This paper presents a review of authors' collective works in the field of two-phase flow modeling done in the past few decades. The paper is aimed at the construction of mathematical models for simulation of particle-laden turbulent flows. A kinetic equation was obtained for the probability density function (PDF) of the particle velocity distribution in turbulent flows. The proposed kinetic equation describes both the interaction of particles with turbulent eddies of the carrier phase and particle-particle collisions. This PDF equation is used for the derivation of different schemes describing turbulent momentum transfer in the dispersed particle phase. The turbulent characteristics of the gaseous phase are calculated on the basis of the k - ε turbulence model with a modulation effect of particles on the turbulence. The constructed models have been applied to the calculation of various two-phase gas-particle turbulent flows in jets and channels as well as particle deposition in tubes and separators. For validating the theoretical and numerical results, a wide range of comparisons with experimental data from Russian and foreign sources has been done.