Presence Of Silica Nanoparticles Research Articles

Enhanced performance of polyurethane foam with presence of silica nanoparticles

Polyurethane foam (PUF) has been widely used in wastewater treatment, and developing such foam with improved stability is highly desirable in industry. In this study, nanocomposite foam with silica nanoparticles was developed, aiming at enhancing the thermal, chemical, and biological stability of material. FT-IR, TEM and TGA techniques were employed to study the performance of nanocomposite foam. The results showed that when the SiO2 nanoparticles were modified by KH550 with an optimized molar ratio, the dispersion of these nanoparticles was enhanced significantly, and the developed nanocomposite foam showed much enhanced thermal stability and marginal weight loss in various chemicals. The nanocomposite foam with 3.0 wt% of nanoparticles exhibited the most significantly biochemical stability.

Phase Equilibria of Clathrate Hydrates of Ethane in the Presence of Silica Nanoparticles and Tetrahydrofuran Aqueous Solution

Phase Equilibria of Clathrate Hydrates of Ethane in the Presence of Silica Nanoparticles and Tetrahydrofuran Aqueous Solution

Multiple Hydrogen Bonding-Assisted High-Strength Hydrogel of Silica/Polyacrylamide Nanocomposite Cross-Linked with Polyethylenimine.

The nanocomposite gel system has been successfully applied as a water shutoff agent to enhance oil recovery (EOR) or for plugging to control lost circulation events. In this study, the silica/polyacrylamide nanocomposite was synthesized via in situ free radical polymerization of acrylamide (AM) monomers in the presence of silica nanoparticles. The composite was cross-linked with polyethylenimine to prepare a high-strength hydrogel. The viscosity test was conducted to determine the gelation time of the gel. Rheological measurements and sand pack breakthrough pressure tests were carried out to measure the gel strength. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) and scanning electron microscopy (SEM) tests were adopted to characterize the structure and morphology of the gel. The results show that compared to polyacrylamide (PAM) gel, the gelation time of the nanocomposite gel will decrease with increasing gel elasticity modulus, and the breakthrough pressure of the nanocomposite gel is 29.82 MPa, which increased by 65%. As shown in the ATR-FTIR test, this can be attributed to the presence of multiple hydrogen bonds for the PAM molecule with both silica and quartz sand particles. In the composite gel, hydrogen bonding mainly forms between the O atoms of PAM and the H atom on the surface of silica, enhancing gel strength and elasticity modulus with more cross-linking density and less porosity. Moreover, H bonding between additional -NH2 of PAM and quartz sand particles helps improve gel plugging pressure. However, in the silica and PAM mixture gel, the H bonding of silica occupies -NH2 of PAM, which became unavailable to attach on the sand surface, reducing the breakthrough pressure by 30%, although it can enhance the rheological strength. This study suggests that in situ composite of silica in PAM can not only greatly improve gel rheological strength but also help maintain the strong adhesion of PAM molecules onto quartz sand, resulting in better plugging performance in the sand reservoir.

Synergistic Effect of Low Salinity Surfactant Nanofluid on the Interfacial Tension of Oil–Water Systems, Wettability Alteration, and Surfactant Adsorption on the Quartz Surface

Interfacial tension (IFT) and wettability are the two major factors influencing oil recovery. The synergistic effect of low salinity water (LSW) with chemical agents such as surfactants, alkalis, and polymer is an emerging technology for enhanced oil recovery (EOR). Recently, the use of nanoparticles for EOR has become the attractive option. This study examines the impact of low salinity surfactant–silica nanofluid (LSS–SNF) on interfacial tension (IFT) and wettability alteration in an oil–water–quartz system using various types of oils, viz., n-heptane, n-decane, benzene, toluene, model oil A, model oil B, and crude oil. Besides, the adsorption of surfactants on the quartz substrate in the presence of silica nanoparticles is also studied. A quartz substrate is particularly chosen to mimic the sandstone formation. It has been observed that the type of oil has a crucial role in the IFT behavior, and different trends have been observed for model oil A and model oil B in the presence of LSS–SNF. Also, a prominent wettability shift is observed on the quartz substrate for the acidic (model oil A) than the other oil employed. Further, the adsorption studies using an ultraviolet–visible (UV–vis) spectrometer confirm the reduction in surfactant adsorption with an increase in silica nanoparticle concentration. The adsorption of surfactants is also confirmed using scanning electron microscopy (SEM) and energy-dispersive X-ray analysis (EDXA), and the order of adsorption is identical to the Freundlich adsorption isotherm. The outcomes of this study will help us understand the application of silica nanofluid in EOR operation.

