Similar Relationship Research Articles

The Colley Method is an Extension of the Borda Count

Summary The Colley and Massey methods are two well-known methods to rate sports teams. We prove that when the Colley method is applied to election data, then it returns the same outcome as the Borda count, a well-known election procedure. Hence, the Colley method is an extension of the Borda count to partial orderings of candidates. A similar relationship holds between the Massey method and range voting. Real data from Major League Baseball is used.

Structure-aware contrastive hashing for unsupervised cross-modal retrieval

Cross-modal hashing has attracted a lot of attention and achieved remarkable success in large-scale cross-media similarity retrieval applications because of its superior computational efficiency and low storage overhead. However, constructing similarity relationship among samples in cross-modal unsupervised hashing is challenging because of the lack of manual annotation. Most existing unsupervised methods directly use the representations extracted from the backbone of their respective modality to construct instance similarity matrices, leading to inaccurate similarity matrices and resulting in suboptimal hash codes. To address this issue, a novel unsupervised hashing model, named Structure-aware Contrastive Hashing for Unsupervised Cross-modal Retrieval (SACH), is proposed in this paper. Specifically, we concurrently employ both high-dimensional representations and discriminative representations learned by the network to construct a more informative semantic correlative matrix across modalities. Moreover, we design a multimodal structure-aware alignment network to minimize heterogeneous gap in the high-order semantic space of each modality, effectively reducing disparities within heterogeneous data sources and enhancing the consistency of semantic information across modalities. Extensive experimental results on two widely utilized datasets demonstrate the superiority of our proposed SACH method in cross-modal retrieval tasks over existing state-of-the-art methods.

CORPORATE GOVERNANCE AND FINANCIAL PERFORMANCE: A CASE STUDY IN THE PHARMACEUTICAL SECTOR IN MALAYSIA

The introduction of the Malaysian Code of Corporate Governance has been progressively updated since its inception in the year 2000 and the latest update in the year 2021, proves that the government of Malaysia has been serious in regulating to ensure that the companies in Malaysia have been compliant with good corporate governance practices. Observing that it is an evergreen issue and to have more updated research, this study evaluates factors that could influence the effectiveness of corporate governance of five pharmaceutical companies listed in Malaysia and its relationship with the financial performance for the period of 2017 - 2021. The methodologies that have been employed for this study are descriptive statistics, non-parametric correlations, scatter plots and regression linear. The findings reveal that variables of board size, board independence, and disclosure of sustainability reports have correlations with the financial performance measured by the return on assets. However, the disclosure of sustainability reports is the only variable that has a significant correlation with ROA whereas board size and board independence do not possess similar relationships. For a better representation of the results’ precision and robust findings, it is recommended to have a longer study period than five years and a larger sample size by extending it to other sectors.

EcoGenoRisk: Developing a computational ecological risk assessment tool for synthetic biology

The expanding field of synthetic biology (synbio) supports new opportunities in the design of targeted bioproducts or modified microorganisms. However, this rapid development of synbio products raises concerns surrounding the potential risks of modified microorganisms contaminating unintended environments. These potential invasion risks require new bioinformatic tools to inform the design phase. EcoGenoRisk is a newly constructed computational risk assessment tool for invasiveness that aims to predict where synbio microorganisms may establish a population by screening for habitats of genetically similar microorganisms. The first module of the tool identifies genetically similar microorganisms and potential ecological relationships such as competition, mutualism, and inhibition. In total, 520 archaeal and 32,828 bacterial complete assembly genomes were analyzed to test the specificity and accuracy of the tool as well as to characterize the enzymatic profiles of different taxonomic lineages. Additionally, ecological relationships were analyzed to determine which would result in the greatest potential overlap between shared functional profiles. Notably, competition displayed the significantly highest overlap of shared functions between compared genomes. Overall, EcoGenoRisk is a flexible software pipeline that assists environmental risk assessors to query large databases of known microorganisms and prioritize follow-up bench scale studies.

