Similar Change Trend Research Articles

Investigating unfrozen water and its components during freeze–thaw action in loess using a novel NMR technique

AbstractFrost heave and thaw settlement are primarily caused by water migration. Variations in liquid water and its components during freezing and thawing are crucial variables for investigating water migration. Here, a novel soil layer‐scanning method based on magnetic resonance imaging cryogenic soil‐moisture analysis (MRI‐CSMA) was applied to measure dynamic changes of liquid water and its components in nine layers (each 11.1‐mm thick) of four loess samples with different initial water contents (9.2%, 15.7%, 20.0%, and 30.0%) in freezing–thawing experiments under a closed system. The ice–water phase transition and water migration were key factors that controlled the liquid water and its components. During freezing, the liquid water content of each layer (except layer 7) decreased. In the frozen zone (layers 1–6), the liquid water content decreased with decreasing temperature owing to the water–ice phase transition. The lower the temperature, the higher the fraction of water that transitioned to ice. In the unfrozen zone (layers 8–9), parts of the liquid water migrated upward owing to the suction generated at the freezing front. The farther away the freezing front, the smaller the suction and quantity of water migration. During thawing, the liquid water content of each layer increased owing to the ice–water phase transition in the frozen zone and infiltrated down to the unfrozen zone. The contents of the free and adsorbed water exhibited similar change trends to the liquid water content during freezing. However, the change degree of free water was much larger than that of adsorbed water because the phase transition and migration of free water is easier than that of absorbed water. Notably, the liquid water content near the freezing front (layer 7) increased in the early stage of freezing, owing to the combined effect of soil compression and the water–ice phase transition. These results provide a reference for research on water migration in the soil during freezing–thawing and validate the advantage of MRI‐CSMA when characterising water migration in large soil samples.Highlights A novel device (MRI Cryogenic Soil‐Moisture Analyzer) was used. Variations in unfrozen water and its components during freezing were studied. Soil consolidation and pore pressure affect the liquid water change during freezing.

Real-Time Water Level Prediction in Open Channel Water Transfer Projects Based on Time Series Similarity

Changes in the opening of gates in open channel water transfer projects will cause fluctuations in the water level and flow of adjacent open channels and thus bring great challenges for real-time water level prediction. In this paper, a novel slope-similar shape method is proposed for real-time water level prediction when the change of gate opening at the next moment is known. The water level data points of three consecutive moments constitute the query. The slope similarity is used to find the historical water level datasets with similar change trend to the query, and then the best slope similarity dataset is determined according to the similarity index and the gate opening change. The water level difference of the next moment of the best similar data point is the water level difference of the predicted moment, and thus the water level at the next moment can be obtained. A case study is performed with the Middle Route of the South-to-North Water Diversion Project of China. The results show that 87.5% of datasets with a water level variation of less than 0.06 m have an error less than 0.03 m, 71.4% of which have an error less than 0.02 m. In conclusion, the proposed method is feasible, effective, and interpretable, and the study provides valuable insights into the development of scheduling schemes.

Research on the Influence of Processing Parameters on the Specific Tensile Strength of FDM Additive Manufactured PET-G and PLA Materials.

Fused deposition modeling (FDM) is one of the most accessible additive manufacturing (AM) technologies for processing polymeric materials. It allows processing most of thermoplastic polymers, with polyethylene terephthalate glycol-modified (PET-G) and polylactic acid (PLA). AM parts tend to display anisotropic behavior because of layer-by-layer fabrication and various technological parameters that can be set for 3D print, so it is hard to predict and analyze how the manufactured parts would behave under load. This research presents results of classic tensile strength tests performed on 57 PET-G specimens and 57 PLA specimens manufactured with varying technological parameters such as: printing temperature, print orientation, layer height, and infill percentage. Afterward, a comparative analysis is performed, proposing specific tensile strength (STS) as a benchmark to determine how 3D printed parts strength is varying due to beforementioned parameters, eliminating bias induced by varying weight of specimens. The biggest relative increase of UTS and the biggest relative decrease of STS was noted for variable infill percentage (increasing infill—PLA: 37.27% UTS increase and 30.41% STS decrease; PET-G: 24.42% UTS increase and 37.69% STS decrease). The biggest relative increase of STS between examined parameters was observed for both materials as the printing temperature was increased (27.53% for PLA and 12.69% for PET-G). Similar trends in STS changes were observed for both materials. Obtained data shows which FDM AM parameters are the most important to obtain the biggest UTS of manufactured parts, and those do not overlap with parameters needed to obtain optimal strength-to-weight ratio.

