Simple Detection Task Research Articles

Functional Dissociation of Latency-Variable, Stimulus- and Response-Locked Target P3 Sub-components in Task-Switching.

Cognitive control warrants efficient task performance in dynamic and changing environments through adjustments in executive attention, stimulus and response selection. The well-known P300 component of the human event-related potential (ERP) has long been proposed to index “context-updating”—critical for cognitive control—in simple target detection tasks. However, task switching ERP studies have revealed both target P3 (300–350 ms) and later sustained P3-like potentials (400–1,200 ms) to first targets ensuing transition cues, although it remains unclear whether these target P3-like potentials also reflect context updating operations. To address this question, we applied novel single-trial EEG analyses—residue iteration decomposition (RIDE)—in order to disentangle target P3 sub-components in a sample of 22 young adults while they either repeated or switched (updated) task rules. The rationale was to revise the context updating hypothesis of P300 elicitation in the light of new evidence suggesting that “the context” consists of not only the sensory units of stimulation, but also associated motor units, and intermediate low- and high-order sensorimotor units, all of which may need to be dynamically updated on a trial by trial basis. The results showed functionally distinct target P3-like potentials in stimulus-locked, response-locked, and intermediate RIDE component clusters overlying parietal and frontal regions, implying multiple functionally distinct, though temporarily overlapping context updating operations. These findings support a reformulated version of the context updating hypothesis, and reveal a rich family of distinct target P3-like sub-components during the reactive control of target detection in task-switching, plausibly indexing the complex and dynamic workings of frontoparietal cortical networks subserving cognitive control.

Superstitious Perception: Comparing Perceptual Prediction by Humans and Neural Networks.

Recent developments in convolutional neural networks (CNNs) have introduced new ways to model the complex processes of human vision. To date, the comparison of human vision and CNNs has focused on internal representations (i.e., receptive fields), with behavioral comparisons left largely unexplored. Here, we probe the influence of cognitive strategy on the similarity between CNN output and human behavior. We gave study participants a superstitious perception task (i.e., we asked them to detect an assigned target in white noise) while asking them to engage in either an active or passive attentional strategy. Previous research has shown that an active attentional strategy tends to engage central executive functions, whereas a passive strategy allows perceptual processes to unfold with limited central control. The results showed that the pattern of human responses in the superstitious perception task depended significantly on task strategy. Specifically, detecting targets superstitiously (i.e., false alarms) was correlated with evidence of a target's presence in the passive condition, but not in the active condition.Human data were compared to the performance of a CNN performing the same task, with the decision criterion of the CNN set to match the false alarm rates observed in the two strategy conditions of the human participants. CNN responses resembled those of human participants in the passive condition more closely than those in the active condition. This observation suggests that the CNN does a better job of mimicking human behavior when central executive functions are not engaged than when they are engaged. This, in turn, has important implications for what human participants are doing in the superstitious perception task. Namely, it implies that superstitious perception may have two important ingredients that are somewhat dissociable. First, there is the ability to detect weak signals in noise that correspond to the target image. This appears to be what participants are doing under passive strategy conditions; they allow externally generated signals to dominate their perceptual experience. Second, there is the ability to ignore the noise in favor of basing responses solely on internally generated signals. This seems to correspond more closely to what participants are doing under active strategy conditions, when attention is controlled by representations in memory. This research emphasizes the importance of modeling the full range of human responsiveness in even a simple noisy detection task.

A model observer study using acquired mammographic images of an anthropomorphic breast phantom.

