Simple Screening Tool Research Articles

Cut-off of Anthropometric Measurements and Nutritional Status among Elderly Outpatients in a Tertiary Health Care Center in Telangana.

Introduction:Geriatric population is most vulnerable to various emerging communicable and noncommunicable diseases due to various socio-economic, physiological, psychological and nutritional risk factors. Adequate nutritional status is utmost important in older age as it helps in maintaining the immune response and preventing the morbidities and mortalities in this age. Thus, the opportunistic screening of malnutrition among geriatric population gives an extra edge for achievement of healthy ageing in the elderly. The objective of the present study was to assess the nutritional status among the elderly population and provide cut-off values of various anthropometric measurements for detecting the risk of malnutrition among old age people. Materials and methods:The present cross-sectional study was carried out among people aged . 60 years who visited the geriatric clinic of a tertiary health care center between May and December 2021. The nutritional status of the 468 selected elderly was assessed using the Mini Nutritional Assessment (MNA) tool and various anthropometric measurements. Receiver operating characteristic (ROC) curve and Youden index were used to determine the cut-off values of anthropometric measurements. Correlation between various anthropometric parameters was studied. Data was analyzed using SPSS vs. 20 software. Results:Out of the 468 subjects, around one third had a risk of malnutrition and 7% malnutrition as per the MNA scale. Cut-off values of triceps skinfold thickness, neck circumference and arm muscle circumference were 12.5 cm, 32.5 cm, 18.3 cm and 11.5 cm, 35.5 cm, 21.2 cm for detecting malnutrition and risk of malnutrition, respectively. Neck circumference was found to be the most suitable measurement, with a cut-off value of 32.5 cm and 35.5 cm for detecting malnutrition and risk of malnutrition, respectively, as it possessed the highest Youden index and AUC. Conclusion:The prevalence of malnutrition was found to be low in the present study setting. Our findings firmly established that the neck circumference could be used as a simple, rapid, non-invasive and valid screening tool, with high sensitivity and specificity for detecting the risk of malnutrition in geriatric clinics or primary health care settings.

The role of Zulewski’s clinical score in screening for hypothyroidism in post-radiation therapy nasopharyngeal carcinoma patients

Background: Nasopharyngeal carcinoma (NPC) is a leading cause of cancer related death in Asia; and the fourth most common malignancy in Indonesia. Hypothyroidism is one of the most commonly overlooked radiotherapy-induced late side effect due to its gradual occurrence despite its irreversibility. Unfortunately, thyroid evaluation is not widely accessible throughout Indonesia. Therefore, it is quite important to utilize a simple and reliable surrogate tool for hypothyroidism screening. This study aims to evaluate thyroid function and to validate Zulewski’s scoring system as a temporary surrogate marker for hypothyroidism in post-RT NPC patients. Method: This is a cross-sectional study involving NPC patients between November 2015 and March 2016 at Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. The patients had completed radiation therapy (RT) within the preceding six months. They were evaluated for signs and symptoms of hypothyroidism with Zulewski’s clinical scoring system and with serological analysis of thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels. Results: There were 97 patients in this study. 28 (28.9%) subjects experienced hypothyroidism based on the TSH and FT4 levels, with subclinical hypothyroidism (13.4%) as the most common type, followed by overt hypothyroidism (9.3%) and hypothyroxinemia (6.2%). From the subjects with hypothyroidism, 19.6% had Zulewski’s clinical score <5, while 40.5% had scores ≥5. Subjects with <5 Zulewski’s clinical score exhibited signs and symptoms more related to the NPC itself, while those who scored ≥5 showed signs and symptoms more closely related to hypothyroidism. Conclusion: This study shows that hypothyroidism is commonly exhibited in NPC patients after radiotherapy (28.9%). Zulewski’s clinical score of ≥5 indicates signs and symptoms more closely related to hypothyroidism.