Microwave Irradiation: Effects on the Change of Colour Characteristics and Main Phenolic Compounds of Cabernet Gernischt Dry Red Wine during Storage.

Wine colour is an essential organoleptic property considered by consumers. In this paper, the potential effects on colour characteristics and the content of main phenolic compounds in red wine under microwave irradiation were investigated during wine storage. The results showed that the changing trend of colour characteristics of microwave-treated and untreated wines was very similar. Moreover, total phenolic compounds, total monomeric anthocyanins, main anthocyanins, main flavonoids, and main phenolic acids (gallic acid; caffeic acid; syringic acid; (+)-catechin; Cy-3-glu; Mv-3-glu) also showed similar change trends during storage. In other words, microwave irradiation had a long-term effect on the colour properties and main phenolic compounds of red wine, changes that require long-time aging in traditional processing. In terms of the studied parameters, the changes in microwave-treated wine were faster than those in untreated wine. These results showed that microwave technology, as a promising artificial aging technology, could in a short time produce red wine of similar quality to traditional aging.

Screw Analysis, Modeling and Experiment on the Mechanics of Tibia Orthopedic with the Ilizarov External Fixator.

The Ilizarov external fixator plays an important role in the correction of complex malformed limbs. Our purpose in this work was to reveal the transmission of adjustable forces between the external fixator and the broken bone, and express the stress distribution at the end of the broken bone during the orthopedic treatment. Firstly, the screw model of the fixator was established and the theoretical relationship between the adjustable force and the stress was obtained. A sheep tibia was taken as a representative research object and its ediTable 3D entity was obtained by CT scanning. Then the mechanical model of the fixator and tibia was built using the ABAQUS software. Correction experiments were performed on the sheep tibia to measure the adjustable/support forces and tensions of the tibia. The measured results were imported to the screw and mechanical model, and the theoretical and simulation values were calculated. The theoretical tensions calculated by the screw model had a similar shape and doubled the value compared with that of the measured results. The transfer efficiency between the two results was improved and kept at about 50% after the initial 2~3 periods. The maximum stress occurring at the surface of the broken bone end was near the Kirschner wire pinhole. The simulation results for the tensions from the mechanical model showed a similar change trend, and the value was slightly higher. A biomechanical model of the Ilizarov external fixator was derived and verified through calculations, simulations and experiments. The change law of the adjustable forces and the tensions existing in the broken sheep tibias is presented herein, and offers a helpful contribution to orthopedic treatment.

An interval prediction method for quantifying the uncertainties of cooling load based on time classification

The uncertainties of cooling load significantly impact the operations performance of building energy systems. A novel interval prediction method is proposed to quantify the uncertainties of cooling load. Due to the cooling load having a similar changing trend from 1:00 to 24:00, a cooling load classification method based on the time of the day is proposed to analyze the uncertainty. Firstly, the gated recurrent unit algorithm is used to construct the point prediction model. Secondly, the kernel density estimation method is employed for probability statistics of prediction error. Moreover, the percentile method constructs the upper and lower bounds of the cooling load prediction interval with given confidence levels. Finally, a commonly used interval prediction method is compared to the proposed method, and a real cooling load dataset is used to assess the prediction method. The results demonstrate that the point prediction model has a mean absolute percentage error of 10.19% in the interval prediction dataset. The interval prediction results illustrate that the prediction interval coverage probability is 91.75%, and the prediction interval normalized average width is 20.83% in the confidence level of 90%. Compared with the commonly used method, the proposed method has a narrower interval.