Promotion of protein assembly by nanoparticles: From in vitro to in-cell.

Engineered nanomaterials are increasingly being studied for biomedical applications such as in diagnosis and therapeutics, due to their similarity in size to subcellular scales, and their tunable physico-chemical properties. Nanomaterials acquire a biomolecular corona upon introduction to biological media, which can influence their biological identity and subsequently, their interactions within the cell. Nanoparticle-protein interactions at the nano-bio interface also affect proteins in the corona, leading to biological transformations such as a change in protein function, unmasking new epitopes, and fibrilization. Silica nanoparticles - one of the most widely studied nanomaterials in biomedical applications - were reported to show a dose-dependent or surface ligand-dependent effect on the kinetics and morphology of protein self-assembly in systems like amyloid-β fibrils, α-synuclein and lysozyme. The interaction of silica nanoparticles with polymerizing cytoskeletal proteins, specifically tubulin proteins, has not been investigated quantitatively. BtubA and BtubB are a pair of bacterial tubulin proteins identified in Prosthecobacter strains, acquired by bacteria from eukaryotic cells via horizontal gene transfer. BtubAB dimers are known to self-assemble like eukaryotic tubulin, forming four-stranded microtubules in vitro as well as five-stranded microtubules in vivo. FRET-labeling of each of the Btub monomers with a donor (mEGFP) and acceptor (mRuby3) fluorescent protein provides a quantitative tool to measure the binding interactions of BtubAB dimers in the presence of silica nanoparticles in vitro and in cell using fluorescence spectroscopy and microscopy. We show that silica nanoparticles enhance BtubAB dimerization in vitro, whereas they appear to have little effect on bacterial tubulin self-assembly in the complex mammalian cellular environment.

An experimental evaluation of polyamide membrane-silica nanoparticles for the concentration of pomegranate juice

Membrane processes are used in the food and nutrient industry in terms of their proper performance and selective separation. Using the membranes in fruit juice concentrating operations improves its quality via shelf-life increases. The advantage of reverse osmosis (RO) and membrane technology over other methods is its non-chemical reaction to fruit juice which increases the concentration of fruit juice. The membranes were made of three layers of non-woven polyester layer for the mechanical strength of the membrane, polyester sulfone polymer with polyamide consisting of polymerization of M-Phenylenediamine (MPD) and benzene tricarbonyl chloride. Trimethyl chloride (TMC) was used to modify the properties of the membrane in the second layer using silica nanoparticles. The feed was sugar-free pomegranate juice added by SUNICH Company with an initial Brix value of 14.9% and an input feed of 6.6% to the RO system. The DESIGN-EXPERT method for the design of experiments (DOE) by considering three parameters of weight percentage of polyester sulfone polymer (12, 16, and 20%), silica nanoparticles (0, 0.1, and 0.2 wt%), and operating pressure were used (20, 25, and 30 times). Under optimal conditions, 46.15% of the concentrated pomegranate juice were obtained by experiment and the amount of brix increased from 33.24% to 47.21%. Scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR), and contact angle tests for membranes were used. In the analysis of contact angle by examining the degree of hydrophilicity and contact angle of water droplets, it was found that the presence of silica nanoparticles and polyamide layer caused more hydrophilicity of membranes. It can be concluded that the pressure parameter, together with the presence of nanoparticles and polymer percentages, contribute to the most successful procedure of concentrating pomegranate juice.

