Simple Interference Research Articles

A Synchronous Fluorescence Spectrofluorometric Method for the Simultaneous Determination of Clonazepam and Paroxetine Hydrochloride in Combined Pharmaceutical Dose Form

First derivative synchronous spectrofluorimetry has been found to be superior because of its highly specific spectral discrimination and readily available solvent, it is economical, eco-friendly, and lacks an extraction procedure. In the present study, a new simple, sensitive, and time-saving first derivative synchronous spectrofluorimetry method has been developed for simultaneous estimation of clonazepam (CLO) and paroxetine hydrochloride (PH) in pharmaceutical dose forms. CLO was determined at the emission wavelength of 512.79 nm (zero-crossing wavelength point of PH). Similarly, PH was measured at 336.00 nm (zero-crossing wavelength point of CLO). The first derivative amplitude-concentration plots were rectilinear over the range of 1-5 μg/ mL for CLO and 5-25 μg/mL for PH. The method was validated statistically as per the ICH guidelines. The limits of detection were 0.055 and 0.033 μg/mL and quantification limits were 0.169 and 0.102 μg/mL for CLO and PH, respectively. The percentage recovery in commercial formulation was found to be in the range 100.45% and 99.38% for CLO and PH, respectively, by the proposed method, and percent relative standard deviation values for precision and accuracy studies were found to be less than 2. This spectrofluorimetry method has been found to have several advantages such as simple spectra, high selectivity, and low interference. By virtue of its high sensitivity, this method could be applied to the analysis of both CLO and PH in their co-formulated dose forms.

Compensation of high order harmonic long quantum-path attosecond chirp

We propose a method to compensate for the extreme ultra violet (XUV) attosecond chirp associated with the long quantum-path in the high harmonic generation process. Our method employs an isolated attosecond pulse (IAP) issued from the short trajectory contribution in a primary target to assist the infrared driving field to produce high harmonics from the long trajectory in a secondary target. In our simulations based on the resolution of the time-dependent Schrödinger equation, the resulting high harmornics present a clear phase compensation of the long quantum-path contribution, near to Fourier transform limited attosecond XUV pulse. Employing time–frequency analysis of the high harmonic dipole, we found that the compensation is not a simple far-field photonic interference between the IAP and the long-path harmonic emission, but a coherent phase transfer from the weak IAP to the long quantum-path electronic wavepacket. Our approach opens the route to utilizing the long quantum-path for the production and applications of attosecond pulses.

Teaching Einsteinian physics at schools: part 2, models and analogies for quantum physics

The Einstein-First project approaches the teaching of Einsteinian physics through the use of physical models and analogies. This paper presents an approach to the teaching of quantum physics which begins by emphasising the particle-nature of light through the use of toy projectiles to represent photons. This allows key concepts including the spacing between photons, and photon momentum to be introduced. This in-turn allows an intuitive understanding of the uncertainty principle. We present optical interference in the context of individual photons, using actual videos showing the development of images one at a time. This enables simple laser interference experiments to be interpreted through the statistical arrival of photons. The wave aspects of quantum phenomenon are interpreted in terms of the wavelike nature of the arrival probabilities.

Implementing a distance-based classifier with a quantum interference circuit

Lately, much attention has been given to quantum algorithms that solve pattern recognition tasks in machine learning. Many of these quantum machine learning algorithms try to implement classical models on large-scale universal quantum computers that have access to non-trivial subroutines such as Hamiltonian simulation, amplitude amplification and phase estimation. We approach the problem from the opposite direction and analyse a distance-based classifier that is realised by a simple quantum interference circuit. After state preparation, the circuit only consists of a Hadamard gate as well as two single-qubit measurements, and computes the distance between data points in quantum parallel. We demonstrate the proof of principle using the IBM Quantum Experience and analyse the performance of the classifier with numerical simulations.

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers.

