Enhancing domestic tourism resilience (DTR) is crucial to achieving high-quality development of the tourism industry. However, owing to the vulnerability of the tourism industry during the COVID-19 pandemic, the enhancement pathways and associated mechanisms of DTR need to be further investigated. Therefore, this study measures the DTR of China's 31 provinces by creatively combining the simple harmonic motion and regime-switching vector autoregressive models and explores its characteristics to lay the foundation for an empirical analysis. Furthermore, the study empirically analyzes the enhancement pathways and associated mechanisms of DTR using a spatial econometric model. First, this study found that tourism agglomeration, specialization, and diversification determine the characteristics of dynamic response and spatial distributions of DTR. Second, from the perspective of spatial effects, DTR in one region positively impacts that in adjacent regions, and tourism agglomeration in a specific region positively impacts DTR in adjacent regions. Third, in terms of mechanisms, tourism agglomeration enhances DTR by optimizing industrial structure and improving production efficiency, whereas tourism specialization and diversification enhance DTR by improving production efficiency and optimizing industrial structure, respectively. These findings provide information for the enhancement of DTR and achievement of high-quality development of the tourism industry.