Signs Of Hyperandrogenism Research Articles

Evaluation of serum anti-nuclear antibody among women with PCOS: a hospital based single center cross sectional study

Polycystic ovary syndrome (PCOS), a major endocrinopathy is associated with barrage of metabolic aberrations. Reports in literature on association of PCOS and autoimmunity are conflicting. We aim to evaluate serum levels of anti-nuclear antibody (ANA) among Indian women with PCOS. In this hospital-based single center cross-sectional study, women qualifying a diagnosis of PCOS by Rotterdam criteria 2003 were recruited. Eighty-nine eligible women who consented were enrolled. All these women along with 87 age-matched, healthy controls underwent, clinical (menstrual history, anthropometry, hirsutism scoring), biochemical, hormonal assessment and serum ANA estimation. OGTT after overnight (8–12 h) fast with 75 g oral glucose load was done for 1 h, 2 h glucose and insulin measurements. The mean age of cases and controls was comparable (22.67 ± 5.53 vs. 22.84 ± 3.64 years). The prevalence of ANA positivity was significantly higher among women with PCOS (18.4% vs. 2.29%; p < .001). Though significant correlation was observed between ANA positivity and clinical signs of hyperandrogenism and plasma glucose, no significant correlation was noted between ANA status and other hormonal parameters. Higher prevalence of ANA positivity among women with PCOS, being a marker of autoimmunity, suggests a possible role of autoimmunity in causation of PCOS and needs further elucidation.

LHCG receptor polymorphisms in PCOS patients

ABSTRACTPolycystic ovarian syndrome (PCOS) is a common heterogeneous disorder characterized by multiple clinical features including chronic anovulation, infertility, polycystic ovaries and hyperandrogenic signs. Heredity is an important factor for the development of PCOS, but the search for the specific PCOS related genes is still in progress. Neuroendocrine dysregulation might play a crucial role in the PCOS development, thus the hypothalamic–pituitary secretion as well as gonadotropin receptor changes are important target of research. Two single nucleotide polymorphisms, rs12470652 c.872A>G/p.Asn291Ser and rs2293275 c.935G>A/p.Ser312Asn, in the Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) gene were studied in healthy Bulgarian women and PCOS patients. The prevalence of both polymorphisms was within the expected ranges for Caucasians and did not differ between the two groups. The heterozygous rs2293275 c.935G>A/p.Ser312Asn PCOS carriers reported infertility more often than both homozygous groups (40% vs. 12.5%, p = 0.022). The same polymorphism was associated with insulin levels in obese PCOS women. The obtained results showed that the rs2293275 c.935G>A/p.Ser312Asn genetic variant could modulate the clinical and hormonal characteristics of PCOS, especially in overweight and obese patients. Thus, larger studies in different ethnic groups and variable PCOS subgroups could reveal important genotype–phenotype associations.

A cross sectional study of polycystic ovarian syndrome among young women in Bhopal, Central India

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women of reproductive age groups. It is one of the leading causes of poor fertility. Risk factors include obesity, not enough physical exercise, and a family history. Most studies in India report prevalence of PCOS as 9.13% to 36%. Behaviour and life style modifications are important part of treatment for PCOS. A number of cases in the community due to lack of awareness and proper guidance, it remains undiagnosed. Aim of this study was to find the prevalence of PCOS among the young females of Bhopal city. Thus, risk assessment in the form of a survey would be one of the strategies to identify this syndrome early so as to encourage young women to seek timely treatment and prevent its long term complications. Methods: Non comparative cross sectional study for duration of 8 month. Results: The prevalence of PCOS in this study was 8.20%. Among all the risk factors, BMI ≥25 (P value &lt; 0.0001) and waist hip ratio ≥0.85 (&lt;0.0001) were strongly associated with the presence of PCOS and Lack of awareness, there were in girls (78.4%). Conclusions: Women who were having BMI ≥25 and waist hip ratio ≥0.85 should be educated about its complications and should be advised weight loss. Girls who had irregularity of menses and signs of hyperandrogenism should be investigated and must be managed accordingly. Early diagnosis of PCOS and its prompt treatment will help the girls to improve quality of life.