New materials and methods are needed to better control the binding vs. release of nucleic acids for a wide range of applications that require the precise regulation of gene activity. In particular, novel stimuli-responsive materials with improved spatiotemporal control over gene expression would unlock translatable platforms in drug discovery and regenerative medicine technologies. Furthermore, an enhanced ability to control nucleic acid release from materials would enable the development of streamlined methods to predict nanocarrier efficacy a priori, leading to expedited screening of delivery vehicles. Herein, we present a protocol for predicting gene silencing efficiencies and achieving spatiotemporal control over gene expression through a modular photo-responsive nanocarrier system. Small interfering RNA (siRNA) is complexed with mPEG-b-poly(5-(3-(amino)propoxy)-2-nitrobenzyl methacrylate) (mPEG-b-P(APNBMA)) polymers to form stable nanocarriers that can be controlled with light to facilitate tunable, on/off siRNA release. We outline two complementary assays employing fluorescence correlation spectroscopy and gel electrophoresis for the accurate quantification of siRNA release from solutions mimicking intracellular environments. Information gained from these assays was incorporated into a simple RNA interference (RNAi) kinetic model to predict the dynamic silencing responses to various photo-stimulus conditions. In turn, these optimized irradiation conditions allowed refinement of a new protocol for spatiotemporally controlling gene silencing. This method can generate cellular patterns in gene expression with cell-to-cell resolution and no detectable off-target effects. Taken together, our approach offers an easy-to-use method for predicting dynamic changes in gene expression and precisely controlling siRNA activity in space and time. This set of assays can be readily adapted to test a wide variety of other stimuli-responsive systems in order to address key challenges pertinent to a multitude of applications in biomedical research and medicine.

Quantum interferences induced by multiple scattering paths of the electron prior to emission in large molecules

We theoretically investigate electron emission process from a dimer generated by swift highly charged ions. The process under consideration is dealt with a non-perturbative approach by solving the time-dependent Schrödinger equation on a two-dimensional spatial grid. Numerical calculations show rich structures related to the multiple scattering paths of the electron prior to emission. This manifests by the emergence of additional oscillations with high-frequency superimposed on the Young-type oscillatory structure in the observed electron-ejected spectrum. This is not the case when calculations are performed based on the superposition principle, in which the final wave function is just a coherent sum of component wave functions described the electron emission from two-independent atoms. Within this assumption, only a direct electron emission process is taken into account. We find that contributions arising from these multiple scattering paths modify the dynamic electron emission process, and therefore, show the incorrect applicability of the above-mentioned principle, in concordance with the recent findings based on a simple three-slit interference experiment, reported in Sawant et al. (2014).

Active Listening Delays Attentional Disengagement and Saccadic Eye Movements.

Successful goal-directed visual behavior depends on efficient disengagement of attention. Attention must be withdrawn from its current focus before being redeployed to a new object or internal process. Previous research has demonstrated that occupying cognitive processes with a secondary cellular phone conversation impairs attentional functioning and driving behavior. For example, attentional processing is significantly impacted by concurrent cell phone use, resulting in decreased explicit memory for on-road information. Here, we examined the impact of a critical component of cell-phone use-active listening-on the effectiveness of attentional disengagement. In the gap task-a saccadic manipulation of attentional disengagement-we measured saccade latencies while participants performed a secondary active listening task. Saccadic latencies significantly increased under an active listening load only when attention needed to be disengaged, indicating that active listening delays a disengagement operation. Simple dual-task interference did not account for the observed results. Rather, active cognitive engagement is required for measurable disengagement slowing to be observed. These results have implications for investigations of attention, gaze behavior, and distracted driving. Secondary tasks such as active listening or cell-phone conversations can have wide-ranging impacts on cognitive functioning, potentially impairing relatively elementary operations of attentional function, including disengagement.

Multi-Disciplinary System Design Optimization of a Launch Vehicle Upper-Stage

The design method presented in this paper is related to the upper-stage system and its instrumentation, expedition and facilitation so as to transfer the satellite from the destination orbit to the target orbit. We used an integrated design method with a structure based on multidisciplinary system design optimization and developed a simple systematic interference method for designing aerospace products. The subsystems’ convergence in an optimized environment, matrix relationship, and integration of the subsystems’ parameters and presentation of design give results while meeting all requirements and considering the limitations of the design were the main aims of the research. Instead of a merely mathematical optimization design, in the present study a new design method with a systematic multipurpose optimization approach was designed. In this context, the optimization means the parameters are optimized as a result of the design convergence coefficients. Validation of the design method was not only obtained through comparison with a specific product but also with the systematic parameters of all upper-stage systems with a similar operation through the results of statistical design graphs. The approximate similarities of the results indicate an acceptable and genuine design with a quite systematic approach which is better than an unreal and merely optimized design.