Environmental impact assessment of nanofluids containing mixtures of surfactants and silica nanoparticles

Due to widespread use of nanoparticles in surfactant-based formulations, their release into the environment and wastewater is unavoidable and toxic for biota and/or wastewater treatment processes. Because of concerns over the environmental impacts of nanofluids, studies of the fate and environmental impacts, hazards, and toxicities of nanoparticles are beginning. However, interactions between nanoparticles and surfactants and the biodegradability of these mixtures have been little studied until now. In this work, the environmental impacts of nanofluids containing mixtures of surfactants and silica nanoparticles were valuated. The systems studied were hydrophilic silica nanoparticles (sizes 7 and 12 nm), a nonionic surfactant (alkyl polyglucoside), an anionic surfactant (ether carboxylic acid), and mixtures of them. The ultimate aerobic biodegradation and the interfacial and adsorption properties of surfactants, nanoparticles, and mixtures during biodegradation were also evaluated. Ultimate biodegradation was studied below and above the CMCs of the individual surfactants. The interfacial and adsorption properties of surfactant solutions containing nanoparticles were influenced by the addition of silica particles. It was determined that silica nanoparticles reduced the capability of the nonionic surfactant alkyl polyglucoside to decrease the surface tension. Thus, silica NPs promoted a considerable increase in the surfactant CMC, whereas the effect was opposite in the case of the anionic surfactant ether carboxylic acid. Increasing concentrations of surfactant and nanoparticles in the test medium caused decreases in the maximum levels of mineralization reached for both types of surfactants. The presence of silica nanoparticles in the medium reduced the biodegradability of binary mixtures containing nonionic and anionic surfactants, and this effect was more pronounced for larger nanoparticles. These results could be useful in modelling the behaviour of nanofluids in aquatic environments and in selecting appropriate nanofluids containing nanoparticles and surfactants with low environmental impact.Graphical abstract

Mineralogy of tricalcium aluminate hydration with silica nanoparticles

Formation of siliceous-hydrogarnet (Si-hydrogarnet) and stability of katoite (C3AH6) in tricalcium aluminate (C3A) system in presence of silica nanoparticles (n-SiO2) have been examined in the present study. C3A hydration in presence of n-SiO2 upto 24 h show retardation in hydration due to the surface coverage of C3A grain through calcium-silicate-hydrate (C-S-H)/calcium-alumino-silicate-hydrate (C-A-S-H) (previous study). However, in the present investigation, hydration was studied upto 10 days using QXRD, TGA, FTIR, FESEM, EDS and Mapping and 29Si NMR techniques. QXRD results show that in case of control samples, the katoite content increases from 61 to 73%, while in n-SiO2 incorporated C3A samples, it decreases from 28 to 15% as the hydration proceeds showing katoite phase destabilization in presence of n-SiO2. Further, FTIR results show symmetric stretching vibration of Si-O-Si at ∼784 cm−1 and ∼818 cm−1, while asymmetric stretching vibration of Si–O–Si/Si-O-Al at ∼1028 cm−1 indicating the formation of C-S-H/C-A-S-H and Si-hydrogarnet in presence of n-SiO2. In 29Si NMR results, Q2u peak at −89 ppm confirm the formation of Si-hydrogarnet at 10 days of hydration. The present study is important from performance and durability point of view as formation of C-A-S-H and Si-hydrogarnet can act as an aluminum reservoir, which may prevent severe chloride and sulphate attack.