Evaluation of the correlation between insulin like factor 3, polycystic ovary syndrome, and ovarian maldescent

The aim of this study was to investigate a proposed correlation between the incidentally discovered undescended ovaries and their confirmed diagnosis as a polycystic ovary disease (PCOD) for all cases included, and to evaluate the role of estimated insulin like factor 3 (INSL3) circulating level in the pathogenesis of both abnormal findings. The study group (A) comprised 35 women whose ovaries had been incidentally found to be undescended during the routine laparoscopy for infertility causes, and all had been diagnosed as PCOD. The control category included two subgroups; subgroup (B) included 35 women group, diagnosed as PCOD but with normally allocated ovaries in the true pelvis, and subgroup (C) included 35 healthy women with regular menses and no signs of hyperandrogenism. Correlations between the level of INSL3 and other PCOD relevant biochemical tests: [e.g. BMI, waist-to-hip ratio (WHR), LH, FSH, androstendione (A), total and free testosterone (T & Ft), DHEA-S, and SHBG] had been also investigated. INSL3 levels were significantly higher in PCOD groups (A) and (B) compared to the healthy fertile control subgroup (C) (80.5 ± 29.4, 65.11 ± 15.6, and 41.11 ± 10.2 pg/mL, respectively), and was highest in group (A). Moreover, we identified a strong correlation between INSL3 and androstenedione (r = 0.42, p = 0.0012), and free (r = 0.42, p = .0123) and total testosterone (r = 0.41, p = .004) in the PCOD (A) and (B) subgroup compared to the levels in subgroup (C). LH was significantly higher in all PCOD women in groups (A&B) (12. 3 ± 3.4, and 11.2 ± 1.4 mIU/L, respectively) compared to those in group (A) (5.7 ± 2.5 mIU/L), with a fair correlation with INSL3. However, there was no statistically significant correlation between INSL3 and FSH, DHEA-S, glucose, basal insulin concentration or HOMA-IR in all PCOD women. The strong positive correlation between INSL3, and high ovarian androgens levels in all PCOD women, which appeared clearly in undescended polycystic ovaries could support the proposed syndrome hypothesis between those abnormal findings.

Sexual function in women with polycystic ovary syndrome and their hormonal and clinical correlations.

Polycystic ovary syndrome (PCOS) appears to be related to sexual dysfunction, especially if associated with obvious clinical and hormonal signs of hyperandrogenism. The objective of this study was to determine the correlation of PCOS and its hormonal and clinical parameters with sexual function. This prospective, cross-sectional study conducted on 18-45-year-old PCOS women (according to the Rotterdam criteria), who were referred to the Reproductive Endocrinology Research Center, Iran, was invited to participate from January 2012 to December 2015. The Female Sexual Function Index (FSFI) was used to evaluate sexual function, and serum levels of total and free testosterone, androstenedione, and sex hormone-binding globulin (SHBG) were determined and employed to calculate free androgen index (FAI) values. Univariate and multiple logistic regression analyses were performed to examine the association between sexual dysfunction and independent variables. In all, 783 participated in the study and 492 women fully completed the Female Sexual Function Index (FSFI) questionnaire. Of these, 226 (45.75%) women met the criteria for sexual dysfunction. The mean age of women was 24.91 ± 4.90 years. No significant association between having a low score for any FSFI domain and having a low serum total or free testosterone or androstenedione and SHBG level was demonstrated. There was association between FAI > 4.5 and increased sexual function score but it is not significant. Logistic regression analysis showed that there were significant associations between sexual function score and the literacy, alopecia, and infertility. No evidence of associations between low scores for any of the sexual domains evaluated and low serum total and free testosterone levels, but the low literacy, alopecia, and infertility contributed to low sexual function in women with PCOS. The burden of PCOS and sexual dysfunction suggests the need for further attention to this patient population.