Low Cost Method for Generating Periodic Nanostructures by Interference Lithography Without the Use of an Anti-Reflection Coating

ABSTRACTInterference lithography has proven to be a useful technique for generating periodic sub-diffraction limited nanostructures. Interference lithography can be implemented by exposing a photoresist polymer to laser light using a two-beam arrangement or a one-beam configuration based on a Lloyd’s Mirror Interferometer. For typical photoresist layers, an anti-reflection coating must be deposited on the substrate to prevent adverse reflections from cancelling the holographic pattern of the interfering beams. For silicon substrates, such coatings are typically multilayered and complex in composition. By thinning the photoresist layer to a thickness well below the quarter wavelength of the exposing beam, we demonstrate that interference gratings can be generated without an anti-reflection coating on the substrate. We used ammonium dichromate doped polyvinyl alcohol as the positive photoresist because it provides excellent pinhole free layers down to thicknesses of 40 nm, and can be cross-linked by a low-cost single mode 457 nm laser and etched in water. Gratings with a period of 320 nm and depth of 4 nm were realized, as well as a variety of morphologies depending on the photoresist thickness. This simplified interference lithography technique promises to be useful for generating periodic nanostructures with high fidelity and minimal substrate treatments.

Combination of Interleukin-11Rα chimeric antigen receptor T-cells and programmed death-1 blockade as an approach to targeting osteosarcoma cells In vitro

Aim: To test whether combining interleukin (IL)-11Rα chimeric antigen receptor (CAR) T-cells with an anti-programmed death (PD-1) antibody (an immune checkpoint inhibitor) is an effective therapeutic approach in osteosarcoma (OS), allowing improved tumor eradication. Methods: IL-11Rα-CAR T-cells were cocultured in vitro with human LM7 OS tumor cells (with and without anti-PD-1 antibody). Coculture of LM7 cells with purified T-cells served as the control. Cytotoxicity and surface PD-1 expression were analyzed in all groups. Results: PD-1 expression increased during expansion of CAR T-cells. Exposure of immune cells to tumor cells in vitro subsequently decreased surface PD-1 expression on the CAR T-cells. Addition of an anti-PD-1 antibody (Clone J110) to further decrease surface PD-1 expression on CAR T-cells before coculture did not enhance cytotoxic effects of the CAR T-cells against LM7 cells. Conclusion: This combination of IL-11Rα-CAR T-cells and an anti-PD-1 antibody did not provide any additional cytotoxic benefit over IL-11Rα-CAR T-cell therapy alone in this setting. Further studies are needed as simple interference with surface PD-1 expression alone may not be sufficient to inhibit this immune checkpoint pathway to then enhance IL-11Rα-CAR T-cell therapeutic effects.

Decoherence by coupling to internal vibrational modes

We consider a composite system consisting of coupled particles, and investigate decoherence due to coupling of the center-of-mass degree of freedom with the internal degrees of freedom. For a simple model of two bound particles, we show that in general such a decoherence effect exists, and leads to suppression of interference between different paths of the center-of-mass. For the special case of two harmonically-bound particles moving in an external potential in one dimension, we show that the coupling between the center-of-mass and internal degrees of freedom can be approximated as parametric driving, and that nontrivial coupling depends on the second derivative of the external potential. We find a partial solution to this parametric driving problem. For a simple interference experiment, consisting of two wave packets scattering off of a square well, we perform numerical simulations and show a close connection between suppression of interference and entanglement between the center-of-mass and internal degrees of freedom. We also propose a measure of compositeness which quantifies the extent to which a composite system cannot be approximated as a single, indivisible particle. We numerically calculate this quantity for our square well example system.

Inter-Cell Interference Coordination for Control Channels in LTE Heterogeneous Networks

In heterogeneous cellular networks for mobile communications, small cells are deployed within the coverage range of primary macro cells to provide for a localized capacity boost in traffic hotspots. Sharing of communication channels among the small-cell and macro-cell tiers is spectrally efficient, but causes failures of control signaling and data channels due to unmitigated co-channel interference. Consequently, the small-cell coverage range and capacity deteriorate. In Long Term Evolution (LTE) networks, the performance of control channels such as the physical downlink control channels (PDCCH) is of particular concern because they are protected only by simple interference averaging based on pseudo-random subcarrier allocation. Observing that the randomization algorithms are primarily seeded by the physical cell identifiers (PCIs) and cell radio network temporary identifier (C-RNTIs), we show that efficient interference-aware scheduling of control transmissions can be enabled by optimized allocation of PCIs, C-RNTIs and PDCCH resources. Simulations of a 3 GPP-compliant heterogeneous network show that the small-cell size can be doubled for a better macro-cell traffic offload by trading the number of active PDCCHs for a higher small-cell expansion bias. Alternatively, the small-cell PDCCH capacity can be at least tripled for high-load applications such as Voice over LTE by using selective macro-cell PDCCH muting.

