This study evaluated the effects of ultrasonic, sonic, and conventional instrumentation techniques on curved root canals. Fifty resin blocks with curved canals were divided into five groups. Each group was instrumented by one of the following techniques: conventional hand instrumentation, sonic instrumentation using the Medidenta MM3000 unit, sonic instrumentation using the Syntex Endostar 5 unit, ultrasonic instrumentation using the Caulk Cavi-Endo unit, and ultrasonic instrumentation using the Osada Enac OE-2 unit. All preparations were made to the size of a#35 K-type file. Measurements of the amount of transportation of the canal were made at the apical and middle portions of the preparations. The results were significantly different based on statistical analysis of variance. A multiple comparison test revealed that the Medidenta and Caulk systems transported significantly less at the apex of the curved canals than the Syntex system and hand instrumentation techniques. The Medidenta, Syntex, and hand instrumentation transported significantly less in the middle portion of the curved canals than the Caulk and Osada systems. This study evaluated the effects of ultrasonic, sonic, and conventional instrumentation techniques on curved root canals. Fifty resin blocks with curved canals were divided into five groups. Each group was instrumented by one of the following techniques: conventional hand instrumentation, sonic instrumentation using the Medidenta MM3000 unit, sonic instrumentation using the Syntex Endostar 5 unit, ultrasonic instrumentation using the Caulk Cavi-Endo unit, and ultrasonic instrumentation using the Osada Enac OE-2 unit. All preparations were made to the size of a#35 K-type file. Measurements of the amount of transportation of the canal were made at the apical and middle portions of the preparations. The results were significantly different based on statistical analysis of variance. A multiple comparison test revealed that the Medidenta and Caulk systems transported significantly less at the apex of the curved canals than the Syntex system and hand instrumentation techniques. The Medidenta, Syntex, and hand instrumentation transported significantly less in the middle portion of the curved canals than the Caulk and Osada systems.