Nouveautés dans l’hyperplasie congénitale des surrénales: New insights in congenital adrenal hyperplasia

Congenital adrenal hyperplasia is an autosomal recessive disease due to functional abnormalities of adrenal steroid enzymes. The most common form of the disease is due to a 21-hydroxylase deficiency. The classical forms (most severe) are characterized by a deficiency in cortisol and sometimes in aldosterone, which may compromise the vital prognosis of neonates, and by an increase in androgen synthesis, leading to the virilization of girls’ external genitalia at birth, followed by clinical signs of hyperandrogenism during childhood and adolescence. Neonatal screening has improved management and reduced morbidity and mortality in the neonatal period, but its performance could be broadly optimised by adjusting the assay techniques or the biomarkers used. The genetic diagnosis is difficult owing to the large genetic heterogeneity of the 6p21.3 region, which contains the CYP21A2 gene, especially with respect to the use of new-generation techniques of sequencing. Prenatal diagnosis is now possible as early as 6 weeks of gestation, but prenatal treatment remains controversial, awaiting results from prospective cohorts evaluating its long-term impact. Since conventional therapies have limitations, new therapies are currently being developed to allow better control of androgen synthesis and a substitutive treatment that respects the physiological rhythm of cortisol secretion, which would limit the development of long-term complications.

Differences in clinical and endocrine features between obese and non-obese women in polycystic ovarian syndrome

Background and objectives: The polycystic ovary syndrome is one of the commonest endocrine disturbance affecting 5-8% of reproductive age women. It is a heterogenous disorder that mainly presents with features of hyperandro- genism and anovulation. These clinical features are further affected by body mass index at presentation. This study aimed to estimate the impact of obesity on the clinical features of polycystic ovary syndrome and to compare hor- monal and ultrasonography features between obese and non-obese polycystic ovary syndrome women.Methods: a cross-sectional comparative study carried on 230 infertile women with criteria of polycystic ovary syndrome attend- ing Private Hawler Centre for Infertility and in vitro fertilization, Erbil, Iraq, in the period between the 1st of October 2015 and the 1st of April 2016. Results: Out of 230 polycystic ovarian syndrome women, the BMI was 25 kg/m2 in 123 ladies (53.48%); 32 ladies 13.9% were overweight and 91 ladies 39.5% were obese. Obese polycystic ovary syndrome women had more sedentary life, more family history of polycystic ovary syndrome and associated with higher miscarriage rate. Amenorrhea and oligomenorrhoea were found more frequently in obese women 24.4% and 62.6% respectively than non-obese polycystic ovary syndrome women 21.5% and 53.3%. Conclusions: Obesity has a significant impact on the appearance of clinical features of polycystic ovary syndrome among infertile women, signs of hyperandrogenism, maximum ovarian volume and mean serum level of hormones including luteinizing hormone, progesterone and testosterone were significantly more reported in obese than non-obese polycystic ovary syndrome women.

Lifestyle and PCOS: From the womb to the menopause

The polycystic ovary syndrome (PCOS) may be diagnosed in adolescence or during the reproductive years by menstrual irregularities and signs of hyperandrogenism. Reports indicate that metabolic changes are imprinted during the intrauterine life and surge at any time during lifetime, moreover after the menopause. Although the causes of PCOS are not clearly established, there are different phenotypes and clinical trajectories and risks which may be subject to intervention. In this sense, weight reduction, exercise and insulin sensitizers can improve clinical symptoms and phenotypes. In general, obesity worsens clinical symptoms and co-morbidity, hence changes in lifestyles and habits may be important, especially when severe forms of PCOS are associated to increased cardiovascular, cancer, sleep-apnea and metabolic disorder risks in postmenopausal women. Endocrine treatments during reproductive years may reduce these risks during the second half of life.