Kinetics of Methane Hydrate Formation in the Presence of Silica Nanoparticles and Cetyltrimethylammonium Bromide

AbstractHydrate technology promoted the development of natural gas industry. Nanoparticles showed a broad prospect for hydrate technology because of their excellent mass and heat transfer characteristics. At an experimental temperature of 275.15 K and pressure of 5 MPa, silica nanoparticles and cetyltrimethylammonium bromide (CTAB) were used to investigate the characteristics (pressure drop, gas storage capacity, and formation rate). The experimental results showed that the higher the concentration of silica nanofluid, the shorter the induction time. Among the four silica nanoparticles concentration (0.1, 0.2, 0.3, and 0.5 wt%) tested in this work, the concentration of 0.3 wt% was optimal for the enhancement of CH4 hydrate formation. In the complex system composed of silica nanoparticles and CTAB, the surface of silica nanoparticles was positively charged by hydrolysis. The cationic active groups ionized by surfactants were aggregated to the surface of the particles under the Coulomb force. Methane molecules were gathered to hydrophobic groups by non‐polar adsorption, which was more conducive to hydrate formation. Compared to silica nanofluid, the total time for hydrate formation decreased by 66.2 %.

The impact of salinity, alkalinity and nanoparticle concentration on zeta-potential of sand minerals and their implication on sand production

The effect of brine salinity, cation type, pH, and produced sand on zeta potential (ZP) measurements with and without the presence of silica nanoparticles is investigated through pH measurement, static tests for sand and ZP measurements as well as Field Emission Scanning Electron Microscope (FESEM) analyses. Three important factors were investigated: composition of the injected brine, surface charge and pH. Their influence on stability of nanoparticles in the injected brine and amount of sand segregation was determined and the analysis of the new outcomes based on rock/brine ZP measurements was reported. The results show that the use of silica nanoparticles with high pH helps in preventing sand production and that pH has a main effect on the surface charge of the sand particle released, affecting the ZP of the solution. Nanoparticles can be active as a coating on sand grains and prevent sand segregation during water flooding. Divalent cations have been found to acquire a more substantial impact on neutralizing the negative charge of the sand particles than monovalent cations at the same concentration and pH conditions at 25 ℃. The value of ZP becomes of higher negative value with the decrease of brine salinity. The effectiveness of SiO2 nanoparticles is quite different for soft water and smart water. For soft water, the nanoparticles work more effective at pH higher than 8; and for smart water, the nanoparticles perform better at pH lower than 8. To reduce sand production with the use of silica nanoparticles, it is highly suggested to increase pH, as pH and sand production mechanisms were observed to be inversely related.

Experimental Investigation of the Effect of Silica Nanoparticles on Interfacial Tension and Wettability during Low Salinity Water Flooding: A Micromodel Study

Objective The present paper investigates the effect of nanoparticle concentrations on the interfacial tension and wettability during the low salinity water flooding (LSWF) at microscale. Method A wide range of LSW concentrations were prepared and investigated for their ability to modulate the interfacial tension with crude oil. The impact of salinity on the fluid-rock interactions was studied through contact angle measurements on water-wet, intermediate-wet and oil-wet glass substrates. Nanofluid systems at a fixed concentration of 0.1wt% were prepared by mixing the hydrophilic silica NPs with a wide range of LSW concentrations. Likewise, the impact of silica nanoparticles on the IFT was investigated. Results The fluids interactions results suggest that the lowest IFT value can be achieved at 5000ppm. Contact angle studies in all wettability systems indicated a negligible effect of water salinity on the wettability alteration. However, the presence of silica nanoparticles in low saline water significantly reduced the values of IFT and contact angle. Consequently, the wettability was altered to a more water-wet condition. Conclusion Oil displacement experiments in both water-wet, intermediate-wet and oil-wet glass micromodels indicated that LSW-augmented functional silica nanoparticles can offer enormous potential for improving oil recovery. A synergistic effect of LSW and the adsorption of nanoparticles at the interfaces appears to explain the improved oil sweep efficiency.

