Background: Thromboangiitis Obliterans (TAO), commonly Buerger’s disease, is associated with high risk of adverse outcomes, particularly higher amputation rate despite all the effort. The role of endovascular therapy (EVT) in TAO has been questioned owing to the technically challenging distal distribution of lesions and high rate of restenosis. Methods: Among 765 consecutive patients (pts) with significant peripheral artery disease (PAD) who underwent endovascular therapy (EVT) from Jan 2004 to June 2016, we identified 25 patients diagnosed as TAO with critical limb ischemia (CLI) who underwent EVT . Various clinical, coronary and peripheral angiographic characteristics and 5-year clinical outcomes were examined. Results: The prevalence of TAO among PAD pts undergoing EVT was 3.27% (23 males; 3.86% and 1.18% among total male and female, respectively). The mean age was 48.6 ± 16.8 (SD) and 23 (92%) had a history of smoking. Pts commonly presented with lower limb wounds, gangrene, claudication, diabetic foot and resting pain in deceasing order [N(%): 15(60), 11(44), 9(36), 5(20) and 1(4)], with 77.4% of limbs higher than Rutherford grade 2. A total 25 pts, 31 limbs and 81 lesions were treated with stent or balloon angioplasty [24 (29.6%) and 53 (65.4%) lesions, respectively], achieving clinical success in 73 (90.1%) lesions. Over half lesions were chronic total occlusions (56, 69.1%) and distributed peripherally (Table). Although nearly half patients underwent repeated procedures, limb salvage was achieved in most patients after 5 years. Conclusion: TAO is known for its poor prognosis in terms of limb salvage and peripherally located lower extremity lesions which are technically difficult to approach. Our experience with 25 patients with 81 lesions show promising long-term limb salvage outcomes following repetitive EVT with optimal medical therapy.