Epigenetic Marks, DNA Damage Markers, or Both? The Impact of Desiccation and Accelerated Aging on Nucleobase Modifications in Plant Genomic DNA.

Modifications of DNA nucleobases are present in all forms of life. The purpose of these modifications in eukaryotic cells, however, is not always clear. Although the role of 5-methylcytosine (m5C) in epigenetic regulation and the maintenance of stability in plant genomes is becoming better understood, knowledge pertaining to the origin and function of oxidized nucleobases is still scarce. The formation of 5-hydroxymetylcytosine (hm5C) in plant genomes is especially debatable. DNA modifications, functioning as regulatory factors or serving as DNA injury markers, may have an effect on DNA structure and the interaction of genomic DNA with proteins. Thus, these modifications can influence plant development and adaptation to environmental stress. Here, for the first time, the changes in DNA global levels of m5C, hm5C, and 8-oxo-7,8-dihydroguanine (8-oxoG) measured by ELISA have been documented in recalcitrant embryonic axes subjected to desiccation and accelerated aging. We demonstrated that tissue desiccation induces a similar trend in changes in the global level of hm5C and 8-oxoG, which may suggest that they both originate from the activity of reactive oxygen species (ROS). Our study supports the premise that m5C can serve as a marker of plant tissue viability whereas oxidized nucleobases, although indicating a cellular redox state, cannot.

Cortical complexity and connectivity during isoflurane-induced general anesthesia: a rat study

Objective. The investigation of neurophysiologic mechanisms of anesthetic drug-induced loss of consciousness (LOC) by using the entropy, complexity, and information integration theories at the mesoscopic level has been a hot topic in recent years. However, systematic research is still lacking. Approach. We analyzed electrocorticography (ECoG) data recorded from nine rats during isoflurane-induced unconsciousness. To characterize the complexity and connectivity changes, we investigated ECoG power, symbolic dynamic-based entropy (i.e. permutation entropy (PE)), complexity (i.e. permutation Lempel-Ziv complexity (PLZC)), information integration (i.e. permutation cross mutual information (PCMI)), and PCMI-based cortical brain networks in the frontal, parietal, and occipital cortical regions. Main results. Firstly, LOC was accompanied by a raised power in the ECoG beta (12–30 Hz) but a decreased power in the high gamma (55–95 Hz) frequency band in all three brain regions. Secondly, PE and PLZC showed similar change trends in the lower frequency band (0.1–45 Hz), declining after LOC (p < 0.05) and increasing after recovery of consciousness (p < 0.001). Thirdly, intra-frontal and inter-frontal-parietal PCMI declined after LOC, in both lower (0.1–45 Hz) and higher frequency bands (55–95 Hz) (p < 0.001). Finally, the local network parameters of the nodal clustering coefficient and nodal efficiency in the frontal region decreased after LOC, in both the lower and higher frequency bands (p < 0.05). Moreover, global network parameters of the normalized average clustering coefficient and small world index increased slightly after LOC in the lower frequency band. However, this increase was not statistically significant. Significance. The PE, PLZC, PCMI and PCMI-based brain networks are effective metrics for qualifying the effects of isoflurane.

Effect of Helicobacter Pylori Eradication on Human Gastric Microbiota: A Systematic Review and Meta-Analysis.