Geometric phase effects in ultracold hydrogen exchange reaction

The role of the geometric phase effect on chemical reaction dynamics is explored by examining the hydrogen exchange process in the fundamental H+HD reaction. Results are presented for vibrationally excited HD molecules in the v = 4 vibrational level and for collision energies ranging from 1 μK to 100 K. It is found that, for collision energies below 3 K, inclusion of the geometric phase leads to dramatic enhancement or suppression of the reaction rates depending on the final quantum state of the HD molecule. The effect was found to be the most prominent for rotationally resolved integral and differential cross sections but it persists to a lesser extent in the vibrationally resolved and total reaction rate coefficients. However, no significant GP effect is present in the reactive channel leading to the D+H2 product or in the D+H2 HD+H reaction. A simple interference mechanism involving inelastic (nonreactive) and exchange scattering amplitudes is invoked to account for the observed GP effects. The computed results also reveal a shape resonance in the H+HD reaction near 1 K and the GP effect is found to influence the magnitude of the resonant part of the cross section. Experimental detection of the resonance may allow a sensitive probe of the GP effect in the H+HD reaction.

The Technology of the Near-Field Interference Microwave Sensing

We describe the operation of a simple near-field interference microwave microscope. The microscope contains two identical probes which are connected to the ends of segments of the coaxial transmission line. The probes are constructed from an open-ended conical coaxial line and are excited by applied microwave voltage in the frequency range of 0.6 – 7.0 GHz. The computer simulation of the field distribution near the aperture of a separate probe was performed. The test objects are placed in the gap between the probes apertures. The main attention was concentrated on motor fuels to detect other impurities. In particular, diesel fuel was studied with impurities in the form of kerosene and synthetic motor oil in different proportions. It is shown that the microscope can reliably detect these impurities even if their content is relatively small. It was also demonstrated that the microscope can be used for determination of the alcohol quality and spirit-based solutions.

A substructuring approach for modeling the acoustic scattering from stiffened submerged shells coupled to non-axisymmetric internal structures.

The scattered pressure from a stiffened axisymmetric submerged shell impinged by acoustic plane waves has been investigated experimentally, analytically and through numerical models. In the case where the shell is periodically stiffened, it is shown that helical, Bragg, and Bloch-Floquet waves can propagate. The influence of non-axisymmetric internal frames on these scattering phenomena is nevertheless not well known, as it can considerably increase the computational cost. To overcome this issue, the condensed transfer function (CTF) method, which has been developed to couple subsystems along linear junctions in the case of a mechanical excitation, is extended to acoustical excitations. It consists in approximating transfer functions on the junctions and deducing the behavior of the coupled system using the superposition principle and the continuity equations at the junctions. In particular, the CTF method can be used to couple a dedicated model of an axisymmetric stiffened submerged shell with non-axisymmetric internal structures modeled by the finite element method. Incident plane waves are introduced in the formulation and far-field reradiated pressure is estimated. An application consisting of a stiffened shell with curved plates connecting the ribs is considered. Supplementary Bloch-Floquet trajectories are observed in the frequency-angle spectrum and are explained using a simplified interference model.

Efficient CFO Compensation Method in Uplink OFDMA for Mobile WiMax

Mobile WiMax uses Orthogonal Frequency Division Multiple Access (OFDMA) in uplink where synchronization is a complex task as each user presents a different carrier frequency offset (CFO). In the Data Aided Phase Incremental Technique (DA-PIT) estimation is performed after FFT operation to use the received frequency domain pilot subcarrier information. As estimation is done in the presence of noise, there exists some offset error, which is called residual frequency offset (RFO). The Simple Time Domain Multi User Interference Cancellation scheme (SI-MUIC) is a time domain approach which takes a longer time delay to compensate the CFO effect for the last user. Decorrelation-Successive Interference Cancellation (DC-SC) and Integrated Estimation and Compensation (IEC) are frequency domain approaches that compensate the CFO effect with a more complex method for ICI cancellation. The Modified Integrated Estimation and Compensation technique (Modified IEC) is proposed for better residual CFO compensation. The proposed technique has better performance due to its efficient suppression of ICI and MUI. The difference between the CFOs of two OFDMA symbols lies within the range of RFO that is not considered in the conventional compensation techniques, such as the SI-MUIC, DC-SC and IEC compensation techniques.