To study the feasibility of a task-based framework composed of an anthropomorphic breast phantom and mathematical model observers (MOs) for the evaluation of system-processed mammographic images. A prototype anthropomorphic breast phantom with inserted gold discs of 0.1 mm and 0.25 mm diameter was imaged with two digital mammography systems (system A and B) at four different dose levels. From the acquired processed and unprocessed images, signal-present and signal-absent regions of interest (ROIs) were extracted. The ROIs were evaluated by a non-pre-whitening MO with eye filter (NPWE) and by three human observers in a two-alternative forced-choice experiment. We compared the human and the MO performance on a simple detection task of the calcification-like discs in ROIs with and without postprocessing. Proportion of correct responses of the human (PCH ) and NPWE (PCNPWE ) experiments was calculated and the correlation between the two was analyzed using a mixed-effect regression model. Correlation results including the goodness of fit (r2 ) of PCH and PCNPWE for all different parameters investigated were evaluated to determine whether NPWE MO can be used to predict human observer performance. PCH and PCNPWE increased with dose for all conditions investigated (signal size, processing status, and different system). In case of the 0.1 mm discs, for system A, r2 between PCH with PCNPWE was 0.81. For system B, r2 was 0.93. In case of the 0.25 mm discs, r2 in system A was 0.79 and for system B, r2 was 0.82. For the combined parameters investigated, and after excluding the 0.1 mm discs on system A because the results were influenced by aliasing, the overall r2 was 0.81. Image processing did not affect the detectability of calcification-like signals. No significant difference (P > 0.05) was found between the predicted PCH(pred) by the MO and the PCH for all different conditions. The framework seems promising to be used in objective image quality assessment. It was found to be relatively robust for the range of parameters investigated. However, further optimization of the anthropomorphic breast phantom and investigation of other MOs for a broader range of image quality assessment tasks is needed.

Differences in change blindness to real-life scenes in adults with autism spectrum conditions

People often fail to detect large changes to visual scenes following a brief interruption, an effect known as ‘change blindness’. People with autism spectrum conditions (ASC) have superior attention to detail and better discrimination of targets, and often notice small details that are missed by others. Together these predict people with autism should show enhanced perception of changes in simple change detection paradigms, including reduced change blindness. However, change blindness studies to date have reported mixed results in ASC, which have sometimes included no differences to controls or even enhanced change blindness. Attenuated change blindness has only been reported to date in ASC in children and adolescents, with no study reporting reduced change blindness in adults with ASC. The present study used a change blindness flicker task to investigate the detection of changes in images of everyday life in adults with ASC (n = 22) and controls (n = 22) using a simple change detection task design and full range of original scenes as stimuli. Results showed the adults with ASC had reduced change blindness compared to adult controls for changes to items of marginal interest in scenes, with no group difference for changes to items of central interest. There were no group differences in overall response latencies to correctly detect changes nor in the overall number of missed detections in the experiment. However, the ASC group showed greater missed changes for marginal interest changes of location, showing some evidence of greater change blindness as well. These findings show both reduced change blindness to marginal interest changes in ASC, based on response latencies, as well as greater change blindness to changes of location of marginal interest items, based on detection rates. The findings of reduced change blindness are consistent with clinical reports that people with ASC often notice small changes to less salient items within their environment, and are in-line with theories of enhanced local processing and greater attention to detail in ASC. The findings of lower detection rates for one of the marginal interest conditions may be related to problems in shifting attention or an overly focused attention spotlight.

A Brief Exposure to Leftward Prismatic Adaptation Enhances the Representation of the Ipsilateral, Right Visual Field in the Right Inferior Parietal Lobule.

A brief exposure to rightward prismatic adaptation (PA) was shown to shift visual field representation within the inferior parietal lobule (IPL) from the right to the left hemisphere. This change in hemispheric dominance could be interpreted as (1) a general effect of discrepancy in visuomotor alignment caused by PA or (2) a direction-specific effect of rightward PA. To test these hypotheses, we compared the effects of rightward and leftward PA on visual representation in normal human subjects. Three groups of normal subjects underwent an fMRI evaluation using a simple visual detection task before and after brief PA exposure using leftward- or rightward-deviating prisms or no prisms (L-PA, R-PA, neutral groups). A two-way ANOVA group × session revealed a significant interaction suggesting that PA-induced modulation is direction specific. Post hoc analysis showed that L-PA enhanced the representation of the right visual field within the right IPL. Thus, a brief exposure to L-PA enhanced right hemispheric dominance within the ventral attentional system, which is the opposite effect of the previously described shift in hemispheric dominance following R-PA. The direction-specific effects suggest that the underlying neural mechanisms involve the fine-tuning of specific visuomotor networks. The enhancement of right hemispheric dominance following L-PA offers a parsimonious explanation for neglect-like symptoms described previously in normal subjects.