Evaluation of different diagnostic tools for detection of acquired von Willebrand syndrome in patients with polycythemia vera or essential thrombocythemia

IntroductionPatients with myeloproliferative neoplasms (MPNs) are at increased risk of both thromboembolic and hemorrhagic complications. Among the risk factors for bleeding is the development of an acquired qualitative von Willebrand factor defect with loss of larger VWF plasma multimers, resulting in acquired von Willebrand syndrome (aVWS). The diagnosis of aVWS is challenging, because no single automated test is sufficient to prove or exclude aVWS. We aimed to compare different diagnostic tools used for the detection of MPN-associated aVWS in daily practice. MethodsPatients with polycythemia vera (PV) or essential thrombocythemia (ET), who had been routinely assessed for quantitative and qualitative abnormalities of plasma VWF, were retrospectively studied. ResultsSixty-four patients (37 with PV and 27 with ET) were analyzed. Using multimer analysis of plasma VWF, aVWS with a loss of VWF high-molecular-weight multimers was detected in 51.4 % and 55.6 % of PV and ET patients, respectively. A VWF:GPIbM/Ag threshold of <0.8 was defined as useful screening tool for aVWS, with acceptable sensitivity (88.2 %) and specificity (76.7 %) and good agreement with VWF multimer analysis (κ = 0.653). VWF:GPIbM/Ag showed better performance than VWF:CB/Ag. Regarding hematological parameters, there was no difference in hematocrit between patients with and without aVWS. However, leukocyte and platelet counts were significantly increased in the aVWS cohort. ConclusionFor the first time, we identified a VWF:GPIbM/Ag ratio of <0.8 as simple screening tool for aVWS in patients with PV or ET. This observation, however, should be confirmed in a larger patient cohort.

Deep learning assessment of left ventricular hypertrophy based on electrocardiogram.

BackgroundCurrent electrocardiogram (ECG) criteria of left ventricular hypertrophy (LVH) have low sensitivity. Deep learning (DL) techniques have been widely used to detect cardiac diseases due to its ability of automatic feature extraction of ECG. However, DL was rarely applied in LVH diagnosis. Our study aimed to construct a DL model for rapid and effective detection of LVH using 12-lead ECG.MethodsWe built a DL model based on convolutional neural network-long short-term memory (CNN-LSTM) to detect LVH using 12-lead ECG. The echocardiogram and ECG of 1,863 patients obtained within 1 week after hospital admission were analyzed. Patients were evenly allocated into 3 sets at 3:1:1 ratio: the training set (n = 1,120), the validation set (n = 371) and the test set 1 (n = 372). In addition, we recruited 453 hospitalized patients into the internal test set 2. Different DL model of each subgroup was developed according to gender and relative wall thickness (RWT).ResultsThe LVH was predicted by the CNN-LSTM model with an area under the curve (AUC) of 0.62 (sensitivity 68%, specificity 57%) in the test set 1, which outperformed Cornell voltage criteria (AUC: 0.57, sensitivity 48%, specificity 72%) and Sokolow-Lyon voltage (AUC: 0.51, sensitivity 14%, specificity 96%). In the internal test set 2, the CNN-LSTM model had a stable performance in predicting LVH with an AUC of 0.59 (sensitivity 65%, specificity 57%). In the subgroup analysis, the CNN-LSTM model predicted LVH by 12-lead ECG with an AUC of 0.66 (sensitivity 72%, specificity 60%) for male patients, which performed better than that for female patients (AUC: 0.59, sensitivity 50%, specificity 71%).ConclusionOur study established a CNN-LSTM model to diagnose LVH by 12-lead ECG with higher sensitivity than current ECG diagnostic criteria. This CNN-LSTM model may be a simple and effective screening tool of LVH.

Maasai women hearing voices: Implications for global mental health.

There is a sparse literature on women who hear voices globally, even though there are documented gendered dimensions of distress in the context of globalization and climate change and research indicates that trauma and psychosocial stress may be related to an increased prevalence of voice-hearing or auditory verbal hallucinations (AVHs). There is also a gap in the cultural phenomenology of voice-hearing in general, as well as idioms of distress for non-western peoples. This article presents results of a mixed methods study that: 1) estimated community prevalence of voice-hearing among Maasai women in northern Tanzania; 2) examined any demographic correlates and two specific hypothesized correlates (i.e., psychological stress and potentially traumatic events); and 3) engaged women in semi-structured interviews about their everyday lives and the phenomenological experience of voice-hearing. The prevalence of voice-hearing (39.4%) in this nonclinical sample (n = 71) was quite high compared to other studies in sub-Saharan Africa. Most women also reported high psychosocial stress and traumatic life events. They also talked about gendered conditions of social adversity in a context of rapid social, economic, and climate change. Women who reported hearing voices had a statistically significantly higher level of psychological distress, met criteria for severe psychological distress, and reported more potentially traumatic life events. In a logistic regression model, psychosocial stress predicted voice-hearing. The presence of distressing voices may offer a straightforward way to quickly identify people in the community experiencing the most extreme levels of psychosocial stress and traumatic events-a potentially simple but effective screening tool for health workers on the ground.

