A new simple, accurate, profitable, rapid-fire and precise rear phase high performance liquid chromatographic system has been developed for the validated of Fosamprenavir in bulk form and its pharmaceutical lozenge form. Chromatographic separation was carried out on Zorbax C mm mm m Make X terra 18 4.6 X 250 , 5 , ( ) column using a admixture of Acetonitrile Methanol Water (503020 v/ v) as the mobile phase at an inflow rate of1.0ml min , the discovery was carried out at 265nm. The retention time of the Fosamprenavir was set up to be5.462 0.02 ± min . The system was validated according to ICH guidelines for linearity, perceptivity, delicacy, perfection, particularity and robustness. The response was set up to be direct in the medicine attention range of 50 90 − mcg ml for Fosamprenavir. The correlation measure was set up to be 0.999. The LOD and LOQ for Fosamprenavir were set up to be 1.6µg ml and 4.8µg ml independently. The proposed system was set up to be good chance recovery for Fosamprenavir, which indicates that the proposed system is largely accurate. The system perfection for the determination of assay was below 2.0 RSD. The system is useful in the quality control of bulk and retailed pharmaceutical phrasings