A profitability analysis of a large scale supercritical fluid extraction (SFE) process to obtain natural extracts from rocket salad is presented in this work. An industrial-scale SFE plant is designed using process simulation techniques based on experimental data. Afterward, the effect of operative parameters on the process costs is evaluated. At the optimum conditions, the economic and financial analysis is performed, and the influence of the price of rocket salad on the price of the natural extract is assessed. Results indicate that the raw materials account for 67% of the total production costs. The proposed industrial application could be economically viable with a pay-back period of 10years if the price of the rocket salad extract is larger than 21.9US$kg−1, considering the current wholesale price in the market, or 17.0US$kg−1 if using non-saleable rocket salad. Both scenarios make the process economically sustainable and competitive with the current price of natural extracts obtained by extraction with organic solvents.