The novel ternary Bi2MoO6/Bi2SiO5/Bi12SiO20 nanophotocatalyst as a cascaded pseudo-type II configuration was synthesized at different values of Si and Bi2MoO6 via a simultaneous ultrasound-boosted ionic exchange-solvothermal approach to degrade fluoroquinolones contaminants under solar light. The influence of ultrasound irradiation was assessed and Bi2MoO6/Bi2SiO5/Bi12SiO20 (Si-2)-U sample was designated as the most effective sample with the best performance. To illustrate the efficacious performance of the referred sample, PL, XRD, UV–Vis DRS, FESEM, TEM, BET-BJH analyses were carried out. Regarding the phase diagram obtained by XRD analysis, the amount of Bi2MoO6, Bi2SiO5, and Bi12SiO20 for Bi2MoO6/Bi2SiO5/Bi12SiO20 (Si-2)-U was 27%, 13% and 60%, respectively. In contrast, without ultrasound irradiation, these amounts were obtained which are 39.6%, 37.6%, and 22.8% for Bi2MoO6, Bi2SiO5, and Bi12SiO20, correspondingly. BET-BJH technique displayed 20.8 m2/g surface area, 0.1805 cm3/g pore volume, and 34.7 nm mean pore diameter. DRS presented two absorption edges for the best nanocomposite at 414.7 (2.99 eV) and 489.3 (2.53 eV) nm. In addition, morphology observations proved the microcube architecture covered by nanosheets assembled of spherical nanoparticles. The photodegradation of levofloxacin, ofloxacin and ciprofloxacin over Bi2MoO6/Bi2SiO5/Bi12SiO20 (Si-2)-U was 96.9%, 83.6%, and 70.3%, subsequently that the kinetic constant was 2.6 times of nanocomposite synthesized without the usage of ultrasound energy. The perfect performance and suitable reusability of Bi2MoO6/Bi2SiO5/Bi12SiO20 (Si-2)-U nanophotocatalyst can be attributed to the proper composition and presence of ultrasound energy during synthesis, leading to the operative mass transfer, pollutant adsorption, light harvesting/diffusion, and charge separation.