Seismic performance of a frame‐supported shear wall over‐track building through shaking table test

SummaryThis research deals with a frame‐supported shear wall for urban over‐track building of vehicle depot in Chisha, Guangzhou, China, which is characterized by its remarkable height of 160.8 m. Technical issues are commonly encountered in these kinds of buildings due to discontinuous vertical structural rigidity, large podium, and structural transition. These challenges significantly impact the engineering process, especially when the rigidity difference between transfer story exceeding the threefold, as well as the building height exceeds limit as in code. In this paper, a shaking table test was developed based on a 1:10 scaled model of the structure. Using similarity theory, the dynamic similarity relationship was established for the design of the model. Subsequently, the experimental model was constructed with the configuration of critical parameters such as mass design, sensor placement, and seismic test conditions. This was followed by in‐depth analysis, recording component failures and investigating key aspects such as dynamic characteristics, that is, acceleration and displacement responses and shear force distribution under different earthquake intensities. A theoretical seismic response of the prototype structure was derived from the test results. The shaking table tests confirmed that the structure met the stringent seismic design requirements as prescribed in the Chinese standards, with no damage under minor earthquakes, repairability under moderate earthquakes, and collapse prevention under rare earthquakes. The results of the study provide valuable insights along with improvement measures for the design and development of similar urban over‐track buildings, potentially contributing to more efficient land use in urban China.

Cost-Effectiveness Evaluation of Oral CGRP Antagonists, Atogepant and Rimegepant, for the Preventative Treatment of Episodic Migraine: Results from a US Societal Perspective Model.

Two oral calcitonin gene-related peptide (CGRP) antagonists, atogepant and rimegepant, were approved in 2021 for the preventive treatment of episodic migraine (EM), yet no formal cost-effectiveness analysis has been published. The objective of this study was to evaluate the cost-effectiveness of atogepant 60 mg and rimegepant 75 mg compared with placebo. A decision tree model was constructed over a 1-year time horizon from a US societal perspective. Patient cohorts were simulated using baseline and change from baseline monthly migraine days (MMDs) reported in the trials to incorporate responder rates and within patient response into the model. Due to heterogeneity between the trial populations, each medication was compared with its respective trial's placebo group. Direct healthcare resource costs, productivity costs, acute medication costs, and quality-of-life values were obtained from the literature. The atogepant cohort experienced an incremental increase in healthcare plus productivity costs of $11,978 when compared with placebo, with a gain of 0.026 quality-adjusted life-years (QALYs). This yielded an incremental cost-effectiveness ratio (ICER) of more than $450,000/QALY. The rimegepant cohort experienced an incremental increase of $21,692 when compared with placebo, with a gain of 0.024 QALYs. This yields an ICER of more than $890,000/QALY when comparing rimegepant with placebo. Cost savings between atogepant and atogepant placebo were greatest with respect to acute medication costs at $735 of savings over 1 year, followed by savings of $135 for healthcare resource utilization and $34 for productivity costs. A similar relationship was seen between rimegepant and rimegepant placebo. One-way deterministic sensitivity analysis found that monthly acquisition costs of atogepant and rimegepant had the largest impact on the ICER, respectively. Atogepant and rimegepant were both unable to meet generally accepted cost-effectiveness thresholds < 150,0000/QALY. Additional studies are needed to better guide decision making regarding oral CGRPs' place in therapy.

