Solid-state nanopores offer a novel platform for single molecule analysis and characterization. In particular, they have attracted significant attention as tools for high-throughput, robust, and low-error DNA sequencing. The successful implementation of solid-state nanopores in emerging third-generation DNA sequencing applications is contingent upon developing methods for scalable fabrication, high-accuracy output, and integration with low-noise electronic architectures. In this presentation, I will cover recent progress our group has made in the production, characterization, and integration of these devices. New high-resolution methods for fabricating nanopores down to the single-atom level (0.5 nm) - ion beam irradiation, photo-oxidation, and controlled chemical etching - will first be discussed. I will then describe recent successes in incorporating solid-state nanopores with high-frequency (10 MHz), low-noise amplifiers and subsequent advances in signal processing. Lastly, a brief perspective on the outlook of solid-state nanopores as well as ongoing work with ion-channel-like pores in two-dimensional (2D) materials will be provided.