A CROSS SECTIONAL STUDY ON ASSESSMENT OF THE RISK OF DEVELOPING TYPE2 DIABETES MELLITUS USING INDIAN DIABETIC RISK SCORE (IDRS) AMONG THE FEMALE SANITARY WORKERS OF A TERTIARY CARE CENTRE IN CHENGALPATTU DISTRICT, TAMILNADU

Introduction: Currently 537 million peoples globally and 74.2 million peoples in India are living with Diabetes. This is projected to 134 million in India and 783 million globally by 2045 . This study uses Indian Diabetic Risk Score for assessment of risk status in sanitary workers in tertiary care centre . Objective: 1.To assess the risk of developing Type2 Diabetes Mellitus using Indian Diabetic Risk Score (IDRS) among the female sanitary workers of a tertiary care centre in Chengalpattu . 2. To classify the risk status using Random Blood Sugar level among the study participants. Methodology: A cross sectional study was conducted among 103 female sanitary workers in Chengalpattu Medical College during June 2022 . After obtaining Institutional Ethical Committee permission ,the data was collected by using semi structured questionnaire. Anthropometric measurements and Random Blood Sugar testing were done and IDRS risk score was assessed. The data was entered in Microsoft Excel and analyzed using SPSS version 25. Result : The mean age of the study participant was 42.43 ± 8.182 years . Among the 103 study participants , 65.0% had medium risk, 25.2% had high risk . There was a statistically significant association was found between increase in age(p=0.000*) , Waist Circumference(p=0.000*) , and BMI (p=0.006*) with IDRS risk status. Conclusion: Majority of the study participant belonged to medium risk followed by high risk group. Hence IDRS is a simple and cost effective screening tool for early identification of risk of developing Diabetes.

Screening, Diagnosis, and Management of Parkinson's Disease Psychosis: Recommendations From an Expert Panel.

IntroductionHallucinations and delusions present with psychosis are debilitating non-motor symptoms of Parkinson’s disease, with a prevalence of up to 50–70% at some point during the course of the disease. Often patients and caregivers do not report the presence of hallucinations or delusions unless specifically questioned. A panel of experts in neurology and geriatric psychiatry convened to develop a simple screening tool and guidance on diagnosis and treatment of Parkinson’s disease psychosis (PDP).MethodsThe working group reviewed literature for existing PDP guidelines on diagnosis and management and identified gaps in recommendations. The group discussed and developed a screening tool and treatment guidance that addressed the gaps in existing methodology based on their clinical experience.ResultsThe proposed screening tool consists of two parts: (1) a brief pre-visit screening portion to be completed by the patient and caregiver, and (2) a clinician portion to be completed via clinical interview of the patient and caregiver. If psychotic symptoms are present, an appropriate treatment plan is developed for PDP based on evaluation.ConclusionsThis simple screening tool and treatment guidance offers a practical clinical approach for clinicians in the diagnosis and management of PDP.

Community Screening of Probable Dementia at Primary Care Center in Western India: A Pilot Project.

Introduction Timely detecting dementia is an important goal of clinicians and public health professionals alike for better management and prevention of complications. Community screening of dementia could be a powerful strategy. Facilities for dementia screening at primary care level are virtually nonexistent and are a prominent implementation gap. Hence, a study was done to assess the feasibility of dementia screening at primary care using General Practitioner Assessment of Cognition (GPCoG) scale among older adults with subjective memory complaints. It was further aimed to assess the frequency of cardiovascular risk factors in those who met screening criteria for cognitive impairment. Materials and Methods Older adults coming to three urban primary care centers in western India for screening of noncommunicable diseases such as diabetes and hypertension (opportunistic screening) with subjective memory complaints were enrolled and screened for dementia using GPCoG. A Mini-Mental State Examination (MMSE) was done in patients who came alone for referral purpose in case the score levels in GPCoG examination met cutoff limits for informant interview. Written medical records were examined to assess status of comorbid vascular risk factors such as diabetes, hypertension, coronary artery disease, and cerebrovascular accidents. Results A total of 350 older adults (M:F = 276: 74; mean age ± 68 ± 6.7 years) were screened out of 3,000 older adults who reported during the study period. There were 161 older adults with GPCoG score less than or equal to 5 (56.14%) and 149 subjects with MMSE less than or equal to 24 indicating significant cognitive impairment (42.5%). There were very few ( n = 11, 3.14%) out of 350 people who came with caregivers; hence, MMSE was done along with for referral to healthcare providers. A total of 142 had comorbid diabetes/and or hypertension (40.5%). A total of 86 had diabetes alone (24.5%) and a total of 128 had hypertension (36.5%). Conclusion Current study results indicate that using a simple screening tool such as GPCoG, community screening of probable dementia, is feasible in primary care settings, as is indicated by significant yield of probable dementia cases (42.5%). These cases can be referred to appropriate centers for further workup, confirmation of diagnosis, and treatment. Also, detection of comorbid cardiovascular conditions, for example, diabetes and hypertension, that can be managed along with cognitive impairment/dementia for potential prevention/further deterioration, which can strengthen noncommunicable disease screening.

