On average, one hundred people die each year under avalanche snow. Despite extensive global research on gas exchange in buried avalanche victims, it remains unclear how the diffusion of respiratory gases affects survival under avalanche snow. This study aims to determine how oxygen and carbon dioxide diffuse through snow, as well as through wet and dry perlite, which may serve as a surrogate for avalanche snow. A custom-made apparatus to study the diffusion of respiratory gases consisted of a plastic cylinder (1200 mm long, ID 300 mm) with 13 gas sampling needles evenly spaced along the axis of the cylinder filled with the tested material. Following 60 min of free diffusion, gas samples were analyzed using a vital signs monitor with a module for respiratory gas analysis (E-CAiOVX, Datex-Ohmeda, GE Healthcare, Chicago, IL, USA). A combination of 16% oxygen, 5% carbon dioxide, and 79% nitrogen was used. The rates of diffusion for both respiratory gases were comparable in snow and both forms of perlite. Oxygen propagated faster than carbon dioxide. Due to similar diffusion characteristics to snow, perlite possesses the potential to stand in as an effective substitute for soft snow for the study of respiratory dynamics, for conducting breathing experiments, and for testing avalanche safety equipment.