Paratubal Cyst Size Correlates With Obesity and Dysregulation of the Wnt Signaling Pathway

Study ObjectiveParatubal cysts (PTCs) occur in 7%-10% of women, regardless of age. Although common, PTCs often are found incidentally because of the potential for these cysts to be asymptomatic. The specific aims of the study were to determine if PTC number and size correlated with signs of hyperandrogenism and obesity, as well as to investigate the molecular profiles of these PTCs in samples derived from female adolescents. Design, Setting, Participants, Interventions, and Main Outcome MeasuresA prospective cohort study was performed in a single children's hospital. Girls 18 years of age or younger who underwent surgery for PTC suspected on the basis of the presence of a persistent adnexal cyst on imaging or a concern for adnexal torsion involving a cyst were consented to participate in the study. ResultsNineteen patients met enrollment criteria with a mean age at menarche of 11.2 ± 1.3 years. Most of the patients (84%; n = 16/19) had adnexal torsion at the time of diagnosis of PTC. Irregular menses and hirsutism was found in 52.6% (n = 10/19) of the patients, among whom 36.8% (n = 7/19) were obese. The mean PTC size was 10.4 ± 4.3 cm with 57.9% (n = 11/19) of the cohort having more than 1 PTC. When patients were compared on the basis of their body mass index, the size of PTCs was significantly larger in the overweight/obese group. The wingless-type (WNT) signaling members catenin beta 1 (CTNBB1) and wingless-type MMTV integration site family, member 7A (WNT7A) were upregulated in 86% (n = 12/14) and 79% (n = 11/14) of the patients, respectively. WNT7A was significantly upregulated in girls with 1 cyst and low body mass index. ConclusionA correlation exists between obesity, cyst size, and hyperandrogenism. Activation of the WNT/CTNBB1 pathway via WNT7A might play a role in PTC development.

Discriminating between virilizing ovary tumors and ovary hyperthecosis in postmenopausal women: clinical data, hormonal profiles and image studies.

The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is often difficult. To evaluate the contribution of clinical features, hormonal profiles and radiological studies to the differential diagnosis of VOT and OH. A retrospective study. A tertiary center. Clinical data, hormonal status (T, E2, LH and FSH), pelvic images (transvaginal sonography and MRI) and anatomopathology were reviewed. Thirty-four postmenopausal women with a diagnosis of VOT (13 women) and OH (21 women) were evaluated retrospectively. Clinical signs of hyperandrogenism were more prevalent in the VOT group than the OH group. Although the VOT group showed higher T and E2 levels and lower gonadotropin levels than the OH group, a great overlap occurred among the hormone levels. A pelvic MRI provided an accurate differentiation of these two conditions. In this group of patients, the main features contributing to the differential diagnosis of VOT and OH were serum levels of testosterone and gonadotropins and the presence of an ovarian nodule identified on the MRI. Although the association of clinical, hormonal and radiological features contributes to the differential diagnosis of these two conditions, histopathological analysis remains the gold standard for the diagnosis of ovarian hyperandrogenism in postmenopausal women.

Clinical Presentation of Polycystic Ovary Syndrome among Saudi Arabian Women - Jeddah, Saudi Arabia

