has correlated alpha-galactosidase (GLA) specific variants with meningitis. We present in this manuscript a family in which a novel GLA pathogenic variant was associated with aseptic meningitis in 2 of 5 family members. This study began with identifying the proband, then screening family members for FD symptoms and evaluating symptomatic individuals for genetic and biochemical status. All patients underwent magnetic resonance imaging, and those with headache underwent cerebrospinal fluid (CSF) analysis. Five patients (3 females) from a single family were included in this study. Mean age at diagnosis was 20.6years. Two patients (40%) had aseptic meningitis; one of them also had cerebrovascular events. C-reactive protein and erythrocyte sedimentation rate were elevated during aseptic meningitis episodes. Both patients responded to intravenous methylprednisolone with resolution of fever, headache, and vomiting. One of them recurred and needed chronic immunosuppression with azathioprine. We described aseptic meningitis in a family with a novel GLA variant. Meningitis might be a common phenomenon in FD and not a particularity of this variant. Understanding the mechanisms underlying meningitis and its association with cerebrovascular events may lead to a new paradigm of treatment for stroke in these patients. Further prospective studies with CSF collection in patients with FD and recurrent headache could help to elucidate this question.

Genetic landscape of a large cohort of Primary Ovarian Insufficiency: New genes and pathways and implications for personalized medicine.

SummaryBackgroundPrimary Ovarian Insufficiency (POI), a public health problem, affects 1-3.7% of women under 40 yielding infertility and a shorter lifespan. Most causes are unknown. Recently, genetic causes were identified, mostly in single families. We studied an unprecedented large cohort of POI to unravel its molecular pathophysiology.Methods375 patients with 70 families were studied using targeted (88 genes) or whole exome sequencing with pathogenic/likely-pathogenic variant selection. Mitomycin-induced chromosome breakages were studied in patients’ lymphocytes if necessary.FindingsA high-yield of 29.3% supports a clinical genetic diagnosis of POI. In addition, we found strong evidence of pathogenicity for nine genes not previously related to a Mendelian phenotype or POI: ELAVL2, NLRP11, CENPE, SPATA33, CCDC150, CCDC185, including DNA repair genes: C17orf53(HROB), HELQ, SWI5 yielding high chromosomal fragility. We confirmed the causal role of BRCA2, FANCM, BNC1, ERCC6, MSH4, BMPR1A, BMPR1B, BMPR2, ESR2, CAV1, SPIDR, RCBTB1 and ATG7 previously reported in isolated patients/families. In 8.5% of cases, POI is the only symptom of a multi-organ genetic disease. New pathways were identified: NF-kB, post-translational regulation, and mitophagy (mitochondrial autophagy), providing future therapeutic targets. Three new genes have been shown to affect the age of natural menopause supporting a genetic link.InterpretationWe have developed high-performance genetic diagnostic of POI, dissecting the molecular pathogenesis of POI and enabling personalized medicine to i) prevent/cure comorbidities for tumour/cancer susceptibility genes that could affect life-expectancy (37.4% of cases), or for genetically-revealed syndromic POI (8.5% of cases), ii) predict residual ovarian reserve (60.5% of cases). Genetic diagnosis could help to identify patients who may benefit from the promising in vitro activation-IVA technique in the near future, greatly improving its success in treating infertility.FundingUniversité Paris Saclay, Agence Nationale de Biomédecine.

Generation and characterization of two iPSC lines carrying heterozygous or homozygous nonsense mutation in PROM1 gene from a single family

PROM1-related retinal dystrophy (PROM1-RD) is a group of hereditary retinal disorder characterized by the progressive damage of the photoreceptors. We generated and identified two induced pluripotent stem cell (iPSC) lines carrying homozygous or heterozygous nonsense mutation c.619G > T (p.E207X) in PROM1 gene from a patient with PROM1-RD and his healthy mother, respectively. Both iPSC lines maintained the typical stem cell morphology, genomic stability and pluripotency. These iPSC lines have great potential to elucidate the disease mechanisms and develop the feasible treatments of PROM1-RD.

