Let $U$ be a regular connected affine semi-local scheme over a field $k$. Let $G$ be a reductive group scheme over $U$. Assuming that $G$ has an appropriate parabolic subgroup scheme, we prove the following statement. Given an affine $k$-scheme $W$, a principal $G$-bundle over $W\times_kU$ is trivial if it is trivial over the generic fiber of the projection $W\times_kU\to U$. We also simplify the proof of the Grothendieck-Serre conjecture: let $U$ be a regular connected affine semi-local scheme over a field $k$. Let $G$ be a reductive group scheme over $U$. A principal $G$-bundle over $U$ is trivial if it is trivial over the generic point of $U$. We generalize some other related results from the simple simply-connected case to the case of arbitrary reductive group schemes.
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