Divided attention effects are larger for change detection than for simple detection

Studies of divided visual attention have largely depended on detection and search tasks because they minimize the role of memory and decision. Recently, the change detection paradigm has been used to study divided attention and the results interpreted as due to perception. Instead, might the divided attention effects in change detection be "inflated" by memory and decision? To consider this, we compare divided attention effects for change detection and simple detection. Subjects were presented two intervals of dynamic 1/f noise patches on the left and right side of fixation and were cued beforehand to attend to either one side (selective attention) or both sides (divided attention). For the change detection task, Gabor patches were embedded in the noise on both sides, in both intervals, with a 50% chance of a 90 degree change in orientation from the first interval to the second. The probability of change was independent across sides. For the simple detection task, Gabor patches appeared in each side with 50% probability and subjects were asked to detect the presence of the patch. For the change detection task, subjects performed worse in the divided attention condition compared to the selective attention condition. However, for the simple detection task, there was almost no cost of divided attention compared to selective attention. In summary, for nearly identical stimuli, we show that the magnitude of divided attention effects depends strongly on the task. Ongoing studies examine whether these task effects depend only on perception or also on memory and/or decision. Meeting abstract presented at VSS 2017

The role of extra-foveal processing in 3D imaging.

The field of medical image quality has relied on the assumption that metrics of image quality for simple visual detection tasks are a reliable proxy for the more clinically realistic visual search tasks. Rank order of signal detectability across conditions often generalizes from detection to search tasks. Here, we argue that search in 3D images represents a paradigm shift in medical imaging: radiologists typically cannot exhaustively scrutinize all regions of interest with the high acuity fovea requiring detection of signals with extra-foveal areas (visual periphery) of the human retina. We hypothesize that extra-foveal processing can alter the detectability of certain types of signals in medical images with important implications for search in 3D medical images. We compare visual search of two different types of signals in 2D vs. 3D images. We show that a small microcalcification-like signal is more highly detectable than a larger mass-like signal in 2D search, but its detectability largely decreases (relative to the larger signal) in the 3D search task. Utilizing measurements of observer detectability as a function retinal eccentricity and observer eye fixations we can predict the pattern of results in the 2D and 3D search studies. Our findings: 1) suggest that observer performance findings with 2D search might not always generalize to 3D search; 2) motivate the development of a new family of model observers that take into account the inhomogeneous visual processing across the retina (foveated model observers).

Vision of the body improves inter-hemispheric integration of tactile-motor responses

Sensory input from and motor output to the two sides of the body needs to be continuously integrated between the two cerebral hemispheres. This integration can be measured through its cost in terms of processing speed. In simple detection tasks, reaction times (RTs) are faster when stimuli are presented to the side of the body ipsilateral to the body part used to respond. This advantage – the contralateral-ipsilateral difference (also known as the crossed-uncrossed difference: CUD) – is thought to reflect inter-hemispheric interactions needed for sensorimotor information to be integrated between the two hemispheres. Several studies have shown that non-informative vision of the body enhances performance in tactile tasks. However, it is unknown whether the CUD can be similarly affected by vision. Here, we investigated whether the CUD is modulated by vision of the body (i.e., the stimulated hand) by presenting tactile stimuli unpredictably on the middle fingers when one hand was visible (i.e., either the right or left hand). Participants detected the stimulus and responded as fast as possible using either their left or right foot. Consistent with previous results, a clear CUD (5.8ms) was apparent on the unseen hand. Critically, however, no such effect was found on the hand that was visible (−2.2ms). Thus, when touch is delivered to a seen hand, the usual cost in processing speed of responding with a contralateral effector is eliminated. This result suggests that vision of the body improves the interhemispheric integration of tactile-motor responses.

The variability of multisensory processes of natural stimuli in human and non-human primates in a detection task.