Three Cases of Familial Moyamoya Disease with RASA1 Mutations—A Case Report

The prevalence of moyamoya disease (MMD) is relatively high in East Asia, whereas the susceptibility genes of MMD have not been identified. Here, we reported 3 patients diagnosed with MMD from 1 single family, including a 53-year-old mother (case 1) and her 32-year-old and 29-year-old daughters (cases 2 and 3). The younger daughter was diagnosed with cerebral hemorrhage. Computed tomographic angiogram showed the typical signs of MMD in 3 patients. Clinical whole-exome sequencing was performed in 3 daughters of case 1, and RASA1 mutations in chr5: 87,376,389 and NM_002890.2: c.2012-4C>T were determined to have the strongest correlation with MMD. RASA1 mutations were verified in case 1, husband of case 1 and the descendant of case 3 by using Sanger sequencing. According to the findings of literature review, this is the first study indicating the association between RASA1 mutations and MMD.

The elusive pursuit of good enough fatherhood, and the single parent family as a modern phenomenon

ABSTRACT This paper looks at the role of fathers in the family. Structured around three poems, it emphasises the need for a triangular structure in the mind, enabling the child (and any individual) to look at ‘reality’, internal and thus external too, from a third position. The Oedipal situation, what Hanna Segal called ‘the core complex’, lies deep within the mind of any individual, and continues to have vital relevance in the lives of modern families. Clinical material is included in the paper to illustrate the points made.

Dr. Bobby Wilson and Southeastern Geographer

Dr. Bobby Wilson and Southeastern Geographer Brian Williams (bio) Professor Bobby Wilson’s enduring and paradigm-shifting influence on the geographical study of race and the United States South is evident in his longstanding engagement with the Southeastern Division of the American Association of Geographers, and his extensive contributions to this journal. The lifetime of scholarship that he leaves behind is a testament to his unwavering commitment to critically understanding and situating racism, resistance, and Black experience historically, and geographically. His scholarship is remarkable in its attention to both the everyday dimensions of racism, and the multiscalar political-economic relations that shape and reconstitute place and region. Dr. Wilson took a job at the University of Alabama-Birmingham in 1974, and published six articles in Southeastern Geographer over the next three decades (Wilson 1977, Wilson 1985, Wilson 1989, Wilson 1995, Wilson 2002a, Wilson 2007). As Dr. Wilson recounted in a 2019 interview, when he first moved to Birmingham, he frequented the public library downtown for his research. There, on a wall in the southern history section, he noticed a racial zoning map: They didn’t try to hide it…for a number of years it stayed up there. And that was a pivotal moment in my research. I finally figured out what I needed to do. And that’s where it all began. Birmingham. The industrial city of the South. Also one of the most significant places in the civil rights struggle. The dogs. The water hoses turned loose on kids remains a vivid issue in our heads today…I started from that point, I started from that particular point (Wilson 2019). His scholarly commitment to geographies of justice in the South started with place — in a library, in Birmingham, with racial zoning maps and the brazenly displayed injustice of institutionalized inequity — and tirelessly worked to situate, to reveal, to explain, and to denaturalize oppression. This anti-essentialist attention to tracing, contextualizing, and situating the geographies of racism and injustice animated his subsequent work. His project of “critically understanding race-connected practices” (Wilson 2002b, 32), as he would later term it, represented a lifetime of scholarship that transformed and enlivened both Southeastern Geographer and the discipline of geography more broadly. His first article in Southeastern Geographer looked at segregation patterns and the role of multifamily housing units and single family housing in housing opportunities for Black families in Birmingham (Wilson 1977). This article exhibited Dr. Wilson’s meticulous attention to the ways that racism takes place and shapes space. Though written in [End Page 192] the language of spatial science that dominated urban geographical scholarship in the pages of this journal at that time, this article exemplified his keen attention to the deep historical dynamics that shape racially uneven outcomes. Though in one sense modest in its scope and claims, this intervention represented a radical challenge to the work that dominated the pages of Southeastern Geographer at the time. In fact, readers of that issue of Southeastern Geographer would have first encountered Merle Prunty’s 1976 presidential address to SEDAAG, a sweeping discourse on southern industrialization, modernization, and culture, which universalizes the perspective of white southern men as the view of “the southerner” (Prunty 1977). Dr. Wilson published his second article in Southeastern Geographer at the height of the Reagan era, focusing on the history and reality of racial segregation in Birmingham, and its implications for Black residents of Birmingham (Wilson 1985). A crucial part of this history was the Medical Center Expansion Urban Renewal Project, which displaced almost 1,000 Black families to make way for the UAB medical center. Dr. Wilson only briefly mentions this fact in his article, but the brief implication of his employing institution must have represented a conscious decision, one borne of conviction and a scholarly dedication to justice. Although these first articles were couched in the conventional language of spatial science, they were strategic and important interventions, guided by his enduring commitment to people and place in Birmingham. They were also radical departures from the standard fare of Southeastern Geographer. From 1977 to 1985, the years of his first and second articles in Southeastern Geographer, there were only eight articles that focused on...