Effect of protein adsorption on the dissolution kinetics of silica nanoparticles

Nanoparticulate systems in the presence of proteins are highly relevant for various biomedical applications such as photo-thermal therapy and targeted drug delivery. These involve a complex interplay between the charge state of nanoparticles and protein, the resulting protein conformation, adsorption equilibrium and adsorption kinetics, as well as particle dissolution. SiO2 is a common constituent of bioactive glasses used in biomedical applications. In this context, the dissolution behavior of silica particles in the presence of a model protein, bovine serum albumin (BSA), at physiologically relevant pH conditions was studied. Sedimentation analysis using an analytical ultracentrifuge showed that BSA in the supernatant solution is not affected by the presence of silica nanoparticles. However, zeta potential measurements revealed that the presence of the protein alters the particles’ charge state. Adsorption and dissolution studies demonstrated that the presence of the protein significantly enhances the dissolution kinetics via interactions of positively charged amino acids in the protein with the negative silica surface and interaction of BSA with dissolved silicate species. Our study provides comprehensive insights into the complex interactions between proteins and oxide nanoparticles and establishes a reliable protocol paving the way for future investigations in more complex systems involving biological solutions as well as bioactive materials.

Size effect and mucus role on the intestinal toxicity of the E551 food additive and engineered silica nanoparticles

The E551 food additive is composed of synthetic amorphous silica particles. The current regulation does not mention any specifications regarding their size and granulometric distribution, thus allowing the presence of silica nanoparticles despite their potential toxicity. The digestion process could modify their physicochemical properties and then influence their toxicological profile. After physicochemical characterization, subacute toxicity of engineered silica nanoparticles from 20 to 200 nm, native and digested E551 additives were evaluated from in vitro models of the intestinal barrier. Single cultures and a co-culture of enterocytes and mucus-secreting cells were established to investigate the mucus role. Toxicological endpoints including cytotoxicity, ROS production, intestinal permeability increase, and actin filament disruption were addressed after a 7-day exposure. The results showed a size-dependent effect of silica nanoparticles on cytotoxicity and intestinal permeability. A time-dependent disruption of actin filaments was observed in Caco-2 cells. The mucus layer spread on the HT29-MTX single culture acted as an efficient protective barrier while in the co-culture, small nanoparticles were able to cross it to reach the cells. From a hydrodynamic diameter of 70 nm, nanoparticles were not internalized in the intestinal cells, even in mucus-free models. Digestion did not affect the physicochemical properties of the additive. Due to a mean hydrodynamic diameter close to 200 nm, both native and digested E551 additives did not induce any toxic effect in intestinal barrier models. This study emphasized a cutoff size of 70 nm from which the interactions of the E551 additive with intestinal cells would be limited.

An experimental study of the combination of smart water and silica nanoparticles to improve the recovery of asphaltenic oil from carbonate reservoirs

Within recent decades, smart water (SW) injection has become an attractive approach to improve oil recovery from conventional oil reservoirs. However, less attention has been devoted to the application of this method to asphaltenic oil reservoirs. This study aims to evaluate the performance of the injection of SW + silica nanoparticles (SNPs) in improving oil recovery from such reservoirs. To this end, an extended series of measurements were conducted, including of oil-water interfacial tension (IFT), wettability, emulsion formation/stability, and core flooding tests. After the introduction of SNPs to formation brine (FB) and SW solutions, oil-water IFT was reduced by 17.5% and 52.5% respectively compared to their corresponding initial values. In addition, the SW + SNP solution could improve the wettability of the rock surface compared to FB + SNPs. Interestingly, we found that, due to its high asphaltene content, the crude oil used forms sludge in contact with FB, which will impose serious operational problems and production costs associated with the system. However, we observe that the presence of SNPs restrains sludge formation by breaking down asphaltene molecules as well as destabilizing oil-water emulsions. This is demonstrated by several centrifuge tests conducted to evaluate emulsion stability in the presence of FB + SNP and SW + SNP solutions. SARA analyses were also performed on the oil produced from core plugs after the injection of SW and SW + SNPs to better understand the role of SNPs in the deposition of complex structures like asphaltenes and resins groups in crude oil. • The performance of smart water + silica nanoparticles in IFT reduction and wettability alteration. • Crude oil-water emulsion stability in the presence of silica nanoparticles. • Application of SARA analyses to study asphaltene precipitation during core flooding tests. • Micrograph studies for emulsion stability in the presence of various aqueous solutions.