Background Helicobacter pylori (H. pylori) infection is a major risk factor for gastric cancer and eradication of H. pylori is recommended as an effective gastric cancer prevention strategy. The infected individuals show microbial dysbiosis of gastric microbiota. In recent years, agrowing number of studies have focused on gastric microbiota changes following H. pylori eradication. In the present study, we aim to evaluate the influence of successful H. pylori eradication on the short-term and long-term alterations of human gastric microbiota using a method of systematic review and meta-analysis.MethodsWe did a systematic search based on three databases (PubMed, EMBASE, and Web of Science) in November 2021. Additional articles were also identified by reviewing references cited in the included papers. Human studies that reported changes in gastric microbiota following successful H. pylori eradication were enrolled. PROSPERO registration number: CRD42021293796.ResultsIn total, nine studies enrolling 546 participants were included. Regarding quadruple therapy, alpha diversity indexes increased within 1 month after eradication; significant differences in gastric microbial community structure between before and after eradication were also seen within 1 month. The trends of the above-mentioned diversity changes persisted with a follow-up of 6 months. The microbial composition altered significantly after eradication and the relative abundance of H. pylori-related taxa decreased. Accordingly, gastric commonly dominant commensals were enriched. Bioinformatic analyses of microbiota functions showed that bacteria reproduction-related pathways were down-regulated and pathways of gastric acid secretion, etc. were up-regulated. For triple therapy, similar trends of alpha diversity and beta diversity changes were observed in the short-term and long-term follow-up. Also, after eradication, H. pylori was not the gastric dominant bacteria and similar changes in gastric microbial composition were found. For gastric microbial interactions, a decrease in microbial interactions was seen after eradication. Additionally, regarding whether successful H. pylori eradication could restore gastric microbiota to uninfected status, the results remain controversial.ConclusionIn conclusion, successful H. pylori eradication could reverse the gastric microbiota dysbiosis and show beneficial effects on gastric microbiota. Our findings may provide new insight for exploring the role of H. pylori and the whole gastric microbiota in gastric carcinogenesis.

Neurovascular coupling analysis of working memory based on electroencephalography and functional near-infrared spectroscopy

Working memory is an important foundation for advanced cognitive function. The paper combines the spatiotemporal advantages of electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) to explore the neurovascular coupling mechanism of working memory. In the data analysis, the convolution matrix of time series of different trials in EEG data and hemodynamic response function (HRF) and the blood oxygen change matrix of fNIRS are extracted as the coupling characteristics. Then, canonical correlation analysis (CCA) is used to calculate the cross correlation between the two modal features. The results show that CCA algorithm can extract the similar change trend of related components between trials, and fNIRS activation of frontal pole region and dorsolateral prefrontal lobe are correlated with the delta, theta, and alpha rhythms of EEG data. This study reveals the mechanism of neurovascular coupling of working memory, and provides a new method for fusion of EEG data and fNIRS data.

On the influence of loading force on the vibration characteristics of a giant magnetostrictive transducer

The vibration characteristics of a giant magnetostrictive transducer play a significant role in the stability and processing effect of spinning ultrasonic machining. The output characterization of the giant magnetostrictive transducer is unstable subject to an powerful external load, which severely restricts the application of giant magnetostrictive transducer in industry. In this study, the effect of change of load force and electrical parameter in the different directions on the high-frequency (about 20 kHz) vibration output characteristics of the giant magnetostrictive transducer is investigated, through finite element analysis and static loading experimental. The result shows that the electrical parameter of a giant magnetostrictive transducer has a similar changing trend with the increasing of the axis and radial force load; The resonant frequency also increases with the increase of electrical parameter and load force; The amplitude attenuation of ultrasonic vibration will become extraordinary intense even almost to stop beat when the axis force load increase to 750 N and radial force load increase to 550 N; The gradient of resonant frequency in a radial direction is more significant than that in an axial direction. Based on the results of theoretical analysis and static loading experimental, the measures to reduce amplitude attenuation and improve output stability of amplitude under resonant frequency are proposed. The results can provide theoretical guidance for a magnetostrictive transducer used in the actual spinning ultrasonic vibration processings.

