Medical image segmentation has always been a challenging task. This paper proposes a new LUneXt medical image segmentation model based on the characteristics analysis of medical image data sets and testing of different nonlinear activation units. Both normalized activations for the original negative input image activation have good optimization capabilities for the tokenization module parameters proposed in the original UneXt model. Using different activation coefficients for different foreground and background areas has achieved better results. The experimental results of this paper on the Breast Ultrasound Images (BUSI) data set reached an intersection over union (IoU) value of 62.64%, a Dice value of 76.12%, and a single inference speed of 807.57[Formula: see text]ms. The experimental IoU value of the International Skin Imaging Collaboration (ISIC 2018) data set reached 82.95%, and the Dice value reached 90.50%. The single inference speed reached 842.58[Formula: see text]ms. The LUneXt model is more robust than other models. While improving model performance, it does not introduce higher computational complexity and does not have a major impact on the processing speed of a single image.
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