Dynamics of diabatically forced anticyclonic plumes in the stratosphere

AbstractA new class of vortices has been observed in the stratosphere following extreme wildfires (Canada 2017, Australia 2020) and volcanic eruptions (Raikoke 2019). These vortices are long‐lived mesoscale anticyclones (hundreds to 1,000 km in diameter) trapping plumes of aerosols and combustion/volcanic compounds. Owing to their unusual composition, these anticyclonically trapped plumes (ATPs) are associated with a significant radiative heating, which fuels their ascent through the stratosphere. This article investigates the dynamics of ATPs using two complementary approaches: analytically, in a potential vorticity (PV) perspective, and through idealised numerical simulations with the Weather Research and Forecasting (WRF) model. In both cases, we consider the vortical flow forced by a heating Lagrangian tracer. By reformulating the problem in the potential radius–potential temperature coordinate system introduced for tropical cyclones, we first clarify that ATP formation is concomitant with the injection of air into the stratosphere at extratropical latitudes. Then, we derive a set of simplified one‐dimensional equations describing the subsequent evolution of the flow after the injection. The equation obtained for the tracer is a variant of the classical Burgers' equation. In qualitative agreement with the three‐dimensional WRF simulations, this theoretical model predicts that ATPs develop an upper tracer front associated with sustained near‐zero anticyclonic PV, followed by a smooth tracer tail of cyclonic PV. Radiative relaxation of the temperature perturbations induced by the anticyclone and the presence of an initial PV anomaly tend to stabilise ATPs during their ascent. Finally, we note that the theory predicts a similar relationship between the plume and anticyclonic PV for cooled ATPs, which is supported by three‐dimensional simulations and may apply to the 2022 Hunga volcanic plume.

Flavonoids commonly induce hormetic responses.

The present paper provides a new perspective of previously published findings by Siwak (Food Chem 141:1227-1241, 2013) which showed that 15 structurally diverse flavonoids reduced toxicity (i.e., enhanced cell viability) from hypochlorite using the MTT assay within a pre-conditioning experimental protocol, with each agent showing a similar biphasic concentration response relationship. We use this Commentary to point out that each of the concentration response relationships are consistent with the hormetic dose response. The paper of Siwak (Food Chem 141:1227-1241, 2013) is unique in that it provides a comparison of a relatively large number of agents using the identical experimental protocol.

Time-Aware Dual LSTM Neural Network with Similarity Graph Learning for Remote Sensing Service Recommendation.

Technological progress has led to significant advancements in Earth observation and satellite systems. However, some services associated with remote sensing face issues related to timeliness and relevance, which affect the application of remote sensing resources in various fields and disciplines. The challenge now is to help end-users make precise decisions and recommendations for relevant resources that meet the demands of their specific domains from the vast array of remote sensing resources available. In this study, we propose a remote sensing resource service recommendation model that incorporates a time-aware dual LSTM neural network with similarity graph learning. We further use the stream push technology to enhance the model. We first construct interaction history behavior sequences based on users' resource search history. Then, we establish a category similarity relationship graph structure based on the cosine similarity matrix between remote sensing resource categories. Next, we use LSTM to represent historical sequences and Graph Convolutional Networks (GCN) to represent graph structures. We construct similarity relationship sequences by combining historical sequences to explore exact similarity relationships using LSTM. We embed user IDs to model users' unique characteristics. By implementing three modeling approaches, we can achieve precise recommendations for remote sensing services. Finally, we conduct experiments to evaluate our methods using three datasets, and the experimental results show that our method outperforms the state-of-the-art algorithms.

Policy uncertainty and idiosyncratic volatility on Nikkei 225 stocks

ABSTRACT The main purpose of this study is to empirically examine the relationship between policy uncertainty and idiosyncratic volatility in Nikkei 225 stocks. We conclude that there is a positive relationship between economic policy uncertainty and idiosyncratic volatility. After examining additional uncertainty measures, we find similar positive relationships between monetary, fiscal, and trade policy uncertainty measures and idiosyncratic volatility except exchange rate policy. Industry analysis reveals much detailed information about how each Japanese industry responds to uncertainty, and the results emphasize the critical roles of government officers and policymakers in the stock markets.

Understanding the impact of munia birds (Aves: Passeriformes: Estrildidae) on rice farming: Behavior, distribution, and bioacoustic parameters

