Background and Objectives: Appendiceal stump closure during laparoscopic appendectomy (LA) is an important step. This study was an attempt to evaluate the ease of use and safety of titanium clips compared to Roeder's knot in the appendiceal stump closure in patients undergoing LA by comparing complications (intraoperative and postoperative), hospital stay, and follow-up period. Materials and Methods: This 1-year randomized controlled trial was done in under the Department of General Surgery, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum from January 2014 to December 2014. A total of 60 patients were divided into two groups of 30 each that is, Group R (Roeder's knot using silk suture and Group T (titanium clips). Results: In this study 53.33% of the patients in Group R were females as compared to 36.67% in Group T ( P = 0.795). The mean age in Group R was 29.77 ± 11.24 years and in Group T, it was 29.53 ± 8.96 ( P = 0.929). Other preoperative characteristics of the study population in Group R and T were comparable ( P > 0.050). Significantly higher number of patients (60%) in Group T required lower operative time (45–60 min) compared to Group R (83.33% patients required 61–75 min P P P P = 0.177), postoperative complications ( P = 0.303), and follow-up period in both the groups were comparable ( P > 0.050). Conclusion and Interpretation: Appendiceal stump closure with titanium clips is advantageous in terms of operative time, pressure gradient, and offers early resumption of daily activities.