BackgroundBehavioral studies in both human and animals generally converge to the dogma that multisensory integration improves reaction times (RTs) in comparison to unimodal stimulation. These multisensory effects depend on diverse conditions among which the most studied were the spatial and temporal congruences. Further, most of the studies are using relatively simple stimuli while in everyday life, we are confronted to a large variety of complex stimulations constantly changing our attentional focus over time, a modality switch that can impact on stimuli detection. In the present study, we examined the potential sources of the variability in reaction times and multisensory gains with respect to the intrinsic features of a large set of natural stimuli.Methodology/Principle findingsRhesus macaque monkeys and human subjects performed a simple audio-visual stimulus detection task in which a large collection of unimodal and bimodal natural stimuli with semantic specificities was presented at different saliencies. Although we were able to reproduce the well-established redundant signal effect, we failed to reveal a systematic violation of the race model which is considered to demonstrate multisensory integration. In both monkeys and human species, our study revealed a large range of multisensory gains, with negative and positive values. While modality switch has clear effects on reaction times, one of the main causes of the variability of multisensory gains appeared to be linked to the intrinsic physical parameters of the stimuli.Conclusion/SignificanceBased on the variability of multisensory benefits, our results suggest that the neuronal mechanisms responsible of the redundant effect (interactions vs. integration) are highly dependent on the stimulus complexity suggesting different implications of uni- and multisensory brain regions. Further, in a simple detection task, the semantic values of individual stimuli tend to have no significant impact on task performances, an effect which is probably present in more cognitive tasks.

P189 Transcranial modulation of visually induced gamma power: a concurrent TACS-MEG study

Introduction Alpha oscillations (8–12 Hz) are proposed to mediate ‘attentional gating’ by suppressing neuronal processing in task-irrelevant sensory regions, reflected by ‘pulsed-inhibition’ of stimulus-induced gamma-band activity (40–100 Hz). Concurrent TACS-MEG has the potential to reveal TACS entrainment of alpha oscillations at the stimulation site and thus their causal impact on neuronal activity representing stimulus processing. Objectives We aimed to provide evidence that TACS can entrain the phase of alpha oscillations in the visual cortex by assessing its modulatory impact on the power of visual stimulus-induced gamma oscillations via simultaneous MEG recordings. Materials & methods TACS was applied during MEG in intermingled 5.4s trials either in Oz-Cz or FPz-Cz montage. Montage and stimulation frequency were randomized across trials, applying either individual alpha frequency (IAF), IAF−4 Hz, IAF+4 Hz, or no stimulation, resulting in a 2 (Montage) × 3 (Frequency) design plus a ‘NoStim’ condition. Stimulation intensity for both montages was adjusted separately to 95% retinal phosphene threshold. Participants performed a simple visual detection task, attending an inward moving grating, known to induce strong occipital gamma responses. TACS artifacts were reduced via regression methods, LCMV beamformer time-course extraction from the visual cortex, and high-pass filtering. Importantly, the gamma frequency of interest (∼50–60 Hz) was largely unaffected by TACS artifacts. We compared TACS-to-gamma phase-power coupling (PAC) for the respective experimental conditions. Results We found a rhythmic modulation of stimulus-induced gamma power by TACS at IAF (i.e., TACS-gamma phase-amplitude coupling) for the Oz-Cz montage, but not for the FPz-Cz montage which was introduced to control for subthreshold retinal entrainment effects. Conclusion Our findings (i) demonstrate that concurrent TACS-MEG can principally be used to study cross-frequency-coupling between transcranially entrained slower and spontaneous or stimulus-related faster oscillations, (ii) cannot merely result from subthreshold retinal entrainment, and (iii) suggest that alpha oscillations are indeed a possible means for top-down suppression of bottom-up sensory processing.

Audiogram of the kea parrot, Nestor notabilis.