Abstract. Kurnianto AS, Dewi N, Haryadi NT, Arma WA, Maulana R, Sari YH, Hamidah W, Magvira NL, Kadafi AM. 2024. Understanding the impact of munia birds (Aves: Passeriformes: Estrildidae) on rice farming: Behavior, distribution, and bioacoustic parameters. Biodiversitas 25: 186-196. Munia birds represent a significant challenge in rice farming. This study investigates the role of Munia birds (Aves: Passeriformes: Estrildidae) within rice agroecosystems. Utilizing point count observation methods in Desa Rowosari, Jember, across two farming models (organic and conventional), we assessed the behavior, population distribution, and bioacoustic parameters of Munia species. A total of 3820 Munia individuals were documented: 2187 Javan Munia (Lonchura leucogastroides Moore, 1858), 1214 Scaly-breasted Munia (Lonchura punctulate Linnaeus, 1758), and 419 White-capped Munia (Lonchura ferruginosa Sparrman, 1789). Bioacoustic recordings were conducted using the TASCAM DR 60D recorder, complemented by statistical tests in SPSS 16.0 and visual data representations via Matplotlib and Seaborn libraries. Findings revealed that Munias inflict damages ranging from 10.85% to 30% on rice crops. Notably, JM's bioacoustic bandwidth displayed adaptability between organic and conventional cultivation environments (P value=0.0129). In terms of population distribution, SbM has the highest population density on conventional (density=22.38), JM has the highest density on organic (density-32.55). Passing through activity is more observed in both types of organic and conventional management models. Scaly-breasted Munia dominates in three time groups, both in the morning (x ?= 224.75), mid day (x ?= 163.75), and afternoon (x ?= 198.25). However, PCA depiction indicates that the activity of passing through is dominated by JM. JM and SbM are depicted gathering in the center, indicating a similar average relationship between populations. While Munias pose potential threats as pests, their absence could surge insect populations, underscoring their ecological significance. This study accentuates the importance of an informed management strategy, considering Munia's multifaceted impact on agroecosystems.

(384) Post-Vasectomy Semen Analysis Compliance Correlated with Patient Driving Distance to Drop-off Site

Abstract Introduction Successful vasectomy is confirmed with post-vasectomy semen analysis (PVSA) completed eight to sixteen weeks after the procedure. However, compliance rates remain low throughout the literature with an estimated 34% to 58% of patients never receiving a PVSA. Objective We sought to quantify the relationship between driving time and compliance with PVSA. Methods A retrospective chart review was conducted of vasectomies provided by urologists from an academic hospital system between 4/1/2020 and 12/31/2022. Physicians who primarily performed in-office PVSA or referred patients to outside clinics were excluded from the study. Compliance with post-vasectomy semen analysis was defined as at least 1 PVSA sample submitted. In our study we considered variables including age, virtual or in-person preoperative visit, paternity, and driving time. The shortest driving time was calculated from each patient’s residence to the single PVSA drop-off site using ArcGIS. The study received IRB approval. The factors associated with compliance were analyzed via multivariable logistic regression. Driving time, age at vasectomy, paternity, and preop location were included as predictors. Driving time and age were included as continuous variables. For driving time the odds ratio reflects the change in odds of PVSA per 30 minutes of driving; for age the odds ratio reflects the change in odds of PVSA per 10 years of age. A generalized additive model was used to explore a nonlinear relationship between driving time and PVSA compliance. Results A total of 515 patients were included in the analysis. 296 patients obtained a PVSA (57.5%). Of those who obtained a PVSA, 41% took more than 16 weeks to do so. The median driving distance for those who obtained a PVSA was 18.9 miles (11.3, 26.4) and 22.3 miles (13.9, 34.3) for those who did not (p&amp;lt;0.01). The median estimated driving times for those who did and did not provide PVSA were 30.6 minutes (23.0, 42.1) and 34.2 minutes (25.5, 46.8) respectively (p&amp;lt;0.05). Adjusted for age, paternity, and pre-op location, each 30 minutes of driving time was associated with a 48% (63%, 27%) reduction in the odds of obtaining a PVSA (p&amp;lt;0.001). Age at vasectomy, paternity, and pre-op location were not found to be associated with decreased PVSA compliance. (Table 1). The generalized additive model shows a similar relationship between driving distance and compliance (Figure 1). Conclusions These results demonstrate a statistically significant correlation between longer driving time to a drop-off site and probability of PVSA non-compliance. However, factors such as paternity, age at vasectomy, and pre-op visit format were not significant. Increasing access to semen analysis drop-off centers close to patients residences may serve to increase compliance with PVSA. At-home PVSA kits and in-office semen analyses are other options for reducing this barrier. Further research is needed to see if this relationship between driving time and compliance is seen in other aspects of medical care. Disclosure No.