Background: Polycystic ovary (PCO) is a highly variable condition with a wide array of presentations. The Polycystic ovary syndrome should meet at least two of the following three criteria: oligo- or anovulation; clinical and/or biochemical signs of hyperandrogenism; polycystic ovaries on ultrasound. The prevalence of PCO is largely unknown in Saudi Arabia. Objectives: The aim of this study was to investigate the reproductive hormones levels in patients with polycystic ovary syndrome (PCOS) in addition to the effect of age and body mass index (BMI) on the hormonal findings ,ultrasound and to determine the clinical, biochemical, and etiologic features of hirsutism in Saudi females. Methodology: A cross sectional study has been conducted among total of 183 patients diagnosed with PCOS had been assessed clinically along with measuring the level of reproductive hormones in Obstetrics and Gynecology Clinic at King Abdul-Aziz hospital and oncology center in Jeddah, Saudi Arabia, between June 2015 and June 2016. Conclusion: Elevated levels of luteinizing hormone / Follicle stimulating hormone LH/FSH and testosterone and reduced FSH, hormone-binding globulin (SHBG), and progesterone were predictors of PCOS. This was independent of BMI or age. Future studies with larger sample size and data on insulin levels are needed for greater understanding of the manifestations of PCOS in the Saudi population.

CLINICAL PRESENTATION OF POLYCYSTIC OVARY SYNDROME AMONG SAUDI ARABIAN WOMEN – JEDDAH – SAUDI ARABIA.

30Mar 2017 CLINICAL PRESENTATION OF POLYCYSTIC OVARY SYNDROME AMONG SAUDI ARABIAN WOMEN ? JEDDAH ? SAUDI ARABIA. Najla Abdullahh Alsibyani , Mohammed A Malibary , Ahmad Ayed Derham , Abdulrahman Abdulelah Almnabri , Nuha Khalid Jazzar , Rzan Waleed Melibari , Reem Aaidh Alnefayi and Alanoud Saed Alnefaie. Battarjee Medical College. King Abdulaziz University. Um Alqura University. Ibn Sina National College.

Using kisspeptin to assess GnRH function in an unusual case of primary amenorrhoea.

SummaryPrimary amenorrhoea is defined as the failure to commence menstruation by the age of 15 years, in the presence of normal secondary sexual development. The potential causes of primary amenorrhoea extend from structural to chromosomal abnormalities. Polycystic ovarian syndrome (PCOS) is a common cause of secondary amenorrhoea but an uncommon cause of primary amenorrhoea. An early and prompt diagnosis of PCOS is important, as up to 30% of these women are predisposed to glucose intolerance and obesity, with the subgroup of women presenting with primary amenorrhoea and PCOS displaying a higher incidence of metabolic dysfunction. We describe a case of an 18-year-old female presenting with primary amenorrhoea of unknown aetiology. Although initial investigations did not demonstrate clinical or biochemical hyperandrogenism or any radiological evidence of polycystic ovaries, a raised luteinising hormone (LH) suggested a diagnosis of PCOS. If PCOS was the correct diagnosis, then one would expect intact hypothalamic GnRH and pituitary gonadotropin release. We used the novel hormone kisspeptin to confirm intact hypothalamic GnRH release and a GnRH stimulation test to confirm intact pituitary gonadotroph function. This case highlights that kisspeptin is a potential unique tool to test GnRH function in patients presenting with reproductive disorders.Learning points:Polycystic ovarian syndrome (PCOS) can present with primary amenorrhoea, and therefore, should be considered in the differential diagnosis.PCOS is a heterogeneous condition that may present in lean women with few or absent signs of hyperandrogenism.GnRH stimulation tests are useful in evaluating pituitary function; however, to date, we do not have a viable test of GnRH function. Kisspeptin has the potential to form a novel diagnostic tool for assessing hypothalamic GnRH function by monitoring gonadotropin response as a surrogate marker of GnRH release.Confirmation of intact GnRH function helps consolidate a diagnosis in primary amenorrhoea and gives an indication of future fertility.