Vocal communication requires the sender to produce a sound, which transmits through the environment and is perceived by the receiver. Perception is dependent on the quality of the received signal and the receiver's frequency and amplitude sensitivity; hearing sensitivity of animals can be tested using behavioural detection tasks, showing the physical limitations of sound perception. Kea parrots (Nestor notabilis) were tested for their ability to hear sounds that varied in terms of both frequency and amplitude by means of a simple auditory detection task. Audiograms for three kea were similar, with the region of highest sensitivity (1-5 kHz) corresponding to the frequency of the highest amplitude in kea calls. Compared with other parrots and other bird taxa, the overall shape of the kea audiogram follows a similar pattern. However, two potentially interesting differences to the audiograms of other birds were found: an increase in sensitivity at approximately 12 kHz and a decreased sensitivity to frequencies below 1 kHz.

Multisensory signalling enhances pupil dilation.

Detecting and integrating information across the senses is an advantageous mechanism to efficiently respond to the environment. In this study, a simple auditory-visual detection task was employed to test whether pupil dilation, generally associated with successful target detection, could be used as a reliable measure for studying multisensory integration processing in humans. We recorded reaction times and pupil dilation in response to a series of visual and auditory stimuli, which were presented either alone or in combination. The results indicated faster reaction times and larger pupil diameter to the presentation of combined auditory and visual stimuli than the same stimuli when presented in isolation. Moreover, the responses to the multisensory condition exceeded the linear summation of the responses obtained in each unimodal condition. Importantly, faster reaction times corresponded to larger pupil dilation, suggesting that also the latter can be a reliable measure of multisensory processes. This study will serve as a foundation for the investigation of auditory-visual integration in populations where simple reaction times cannot be collected, such as developmental and clinical populations.

Age Differences in Visual-Auditory Self-Motion Perception during a Simulated Driving Task.

Recent evidence suggests that visual-auditory cue integration may change as a function of age such that integration is heightened among older adults. Our goal was to determine whether these changes in multisensory integration are also observed in the context of self-motion perception under realistic task constraints. Thus, we developed a simulated driving paradigm in which we provided older and younger adults with visual motion cues (i.e., optic flow) and systematically manipulated the presence or absence of congruent auditory cues to self-motion (i.e., engine, tire, and wind sounds). Results demonstrated that the presence or absence of congruent auditory input had different effects on older and younger adults. Both age groups demonstrated a reduction in speed variability when auditory cues were present compared to when they were absent, but older adults demonstrated a proportionally greater reduction in speed variability under combined sensory conditions. These results are consistent with evidence indicating that multisensory integration is heightened in older adults. Importantly, this study is the first to provide evidence to suggest that age differences in multisensory integration may generalize from simple stimulus detection tasks to the integration of the more complex and dynamic visual and auditory cues that are experienced during self-motion.

Deficits in voice and multisensory processing in patients with Prader-Willi syndrome

Prader-Willi syndrome (PWS) is a rare neurodevelopmental and genetic disorder that is characterized by various expression of endocrine, cognitive and behavioral problems, among which a true obsession for food and a deficit of satiety that leads to hyperphagia and severe obesity. Neuropsychological studies have reported that PWS display altered social interactions with a specific weakness in interpreting social information and in responding to them, a symptom closed to that observed in autism spectrum disorders (ASD). Based on the hypothesis that atypical multisensory integration such as face and voice interactions would contribute in PWS to social impairment we investigate the abilities of PWS to process communication signals including the human voice. Patients with PWS recruited from the national reference center for PWS performed a simple detection task of stimuli presented in an uni-o or bimodal condition, as well as a voice discrimination task. Compared to control typically developing (TD) individuals, PWS present a specific deficit in discriminating human voices from environmental sounds. Further, PWS present a much lower multisensory benefits with an absence of violation of the race model indicating that multisensory information do not converge and interact prior to the initiation of the behavioral response. All the deficits observed in PWS were stronger for the subgroup of patients suffering from Uniparental Disomy, a population known to be more sensitive to ASD. Altogether, our study suggests that the deficits in social behavior observed in PWS derive at least partly from an impairment in deciphering the social information carried by voice signals, face signals, and the combination of both. In addition, our work is in agreement with the brain imaging studies revealing an alteration in PWS of the “social brain network” including the STS region involved in processing human voices.

Visual-search observers for assessing tomographic x-ray image quality.