Retrofitting of Reinforced Concrete Beams using Lightweight RC Jacket Containing Silica Nano Particles and Glass Fiber

The concrete jacket method is a common method used in retrofitting buildings. Although this method has many advantages, engineers criticize it due to an increase in the structure's weight. In the present study, lightweight concretes containing silica nanoparticles (SNPs) and glass fibers (GF) have been used in concrete jackets to strengthen concrete beams. Several reinforced concrete (RC) beams were constructed and retrofitted using the proposed lightweight concrete jackets and their response to four-point loading was evaluated. The SNPs amount in the lightweight concrete jackets was 0, 2, 4, and 6% by weight of cement and the amount of GF was 1.5% by volume of concrete. Load-deflection curves were extracted and the response of the beams was examined by parameters such as crack load, yield load, maximum load, energy absorption capacity, and ductility. The proposed lightweight concrete jacket containing 1.5% of GFs in which 0, 2, 4, and 6% of SNPs were used, increased the energy absorption capacity by 33%, 54%, 61%, and 62%, respectively. The presence of SNPs in lightweight concrete reinforced by GFs leads to the filling of small cavities in the concrete. Also, the bearing capacity of the retrofitted RC beams increased with an increase in SNPs in the concrete jacket. A portion of this increase can be attributed to an increase in tensile and compressive strength of the proposed concrete, and the other part can be attributed to the effect of SNPs on the surrounding surfaces of the main beam and jacket.

Analysis of asphaltene nano-aggregates formation using dynamic light scattering: Experimental and kinetic modeling

In this study, the kinetics of the aggregate behavior of asphaltene particles in a very dilute concentration range of 6.25-50 mg/L in toluene was investigated using the dynamic light scattering (DLS) technique. Then, the kinetics of asphaltene aggregation was analyzed by a proposed model based on the mass action law concept. Also, the presence of silica nanoparticles, SiO2-NPs, was investigated for the analysis of asphaltene aggregation behavior. The DLS results showed that by selecting the optimum sonication time of 6 min, asphaltene monomers (1 nm) at concentrations of 6.25, 12.5, and 25 mg/L did not incline to form asphaltene nano-aggregates over time. However, at a concentration of 50 mg/L, at the initial moments, the asphaltene particles began to form large clusters and clots. The results obtained by model optimization showed good agreement with experimental data with acceptable accuracy and mean absolute percentage errors of 10.41% and 5.21% for concentrations of 6.25 and 12.5 mg/L, respectively. Also, the results showed that in the mixing ratios of and of asphaltene concentration to the concentration of nanofluid, SiO2-NPs were placed between the polar particles of asphaltene and created a new structure in the colloidal solution that prevented the self-association of asphaltene molecules and increased the kinetic stability of the asphaltene particles.

Structure-properties relation in thermoplastic polymer/silica nanocomposites in presence of stearic acid as modifier agent

In the present study, several polypropylene/silica nanocomposites (PP/SiO2), containing 3 and 5 wt.% of untreated silica nanoparticles in presence of stearic acid (SA) as modifier agent, were prepared by melt mixing. Various analyses were used to characterize the dispersion and the properties of nanocomposites. Mechanical properties were found to increase and to be mainly affected by the content of silica and modifier agent. For the tensile modulus and yield point, a maximum was observed, corresponding to the samples in presence of 1% SA. In addition, an improvement in thermal stability and impact strength was obtained.