The cut off of Ferriman Gallwey score for PCOS in Asia and the degree of hyperandrogenism indicator

&lt;p&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To determine the distribution of the Ferriman–Gallwey score in Asia and to study any association between hirsutism and endocrine markers, and also to find the cut off of F-G score. &lt;/p&gt;&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Hirsutism is the most widely used clinical diagnostic criterion for hyperandrogenism, it is present in approximately 70% of PCOS women. Using the Ferriman- Gallwey (F-G) scoring systems for evaluation of hirsutism, the degrees of hyperandrogenism from different regions are distinct and have different cut off.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Material and methods: &lt;/strong&gt;A descriptive cross-sectional study was carried out at Dr. Cipto Mangunkusumo General Hospital Jakarta in 2015. Reproductive age women who commits with PCOS criteria were included in the study. Clinical data was taken by interview, physical examination and US examination. Patient’s blood was taken for FTI, and testosterone.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The data indicated that 32.4% PCOS woman shows clinical signs of hyperandrogenism, with the minimum score of hirsutism 2 and based on laboratory findings 34.3% subjects show high FTI and testosterone level. However not all patient with high androgen level have a high score of hirsutism. &lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; Clinical and laboratory finding of hyperandrogenism have a correlation to determine the score of Ferriman–Gallwey (F-G). The cut off is lower than European and west countries.&lt;/p&gt;

ПОСТГІСТЕРЕКТОМІЧНІ ПОРУШЕННЯ ТА ОСОБЛИВОСТІ ОЦІНКИ ЯКОСТІ ЖИТТЯ.

В останні роки відмічається розвиток міоми матки у жінок з нереалізованою репродуктивною функцією, причому зростає частка поєднаних форм гіперпластичних процесів репродуктивної системи – у 20–25 % жінок у віці до 30 років і у 60 % – у віці старше 40 років. Мета – оцінка окремих показників метаболічного гомеостазу у пацієнток з міомою матки після оперативного її оздоровлення та оцінка показників якості життя. Проведено комплексне обстеження і оперативне лікування 40 жінок репродуктивного віку з міомою матки, яким виконано гістеректомію зі збереженням придатків. У контрольну групу ввійшли 20 соматично здорових жінок. Використано загальноприйняті клініко-лабораторні обстеження, лабораторну оцінку гормонального статусу, ліпідного профілю, оцінку характеру розподілу жирової тканини і ступеня ожиріння за індексом маси тіла, ультразвукове дослідження (УЗД) органів малого таза, печінки, нирок, щитоподібної залози, молочних залоз. Якість життя вивчали на основі комплексної оцінки, з використанням модифікованої шкали SF-36 та дослідженням таких важливих показників, як енергійність, сон, емоційні реакції, соціальна ізоляція, фізична активність, больові відчуття. Усі види статистичної обробки виконано за допомогою стандартного пакета «Statistica for Windows – 6,0». Загалом, при аналізі показників гормонального профілю у жінок із проявами постгістеректомічного синдрому через 5 років після операції встановлено у 36,66 % випадків статистично достовірне підвищення рівня пролактину, у 40,00 % – гіпоестрогенію та у 46,66 % пацієнток – ознаки гіперандрогенії, підтверджені лабораторними критеріями. Зміна якості життя у пацієнток із гіперпластичними процесами матки у післяопераційному періоді проявлялася: зниженням фізичної активності у 43,33 % випадків, ростом сексуальних дисфункцій – у 36,66 %, пригніченням психічного стану, конфліктною спрямованістю соціальної поведінки, ослабленням ролевих функцій та суб’єктивним погіршенням загального здоров’я та якості життя у 51,66 % випадків. Віддалені наслідки після оперативного втручання супроводжуються прогресивною гіпоестрогенією із погіршенням функції яєчників, що відображалося у зменшенні їх об’єму при ультразвуковому дослідженні, зменшенні числа та розмірів фолікулів, погіршенні кровопостачання яєчників, зниженні кровотоку в басейні внутрішньої здухвинної артерії та суб’єктивним погіршенням загального здоров’я та якості життя.