Mathematical model observers commonly used for diagnostic image-quality assessments in x-ray imaging research are generally constrained to relatively simple detection tasks due to their need for statistical prior information. Visual-search (VS) model observers that employ morphological features in sequential search and analysis stages have less need for such information and fewer task constraints. The authors compared four VS observers against human observers and an existing scanning model observer in a pilot study that quantified how mass detection and localization in simulated digital breast tomosynthesis (DBT) can be affected by the number P of acquired projections. Digital breast phantoms with embedded spherical masses provided single-target cases for a localization receiver operating characteristic (LROC) study. DBT projection sets based on an acquisition arc of 60° were generated for values of P between 3 and 51. DBT volumes were reconstructed using filtered backprojection with a constant 3D Butterworth postfilter; extracted 2D slices were used as test images. Three imaging physicists participated as observers. A scanning channelized nonprewhitening (CNPW) observer had knowledge of the mean lesion-absent images. The VS observers computed an initial single-feature search statistic that identified candidate locations as local maxima of either a template matched-filter (MF) image or a gradient-template MF (GMF) image. Search inefficiencies that modified the statistic were also considered. Subsequent VS candidate analyses were carried out with (i) the CNPW statistical discriminant and (ii) the discriminant computed from GMF training images. These location-invariant discriminants did not utilize covariance information. All observers read 36 training images and 108 study images per P value. Performance was scored in terms of area under the LROC curve. Average human-observer performance was stable for P between 7 and 35. In the absence of search inefficiencies, the VS models based on the GMF analysis provided the best correlation (Pearson ρ ≥ 0.62) with the human results. The CNPW-based VS observers deviated from the humans primarily at lower values of P. In this limited study, search inefficiencies allowed for good quantitative agreement with the humans for most of the VS observers. The computationally efficient training requirements for the VS observer are suitable for high-resolution imaging, indicating that the observer framework has the potential to overcome important task limitations of current model observers for x-ray applications.

Contralesional distractors enhance ipsilesional target processing after right-hemispheric stroke

Stroke can result in marked impairments in the processing of information presented in contralesional space. The present prospective study investigated how a contralesional distractor affects ipsilesional perception in patients with a right-hemispheric stroke. In a simple target detection task, the influence of the distractor on reaction times (RTs) was examined in stroke patients and compared to the performance of healthy elderly controls. Distractor interference effects were related to measures of neglect and extinction using a regression analysis. Moreover, the magnitude of the behavioural distractor effect entered a voxel-based lesion-symptom mapping (VLSM) analysis with the hypothesis that parietal and temporoparietal lesions are related to altered distractor processing. While the presence of a distractor in the opposite hemifield slowed down RTs in healthy controls for left and right targets, this effect was only observed for contralesional left targets in the group of right-hemispheric patients. In stark contrast, the presence of a distractor in the contralesional hemifield expedited ipsilesional (i.e., right) target detection. This effect was significantly related to lesions in the anterior middle temporal and temporoparietal cortex, external and internal capsule, as well as the superior longitudinal fascicle (SLF). These results elucidate the nature of the disruption of attentive processing in the contralesional hemifield after right-hemispheric stroke. More specifically, they shed light on the abnormal prioritisation of ipsilesional information: our data suggest that damage to the temporal and temporoparietal cortex and white matter tracts may transform contralesional stimulation into an unspecific saliency signal contributing to facilitated information processing in ipsilesional space.

Efficient mental workload estimation using task-independent EEG features

Objective. Mental workload is frequently estimated by EEG-based mental state monitoring systems. Usually, these systems use spectral markers and event-related potentials (ERPs). To our knowledge, no study has directly compared their performance for mental workload assessment, nor evaluated the stability in time of these markers and of the performance of the associated mental workload estimators. This study proposes a comparison of two processing chains, one based on the power in five frequency bands, and one based on ERPs, both including a spatial filtering step (respectively CSP and CCA), an FLDA classification and a 10-fold cross-validation. Approach. To get closer to a real life implementation, spectral markers were extracted from a short window (i.e. towards reactive systems) that did not include any motor activity and the analyzed ERPs were elicited by a task-independent probe that required a reflex-like answer (i.e. close to the ones required by dead man’s vigilance devices). The data were acquired from 20 participants who performed a Sternberg memory task for 90 min (i.e. 2/6 digits to memorize) inside which a simple detection task was inserted. The results were compared both when the testing was performed at the beginning and end of the session. Main results. Both chains performed significantly better than random; however the one based on the spectral markers had a low performance (60%) and was not stable in time. Conversely, the ERP-based chain gave very high results (91%) and was stable in time. Significance. This study demonstrates that an efficient and stable in time workload estimation can be achieved using task-independent spatially filtered ERPs elicited in a minimally intrusive manner.