Interference Confocal Microscope Integrated with Spatial Phase Shifter.

We present an interference confocal microscope (ICM) with a new single-body four-step simultaneous phase-shifter device designed to obtain high immunity to vibration. The proposed ICM combines the respective advantages of simultaneous phase shifting interferometry and bipolar differential confocal microscopy to obtain high axis resolution, large dynamic range, and reduce the sensitivity to vibration and reflectance disturbance seamlessly. A compact single body spatial phase shifter is added to capture four phase-shifted interference signals simultaneously without time delay and construct a stable and space-saving simplified interference confocal microscope system. The test result can be obtained by combining the interference phase response and the bipolar property of differential confocal microscopy without phase unwrapping. Experiments prove that the proposed microscope is capable of providing stable measurements with 1 nm of axial depth resolution for either low- or high-numerical aperture objective lenses.

Stacked‐Disk Nanotower Arrays for Use as Omniphobic Surface‐Enhanced Raman Scattering Substrates

Herein, a simple interference lithographic technique to design omniphobic surface‐enhanced Raman scattering active surfaces composed of stacked‐disk nanotower arrays is reported. To create the nanotower arrays in a highly reproducible fashion, the authors use a single laser exposure onto the photoresist‐on‐dielectric mirror using a phase mask. The interference by the phase shift produces a nanotower array with a submicrometer periodicity, whereas the standing wave effect by reflection from the mirror defines the stacked‐disk structure at each nanotower at sub‐100 nm periodicity. The stacked‐disk nanotowers with silver outer‐coating provide a strong electric field localization at the vertically integrated nanogaps on the side wall. At the same time, the series of reentrant geometry on the side walls can efficiently pin the liquid–air interface for a variety of liquids, including water and toluene, thereby providing omniphobic surface property. The molecules dissolved in either water or toluene at low concentration can be enriched in the drop on the surface in a course of evaporation, which are finally deposited onto a tiny spot. Raman spectra of the molecules are further amplified by the strong electric field at the nanogaps on the side walls of the nanotowers. Therefore, the surfaces provide high sensitivity of Raman analysis for both polar and nonpolar molecules.

Maximum likelihood detection for coded combinerless LINC-OFDM systems

Owning to the high peak-to-average power ratio problem, the power efficiency of orthogonal-frequency-division-multiplexing (OFDM) systems is usually low. It deteriorates in millimeter wave systems in which the design of an efficient linear power amplifier is much more challenging. The linear-amplification-with-nonlinear-component (LINC) technique can serve as a remedy, decomposing the input signal into two constant-envelop component signals followed by high-efficient nonlinear amplifiers. However, the power combiner, a key component used to combine the amplified signals, is difficult to implement. Combinerless LINC systems employ two transmit antennas such that two component signals can be naturally combined at the receiver. Unfortunately, the performance of combinerless LINC-OFDM systems is seriously degraded if difference, even small, exists between the two channels. The maximum likelihood (ML) receiver can effectively solve the problem; however, its computational complexity is prohibitedly high. We propose a coded combinerless LINC-OFDM system, including a convolutional encoder and a list Viterbi algorithm (LVA) decoder, to solve the problem. The LVA can provide a small number of candidates for the ML detector, dramatically reducing the required computational complexity. We also utilize an enhanced zero-forcing equalizer such that the soft-demapping operation can be effectively conducted. Finally, we propose a simple iterative interference cancellation scheme to further enhance the performance. Simulations show that the proposed combinerless LINC-OFDM system can outperform the conventional OFDM while the consumed power is much lower.

Interference cancellation technique for faster‐than‐Nyquist signalling

The faster-than-Nyquist (FTN) signalling is a bandwidth-efficient technology which has drawn attention in the bandwidth-starved world. However, inter-symbol interference is introduced by transmitting signals at a higher signalling rate than allowed by the Nyquist criterion. Decision feedback equalisation (DFE) cancellation is an efficient signal detection scheme for FTN-based communication system. However, since the DFE interference cancellation is executed by overall matrix computation, the required memory size is very large. In order to reduce the complexity of the interference cancellation process, a novel simple interference cancellation is proposed. Simulation results show that the scheme can perform better than DFE, and its complexity is very low because of the absence of QR decomposition.