Validation of the Italian Version of the SARC-F Questionnaire to Assess Sarcopenia in Older Adults.

Background: SARC-F is a simple sarcopenia screening tool. This study aimed to examine the validity of the Italian version of SARC-F. Methods: A total of 97 elderly individuals (37/60 males/females, 65 years and older) who met the study’s selection criteria were included. SARC-F was translated into the Italian language in a culturally responsive manner. The total score was calculated by adding the scores on the five items. The participants were divided into two groups according to the total score (SARC-F < 4 vs. SARC-F ≥ 4), and their associations with various factors (handgrip test, chair stand test, and Skeletal Muscle Index assessed by DXA) have been examined by gender. In addition, the tool’s validity was analyzed by comparing it with different international working group diagnostic criteria for sarcopenia. Results: The total prevalence of sarcopenia according to the SARC-F was 14.2% and, specifically, 12.8% among men and 14.3% in women. The sensitivity of the SARC-F was (male (M): 11–50% and female (F): 22–36%) medium-low compared with the European, international, and Asian criteria of sarcopenia; however, SARC-F showed a high specificity (M: 77.3–100% and F: 79.5–100%) and a moderate Cronbach’s alpha coefficient of (0.669 (CI95%: 0.358–0.830). The participants in the SARC-F ≥ 4 group had poorer handgrip for EWGSOP2 (p < 0.001) and chair stand (p < 0.001) than the participants in the SARC-F < 4 group. Conclusions: The Italian language version of SARC-F showed high specificity, moderate reliability, and good associations with other predictive tests. The Italian version of SARC-F appears to be a useful screening tool for the diagnosis of sarcopenia in Italian elderly populations.

Real-time elastography “FibroScan” compared to simple non-invasive screening tools in the assessment of liver fibrosis in non-alcoholic fatty liver patients

Background and aimNon-alcoholic fatty liver disease (NAFLD) and its subtype non-alcoholic steatohepatitis (NASH) are increasing worldwide. NASH is characterized by active liver inflammation with severe consequences including progressive fibrosis, cirrhosis, and eventually hepatocellular carcinoma. In Egypt, the prevalence of NAFLD diagnosed by ultrasound is about 65.3% in children and 62.7% in adults. Liver biopsy, the only reliable method of differentiating simple steatosis from NASH, has a major disadvantage of being an invasive procedure with various complications. Serum tests have limitations including non-specificity for liver inflammation and affection by clearance rates. This study aimed to assess the reliability of simple non-invasive tests for liver fibrosis (namely fibrosis-4 “FIB-4” score and NAFLD fibrosis score) in comparison with real-time elastography (RTE or FibroScan) in patients diagnosed with NAFLD.Patients and methodsThis observational prospective case–control study was conducted on 100 cases with NAFLD and 30 healthy subjects. All patients and controls were subjected to serological (FIB-4 score and NAFLD fibrosis score) and radiological (ultrasonography and RTE) assessments of liver fibrosis.ResultsIn advanced FIB-4 score ≥ F3, there was a good correlation between the findings of the RTE and each of the FIB-4 scores (with a sensitivity of 90%, specificity of 93.3%, positive predictive value (PPV) of 60%, negative predictive value (NPV) of 98.8%, with a total accuracy of 93%), NAFLD fibrosis score (with a sensitivity of 52.6%, specificity of 93.8%, PPV of 66.7%, NPV of 89.4%, with a total accuracy of 86%), and grading of steatosis by ultrasound.ConclusionsRTE is beneficial in diagnosing and assessing NAFLD, especially in advanced cases “F3 and beyond.”

Improving access to cancer genetic testing for underserved women in southeast Texas.