Evaluating the muscle attachment hypothesis for sagittal cresting in Gorilla and Pongo.

Primate mandibular morphology is often associated with jaw functionality of the masticatory complex in the context of variation in diets. Recent research into the disparities between the diet and jaw functionality in male and female hominoids is inconclusive and suggests that sexual dimorphism in the mandible may be influenced by external factors such as temporalis and masseter muscle morphology, which in turn may be influenced by sexual selection. As the muscles associated with mastication (i.e., the type of chewing exhibited by primates and other mammals) encompass the mandible as well as the neurocranium, including the sagittal crest among some individuals, this study investigates sex-specific associations between regions of the mandibular ramus and neurocranium associated with mastication in a dentally mature sample of Gorilla and Pongo. A total of four cranial and mandibular variables were measured in two Gorilla taxa (Gorilla gorilla gorilla and Gorilla beringei graueri) and one Pongo taxon (Pongo pygmaeus pygmaeus) (n = 220). For all three taxa, we investigate (a) whether the degree of sexual dimorphism in cranial regions associated with sagittal cresting (sagittal crest size (SCS) and temporalis muscle attachment area (TMAA)) is proportional to the degree of mandibular ramus area (MRA) and coronoid process height (CPH) sexual dimorphism, (b) whether there are sex differences in scaling relationships between TMAA and MRA, and (c) whether there are sex differences in the strength of association between TMAA and CPH. We show that for G. g. gorilla, variables associated with sagittal cresting show higher sexual dimorphism values than our two mandibular ramus variables, which is not the case for G. b. graueri or for P. p. pygmaeus. All three taxa show similar sex-specific scaling relationships between TMAA and MRA, where for males this relationship does not diverge from isometry, and for females there is a negative allometric relationship. Our findings also show intraspecific sex differences in allometric slopes between MRA and TMAA for all three taxa. Only G. g. gorilla shows a significant association between TMAA and CPH, which is observed in both sexes. Although there are some statistical associations between the cranial and mandibular regions associated with mastication, our results show that among male gorillas and orangutans, patterns of variation in the sagittal crest, TMAA, mandibular ramus and the coronoid process cannot be explained by the muscle attachment hypothesis alone. These findings have implications surrounding the associations between social behaviour and the morphology of the craniofacial complex.

Molecular and genetic characterization of LEPTOSPIRA spp. collection strains from the St. Petersburg Pasteur institute based on 16S rRNA gene sequencing data

Leptospirosis is a zoonotic disease found virtually worldwide. Microscopic Agglutination Test with live leptospira (MAT) is the reference method for the serological diagnosis of leptospirosis. MAT is based on assessing serum potential to agglutinate live reference serovar Leptospira maintained at a reference laboratory. At some laboratories having own collections of isolated and reference Leptospira strains applicable for serological diagnosis, those microorganisms are maintained for many years by repeated subculturing, that increases markedly a chance of strain cross-contamination. The lack of adequate quality control for reference strains may affect data of epidemiological studies. Control of Leptospira spp. reference strains purity and stability of their antigenic composition is very important for diagnosis of leptospirosis. The study objective was to compare the 16S rRNA gene nucleotide sequences of some Leptospira strains from the collection of the St. Petersburg Pasteur Institute to with relevant sequences uploaded to GenBank. In this study, 38 Leptospira strains were investigated. Nucleotide sequences of 36 strains were deposited in the international GenBank database, inconsistencies were revealed in two strains. The study found that the control Leptospira strains from the collection of the St. Petersburg Pasteur Institute had minimal dissimilarities from international control strains. The analysis of the resultant 16S rRNA sequences has shown the presence of point mutations, transitions, deletions and insertions, regardless of the strain species. The open leptospira pan-genome demonstrates high genomic variability in species due to the capability of leptospira for lateral gene transfer in order to adapt to changing environmental conditions. The massive acquisition and loss of genes give rise to an increased species diversity. The 16S rRNA gene is suitable for screening diagnostics; however, high level of the fragment similarity and close phylogenetic relationship between different species put bounds to its use in genotyping. The presence of point nucleotide mutations is most likely associated with the evolutionary mechanisms of leptospira, their ability to horizontal gene transfer and crossing-over, including ribosomal genes, but this assumption necessitates additional research. For specimen genotyping it is necessary to select alternative genes with high specificity and sufficient level of nucleotide divergence. The study shows a need for genetic analysis of collection strains in order to control the purity of cultures.