Enrichment of polystyrene microplastics induces histological damage, oxidative stress, Keap1-Nrf2 signaling pathway-related gene expression in loach juveniles (Paramisgurnus dabryanus)

Polystyrene microplastics (PS-MPs, particle size<5 mm) cause great harm to aquatic organisms. However, their precise effects are not completely understood. In China, placing plastic film at the pond bottom has become an important loach aquaculture mode. In this mode, MPs will affect loach health. This study investigated the enrichment of PS-MPs and its effects on the growth, liver histomorphology, antioxidant enzymes, and Keap1-Nrf2 signaling pathway-related gene expression in loach juveniles (Paramisgurnus dabryanus). The loach juveniles were raised at the concentration of 1000 μg/L fluorescent polystyrene microplastics (PS-MPs) with particle size of 0.5 µm or 5 µm for seven days, the results showed that fluorescent PS-MPs were found to be enriched in liver, intestine, and gill, and the enrichment amount was higher in liver than in gill and intestine (P < 0.05). Furthermore, the enrichment amount of different-sized PS-MPs was different in liver, gill, and intestine. The loach juveniles were cultured for 21 days in the water of the concentration of 100 or 1000 μg/L PS-MPs with particle size of 0.5 µm or 5 µm, the results showed that the survival rate, weight gain rate, and specific growth rate of loach juveniles were significantly reduced. The histological analysis revealed that PS-MPs caused liver damage. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX), and acetylcholinesterase (AChE) were decreased with the extended exposure to PS-MPs. Generally, the expressions of Nrf2 and Keap1 showed the similar change trend. From 7–14 day, the expression trend of oxidative stressed-related genes was not completely consistent with that of Nrf2 gene, but on day 21, the gene expression trend of oxidative stress-related SOD, CAT, and GSH-PX in the downstream of Keap1-Nrf2 signaling pathway was roughly consistent with that of Nrf2 gene. Basically, the change trends of these three gene expression were similar to those of their corresponding enzyme activities. This study provides theoretical basis for the toxicological effects of PS-MPs on freshwater fish.

Applying a Set of Potential Methods for the Integrated Assessment of the Marine Eco-Environmental Carrying Capacity in Coastal Areas

The accelerated socioeconomic development has placed the coastal ecosystems under stress, which influences the sustainable development of coastal areas. Marine eco-environmental carrying capacity assessment (MECCA) can provide a scientific basis for coordinating coastal socioeconomic development and eco-environmental protection, ensuring a more effective marine ecosystem-based management approach toward sustainability. However, accurate assessment methods are still in the exploratory stage, as there has been a lack of systematic research and applications combining integrated MECCA with a unified method to underpin coastal management processes. In light of this issue, this study applied the marine eco-environmental carrying capacity in coastal waters (MECCCW) conceptual framework to support the establishment of an assessment indicator system for MECCA and used the regularization method and entropy method to determine weights. This study also applied the simplified state space model to comprehensively evaluate and analyze the marine eco-environmental carrying capacity (MECC) of coastal areas. Focusing on the coastal area of Sanya Bay, southern China, as the study area, we assessed the MECC for the period from 2015 to 2020. The state of the MECC was divided into three grades: load capacity, full-load capacity, and overload capacity. The results showed that (1) the MECCA indicator system in Sanya Bay included a total of three criteria and eight assessment indicators and (2) the weights of the environmental carrying capacity (ECC) and human activities (HA) were both relatively higher than that of ecological resilience (ER). The latter result indicates that either ECC or HA could play a more predominant role in the changes of the MECC state in Sanya Bay. The results also indicated that (3) for each criterion, ECC, ER, and HA were at load capacity from 2015 to 2020. In this instance, ECC and HA presented similar change trends in relation to the MECC state of Sanya Bay. Finally, (4) the overall Sanya Bay’s MECC was also at load capacity and weakened, fluctuating between 2015 and 2020. These findings indicate that the coastal area of Sanya Bay is capable of sustainable development, but that there is a need for further eco-environmental improvement. The results of this study can serve as a reference when decisions have to be made about coastal management from an environmental and ecological perspective. Furthermore, this method may provide a feasible approach for integrated MECCA in other coastal areas.