Surface tension behavior of anionic surfactants in the presence of silica nanoparticles

Surface tension behavior of anionic surfactants in the presence of silica nanoparticles

Nanostructural Evolution of Natural Rubber/Silica Nanoparticle Coagulation from Binary Colloidal Suspensions to Composites: Implications for Tire Materials

The liquid mixing process is an advantageous production method which has recently gained industrial interest for elaborating composites based on natural rubber (NR) and filler nanoparticles (NPs). Understanding how the relevant components such as polymer, fillers, as well as proteins and lipids coming from NR organize along the fabrication process is of importance for modulating material properties. Here, we successfully employed a combination of nano-imaging techniques to unravel the structure and evolution of hetero-aggregates formed by colloidal destabilization of a model NR latex - silica NPs liquid mixing process. First, field emission scanning electron microscopy (FESEM) was used to investigate the structures, from the early stage of contact between the particles until the formation of a composite. Results highlight an interaction in the liquid state between NR globules contained within the latex and silica NPs, hindering coalescence among globules. The latter can be achieved by applying shear in suspension or by solvent evaporation obtaining a dried composite. Atomic force microscopy coupled to infrared spectroscopy (AFM-IR) was employed to probe the in-depth nanoscopic distribution of silica NPs revealing a restricted mobility of the NPs during evaporation. Ultimately, the spatial distribution of proteins and lipids of NR, with respect to silica NPs, was investigated using dual color fluorescence images acquired with direct stochastic optical reconstruction microscopy (d-STORM) in a correlative light electron microscopy (CLEM) approach. The presence of silica NPs is found to influence the distribution of proteins and lipids in the composite; biomolecules form clusters of ~200 nm, which are partially colocalized with silica, highlighting an interaction between them. Our work provides comprehensive structural understanding of a model system undergoing liquid mixing, unlocking the potential of combining high-resolution imaging techniques to elucidate the structure of materials for tire applications.

Biodegradable cellulose-based superabsorbent as potent hemostatic agent

This study aims to engineer a novel developed superabsorbent (NDS) as potent hemostatic agent. NDS induces coagulation process due to the high adhesion affinity to the wet tissue, high swelling ratio and clotting potency. NDS controls massive bleedings by inducing the red blood cells accumulation, platelets aggregation and fibrin network formation at the site of bleeding. • NDS acts as brilliant superabsorbent that absorb 60 g of blood per one g of NDS. • NDS as a powerful hemostatic agents activated coagulation cascade process. • Biochemical, hematological, and pathological results didn’t show toxic effects. Engineering of effective and biocompatible hemostatic materials to control massive bleeding is one of the interesting research fields. Herein, cellulose-based polymer modified by silica aerogel and calcium chloride was used for suitable control of bleeding. Novel developed superabsorbent (NDS) was synthesized by chemical and physical cross-linking methods. NDS not only quickly absorbs a high amount of blood component (60 g/g), but it can also adhere strongly (~90 KPa) to damaged tissue. The contributions of the freeze-drying method and presence of silica aerogel as structural modifiers led to the creation of a superabsorbent with a porosity percentage of 70% which creates a significant ability to absorb blood cells. NDS negative surface charge and presence of silica nanoparticles and calcium ions accelerate activation of the coagulation cascade process. Superior hemostatic ability of NDS compared to commercial hemostatic powder (Gelita-Cel® and Traumastem®) was proved by complementary tests such as blood absorption content, RBC attachment, blood clotting index (BCI), platelet adhesion, clotting time test and partial thromboplastin time (PTT). In vivo study results demonstrate that the NDS could successfully decrease bleeding time and blood loss amount in Wistar rat’s cut-out femoral artery, 2.25 and 4.3 fold better than Gelita-Cel® and 2.13 and 4.4 fold better than Traumastem®. NDS biodegradability was proved by its implantation inside the Wistar rat's body during 14 days. Biochemical, hematological, and pathological tests did not show inflammation and toxic effects in the liver and renal tissues, skin tissues, and alteration in complete blood count parameters (CBC) in NDS treated Wistar rats. In conclusion, the cellulose-based NDS hemostatic biomaterial is suggested for future clinical trial studies due to its powerful ability in bleeding control.