The Tactile Window to Consciousness is Characterized by Frequency-Specific Integration and Segregation of the Primary Somatosensory Cortex.

We recently proposed that besides levels of local cortical excitability, also distinct pre-stimulus network states (windows to consciousness) determine whether a near-threshold stimulus will be consciously perceived. In the present magnetoencephalography study, we scrutinised these pre-stimulus network states with a focus on the primary somatosensory cortex. For this purpose participants performed a simple near-threshold tactile detection task. Confirming previous studies, we found reduced alpha and beta power in the somatosensory region contralateral to stimulation prior to correct stimulus detection as compared to undetected stimuli, and stronger event-related responses following successful stimulus detection. As expected, using graph theoretical measures, we also observed modulated pre-stimulus network level integration. Specifically, the right primary somatosensory cortex contralateral to stimulation showed an increased integration in the theta band, and additionally, a decreased integration in the beta band. Overall, these results underline the importance of network states for enabling conscious perception. Moreover, they indicate that also a reduction of irrelevant functional connections contributes to the window to consciousness by tuning pre-stimulus pathways of information flow.

Implicit learning of a speed-contingent target feature.

Previous human implicit learning studies have mostly investigated implicit associations between two consecutive stimuli or between a stimulus and the subsequent response (e.g., Cleeremans, Destrebecqz, & Boyer, Trends in Cognitive Sciences, 2(10), 406-416, 1998). In the present study, participants' response speed was used as a cue to predict an upcoming target feature. We called this new type of cueing, "cueing-by-response" (CBR). We investigated whether CBR could be learned implicitly. Participants performed two tasks: participants quickly responded to a target in the simple detection task and determined the orientation of a new target in the consecutive visual search task. We applied a contingency that the target location in the visual search task was determined by the participant's response speed in the preceding simple detection task. The results demonstrated that participants learned the contingency without conscious awareness; they searched for the target more efficiently in the visual search task as the experiment progressed. But when the target appeared in a random location, this efficiency disappeared. Moreover, the experimental group exhibited faster response speeds to the target in the visual search task compared with the control groups, which had no contingency. These results suggest that individuals may use the relative speed of their own response as a predictive cue to guide spatial attention toward upcoming target locations, and CBR can be implicitly learned.

Effects of concurrent caffeine and mobile phone exposure on local target probability processing in the human brain.

Millions of people use mobile phones (MP) while drinking coffee or other caffeine containing beverages. Little is known about the potential combined effects of MP irradiation and caffeine on cognitive functions. Here we investigated whether caffeine intake and concurrent exposure to Universal Mobile Telecommunications System (UMTS) MP-like irradiation may interactively influence neuro-cognitive function in an active visual oddball paradigm. In a full factorial experimental design, 25 participants performed a simple visual target detection task while reaction time (RT) and electroencephalogram (EEG) was recorded. Target trials were divided into Low and High probability sets based on target-to-target distance. We analyzed single trial RT and alpha-band power (amplitude) in the pre-target interval. We found that RT was shorter in High vs. Low local probability trials, and caffeine further shortened RT in High probability trials relative to the baseline condition suggesting that caffeine improves the efficiency of implicit short-term memory. Caffeine also decreased pre-target alpha amplitude resulting in higher arousal level. Furthermore, pre-target gamma power positively correlated with RT, which may have facilitated target detection. However, in the present pharmacologically validated study UMTS exposure either alone or in combination with caffeine did not alter RT or pre-stimulus oscillatory brain activity.