6548 Background: Hereditary breast cancer accounts for 5-10% of all cases, but only 20% of eligible women undergo NCCN guideline-concordant screening. We demonstrated previously that our simple genetic risk screening tool (GRST) and telegenetics improved adherence to genetic testing guidelines and increased high-risk cancer surveillance. Our objective was to identify women eligible for genetic testing using breast cancer screening clinics in underserved communities as entry points, reach them with our tailored program, and measure impact. Methods: This is a prospective study in women presenting for breast cancer screening at The Rose, which provides breast imaging to underserved patients in Houston, TX. Women who consented to participate filled out the GRST and provided socio-demographic information. Those at high risk for hereditary cancer after GRST scoring were provided with educational materials and sent a saliva-based genetic testing kit. When results included a pathogenic variant (PV) or variant of uncertain significance (VUS), individuals received telegenetic counseling and risk reduction resources. Others were notified of negative results by phone. The program included education for providers about importance of genetic testing. Socio-demographic characteristics were analyzed using descriptive statistics. All statistical tests were two-sided. Results: 501 women filled out the GRST. Median age was 52. Median annual salary was $45,000 (IQR 21-75K). 151 (36.3%) were uninsured. 252 (50.3%) identified as White, 230 (45.9%) as Hispanic/Latino, and 106 (21.2%) as Black/African American. 150 (33%) were eligible for genetic testing; 100 could be contacted. Of the 100, 41 declined testing, 40 were lost to follow-up, 19 agreed, and 15 (10% of those eligible) returned the kits. Results included 11 negative, 2 VUS, 1 PV (NF1). Among 41 who declined testing, reported reasons included not wanting to know the results or preference to follow-up with their primary care doctor in 11 (26.8%) each, not enough time or prior genetic testing in 6 (14.6%) each, no reason given by five, and perception that testing was unnecessary in two. Completion of genetic testing was not associated with insurance, salary, family history, or race/ethnicity (p &gt; 0. 05). Conclusions: Our study was successful in identifying underserved women at high risk of hereditary cancer who have not previously undergone genetic testing using a simple screening tool. We reduced barriers to genetic testing by working with a trusted community organization and using remote testing and telegenetics. We did not find any factors associated with genetic testing completion, though results are limited by small sample size. Given the low proportion of patients who completed testing, the next project phase will focus on improving convenience for patients and exploring patient and program-related reasons for non-completion of testing and strategies to overcome these.

1517-PUB: Prevalence of Self-Reported Central Obesity among Indian Males and Females in a Nationwide Community Screening Program

Background: Central obesity is a risk factor for cardiovascular and metabolic disorders including diabetes, hypertension and dyslipidemia. Index of central obesity (ICO) , defined as ratio of waist circumference and height, has been earlier proposed as a screening tool for central obesity and metabolic syndrome. We report the prevalence of self-reported central obesity based on ICO in a nationwide community screening program from data collected by the Research Society for the Study of Diabetes in India (RSSDI) as part of the Defeat Diabetes Campaign. Methodology: Data collected from the One Nation, One Day, One Million Tests campaign by RSSDI was retrospectively analyzed. A data of 105481 adults was included in the analysis (69483 were males and 35956 females) . ICO (calculated from self-reported waist size &amp; height) cutoff of 0.5 was used to estimate the prevalence of central obesity in the Indian population. Results: 69.3% (n=73072) of the overall cohort was found to be having central obesity, prevalence being slightly higher among females (75.1%) compared to males (66.3%) . Prevalence of central obesity was higher among diabetic subjects (77.8%) compared to the nondiabetes population (64.6%) . Prevalence of central obesity was higher among females with diabetes (81.5%) compared to males (75.9%) . Prevalence of central obesity was 60.8% and 71.8% in males and females without diabetes respectively. Conclusions: Central obesity is highly prevalent in the Indian population, with prevalence being slightly higher among females compared to males and among people living with diabetes when compared to nondiabetes subjects. As central obesity is a known risk factor for CVD and Metabolic disorders - strategies and interventions directed to address central obesity may be developed and implemented to prevent the future incidence of CVD and Metabolic disorders including diabetes. ICO is a simple screening tool in population dense and resource limited settings. Disclosure B.D.Saboo: None. S.Chittawar: None. A.Nanditha: None. R.M.Parikh: None. A.Gupta: Speaker's Bureau; Lupin Pharmaceuticals, Inc., Medtronic, Novartis AG, Novo Nordisk, Sanofi. V.K.Ch: None. B.M.Makkar: None. S.Agarwal: Speaker's Bureau; Novo Nordisk, Roche Diabetes Care, Sanofi, USV Private Limited. P.M.Chawla: Speaker's Bureau; Biocon, Boehringer Ingelheim International GmbH, Eris Lifesciences Ltd., Novo Nordisk, Sanofi. R.R.Kovil: None. S.Bhattacharyya: None.