Changes in Indian culture create more school phobia in children

Breakdown of joint family, increasing number of single family in India lead to send children to school at the early age, which may create school refusal or school phobia among children. Children refuse going to school because they have to spend a lot of time away from home. They miss their parents and are faced with new challenges and pressure in a completely new setting. Author tries to discuss about definition, frequency, causes, symptoms, diagnosis and guidelines for parents and teachers about school phobia or school refusal.

조선시대 상주지역 서원의 동향

During the Joseon Dynasty, the construction of Seowon was delayed in Sangju compared to other areas in Yeongnam. After Donam seowon Confucian Academy, the first Confucian academy in Sangju, was built in 1606, Okseong seowon Confucian Academy and Geunam seowon Confucian Academy were built in the 17th century. In the process of construction of the three Confucian academies, the participation of the Sangju Sajok(士族) is gradually decreasing. Geunam seowon Confucian Academy is opposed by some of the Sangju Sajok and the participation of the Sajok of Mungyeong, Yonggung, and Andong. The differentiation of the Sangju Sajok society appears in the construction of the Confucian academy. In the first half of the 18th century, the construction of Seoin affiliation Seowon and Namin affiliation Seowon increased. Seoin affiliation Seowon was established in Sangju by Seoin affiliation's Sajok with a solid financial foundation, Heungam Seowon, Seosan Seowon, and Ungye Seowon through the support of Sanrim(山林) and government offices. Namin affiliation Seowon is led by families in the area where the Seowon is located, and similar to Geunam seowon Confucian Academy, the participation of not only the Sangju Sajok but also the Sajok of other surrounding regions is shown. In the second half of the 18th century, the family ties and the family-to-family relationship emerged as more important matters in the construction and operation of the Confucian academy than political grandeur. The existing Confucian academy was transformed into a family Confucian academy, and a family Confucian academy was built where a person from a single family was enshrined.

Distribution and Genomic Characterization of Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from a Single Family and Home Environment: A 2-Year Longitudinal Study.

Third-generation cephalosporin-resistant Escherichia coli (CREC), particularly strains producing extended-spectrum β-lactamases (ESBLs), are a global concern. Our study aims to longitudinally assemble the genomic characteristics of CREC isolates from fecal samples from an index patient with recurrent CREC-related urinary tract infections and his family and swabs from his home environment 12 times between 2019 and 2021 to investigate the distribution of antibiotic resistance genes. CREC identified using the VITEK 2 were subjected to nanopore whole-genome sequencing (WGS). The WGS of 27 CREC isolates discovered in 137 specimens (1 urine, 123 feces, and 13 environmental) revealed the predominance of ST101 and ST131. Among these sequence types, blaCTX-M (44.4%, n = 12) was the predominant ESBL gene family, with blaCTX-M-14 (n = 6) being the most common. The remaining 15 (55.6%) isolates harbored blaCMY-2 genes and were clonally diverse. All E. coli isolated from the index patient’s initial urine and fecal samples belonged to O25b:H4-B2-ST131 and carried blaCTX-M-14. The results of sequence analysis indicate plasmid-mediated household transmission of blaCMY-2 or blaCTX-M-55. A strong genomic similarity was discovered between fecal ESBL-producing E. coli and uropathogenic strains. Furthermore, blaCMY-2 genes were widely distributed among the CREC isolated from family members and their home environment.