Síndrome de ovario poliquístico: fenotipos y enfermedad cardiovascular

IntroductionPolycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. It is associated with insulin resistance (IR) and high cardiovascular risk (CVR). According to the Rotterdam consensus, four PCOS phenotypes could be established: three with clinical and/or biochemical hyperandrogenism (HA), and one non-hyperandrogenic (NHA). It is necessary to identify which of these patients are at risk of metabolic disturbances and CVR. Two indexes: lipid accumulation product (LAP) and visceral adiposity index (VAI) have been suggested as reliable markers of IR and CVR in PCOS. ObjectiveThe present study aims to assess the reliability of LAP and VAI as IR markers in a young local population of PCOS patients. Their association with CVR parameters is also evaluated. MethodologyLAP and VAI were calculated in 130 PCOS patients. The PCOS patients were divided in two groups as HA and NHA, taking into account the signs of hyperandrogenism (clinical or biochemical). An evaluation was also made of the metabolic and anthropometric characteristics of the population and their association with CVR and IR. ResultsBoth LAP and VAI showed to be effective markers to asses CVR and IR in these PCOS women (cutoff values: LAP: 14.02 (sensitivity: 93.94% specificity: 93.22%) VAI: 2.17 (sensitivity: 87.88% specificity: 91.38%). There was a positive correlation of both markers with abdominal circumference and triglycerides (TG), and negative with HDL-cholesterol. The risk of IR and metabolic disturbances was similar in both phenotypes (NHA versus HA). ConclusionOur data show that both LAP and VAI are representative markers for assessing IR and associated CVR in PCOS patients. These results also suggest that the NHA phenotype in the population studied shows the same risk of metabolic disturbances and cardiovascular disease when compared to HA phenotypes.

The Relationship Between Acne and Other Hyperandrogenism Signs

Background: One of the significant signs that may occur in patients suffering from hyperandrogenism is acne. It is obvious that knowing the cause and exact reason of each sign helps the physician come up with better examination and conclusion regarding the symptoms related to hyperandrogenism. Methods: We conducted a case-control study at the department of dermatology of Farshchian hospital in Hamadan, Iran, on 110 cases who continuously had been diagnosed with acne. The control subjects were outpatients that did not have acne but came to the clinic for consultation on dermatologic diseases other than hyperandrogenism. The patients were asked about the presence or absence of acne, age, menstrual regularity, body weight, height, hirsutism, androgenetic alopecia, family members with acne history, and food habits. Results: Acne was strongly associated with higher BMI, alopecia, menstrual dysfunction, positive familial history, and overuse of sweet and fatty foods. There was no association between acne and hirsutism. Some degrees of overmatching may arise from choosing dermatologic control subjects as well as from inclusion of other complaints. Conclusions: BMI, Alopecia, menstrual dysfunction, positive familial history, and overuse of sweet and fatty foods may influence the risk of acne.

Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) as Markers of Insulin Resistance and Metabolic Associated Disturbances in Young Argentine Women with Polycystic Ovary Syndrome.

Polycystic ovary syndrome (PCOS) is an endocrine disorder. PCOS women are at high risk of developing insulin resistance (IR) and cardiovascular disorders since young age. We aimed to study the reliability of lipid accumulation product (LAP) and visceral adiposity index (VAI) as markers of metabolic disturbances (MD) associated with IR in young reproductive aged PCOS patients. We also evaluated the association between LAP and VAI and the presence of hyperandrogenism. In a cross-sectional study, 110 PCOS patients and 88 control women (18-35 years old) were recruited. PCOS patients were divided into 2 groups, as hyperandrogenic and non-hyperandrogenic considering the signs of hyperandrogenism (clinical or biochemical). Anthropometric measurements were taken and blood samples collected. Metabolic and anthropometric characteristics and their association with IR and associated MD were evaluated and LAP and VAI were calculated. LAP and VAI were compared with TC/HDL-c and TG/HDL-c to define the best markers of MD in this population. Independently of the phenotype, young PCOS patients showed high IR and dyslipidemia. Both LAP and VAI showed to be more effective markers to assess MD and IR in these young women than TG/HDL-c or TC/HDL-c [cut-off values: LAP: 18.24 (sensitivity: 81.43% specificity: 73.49%), positive predictive value (PPV): 75.0%, negative predictive value (NPV): 77.27%, VAI: 2.19 (sensitivity: 81.16% specificity: 72.15% PPV: 74.65% NPV: 72.22%)]. LAP and VAI are representative markers to assess MD associated with IR in young PCOS patients. All PCOS patients, independently of their androgenic condition, showed high metabolic risk.