Influence of Specific Structure on the Dielectric and Thermal Performance of Bulk Polymers: Atomistic Molecular Dynamics Simulations of XNBR

In this work, we investigate the influence of the molecular structure of carboxylated acrylonitrile-butadiene rubber (XNBR) on the dielectric properties through non-equilibrium molecular dynamics (NEMD) simulations. The NEMD simulations are performed for calculating the permittivity (ε) of XNBR under different alternating electric field strength (Ei), alternating electric field frequency (Ef), and temperature. The simulation results show a similar change trend with the reported experimental consequence of dielectric elastomer. Interestingly, a critical alternating Ei at which the dielectric properties of XNBR with different acrylonitrile contents change seriously is found. Moreover, a deep insight into the mechanisms of the dielectric and thermal performance of XNBR is explored through the analysis from the atomistic level, including intermolecular interaction, fractional free volume, molecular chain migration ability, hydrogen bonds breaking and re-formation, dipole autocorrelation function, phonon vibration power spectrum, and kinetic energy. The research results will inspire the design of polymer structures to obtain high-performance polymer materials. This article is protected by copyright. All rights reserved

Effect of Organoclay Addition on Rheological, Thermal, and Mechanical Properties of Nitrile Rubber/Phenolic Resin Blend.

In this study, the effects of NBR polarity and organoclay addition on the curing, rheological, mechanical, and thermal properties of an NBR/phenolic resin blend were investigated. The samples were prepared using a two-roll mill. The results showed that rheological and tensile properties improved due to the good distribution of nanoparticles, as well as the good compatibility of nitrile butadiene rubber with phenolic resin. The addition of 1.5 phr of nanoparticles to blends containing 33% and 45% acrylonitrile increased the curing torque difference by approximately 12% and 28%, respectively. In addition, the scorch time and curing time decreased in nanocomposites. Adding nanoparticles also increased the viscosity. The addition of phenolic resins and nanoparticles has a similar trend in modulus changes, and both of these factors increase the stiffness and, consequently, the elastic and viscous modulus of the specimens. Adding 1.5 phr of organoclay increased the tensile strength of the blends by around 8% and 13% in the samples with low and high content of acrylonitrile, respectively. Increasing the temperature of the tensile test led to a reduction in the tensile properties of the samples. Tensile strength, elongation at break, modulus, and hardness of the samples increased with increasing organoclay content. In addition, with increasing nanoparticle concentration, the samples underwent lower deterioration in tensile strength and Young’s modulus at different temperatures compared to the blends. In the samples containing 1.5 phr of organoclay, the thermal decomposition temperatures were enhanced by around 24 and 27 °C for low and high acrylonitrile content.

Electron emission induced by keV protons from tungsten surface at different temperatures

The electron emission yield is measured from the tungsten surface bombarded by the protons in an energy range of 50 keV–250 keV at different temperatures. In our experimental results, the total electron emission yield, which contains mainly the kinetic electron emission yield, has a very similar change trend to the electronic stopping power. At the same time, it is found that the ratio of total electron emission yield to electronic stopping power becomes smaller as the incident ion energy increases. The experimental result is explained by the ionization competition mechanism between electrons in different shells of the target atom. The explanation is verified by the opposite trends to the incident energy between the ionization cross section of M and outer shells.

Increasing soil organic carbon sequestration and yield stability by no‐tillage and straw‐returning in wheat–maize rotation

