Simarouba glauca is an evergreen floral tree plant that is endemic to Florida, Lesser Antilles, South America, and the United States. Bitterwood, dysentery barks, Laxmi Taru, and Paradise tree are common names. It produces edible oils from its seeds. Various tree sections are used to treat different ailments. The plant contains many essential phyto constituents of major pharmacological significance. The pharmacological review of SG has proven its medicinal value and has different therapeutic qualities such as analgesic, antimalarial, antimicrobial, antitumor, antiulcer, hypoglycaemic, insecticidal, stomachic, and vermifuge. Several medically active compounds have been found in the plant. A group of triterpenes called Quassinoids is by far the most active compound. Further research into these plants can be concluded that these new pharmacophores can be beneficial for the improvement of mankind’s health and also helps in combating several other disorders. The purpose of this paper is to showcase the pharmacological importance of Simarouba glauca and it can provide a good forum for future researchers to carry out numerous studies on this particular plant species