Metabolic evaluation and measurement of ovarian volume in polycystic ovary sydrome: a cross-sectional observational study

Amac: Polikistik over sendromu (PKOS), hirsutizm veya laboratuvar degerlendirmesinde hiperandrojenemi bulgulari, adet duzensizligi ve anovulasyona bagli infertiliteye yol acabilen ve ureme cagindaki kadinlari etkileyen onemli bir hastaliktir. Beraberinde yer alan insulin direnci ve adipozite artisi kardiyometabolik risk artisina da neden olabilmektedir. Biz calismamizda PKOS dusunulen hastalarin muayene ve laboratuar bulgulari ile overlerin abdominal ultrasonografi ile degerlendirme sonuclarini sunmayi planladik. Gerec ve Yontem: Calismaya endokrinoloji poliklinigine hirsutizm, adet duzensizligi gibi semptomlarla basvuran ve PKOS tanisi dusunulen 22 kadin hasta alindi. Hastalarin yasi, aile oykusu, PKOS fenotipleri, ilk adet yasi, siklus uzunlugu ve fizik muayene bulgulari kaydedildi. Hirsutizm icin Ferriman&Gallwey skoru kullanildi. Biyokimyasal ve hormonal tetkikleri yapilarak HOMA-IR yontemi ile insulin direnci hesaplandi. Abdominal ultrasonografi ile over volumleri olculdu. Verilerin istatistiksel analizi icin SPSS-16 kullanildi. Bulgular: Yas ortalamasi 21.41±0.88 yil olan hastalarin %40.9’u B, %31.8’i C ve %27.3’u A PKOS fenotipik ozelliklerini gosteriyordu. Siklus uzunlugu degerlendirildiginde hastalarin %31.8’inde siklus normal (27-34 gun) bulundu. Hastalarin hepsinde Ferriman&Gallwey skoru ≥7 idi. Hirsutizm orani yuksek olmasina ragmen androjen duzeyleri genellikle normal bulundu (testosteron %72 normal, DHEAS %82 normal). Hastalarin 8’i (% 36) obez ve 3’u (%13.6) fazla kilolu idi. Hastalarin %40.9’unun birinci derece yakininda tip 2 diyabetes mellitus mevcuttu. Tum hastalarin aclik glukoz ve 75 gr OGTT sonrasi glukoz duzeyleri normaldi. HOMA-IR yontemi ile hastalarin %41’inde insulin direnci saptandi. Hastalarin LDL kolesterol ve trigliserid duzeyleri ile AST, ALT ve GGT duzeyleri normal bulunurken, 15 (%68) hastada HDL kolesterol 50 mg/dl altindaydi. Abdominal ultrasonografide over volumleri ortalama sagda 11.6±1.12ml, solda 11.5±1.01ml olculdu ve 13 hastada (%59.1) polikistik over gorunumu mevcuttu. Sonuc: Hastalarimizin tamaminda hirsutizm saptanirken, buyuk kisminda siklus duzensizligi, ultrasonografide over volumu artisi ve PKO gorunumu ile PKOS tanisi desteklenmistir. Ancak PKOS hastalarimizda laboratuar olarak hiperandrojenizm bulgulari, insulin direnci ve obezite daha az oranda gorulmustur

Mccune Albright Syndrome and Polycystic Ovary Syndrome in a Single Individual

Mccune Albright Syndrome and Polycystic Ovary Syndrome in a Single Individual