Abstract B032: Compromised TGFβ signaling and DNA repair primes response to immune checkpoint inhibition by activating NK cells in immunologically cold breast cancers

Abstract We investigated the interplay between immunosuppressive TGFβ signaling and immunogenic DNA repair in response to immune checkpoint inhibition (ICI) in a new model of breast cancer. Transforming growth factor beta (TGFβ) is a canonical suppressor. Cancer cells evade TGFβ either by selectively overcoming TGFβ proliferative barrier or completely shutting down signaling. Loss of TGFβ signaling is accompanied by high immunosuppressive TGFβ activity. We have shown that loss of TGFβ is critical to genomic integrity. It endorses classical DNA repair and inhibits error-prone repair. We described a score, βAlt, that reports the TGFβ/DNA repair functional relationship. Pan-cancer analysis showed that high βAlt cancers, in which the TGFβ target signature is low and DNA repair signature is high, use error-prone DNA repair, are sensitive to chemoradiation and have a greater fraction of the genome altered compared to low βAlt cancers, which maintain TGFβ signaling. We established a novel murine tumor derived transplant model (mTDT) of triple-negative breast cancer, similar to a human PDX, in immunocompetent BALB/cJ mice. Transcriptomics analysis showed that mTDT range from high to low βAlt and from immune poor to immune rich, which was confirmed by multiplex immunstaining. Unsupervised clustering of mTDT based on βAlt score demonstrated that low βAlt was associated with immune rich tumors while high βAlt was associated with immune poor tumors. A similar relationship is evident in the TCGA breast cancers. We then asked how mTDT respond to ICI. Mice bearing mTDT were randomized to monotherapy consisting of single fraction 10 Gy radiation, anti-PD-L1 or TGFβ inhibition, dual or triple treatment. Neither anti-PD-L1 or TGFβ inhibition affected survival, alone or in combination, whereas radiation significantly increased survival. Unexpectedly immune poor, high βAlt mTDT were the most responsive. To evaluate biological correlates, mice were stratified as a function of treatment as responders, in which tumor growth was controlled for 7 days post-treatment, or non-responders, in which tumor growth was uncontrolled. Tumor infiltrating CD45+ cells increased (P=0.02) as did circulating CD8 T cells (P&amp;lt;0.001) in responders. Natural killer (NK) cells were also significantly expanded in responders (P&amp;lt;0.001). TGFβ broadly downregulates chemokine receptor expression necessary to recruit NK cells and impairs NK cell cytotoxic effector function. We depleted NK cells to test whether they were necessary for the pronounced response to triple treatment. NK depletion was completely abrogated response (P&amp;lt;0.00001) indicating NK cells can provoke an ICI response in high βAlt mammary tumors devoid of lymphocytes. This preclinical model and human breast cancer shows that loss of TGFβ signaling resulting in error-prone DNA damage response is strongly associated with immune poor tumors, and suggests that TGFβ inhibition can override NK cell dysfunction to create vulnerability to ICI and anti-tumor immunity. Citation Format: Jade Moore, Jim Gkantalis, Ines Guix, Colin Foster, Mary Helen Barcellos-Hoff. Compromised TGFβ signaling and DNA repair primes response to immune checkpoint inhibition by activating NK cells in immunologically cold breast cancers [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Breast Cancer Research; 2023 Oct 19-22; San Diego, California. Philadelphia (PA): AACR; Cancer Res 2024;84(3 Suppl_1):Abstract nr B032.