Development and internal validation of the Edmonton Obesity Staging System-2 Risk screening Tool (EOSS-2 Risk Tool) for weight-related health complications: a case-control study in a representative sample of Australian adults with overweight and obesity

ObjectiveExcess weight and related health complications remain under diagnosed and poorly treated in general practice. We aimed to develop and validate a brief screening tool for determining the presence of...

Attention Deficit Hyperactivity Disorder in a Male Medium Secure Unit

AimsThe worldwide prevalence of Attention Deficit and Hyperactivity Disorder (ADHD) in the adult population is estimated to be 2.5%. Prevalence studies have shown rates to be consistently around ten times higher in the prison population, but there is less known about secure psychiatric hospital populations. ADHD has relevance as a predictor for offending, for challenging behaviours when incarcerated, for lower quality of life and high costs for both the NHS and prison systems. This service evaluation aimed to establish estimated prevalence of ADHD within one male medium secure unit.MethodsA cross sectional review of computerised medical records for all service users on the male medium secure forensic unit took place, to identify those who met inclusion criteria. Service users who were too acutely unwell or had an established or pending diagnosis of ADHD were excluded.The Brief Barkley Adult ADHD Rating Scale (B-BAARS), a 5 minute screening questionnaire, was given to service users to complete. Anonymised responses were converted to electronic format and the compiled results analysed.ResultsThere were 125 service users at the time of information gathering, with 112 eligible according to inclusion and exclusion criteria. 2 of the excluded service users already had an ADHD diagnosis. 70 service users out of those approached, agreed to take part in the screening (62.5%). 2 out of 70 (2.9%) service users met criteria for a possible diagnosis of ADHD.ConclusionUsing the B-BAARS, 2.9% of service users on the male medium secure forensic unit reported clinically significant symptoms suggestive of a diagnosis of ADHD. This estimate is significantly lower than other studies in prison settings. When combined with the figure for service users with a pre-existing diagnosis, however, the figure is still higher than in the general population (5.5% compared to 2.5%), and illustrates that screening tools can have a useful function in forensic settings.There may have been methodological issues with this evaluation, including the self-reported nature of symptoms, the comparatively high level of functioning required to complete the questionnaire and the low response rate amongst the service users.This evaluation serves to increase awareness about ADHD in the forensic population in general. It also highlights the value of this simple screening tool, or one similar, to clinical teams on the forensic wards. The screening tool could be further utilised in low secure and women's services to establish if results are similar amongst these populations.

Simple tuberculosis screening tool using signs, symptoms, and risk factors to reduce the missed opportunity in the older population

BackgroundThere is a growing concern on how to increase tuberculosis (TB) case detection in resource-poor settings. The healthcare facilities routinely providing services to the elderly for chronic diseases often failed to detect TB cases, causing a missed opportunity. This study aimed to develop a simple and sensitive screening tool using signs, symptoms, and risk factors for TB case detection in the elderly.MethodsThis was a cross-sectional study conducted from August to December 2020. A random sample of 302 subjects was taken from the elderly aged ≥ 60 years attending the outpatient polyclinic at Mangunharjo hospital, Madiun, East Java, Indonesia, for a chronic disease problem. The test was developed using 16 TB signs, symptoms, and risk factors. Test performance was assessed by comparing it against the GeneXpert MTB/RIF.ResultsMarginal analysis resulted in the optimal cut-point of ≥ 7 for the test, which gave an area under the curve (AUC) of 0.62, with the maximum marginal AUC of 0.04 (p < 0.001). The sensitivity and specificity were 60.26% and 64.29%, meaning 60 TB cases for every 100 elderly with TB would be otherwise left undetected if this screening test did not take place.ConclusionA simple TB screening tool with moderate sensitivity and AUC has been developed using TB signs, symptoms, and risk factors. It can be used as an initial step of the systematic TB screening in the elderly visiting healthcare facilities for routine chronic disease examination, with the additional utility of reducing the missed opportunity.

A Delphi study to guide the development of a clinical indicator tool for palliative care in South Africa.