AbstractKnowledge about the changes in soil organic carbon (SOC) stocks and grain yields under different field management practices is necessary for achieving agricultural sustainability. An 8‐yr experiment for testing different tillage and straw management practices was conducted in a wheat (Triticum aestivum L.)–maize (Zea mays L.) rotation system in the southern Loess Plateau of China. Three tillage methods (control with no‐tillage and straw removal [CK], no‐tillage with straw stubbles 30–40 cm in height [NT], and rotary tillage with straw incorporation [RT]) were applied before maize planting, and two straw treatments (straw return [SR] and no straw return [SR0]) were applied after maize harvest. Over the 8 yr, SOC stocks exhibited similar dynamic changing trends in all treatments but were higher under NT, RT, and SR than under CK‐SR0. Compared with the initial soil, SOC stock increased the most (34.1%) in NT‐SR. Compared with the CK‐SR0, the NT‐SR, RT‐SR, CK‐SR, NT‐SR0, and RT‐SR0 increased wheat grain yields by 47.2, 36.8, 24.9, 25.1, and 20.0%, respectively. Similar trends were found for maize grain yields. The NT, RT, and SR increased crop yield stability with the highest sustainable yield index in NT‐SR for both wheat (.67) and maize (.70). Overall, the combination of no‐tillage with wheat straw stubbles 30–40 cm in height and maize straw return was the best strategy for improving SOC stocks, grain yields, and agricultural sustainability for grain production in dry, sub‐humid areas of northwestern China.

Changes in the parameters of intra-tumor and remotely located microvessels during the growth of glioblastoma implanted in the brain of rats.

The morphological method was used to study the structural characteristics of intracellular and remotely located microvessels during the growth of glioblastoma implanted in the right hemisphere of the rat brain. The studies were carried out for 6 hours to 18 days after the implantation of the tumor. An increase in the proportion (in %) of microvessels with a wide diameter was recorded both in the tumor itself and in remote areas of the tissue of both hemispheres of the brain. A similar trend of changes took place in the dynamics of microvascular areas on sections of the ear of rats that do not have a common blood circulation with the brain. The data obtained make it possible to justify the expediency of further identification of remote tests to assess the parameters of the tumor and the therapeutic measures being developed.&#x0D; Key words: glioblastoma, morphometry, diameter of microvessels.&#x0D;

Mechanical behavior and failure mechanisms of cylindrical and prismatic rock specimens under various confining stresses

Although cylindrical and prismatic specimens are often used in laboratory tests, the differences between their deformation and failure characteristics remain unclear. Cylindrical and prismatic specimens of two rocks (marble and granite) were analyzed under various conventional triaxial conditions. The failed prismatic specimens exhibit multiple fractures intersecting in the cross section. With increasing confining pressure, the failure mode of the prismatic specimen changes from tensile failure to shear failure. In the progressive failure process of prismatic specimens, the two lateral strains ε2 and ε3 are the same before the peak, but some differences arise after some degree of post-peak failure, where the acoustic emission (AE) activity clearly increases. The mechanical parameters (peak strength, internal friction angle, cohesion, Young's modulus, and Poisson's ratio) determined for the cylindrical and prismatic specimens are consistent. However, a significant difference in the fracture morphology exists among them, even with similar change trends in the tensile-shear failure mode with confining pressure.

Controlling Mesenchyme Tissue Remodeling via Spatial Arrangement of Mechanical Constraints.

Tissue morphogenetic remodeling plays an important role in tissue repair and homeostasis and is often governed by mechanical stresses. In this study, we integrated an in vitro mesenchymal tissue experimental model with a volumetric contraction-based computational model to investigate how geometrical designs of tissue mechanical constraints affect the tissue remodeling processes. Both experimental data and simulation results verified that the standing posts resisted the bulk contraction of the tissues, leading to tissue thinning around the posts as gap extension and inward remodeling at the edges as tissue compaction. We changed the geometrical designs for the engineered mesenchymal tissues with different shapes of posts arrangements (triangle vs. square), different side lengths (6 mm vs. 8 mm), and insertion of a center post. Both experimental data and simulation results showed similar trends of tissue morphological changes of significant increase of gap extension and deflection compaction with larger tissues. Additionally, insertion of center post changed the mechanical stress distribution within the tissues and stabilized the tissue remodeling. This experimental-computational integrated model can be considered as a promising initiative for future mechanistic understanding of the relationship between mechanical design and tissue remodeling, which could possibly provide design rationale for tissue stability and manufacturing.