Определение диагностической значимости маркеров наследственных болезней обмена с применением метода хромато-масс-спектрометрии

Thorough investigation of metabolome by mass spectrometry is of great importance for personalized and preventive medicine. It is only timely laboratory diagnosis involving the use of high-tech chromatographic analysis methods that can help identify the patients with disorders of amino acid and acylcarnitine metabolism. The study was aimed to determine the efficacy of conventional and additional markers of metabolic disorders of amino acids and acylcarnitines detected by chromatography–mass spectrometry for the diagnosis of congenital metabolic disorders in children, as well as to create specific panels of the most effective indicators and determine the potential diagnostic efficacy of indentification of the relationships between the levels of amino acids and acylcarnitines in pediatric patients with congenital metabolic disorders. We assessed amino acid and acylcarnitine profiles in blood spots by high-performance liquid chromatography–tandem mass spectrometry in patients aged 6 months to 16 years (48 boys and 32 girls) with suspected aminoacidopathy and organic aciduria/acidemia. The comparison group consisted of 35 children with suspected peroxisomal metabolic disorders, the control group included 40 generally healthy children of various age groups. The data obtained were used to conduct the analysis of correlations between the groups of markers. Strong correlation was revealed for the levels of metabolically most closely related compounds (r &lt; 0.8, р &lt; 0.001). However, a similar relationship between metabolically not closely related compounds (correlation coefficient 0.45–0.73 (р &lt; 0.001)) was revealed for some groups of compounds. Thus, the acylcarnitine profile can be proposed as an additional potential marker to be used in cases of borderline phenylalanine levels, and the sum of normalized acylcarnitine levels (С12+С16) can be a potential secondary marker of phenylketonuria.

Statistics Pattern Cointegration Analysis-Based Bit Bounce Detection for Drilling Process

Fault detection is essential for the safety of drilling process. Without proper detection and appropriate treatment of bit bounce, it may result in serious drilling accidents. The data distribution shift will lead to the nonstationary property. Yet the statistics of drilling parameters may have similar equilibrium relationships across different depths due to the existence of automatic drilling control system. To solve the issue of distribution shift, a statistics pattern cointegration analysis based bit bounce detection method for drilling process is proposed. The statistics pattern of drilling parameters is constructed. The cointegration analysis is conducted to discover equilibrium relationships among nonstationary statistics for process monitoring. The corresponding alarm deadband is designed through the analysis of alarm duration and alarm deviation. An industrial case study from an actual drilling process is conducted to demonstrate the effectiveness of the proposed fault detection method. The proposed statistics pattern cointegration analysis approach is conducive to maintaining a satisfactory fault detection performance in the case of distribution shift in the industrial process.

Abstract TP158: Baseline Viscoelastic Hemostatic Assays and Associations With Poor Long-Term Intracerebral Hemorrhage Outcomes

Introduction: Viscoelastic hemostatic assays can detect coagulopathy relevant for intracerebral hemorrhage (ICH) patients at risk for hematoma expansion. However, it is unclear whether these assays associate with long term ICH outcomes. We sought to assess whether baseline coagulopathy detectable via viscoelastic hemostatic assay associates with poor 6-month neurological outcomes after ICH. Methods: Spontaneous ICH patients enrolled in a single-center prospective observational study from 2013 to 2020 who received baseline viscoelastic hemostatic assay testing via Rotational Thromboelastometry (ROTEM) were included. Patients with prior anticoagulant use were excluded. ROTEM assessments of coagulation kinetics and clot strength were the primary exposure variables. Poor 6-month neurological outcome was defined as modified Rankin Scale (mRS) 4-6. Multivariable logistic regression analyses assessed the relationships of ROTEM parameters with 6-month outcomes after adjusting for ICH score, hemoglobin, and sex. Results: Of 44 patients included for analysis, the mean age was 64, 57% were female, 52% had deep ICH, and the median ICH volume was 23.3 mL. Poor 6-month outcome was seen in 61%. We identified that slower coagulation kinetics was associated with poor 6-month outcome as assessed in both extrinsic and intrinsic pathways (EXTEM CFT: adjusted OR 1.06, 95% CI: 1.02-1.12, p=0.02; INTEM CFT: adjusted OR 1.05, 95% CI: 1.01-1.10, p=0.05, respectively). Weaker clot strength was also associated with poor 6-month outcome (EXTEM MCF: adjusted OR 0.78, 95% CI: 0.59-0.93, p=0.03; INTEM MCF: adjusted OR 0.83, 95% CI: 0.68-0.97). We did not identify similar relationships using conventional coagulation assays (ie., PT/PTT/INR, platelet count). Conclusions: We identified that baseline impaired coagulation kinetics and weaker clot strength seen using ROTEM testing associate with poor 6-month ICH outcomes. Further work is needed to clarify the generalizability of these findings and the mechanisms driving these relationships to assess whether viscoelastic guided therapies can potentially be used to improve long-term ICH outcomes.