BackgroundThe South African National Policy Framework and Strategy on Palliative Care (NPFSPC) recommends that when integrating palliative care (PC) into the health system, a PC indicators tool should be used to guide clinicians to recognise a patient who should receive PC. The policy document recommends ‘a simple screening tool developed for use in South Africa that would assist healthcare professionals (HCPs) to recognise patients who may have unmet palliative care needs’.AimThis research study sought to develop South African consensus on indicators for PC to assist clinicians to recognise a patient in need of PC.SettingThe South African healthcare setting.MethodsA Delphi study was considered suitable as a methodology to develop consensus. The methodology was based on the Conducting and REporting of DElphi studies (CREDES) guidance on Delphi studies to ensure rigour and transparency in conducting and reporting. Six different Delphi rounds were used to develop consensus. Each round allowed participants to anonymously rate statements with predefined rating scales.ResultsCognisant of the disparities in healthcare provision and access to equitable healthcare in South Africa, the expert advisory group recommended, especially for South Africa, that ‘this tool is for deteriorating patients with an advanced life-limiting illness where all available and appropriate management for underlying illnesses and reversible complications has been offered’. The expert advisory group felt that disease-specific indicators should be described before the general indicators in the South African indicators tool, so all users of the tool orientate themselves to the disease categories first. This study included three new domains to address the South African context: trauma, infectious diseases and haematological diseases. General indicators for PC aligned with the original Supportive and Palliative Care Indicators Tool (SPICT) tool.ConclusionThe Supportive and Palliative Care Indicators Tool for South Africa (SPICTTM-SA) is a simple screening tool for South Africa that may assist HCPs to recognise patients who may have unmet PC needs.

Development and Validation of a New Screening Tool with Non-Invasive Indicators for Assessment of Malnutrition Risk in Hospitalised Children.

There is no evidence of the most effective nutritional screening tool for hospitalized children. The present study aimed to develop a quick, simple, and valid screening tool for identifying malnutrition risk of hospital admission with non-invasive indicators. A cross-sectional study was conducted. Children`s nutritional baseline using a questionnaire, subjective malnutritional risk, and Subjective Global Nutritional Assessment were assessed on admission. Concurrent validity was assessed using American Society for Parenteral and Enteral Nutrition (ASPEN)and Academy of Nutrition and Dietetics assessment and Subjective Global Nutritional Assessment tool. A new screening tool Simple Pediatric Nutritional risk Screening tool (SPENS) was developed, and sensitivity, specificity and reliability were evaluated. A total of 180 children aged from 1 month to 18 years were included (142 in the development phase and 38 in the validation phase). SPENS consist of four variables and shows almost perfect agreement with subjective malnutritional risk assessment (κ = 0.837) with high sensitivity and specificity (93.3% and 91.3% respectively). Compared with Subjective Global Nutritional Assessment and ASPEN and Academy of Nutrition and Dietetics assessment, SPENS had sensitivity 92.9% and 86.7%, a specificity of 87.5% and 87.0%, and an overall agreement of 0.78 and 0.728, respectively. Due to the fast, simple, easy, and practical to use, screening the SPENS can be performed by nurses, physicians, and dieticians.

Evaluation of the Accuracy of Six Simple Screening Tools for Sarcopenia in Schizophrenic Patients.

Our objective was to evaluate if SARC-F, SARC-CalF, SARC-F-EBM, calf circumference (CC), mid-upper-arm circumference (MUAC) and Ishii test can be used to accurately screen for sarcopenia in schizophrenic patients. We enrolled schizophrenic patients aged 50 or older, who were regularly taking antipsychotic medications, at two mental health centres. Bioimpedance-based muscle-mass was analysed with an InBody 770 instrument, while muscle strength was measured with a digital grip-strength dynamometer. The physical performance of the patients was gauged from their gait speed over 6 m. Standard AWGS2019 diagnostic criteria were used, and the accuracies of the six screening methods were indicated by the sensitivity, negative predictive value (NPV), and area under receiver operating characteristic curve (AUC). A total of 339 stable schizophrenic patients were enrolled. The overall prevalence of sarcopenia was 53.1%, and the prevalence was 55.6% and 47.66%, respectively, for males and females. The prevalence of sarcopenia obesity in the total population was 16.22%, and that of males and females was 18.97% and 10.28%, respectively. The SARC-F, SARC-CalF, SARC-F-EBM, CC, MUAC and Ishii test sensitivity/NPV in screening for sarcopenia were 41.86%/0.52, 79.07%/0.7, 28.68%/0.51, 78.3%/0.71, 76.74%/0.7, 89.92%/0.84, respectively, in males and 45.1%/0.59, 94.12%/0.91, 54.9%/0.7, 92.16%/60.91, 74.51%/0.77, 96.08%/0.94, respectively, in females. In males, the AUCs of the SARC-F, SARC-CalF, SARC-F-EBM, CC, MUAC and Ishii test were 0.601 (95%CI, 0.528-0.673), 0.754 (95%CI,0.69-0.817), 0.657 (95%CI,0.588-0.727), 0.8 (95%CI, 0.744-0.856), 0.781 (95%CI, 0.721-0.84) and 0.88 (95%CI, 0.837-0.922), respectively, and in females, they were 0.587(95%CI,0.479-0.696), 0.794 (95%CI,0.709-0.878), 0.799 (95%CI,0.71-0.888), 0.893 (95%CI, 0.833-0.953), 0.843 (95%CI, 0.772-0.915) and 0.855 (95%CI, 0.784-0.926), respectively. The prevalence of sarcopenia in schizophrenic patients is high. Clinical doctors should screen for sarcopenia in schizophrenic patients and provide timely interventions to reduce the occurrence of adverse events. The above six tools can be used as screening tools, and the Ishii test is the most suitable for screening.

