The estimation of the flow coefficient is a vital hydrological procedure that holds considerable importance in flood prediction, water resource management, and flood mitigation. The precise estimation of the flow coefficient is imperative in mitigating flood-related damages, administering flood alert mechanisms, and regulating water discharge. It is hard to accurately determine the flow coefficient without a good understanding of the river basin’s hydrology, climate, topography, and soil characteristics. A range of methodologies have been documented in the most recent body of literaturefor flow coefficient modeling. The majority of these methods, however, depend on opaque techniques that lack generalizability. Therefore, this research employed three distinct methodologies—specifically, the Adaptive Neural Fuzzy Inference System (ANFIS), the Simple Membership Function, and the Fuzzy Rules Generation Technique (SMRGT) are all examples of fuzzy inference systems, and Artificial Neural Network (ANN), to achieve its objectives. The Aksu River Basin in Antalya, Turkey, was chosen as the study area. The models underwent multiple permutations of precipitation (P), temperature (T), relative humidity (Rh), wind speed (Ws), land use (LU), and soil properties (Sp) data that were tailored to the particular study region. The study analyzed the results using various performance metrics of the model such as mean absolute error (MAE), Nash–Sutcliffe efficiency coefficient (NSE), root mean square error (RMSE), and correlation coefficient (R2). The results indicate that the SMRGT method resulted in a remarkable degree of accuracy in forecasting the flow coefficient, as demonstrated with the minimal RMSE and MAE values and high correlation coefficient values. The study’s findings suggest that the SMRGT method was applied effectively in hydrological analysis to estimate the flow coefficient, contributing to more accurate flood prediction, water resource management, and flood mitigation strategies.