Characteristics of Turbulence Intermittency, Fine Structure, and Flux Correction in the Taklimakan Desert

Abstract The Taklimakan Desert is one of key climate regions in East Asia, both highly influencing and highly sensitive to local/regional climate change. Based on a comprehensive observation experiment from 1 to 31 May 2022 in the hinterland of the Taklimakan Desert, the characteristics and mechanisms of turbulence intermittency are investigated in this study, with the purpose to correct turbulent fluxes. Using an improved algorithm to decompose turbulence and submeso motions, two intermittency regimes are recognized in the Taklimakan Desert, namely, D and T intermittency and onD intermittency. The former occurs under strongly stable conditions, characterized by the coexistence of dynamic and thermodynamic turbulence intermittency. The latter occurs under strongly unstable conditions and represents only dynamic turbulence intermittency. Physically, the D and T intermittency regime is related to submeso waves, whereas the onD regime is caused by the horizontal convergence/divergence of convective circulations. With the influence of intermittency and submeso motions, the observed turbulent statistics deviate from reality, which would mask the similarity relationships. To overcome the problem, turbulent statistics are corrected by removing submeso components from original fluctuations. The effectiveness of this method is demonstrated based on the flux–gradient relationships. It is also suggested that, for a big dataset, the impact of onD intermittency can be simply corrected by a correction factor while that of D and T intermittency cannot. The results of this study are helpful to develop the parameterization of turbulent exchange processes in the Taklimakan Desert, which is significant to improve the accuracy of weather forecasting and climate prediction. Significance Statement The Taklimakan Desert plays an important role in the evolution of weather and climate in East Asia. With strong surface thermal forcing, turbulence often shows distinctive intermittency, which largely constrains the evaluation of land–atmosphere exchange in this key climate region. This study aims to understand the characteristics of turbulence intermittency and its physical mechanisms, and further to correct the influence of turbulence intermittency on turbulent fluxes in the Taklimakan Desert. This is significant because the results are helpful to improve the parameterization of subgrid processes in the key climate region for atmospheric models, which points the way toward enhancing the accuracy of weather forecasting and climate prediction.

A Novel Similarity Approach for Describing the Bulk Shear in the Atmospheric Surface Layer

The Monin–Obukhov Similarity Theory (MOST) is a cornerstone of boundary layer meteorology and the basis of most parameterizations of the atmospheric surface layer. Due to its significance for observations and modelling, we generalize the dimensional analysis of MOST by considering the bulk gradient directly, enabling the study of any sublayer of the atmospheric surface layer. This results in a family of similarity relations describing all gradients from the local gradient to the full-layer bulk gradient. By applying the profiles derived from the law-of-the-wall and MOST, we are able to derive analytic expressions for this family of similarity relations. Under stable conditions, we discover that the log-linear profile of Businger–Dyer generalizes from the local to the bulk shear where the slope is dependent on the choice of the layer. The simplicity of the general log-linear relation allows for estimating the influence of stability on the non-dimensional gradients. It is shown that bulk gradients are less sensitive to stability than the local gradient. By correctly filtering cases where the full-layer bulk gradient is influenced by stability, we demonstrate that MOST is compatible with the Hockey-Stick Transition. For unstable conditions, the Kader and Yaglom (J Fluid Mech 212(151):637-662, 1990) model represents the local gradient well but was not successful in representing the bulk gradient, demonstrating the need for further analysis of scaling relations for the unstable atmospheric surface layer.