Clock drawing errors in the Mini-Cog test predict postoperative delirium following transurethral resection of bladder tumors while awake

BackgroundIn urology, where the proportion of elderly patients is high, a simple, practical, and reliable screening tool to predict the development of postoperative delirium would be useful. This study aimed to evaluate the efficacy of the mini-cognitive assessment instrument (Mini-Cog) test and the clock drawing test (CDT) for predicting postoperative delirium after transurethral resection of bladder tumors (TURBT). MethodsWe conducted a retrospective cohort study of patients who underwent TURBT under awake spinal anesthesia, and who had preoperative cognitive screening based on the Mini-Cog test consisting of the CDT and a 3-word recall task, in our department between 2020 and 2021. We aimed to identify clinical risk factors for post-TURBT delirium and compared the ability of the CDT alone and the Mini-Cog test to predict post-TURBT delirium. ResultsOf the 229 eligible patients, eighty patients (35%) had abnormal CDT outcomes. Postoperative delirium occurred in 26 patients (11%), of whom 21 (81%) had an abnormal CDT. Multivariate analysis demonstrated that a decline in instrumental activities of daily living (odds ratio (OR), 3.1, p = 0.03), previous diagnosis of dementia (OR = 8.7, p = 0.01), and abnormal CDT (OR = 7.8, p < 0.001) were independent risk factors for post-TURBT delirium. The area under the receiver operating characteristic curve in predicting post-TURBT delirium was 0.759 for the CDT alone and 0.705 for the Mini-Cog test, which was not significantly different (p = 0.30). ConclusionsThe CDT from the Mini-Cog test served as a formal, simple, and brief screening tool for assessing cognitive function as its predictive power adequately identified the risk of postoperative delirium in patients undergoing TURBT under spinal anesthesia while awake.

Linezolid-Associated Neuropathy in Patients with MDR/XDR Tuberculosis in Shenzhen, China.

ObjectiveLinezolid is one of the key drugs for the treatment of multidrug-resistant/extensively drug-resistant tuberculosis (MDR/XDR-TB). We aimed to describe the incorporation of the Michigan Neuropathy Screening Instrument (MNSI) and serum trough concentration as screening tools for neurotoxicity in the management of MDR/XDR-TB patients receiving a linezolid-based treatment regimen in Shenzhen, China.MethodsA total of 73 patients on a linezolid-containing anti–MDR/XDR-TB regimen were prospectively enrolled. The MNSI was used for peripheral neuropathy screening. Optic neuropathy was diagnosed by ophthalmologists. Serum trough concentration was recorded and its relationship with neuropathy analyzed.ResultsOf all patients, neuropathy was observed in 40% (29) during anti-TB treatment. Of these, 20 (69%) had peripheral neuritis, seven (24%) optic neuritis, and two (7%) both. Serum trough concentration >2 mg/L was observed in 17 (59%) patients with neuropathy and 13 (30%) patients without neuropathy. There was a significant statistical difference between the two groups (P=0.013). Time to onset of neuropathy from initiation of the linezolid-containing regimen was within 2 months for eight (28%) patients, 2–6 months for 18 (62%) patients, and >6 months for three (10%) patients. Sixteen (55%) patients were adjusted to a lower dose of 300 mg linezolid daily. Four (14%) patients had linezolid permanently removed from their regimen.ConclusionNeuropathy is a commonly reported adverse event associated with long-term use of linezolid. MNSI and serum trough–concentration monitoring can be adopted as simple screening tools for early detection of neuropathy to balance linezolid efficacy and tolerability.